Small molecule strategies to harness the unfolded protein response: where do we go from here?

Name: Work Video:
Duration: 3 min 30 s
Julia M. D. Grandjean; R. Luke Wiseman
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3598, 3664, 3685, 3725], 'response': [3, 19, 234, 250, 641, 691, 804, 834, 946, 974, 1302, 1399, 1448, 1476, 1539, 1788, 1818, 1866, 1887, 1915, 2233, 2480, 2648, 2734, 2792, 3037, 3253, 3406, 3762], '(UPR)': [4, 235], 'plays': [5, 236], 'a': [6, 237, 643, 915, 920, 1366, 1528, 2402, 2407, 2445, 2458, 2463, 2490, 2523, 2874, 3068, 3245, 3462, 3550, 3699, 3715, 3768], 'central': [7, 238, 2046], 'role': [8, 239, 576, 1530], 'in': [9, 18, 66, 71, 96, 113, 117, 128, 140, 163, 187, 205, 208, 240, 249, 297, 302, 327, 344, 348, 359, 371, 394, 418, 436, 439, 583, 589, 620, 640, 657, 835, 900, 909, 935, 1085, 1112, 1229, 1256, 1301, 1373, 1447, 1531, 1538, 1561, 1575, 1648, 1766, 1819, 1851, 1867, 1888, 1916, 1943, 2006, 2018, 2026, 2041, 2146, 2202, 2254, 2279, 2314, 2317, 2342, 2368, 2416, 2496, 2556, 2598, 2647, 2691, 2733, 2895, 2933, 3002, 3036, 3067, 3073, 3137, 3247, 3252, 3279, 3306, 3367, 3554, 3698, 3701, 3722, 3761, 3821], 'regulating': [10, 241, 954, 1374, 1552], 'endoplasmic': [11, 242, 463, 488, 524, 550, 579, 977, 1091, 1114, 1153, 1235, 1258, 1402, 1609, 1911, 2484, 2518, 2650, 2761, 2788, 2897, 3139, 3226, 3285, 3308, 3342, 3431], 'reticulum': [12, 243, 464, 489, 551, 580, 713, 741, 853, 1115, 1154, 1259, 1610, 1912, 2485, 2519, 2651, 2762, 2789, 2898, 3227, 3309, 3343, 3432], '(ER)': [13, 244, 465], 'and': [14, 41, 49, 61, 88, 121, 131, 143, 156, 182, 185, 207, 245, 272, 280, 292, 319, 352, 362, 374, 387, 413, 416, 438, 477, 487, 527, 552, 615, 678, 716, 744, 805, 830, 855, 956, 1027, 1050, 1081, 1157, 1171, 1194, 1225, 1319, 1333, 1338, 1349, 1389, 1477, 1504, 1535, 1595, 1778, 1789, 1814, 1862, 1919, 2199, 2304, 2316, 2410, 2437, 2462, 2470, 2545, 2742, 2750, 2868, 2929, 2970, 3012, 3205, 3215, 3251, 3259, 3275, 3331, 3360, 3505, 3524, 3529, 3593, 3659, 3757, 3817], 'global': [15, 246, 1339], 'cellular': [16, 59, 130, 206, 247, 290, 361, 437, 957, 1340, 1351, 1378, 2315, 2737], 'physiology': [17, 248, 958, 1341], 'to': [20, 54, 93, 100, 108, 152, 211, 251, 285, 324, 331, 339, 383, 442, 642, 662, 779, 905, 931, 1083, 1227, 1303, 1344, 1449, 1466, 1540, 1545, 1565, 1695, 1770, 2047, 2174, 2251, 2266, 2270, 2331, 2345, 2373, 2434, 2486, 2563, 2593, 2649, 2724, 2735, 2763, 2967, 3038, 3200, 3228, 3254, 3277, 3344, 3543, 3763, 3766], 'pathologic': [21, 111, 155, 252, 342, 386, 907, 1541], 'ER': [22, 36, 56, 253, 267, 287, 638, 658, 828, 899, 910, 933, 955, 961, 964, 1025, 1142, 1169, 1307, 1317, 1324, 1337, 1347, 1453, 1542, 1553, 1696, 1812, 1860, 2448, 2455, 2740, 2839, 2854, 2861, 2882, 2930, 3046, 3089, 3249, 3255, 3764], 'stress.': [23, 254], 'UPR': [25, 67, 114, 127, 146, 161, 171, 192, 226, 256, 298, 345, 358, 377, 392, 402, 423, 457, 1133, 1329, 1363, 1463, 1526, 1549, 1562, 1767, 1836, 2000, 2144, 2263, 2278, 2291, 2312, 2432, 2554, 3847], 'is': [26, 257, 466, 648, 940, 1371, 1556, 1646, 1838, 1849, 1939, 2358, 2411, 2438, 2444, 2548, 2731, 3188, 3689, 3714, 3753], 'comprised': [27, 258], 'of': [28, 34, 74, 125, 145, 160, 202, 224, 