Publication Information

{'id': 'https://openalex.org/W3083474699', 'doi': 'https://doi.org/10.3892/ol.2020.12058', 'title': 'High glypican‑1 expression is a prognostic factor for predicting a poor clinical prognosis in patients with hepatocellular carcinoma', 'display_name': 'High glypican‑1 expression is a prognostic factor for predicting a poor clinical prognosis in patients with hepatocellular carcinoma', 'publication_year': 2020, 'publication_date': '2020-09-04', 'ids': {'openalex': 'https://openalex.org/W3083474699', 'doi': 'https://doi.org/10.3892/ol.2020.12058', 'mag': '3083474699', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32963603', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7491109'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/ol.2020.12058', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/ol.2020.12058/download', 'source': {'id': 'https://openalex.org/S58832373', 'display_name': 'Oncology Letters', 'issn_l': '1792-1074', 'issn': ['1792-1074', '1792-1082'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.spandidos-publications.com/10.3892/ol.2020.12058/download', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101964682', 'display_name': 'Guoyong Chen', 'orcid': 'https://orcid.org/0000-0002-0267-8830'}, 'institutions': [{'id': 'https://openalex.org/I4210133534', 'display_name': "Henan Provincial People's Hospital", 'ror': 'https://ror.org/03f72zw41', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210133534']}, {'id': 'https://openalex.org/I173899330', 'display_name': 'Henan University', 'ror': 'https://ror.org/003xyzq10', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I173899330']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Guoyong Chen', 'raw_affiliation_strings': ["Department of Hepatobiliary Surgery, Henan Provincial People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, Henan 450003, P.R. China"], 'affiliations': [{'raw_affiliation_string': "Department of Hepatobiliary Surgery, Henan Provincial People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, Henan 450003, P.R. China", 'institution_ids': ['https://openalex.org/I4210133534', 'https://openalex.org/I173899330']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101645077', 'display_name': 'Hao Wu', 'orcid': 'https://orcid.org/0000-0002-9428-3982'}, 'institutions': [{'id': 'https://openalex.org/I191996457', 'display_name': 'Dalian Medical University', 'ror': 'https://ror.org/04c8eg608', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I191996457']}, {'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}, {'id': 'https://openalex.org/I4210097509', 'display_name': 'Second Affiliated Hospital of Chongqing Medical University', 'ror': 'https://ror.org/00r67fz39', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097509']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hao Wu', 'raw_affiliation_strings': ['Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China', 'institution_ids': ['https://openalex.org/I191996457', 'https://openalex.org/I87780372', 'https://openalex.org/I4210097509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100434072', 'display_name': 'Lei Zhang', 'orcid': 'https://orcid.org/0009-0008-9783-092X'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lei Zhang', 'raw_affiliation_strings': ["Department of Hepatobiliary Surgery, Fengjie People's Hospital, Chongqing 404600, P.R. China"], 'affiliations': [{'raw_affiliation_string': "Department of Hepatobiliary Surgery, Fengjie People's Hospital, Chongqing 404600, P.R. China", 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100769348', 'display_name': 'Sidong Wei', 'orcid': 'https://orcid.org/0000-0002-4518-2296'}, 'institutions': [{'id': 'https://openalex.org/I4210133534', 'display_name': "Henan Provincial People's Hospital", 'ror': 'https://ror.org/03f72zw41', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210133534']}, {'id': 'https://openalex.org/I173899330', 'display_name': 'Henan University', 'ror': 'https://ror.org/003xyzq10', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I173899330']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Sidong