259, 265, 305, 356, 376, 391, 433, 455, 519, 577, 623, 637, 666, 687, 897, 923, 926, 938, 1052, 1089, 1140, 1196, 1233, 1279, 1306, 1312, 1327, 1336, 1377, 1382, 1506, 1548, 1740, 1745, 1773, 1835, 1892, 1974, 2009, 2073, 2079, 2122, 2142, 2149, 2229, 2302, 2311, 2351, 2364, 2380, 2515, 2572, 2712, 2752, 2819, 2825, 2836, 2927, 3007, 3014, 3041, 3085, 3133, 3185, 3195, 3217, 3283, 3333, 3373, 3411, 3500, 3536, 3546, 3588, 3654, 3814], 'three': [29, 260, 1135, 1296, 2452], 'signaling': [30, 51, 68, 107, 115, 162, 261, 282, 299, 338, 346, 393, 950, 1002, 1136, 1297, 1368, 1427, 1468, 1537, 1550, 1563, 1768, 1837, 1848, 1998, 2001, 2145, 2264, 2313, 2356, 2555, 2646, 2758, 3050, 3197, 3223, 3339, 3385], 'pathways': [31, 262, 1137, 1298, 1330, 2002, 2154, 2265], 'activated': [32, 263, 1138, 1300, 2732], 'downstream': [33, 264, 1139, 3193, 3384], 'the': [35, 72, 123, 126, 141, 154, 176, 200, 220, 266, 303, 354, 357, 372, 385, 407, 431, 451, 517, 553, 578, 621, 688, 752, 773, 831, 895, 898, 927, 936, 943, 971, 976, 1004, 1028, 1053, 1086, 1090, 1113, 1141, 1172, 1197, 1230, 1234, 1257, 1280, 1310, 1316, 1323, 1346, 1362, 1396, 1401, 1429, 1507, 1525, 1546, 1576, 1581, 1746, 1815, 1863, 1893, 2007, 2019, 2027, 2042, 2147, 2168, 2230, 2272, 2277, 2309, 2348, 2359, 2365, 2381, 2430, 2440, 2483, 2487, 2549, 2570, 2710, 2719, 2753, 2760, 2764, 2815, 2820, 2822, 2843, 2860, 2869, 2896, 2934, 2972, 3008, 3015, 3032, 3039, 3045, 3074, 3083, 3131, 3138, 3168, 3182, 3192, 3218, 3225, 3229, 3248, 3280, 3284, 3307, 3334, 3341, 3345, 3501, 3508, 3534, 3555, 3589, 3596, 3617, 3624, 3655, 3662, 3680, 3693, 3723, 3845], 'membrane': [37, 268, 2449, 3250], 'proteins': [38, 46, 269, 277, 1145, 1314, 2521, 3043, 3087, 3161], 'IRE1,': [39, 103, 270, 334], 'ATF6,': [40, 104, 271, 335], 'PERK.': [42, 273], 'Once': [43, 274], 'activated,': [44, 275], 'these': [45, 118, 203, 276, 349, 434, 1328, 2153, 2327], 'initiate': [47, 278], 'transcriptional': [48, 279, 1332], 'translational': [50, 222, 281, 453, 1334, 2338], 'that': [52, 216, 283, 447, 1342, 1370, 1455, 1559, 1691, 2030, 2257, 2288, 2335, 2851, 3060, 3079, 3165, 3371, 3718], 'functions': [53, 284, 1051, 1195, 1343, 1364, 1505], 'alleviate': [55, 286, 1345], 'stress,': [57, 288, 714, 1308], 'adapt': [58, 289], 'physiology,': [60, 291, 1379], 'dictate': [62, 293], 'cell': [63, 294, 520, 806, 1478, 1790, 2558], 'fate.': [64, 295], 'Imbalances': [65, 296], 'are': [69, 300, 660, 1299, 1584, 1688, 2037, 3162, 3198], 'implicated': [70, 116, 301, 347, 1850, 2040], 'pathogenesis': [73, 304, 2005, 2049, 2148], 'numerous,': [75, 306], 'etiologically-diverse': [76, 307, 2150], 'diseases,': [77, 81, 84, 308, 312, 315, 675, 1588], 'including': [78, 309, 472, 669, 1309, 1380, 1589, 1775, 2739], 'many': [79, 310, 1852], 'neurodegenerative': [80, 311, 679, 1779, 1854, 1889, 1917], 'misfolding': [83, 314], 'diabetes,': [85, 316, 671], 'ischemic': [86, 317, 676, 2203], 'disorders,': [87, 318, 677], 'cancer.': [89, 320], 'This': [90, 321, 2012, 2248, 3676], 'has': [91, 136, 322, 367, 912, 2249], 'led': [92, 323, 2250], 'significant': [94, 138, 325, 369, 2252], 'interest': [95, 326, 2253], 'establishing': [97, 328, 2255], 'pharmacologic': [98, 329, 903], 'strategies': [99, 177, 330, 408, 930], 'selectively': [101, 332], 'modulate': [102, 333], 'or': [105, 336, 1451, 1572, 1763, 1995, 2033, 2260], 'PERK': [106, 337, 1582, 1686, 1847, 1894], 'both': [109, 340, 1533, 2038, 3358], 'ameliorate': [110, 341, 906], 'imbalances': [112, 343, 908], 'different': [119, 350, 1853, 2541], 'diseases': [120, 351, 680, 1780, 1855, 2151], 'define': [122, 353, 2271], 'importance': [124, 355, 896, 1547, 2141, 2310], 'diverse': [129, 360, 1304, 1375, 1771, 2736], 'organismal': [132, 363, 651], 'contexts.': [133, 364], 'Recently,': [134, 365], 'there': [135, 366], 'been': [137, 368, 3365], 'progress': [139, 370], 'identification': [142, 373], 'characterization': [144, 375], 'modulating': [147, 172, 378, 403], 'compounds,': [148, 173, 379, 404], 'providing': [149, 380], 'new': [150, 381, 2268], 'opportunities': [151, 382, 2269], 'probe': [153, 384], 'potentially': [157, 388], 'therapeutic': [158, 389, 917, 1922, 2158, 2273], 'implications': [159, 390, 3506, 3594, 3660], 'human': [164, 229, 395, 460, 667, 693, 1566, 2010, 2280, 2343, 3530], 'disease.': [165, 230, 396, 461, 2011, 2281], 'Here,': [166, 397, 2282], 'we': [167, 195, 398, 426, 2283, 2322, 2715], 'describe': [168, 399], 'currently': [169, 400, 2285], 'available': [170, 401, 2286, 2328], 'specifically': [174, 405, 2293], 'highlighting': [175, 406, 2294], 'used': [178, 409], 'for': [179, 190, 228, 410, 421, 459, 650, 919, 953, 1551, 2076, 2157, 2234, 2275, 2307, 2340, 2413, 3507, 3595, 3661], 'their': [180, 188, 411, 419, 2299, 2305, 2795], 'discovery': [181, 412], 'specific': [183, 414, 2333], 'advantages': [184, 415], 'disadvantages': [186, 417], 'application': [189, 201, 420, 432, 2341], 'probing': [191, 422], 'function.': [193, 424], 'Furthermore,': [194, 425], 'discuss': [196, 427, 2284], 'lessons': [197, 428, 2324], 'learned': [198, 429, 2325], 'from': [199, 430, 751, 777, 975, 1400, 2172, 2326, 2371, 2482, 2759, 3031, 3224, 3340], 'compounds': [204, 435, 2256, 2287, 2330], 'vivo': [209, 440, 2318], 'models': [210, 441, 1945], 'identify': [212, 443, 2332], 'favorable': [213, 444], 'compound': [214, 445], 'properties': [215, 446, 2334], 'can': [217, 448, 2003], 'help': [218, 449, 2346], 'drive': [219, 450], 'further': [221, 452], 'development': [223, 454, 2045, 2350], 'selective': [225, 456], 'modulators': [227, 458], 'associated': [467, 1585, 1840, 1940, 2552], 'with': [468, 654, 1586, 1650, 1841, 1941, 1969, 2553, 2831, 3044, 3549], 'critical': [469, 1529], 'biological': [470], 'functions,': [471], 'secretion,': [474], 'lipid': [475, 1320, 2743, 2785], 'synthesis,': [476], 'calcium': [478], 'regulation': [479, 636, 1049, 1193, 1503, 2571], '(1Fagone': [480], 'P.': [481, 605, 1000, 1075, 1219, 1425, 1674, 1731, 1907, 1950, 1962, 2098, 2512, 2627, 2748, 3104, 3129, 3159, 3213, 3269, 3329, 3402, 3429, 3709], 'Jackowski': [482], 'S.': [483, 682, 827, 996, 1107, 1251, 1421, 1811, 1859, 1980, 2067, 2114, 2129, 2399, 2637, 2639, 2669, 2698, 2802, 2890, 2957, 3145, 3301, 3444, 3877], 'Membrane': [484, 2784], 'phospholipid': [485], 'synthesis': [486], 'function.J.': [490], 'Lipid': [491], 'Res.': [492, 1032, 1176, 1616], '2009;': [493, 3413], '50': [494], '(18952570):': [495], 