Wei', 'raw_affiliation_strings': ["Department of Hepatobiliary Surgery, Henan Provincial People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, Henan 450003, P.R. China"], 'affiliations': [{'raw_affiliation_string': "Department of Hepatobiliary Surgery, Henan Provincial People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, Henan 450003, P.R. China", 'institution_ids': ['https://openalex.org/I4210133534', 'https://openalex.org/I173899330']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.98, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.999902, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '20', 'issue': '5', 'first_page': '1', 'last_page': '1'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10073', 'display_name': 'Hepatocellular Carcinoma Treatment and Prognosis', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12793', 'display_name': 'Caveolin-1 and cellular processes', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glypican-3', 'display_name': 'Glypican 3', 'score': 0.44801754}, {'id': 'https://openalex.org/keywords/clinical-significance', 'display_name': 'Clinical Significance', 'score': 0.444427}], 'concepts': [{'id': 'https://openalex.org/C2778019345', 'wikidata': 'https://www.wikidata.org/wiki/Q1148337', 'display_name': 'Hepatocellular carcinoma', 'level': 2, 'score': 0.7054615}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.66641515}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.6191619}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.567556}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.5612268}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.53480375}, {'id': 'https://openalex.org/C146357865', 'wikidata': 'https://www.wikidata.org/wiki/Q1123245', 'display_name': 'Stage (stratigraphy)', 'level': 2, 'score': 0.52957654}, {'id': 'https://openalex.org/C50382708', 'wikidata': 'https://www.wikidata.org/wiki/Q223218', 'display_name': 'Proportional hazards model', 'level': 2, 'score': 0.49615917}, {'id': 'https://openalex.org/C67082663', 'wikidata': 'https://www.wikidata.org/wiki/Q3523816', 'display_name': 'Molecular medicine', 'level': 4, 'score': 0.4919481}, {'id': 'https://openalex.org/C2779742787', 'wikidata': 'https://www.wikidata.org/wiki/Q18026064', 'display_name': 'Glypican 3', 'level': 3, 'score': 0.44801754}, {'id': 'https://openalex.org/C63363279', 'wikidata': 'https://www.wikidata.org/wiki/Q5133848', 'display_name': 'Clinical significance', 'level': 2, 'score': 0.444427}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.42125398}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.41826525}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.41323894}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.374125}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22512019}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/ol.2020.12058', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/ol.2020.12058/download', 'source': {'id': 'https://openalex.org/S58832373', 'display_name': 'Oncology Letters', 'issn_l': '1792-1074', 'issn': ['1792-1074', '1792-1082'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491109', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32963603', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/ol.2020.12058', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/ol.2020.12058/download', 'source': {'id': 'https://openalex.org/S58832373', 'display_name': 'Oncology Letters', 'issn_l': '1792-1074', 'issn': ['1792-1074', '1792-1082'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.88, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1500925570', 'https://openalex.org/W1964184380', 'https://openalex.org/W1982576397', 'https://openalex.org/W2009007035', 'https://openalex.org/W2014463647', 'https://openalex.org/W2035841359', 'https://openalex.org/W2066464689', 'https://openalex.org/W2067826589', 'https://openalex.org/W2080129352', 'https://openalex.org/W2097929013', 'https://openalex.org/W2107277218', 'https://openalex.org/W2111778007', 'https://openalex.org/W2118583622', 