'S311-S31610.1194/jlr.R800049-JLR200Abstract': [496], 'Full': [497, 499, 535, 537, 724, 726, 787, 789, 814, 816, 985, 987, 1410, 1412, 1486, 1488, 1798, 1800, 2182, 2184, 2211, 2213, 2530, 2980, 2982, 3731, 3733, 3777, 3779, 3856, 3858], 'Text': [498, 500, 536, 538, 725, 727, 788, 790, 815, 817, 986, 988, 1411, 1413, 1487, 1489, 1799, 1801, 2183, 2185, 2212, 2214, 2531, 2981, 2983, 3732, 3734, 3778, 3780, 3857, 3859], 'PDF': [501, 539, 728, 791, 818, 989, 1414, 1490, 1802, 2186, 2215, 2532, 2984, 3735, 3781, 3860], 'PubMed': [502, 540, 564, 599, 629, 701, 729, 760, 792, 819, 843, 865, 889, 990, 1016, 1037, 1065, 1101, 1127, 1181, 1209, 1245, 1271, 1290, 1415, 1441, 1491, 1519, 1621, 1658, 1756, 1803, 1827, 1875, 1901, 1930, 1986, 2090, 2135, 2187, 2216, 2243, 2391, 2424, 2504, 2533, 2607, 2659, 2704, 2771, 2808, 2910, 2943, 2985, 3021, 3117, 3151, 3176, 3236, 3295, 3321, 3352, 3417, 3450, 3517, 3605, 3671, 3736, 3782, 3829, 3861], 'Scopus': [503, 541, 565, 600, 630, 702, 730, 761, 793, 820, 844, 866, 890, 991, 1017, 1038, 1066, 1102, 1128, 1182, 1210, 1246, 1272, 1291, 1416, 1442, 1492, 1520, 1622, 1659, 1757, 1804, 1828, 1876, 1902, 1931, 1987, 2091, 2136, 2188, 2217, 2244, 2392, 2534, 2660, 2705, 2772, 2809, 2911, 2944, 2986, 3022, 3152, 3177, 3237, 3296, 3322, 3353, 3418, 3451, 3518, 3606, 3672, 3737, 3783, 3830, 3862], '(197)': [504], 'Google': [505, 543, 567, 602, 632, 704, 732, 763, 795, 822, 846, 868, 892, 993, 1019, 1040, 1068, 1104, 1130, 1184, 1212, 1248, 1274, 1293, 1418, 1444, 1494, 1522, 1624, 1661, 1704, 1759, 1806, 1830, 1878, 1904, 1933, 1989, 2093, 2138, 2190, 2219, 2246, 2394, 2425, 2505, 2536, 2608, 2662, 2707, 2774, 2811, 2913, 2946, 2988, 3024, 3118, 3154, 3179, 3239, 3298, 3324, 3355, 3420, 3453, 3520, 3608, 3674, 3739, 3785, 3832, 3864], 'Scholar,': [506, 544, 568, 603, 705, 733, 764, 796, 823, 847, 869, 994, 1020, 1041, 1069, 1105, 1185, 1213, 1249, 1275, 1419, 1495, 1625, 1662, 1705, 1807, 1879, 1905, 2094, 2191, 2220, 2395, 2506, 2609, 2663, 2775, 2914, 2947, 2989, 3119, 3155, 3299, 3325, 3421, 3740, 3786, 3833, 3865], '2Raffaello': [507], 'A.': [508, 1981, 2102, 2104, 2130, 2576, 2665, 2699, 2803, 2916, 3146, 3445, 3484, 3572, 3638, 3746], 'Mammucari': [509], 'C.': [510, 607, 798, 825, 1043, 1187, 1470, 1497, 1637, 1782, 1809, 1857, 1964, 2222, 2955, 3396, 3486, 3574, 3640, 3707], 'Gherardi': [511], 'G.': [512], 'Rizzuto': [513, 612], 'R.': [514, 609, 613, 1719, 1722, 2582, 2777], 'Calcium': [515, 614], 'at': [516, 3458], 'center': [518], 'signaling:': [521], 'interplay': [522], 'between': [523, 2859], 'reticulum,': [525], 'mitochondria,': [526], 'lysosomes.Trends': [528], 'Biochem.': [529, 860], 'Sci.': [530, 1978, 2127, 2696, 2800, 3143, 3442], '2016;': [531, 1617], '41': [532], '(27692849):': [533], '1035-104910.1016/j.tibs.2016.09.001Abstract': [534], '(172)': [542], '3Malhotra': [545], 'J.D.': [546, 2195], 'Kaufman': [547, 683, 850, 968, 1023, 1046, 1167, 1190, 1393, 1500, 2107, 2476], 'R.J.': [548, 684, 851, 969, 1024, 1047, 1168, 1191, 1394, 1501, 1735, 2108, 2477], 'response.Semin.': [556], 'Cell': [557, 592, 695, 781, 1009, 1059, 1203, 1434, 1513, 2176, 2653, 2937], 'Dev.': [558, 1010, 1435, 2499], 'Biol.': [559, 696, 782, 979, 1011, 1060, 1096, 1122, 1204, 1240, 1266, 1404, 1436, 1514, 2177, 2238, 2654, 2905, 2938, 3290, 3316], '2007;': [560], '18': [561, 721], '(18023214):': [562], '716-73110.1016/j.semcdb.2007.09.003Crossref': [563], '(698)': [566], '4Owusu': [569], 'B.Y.': [570], 'Zimmerman': [571], 'K.A.': [572], 'Murphy-Ullrich': [573], 'J.E.': [574], 'calreticulin': [582], 'mediating': [584], 'TGF-β-stimulated': [585], 'extracellular': [586], 'matrix': [587], 'production': [588, 2690], 'fibrotic': [590], 'disease.J.': [591, 694], 'Commun.': [593], 'Signal.': [594], '2018;': [595, 810, 1482, 1700, 1794], '12': [596, 2501], '(29080087):': [597], '289-29910.1007/s12079-017-0426-2Crossref': [598], '(11)': [601, 762], '5Pinton': [604], 'Giorgi': [606], 'Siviero': [608], 'Zecchini': [610], 'E.': [611, 873, 1966, 2063, 2112, 2613], 'apoptosis:': [616], 'ER-mitochondria': [617], 'Ca2+': [618], 'transfer': [619], 'control': [622, 743], 'apoptosis.Oncogene.': [624], '2008;': [625], '27': [626, 784, 1701, 2179], '(18955969):': [627], '6407-641810.1038/onc.2008.308Crossref': [628], '(687)': [631], 'Scholar).': [633, 893, 1131, 1294, 1445, 1523, 1760, 1831, 1934, 1990, 2139, 2247, 2426, 2537, 2708, 2812, 3025, 3180, 3240, 3356, 3454, 3521, 3609, 3675], 'Therefore,': [634], 'proper': [635], 'function': [639, 778, 911, 934, 2173, 2565], 'constantly': [644], 'changing': [645], 'physiologic': [646], 'environment': [647], 'crucial': [649], 'survival.': [652], 'Consistent': [653], 'this,': [655], 'defects': [656], 'biology': [659, 3842], 'linked': [661], 'nearly': [663], 'all': [664, 2369, 2835], 'types': [665, 1305, 1772], 'disease,': [668, 673, 1774], 'cancer,': [670], 'infectious': [672], 'amyloid': [674, 746], '(6Wang': [681], 'impact': [686], 'on': [692, 2718, 3461, 3527], '2012;': [697, 720, 861], '197': [698], '(22733998):': [699], '857-86710.1083/jcb.201110131Crossref': [700], '(606)': [703], '7Cnop': [706], 'M.': [707, 1022, 1166, 1627, 1629, 1633, 1909, 2051, 2071, 2671, 2675, 3794, 3804, 3883], 'Foufelle': [708], 'F.': [709, 2057, 3102], 'Velloso': [710], 'L.A.': [711], 'Endoplasmic': [712, 740, 852], 'obesity': [715], 'diabetes.Trends': [717], 'Mol.': [718, 1058, 1202, 1512, 1698, 1924, 2205], 'Med.': [719, 2206], '(21889406):': [722], '59-6810.1016/j.molmed.2011.07.010Abstract': [723], '(390)': [731], '8Chen': [734], 'J.J.': [735, 3121], 'Genereux': [736], 'J.C.': [737, 1729, 2633], 'Wiseman': [738, 767, 2162, 2196], 'R.L.': [739, 768, 2053, 2163, 2197], 'quality': [742], 'systemic': [745], 'disease:': [747], 'impacting': [748], 'stability': [750], 'inside': [753], 'out.IUBMB': [754], 'Life.': [755], '2015;': [756, 2086], '67': [757], '(26018985):': [758], '404-41310.1002/iub.1386Crossref': [759], '9Plate': [765], 'L.': [766, 1717, 2161, 2993], 'Regulating': [769, 2164], 'secretory': [770, 1383, 2165], 'proteostasis': [771, 2166], 'through': [772, 941, 1459, 1999, 2167, 2566, 2794, 2856, 2873, 3051, 3408, 3616], 'response:': [776, 1079, 1223, 2171, 3273], 'therapy.Trends': [780, 2175], '2017;': [783, 839, 1823, 1871, 1926, 1982, 2131, 2178, 2976, 3113], '(28647092):': [785, 2180], '722-73710.1016/j.tcb.2017.05.006Abstract': [786, 2181], '(39)': [794, 2189], '10Hetz': [797], 'Papa': [799, 997, 1422, 1471, 1783, 3124], 