'https://openalex.org/W2131489568', 'https://openalex.org/W2155247283', 'https://openalex.org/W2212059098', 'https://openalex.org/W2272984102', 'https://openalex.org/W2294283884', 'https://openalex.org/W2294798900', 'https://openalex.org/W2398947085', 'https://openalex.org/W2441351280', 'https://openalex.org/W2523812812', 'https://openalex.org/W2570618306', 'https://openalex.org/W2594591698', 'https://openalex.org/W2594810742', 'https://openalex.org/W2601388231', 'https://openalex.org/W2609386196', 'https://openalex.org/W2794998551', 'https://openalex.org/W2894770232', 'https://openalex.org/W2898595038', 'https://openalex.org/W2912661332', 'https://openalex.org/W3015871015'], 'related_works': ['https://openalex.org/W4372351819', 'https://openalex.org/W2953866084', 'https://openalex.org/W2905335103', 'https://openalex.org/W2884642709', 'https://openalex.org/W2396096014', 'https://openalex.org/W2386104765', 'https://openalex.org/W2247680037', 'https://openalex.org/W2165801694', 'https://openalex.org/W2012899811', 'https://openalex.org/W1990949341'], 'abstract_inverted_index': {'Hepatocellular': [0], 'carcinoma': [1], '(HCC)': [2], 'has': [3], 'a': [4, 10, 215, 230], 'high': [5, 145, 167, 208], 'mortality': [6], 'rate,': [7], 'which': [8], 'imposes': [9], 'huge': [11], 'burden': [12], 'on': [13], 'patients': [14, 87, 135, 198, 219], 'and': [15, 42, 54, 66, 70, 73, 93, 153, 176, 186, 195, 222, 236], 'society.': [16], 'Glypican‑1': [17], '(GPC1)': [18], 'is': [19], 'considered': [20], 'to': [21, 31, 59, 99], 'be': [22, 227], 'an': [23], 'ideal': [24], 'diagnostic': [25], 'marker.': [26], 'The': [27, 106], 'present': [28, 107, 204], 'study': [29], 'aimed': [30], 'investigate': [32, 60], 'GPC1': [33, 61, 79, 111, 131, 146, 163, 168, 187, 209], 'expression': [34, 62, 112, 147, 169, 188, 210], 'in': [35, 46, 63, 71, 86, 115, 119, 126, 134, 139, 197, 218], 'HCC,': [36], 'its': [37, 43], 'association': [38], 'with': [39, 88, 136, 144, 159, 161, 173, 199, 214, 220], 'clinicopathological': [40], 'factors': [41, 192], 'prognostic': [44, 102], 'significance': [45, 103], 'HCC': [47, 65, 72, 116, 127, 137, 221], 'progression.': [48], 'Reverse': [49], 'transcription‑quantitative': [50], 'PCR,': [51], 'western': [52], 'blotting': [53], 'immunohistochemical': [55], 'staining': [56], 'were': [57, 80, 97, 124, 189], 'used': [58, 98, 228], '175': [64], 'paired': [67], 'normal': [68, 74], 'tissues,': [69, 117], 'cells.': [75], 'Serolo2gical': [76], 'levels': [77], 'of': [78, 104, 238], 'examined': [81], 'via': [82], 'enzyme‑linked': [83], 'immunosorbent': [84], 'assay': [85], 'HCC.': [89, 121, 200, 239], 'Kaplan‑Meier': [90], 'survival': [91, 151, 155], 'analysis': [92, 96], 'Cox': [94], 'regression': [95], 'assess': [100], 'the': [101, 203], 'GPC1.': [105], 'results': [108, 123, 205], 'suggested': [109], 'that': [110, 207, 223], 'was': [113, 132, 170, 211], 'upregulated': [114], 'especially': [118], 'metastatic': [120], 'Similar': [122], 'observed': [125], 'cell': [128], 'lines.': [129], 'Serum': [130], 'higher': [133], 'than': [138], 'healthy': [140], 'controls': [141], '(HCs).': [142], 'Patients': [143], 'had': [148], 'shorter': [149], 'recurrence‑free': [150], '(RFS)': [152], 'disease‑specific': [154], '(DSS)': [156], 'times': [157], 'compared': [158], 'those': [160], 'low': [162], 'expression.': [164], 'In': [165, 201], 'addition,': [166], 'significantly': [171], 'associated': [172, 213], 'tumor': [174, 182], 'size': [175], 'Tumor‑Node‑Metastasis': [177], '(TNM)': [178], 'stage': [179, 185], '(P<0.05).': [180], 'Furthermore,': [181], 'size,': [183], 'TNM': [184], 'independent': [190], 'predictive': [191], 'for': [193, 233], 'RFS': [194], 'DSS': [196], 'conclusion,': [202], 'revealed': [206], 'closely': [212], 'poor': [216], 'prognosis': [217], 'it': [224], 'may': [225], 'therefore': [226], 'as': [229], 'potential': [231], 'target': [232], 'accurate': [234], 'diagnosis': [235], 'treatment': [237]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3083474699', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2025-01-05T20:52:28.965228', 'created_date': '2020-09-11'}