'F.R.': [800, 998, 1423, 1472, 1784, 3125], 'fate': [807, 1479, 1791], 'control.Mol.': [808, 1480, 1792], 'Cell.': [809, 1481, 1793, 3851], '69': [811, 1483, 1795], '(29107536):': [812, 1484, 1796], '169-18110.1016/j.molcel.2017.06.017Abstract': [813, 1485, 1797], '(385)': [821, 1493, 1805], '11Hetz': [824, 1808], 'Saxena': [826, 1810, 1858], 'stress': [829, 854, 1026, 1170, 1348, 1611, 1813, 1861, 2479, 2741, 2840, 2855, 2931, 3090, 3256, 3433, 3765], 'neurodegeneration.Nat.': [836, 1820, 1868], 'Rev.': [837, 859, 1008, 1057, 1201, 1433, 1511, 1821, 1869], 'Neurol.': [838, 1822, 1870], '13': [840, 886, 1618, 1824, 1872], '(28731040):': [841, 1825, 1873], '477-49110.1038/nrneurol.2017.99Crossref': [842, 1826, 1874], '(269)': [845, 1829, 1877], '12Back': [848], 'S.H.': [849, 1664, 2110], 'type': [856, 2446], '2': [857, 2940], 'diabetes.Annu.': [858], '81': [862], '(22443930):': [863], '767-79310.1146/annurev-biochem-072909-095555Crossref': [864], '(332)': [867], '13Thiebaut': [870], 'A.M.': [871], 'Hedou': [872], 'Marciniak': [874], 'S.J.': [875], 'Vivien': [876], 'D.': [877, 1073, 1109, 1217, 1253, 1672, 1881, 1952, 2590, 2625, 2673, 2681, 2783, 2892, 2924, 2961, 2999, 3096, 3267, 3303], 'Roussel': [878], 'B.D.': [879], 'Proteostasis': [880, 2198], 'during': [881, 2756, 3088, 3221, 3337], 'cerebral': [882], 'ischemia.Front': [883], 'Neurosci.': [884, 1925], '2019;': [885, 1097, 1123, 1241, 1267, 1897, 2207, 2239, 2906, 3017, 3291, 3317], '(31275110):': [887], '63710.3389/fnins.2019.00637Crossref': [888], '(3)': [891], 'Considering': [894], 'disease': [901, 939, 1567, 1598, 1842, 2048, 2235, 2344], 'pathogenesis,': [902], 'intervention': [904, 2159], 'emerged': [913], 'as': [914, 1365, 2725, 2881, 3244, 3381], 'promising': [916], 'approach': [918, 3843], 'wide': [921], 'variety': [922], 'disorders.': [924], 'One': [925, 2847], 'most': [928, 2360, 2441, 2557, 2816], 'attractive': [929, 2155], 'alter': [932], 'context': [937, 2008], 'targeting': [942, 2228, 2276], '(UPR)—the': [947], 'predominant': [948, 2550], 'stress-responsive': [949], 'pathway': [951, 1369, 2357, 2433, 2481, 3053], 'responsible': [952], 'following': [959, 1353], 'an': [960, 1354, 1608, 2454], 'insult': [962, 1356], '(i.e.': [963], 'stress)': [965], '(14Zhang': [966, 1391], 'K.': [967, 1045, 1189, 1392, 1499, 1676, 2059, 2584, 2683, 2781, 3750, 3800], 'Signaling': [970, 1395], 'reticulum.J.': [978, 1403], 'Chem.': [980, 1405, 2237], '2004;': [981, 1406], '279': [982, 1407], '(15070890):': [983, 1408], '25935-2593810.1074/jbc.R400008200Abstract': [984, 1409], '(460)': [992, 1417], '15Bernales': [995, 1420], 'Walter': [999, 1074, 1218, 1424, 1961, 2511, 2747, 3103, 3128, 3158, 3212, 3268, 3328, 3401, 3428, 3708], 'Intracellular': [1001, 1426], 'by': [1003, 1428, 2686, 2842, 2877, 3383, 3437, 3692, 3755, 3759], 'response.Annu.': [1007, 1432], '2006;': [1012, 1437], '22': [1013, 1438], '(16822172):': [1014, 1439], '487-50810.1146/annurev.cellbio.21.122303.120200Crossref': [1015, 1440], '(404)': [1018, 1443], '16Schroder': [1021], 'response.Mutat.': [1031, 1175], '2005;': [1033, 1177, 3147], '569': [1034, 1178], '(15603751):': [1035, 1179], '29-6310.1016/j.mrfmmm.2004.06.056Crossref': [1036, 1180], '(1243)': [1039, 1183], '17Hetz': [1042, 1186, 1496], 'Zhang': [1044, 1188, 1498, 2917, 3395], 'Mechanisms,': [1048, 1192, 1502], 'response.Nat.': [1056, 1200, 1510, 2936], '2020;': [1061, 1205, 1515, 2655], '21': [1062, 1206, 1516], '(32457508):': [1063, 1207, 1517], '421-43810.1038/s41580-020-0250-zCrossref': [1064, 1208, 1518], '(66)': [1067, 1211, 1521], '18Karagöz': [1070, 1214], 'G.E.': [1071, 1215, 3094, 3265], 'Acosta-Alvear': [1072, 1216, 1951, 3095, 3266], 'detecting': [1080, 1224, 3274], 'responding': [1082, 1226, 3276], 'fluctuations': [1084, 1228, 3278], 'protein-folding': [1087, 1231, 3281], 'capacity': [1088, 1232, 3282], 'reticulum.Cold': [1092, 1236, 3286], 'Spring': [1093, 1119, 1237, 1263, 2902, 3287, 3313], 'Harb.': [1094, 1120, 1238, 1264, 2903, 3288, 3314], 'Perspect.': [1095, 1121, 1239, 1265, 2904, 3289, 3315], '11': [1098, 1124, 1242, 1268, 2907, 3292, 3318], '(30670466):': [1099, 1243, 3293], 'a03388610.1101/cshperspect.a033886Crossref': [1100, 1244, 3294], '(44)': [1103, 1247, 3297], '19Preissler': [1106, 1250, 3300], 'Ron': [1108, 1252, 2589, 2680, 2782, 2891, 2923, 2960, 2998, 3302], 'Early': [1110, 1254, 2893, 3304], 'events': [1111, 1255, 2894, 3194, 3305, 3611], 'response.Cold': [1118, 1262, 2901, 3312], '(30396883):': [1125, 1269, 2908, 3319], 'a03389410.1101/cshperspect.a033894Crossref': [1126, 1270, 2909, 3320], '(34)': [1129, 1273, 2912, 3323], 'comprises': [1134], 'stress–sensing': [1143], 'transmembrane': [1144, 2524, 2796, 3711], 'inositol-requiring': [1146], 'enzyme': [1147], '1': [1148, 3686], '(IRE1),': [1149], 'kinase': [1151, 1155, 1644, 2405, 2460, 2755, 3220, 3336, 3469, 3556, 3712], 'R–like': [1152], '(PERK),': [1156], 'activating': [1158, 3049], 'transcription': [1159, 3771], 'factor': [1160, 1642], '6': [1161, 2421, 3114], '(ATF6)': [1162], '(Fig.': [1163, 1357, 2375, 2467, 3054, 3091, 3208, 3262, 3471, 3559, 3704], '1)': [1164, 2376], '(16Schroder': [1165], '20Hollien': [1276], 'J.': [1277, 1737, 1896, 2378, 2397, 2766, 3231, 3347, 3394, 3512, 3600, 3666, 3788, 3796, 3806, 3824], 'Evolution': [1278, 2379], 'response.Biochim.': [1283, 2384], 'Biophys.': [1284, 2385], 'Acta.': [1285, 2386], '2013;': [1286, 2387, 2700, 2804], '1833': [1287, 2388], '(23369734):': [1288, 2389], '2458-246310.1016/j.bbamcr.2013.01.016Crossref': [1289, 2390], '(85)': [1292, 2393], 'These': [1295, 3610], 'accumulation': [1311, 3040, 3084], 'non-native': [1313, 3064, 3086], 'within': [1315, 1322, 3466], 'lumen': [1318], 'disequilibrium': [1321, 2744], 'membrane.': [1325], 'Activation': [1326], 'elicits': [1331], 'remodeling': [1335], 'promote': [1350, 2004], 'adaption': [1352], 'acute': [1355], '1).': [1358], 'Through': [1359], 'this': [1360, 2713, 3027, 3052, 3537, 3702], 'activity,': [1361], 'protective': [1367, 1460, 1534], 'involved': [1372], 'aspects': [1376], 'maintenance': [1381], 'proteostasis,': [1384], 'proliferation,': [1385], 'redox': [1386], 'regulation,': [1387], 'differentiation,': [1388], 'metabolism': [1390], 'However,': [1446, 3056], 'chronic': [1450, 1936], 'severe': [1452], 'insults': [1454], 'cannot': [1456], 'be': [1457, 2015, 2435], 'alleviated': [1458], 'remodeling,': [1461], 'prolonged': [1462], 'activation': [1464, 2827, 3187, 3207, 3380], 'leads': [1465], 'pro-apoptotic': [1467], '(10Hetz': [1469, 1781], 'Thus,': [1524, 1991], 'serves': [1527], 'dictating': [1532], 'apoptotic': [1536], 'insults.': [1543], 'Due': [1544], 'function,': [1554], 'it': [1555, 2428, 3369], 'not': [1557], 'surprising': [1558], 'alterations': [1560], 'contribute': [1564, 1769], 'pathogenesis.': [1568, 1843], 'For': [1569, 1844, 2709], 'example,': [1570, 1845], 'hypomorphic': [1571], '“loss-of-function”': [1573], 'mutations': [1574, 2025, 2118], 'EIF2AK3': [1577], 'gene,': [1578], 'which': [1579, 2837, 3621, 3688], 'encodes': [1580, 2401], 'protein,': [1583], 'multiple': [1587, 2832], 'Wolcott–Rallison': [1590], 'syndrome,': [1591], 'progressive': [1592, 1748], 'supranuclear': [1593, 1749], 'palsy,': [1594], 'late-stage': [1596], "Alzheimer's": [1597], '(21Bell': [1599], 'M.C.': [1600, 3482, 3570, 3636], 'Meier': [1601], 'S.E.': [1602], 'Ingram': [1603], 'A.L.': [1604], 'Abisambra': [1605], 'J.F.': [1606], 'PERK-opathies:': [1607], 'mechanism': [1612, 2301, 2824, 3132, 3184], 'underlying': [1613], 'neurodegeneration.Curr.': [1614], 'Alzheimer': [1615], '(26679859):': [1619], '150-16310.2174/1567205013666151218145431Crossref': [1620], '(29)': [1623], '22Delepine': [1626], 'Nicolino': [1628], 'Barrett': [1630], 'T.': [1631, 2677, 3476, 3564, 3630, 3744, 3748, 3790, 3798, 3802], 'Golamaully': [1632], 'Lathrop': [1634], 'G.M.': [1635], 'Julier': [1636], 'EIF2AK3,': [1638], 'encoding': [1639, 2517, 3682], 'translation': [1640], 'initiation': [1641], '2-α': [1643], '3,': [1645], 'mutated': [1647], 'patients': [1649], 'Wolcott-Rallison': [1651], 'syndrome.Nat.': [1652], 'Genet.': [1653, 1699, 1751, 2085], '2000;': [1654, 2939], '25': [1655, 2208], '(10932183):': [1656], '406-40910.1038/78085Crossref': [1657], '(0)': [1660], '23Yuan': [1663], 'Hiramatsu': [1665], 'N.': [1666, 2617, 2667, 2949, 2991], 'Liu': [1667], 'Q.': [1668], 'Sun': [1669], 'X.V.': [1670], 'Lenh': [1671], 'Chan': [1673, 2097], 'Chiang': [1675], 'Koo': [1677], 'E.H.': [1678], 'Kao': [1679], 'A.W.': [1680, 2631], 'Litvan': [1681, 1723], 'I.': [1682, 1724, 1960, 2580, 3494, 3582, 3648], 'Lin': [1683, 2115], 'J.H.': [1684, 2116, 2586], 'Tauopathy-associated': [1685], 'alleles': [1687], 'functional': [1689], 'hypomorphs': [1690], 'increase': [1692, 2032], 'neuronal': [1693], 'vulnerability': [1694], 'stress.Hum.': [1697], '(30137327):': [1702], '3951-396310.1093/hmg/ddy297PubMed': [1703], '24Höglinger': [1706], 'G.U.': [1707], 'Melhem': [1708], 'N.M.': [1709, 2061], 'Dickson': [1710], 'D.W.': [1711], 'Sleiman': [1712], 'P.M.': [1713], 'Wang': [1714, 2064, 2577, 3838], 'L.S.': [1715], 'Klei': [1716], 'Rademakers': [1718], 'de': [1720], 'Silva': [1721], 'Riley': [1725], 'D.E.': [1726], 'van': [1727, 2778], 'Swieten': [1728], 'Heutink': [1730], 'Wszolek': [1732], 'Z.K.': [1733], 'Uitti': [1734], 'Vandrovcova': [1736], 'et': [1738], 'al.Identification': [1739], 'common': [1741], 'variants': [1742], 'influencing': [1743], 'risk': [1744], 'tauopathy': [1747], 'palsy.Nat.': [1750], '2011;': [1752, 3172, 3513, 3601, 3667], '43': [1753], '(21685912):': [1754], '699-70510.1038/ng.859Crossref': [1755], '(318)': [1758], 'Similarly,': [1761, 1935], 'environmental': [1762], 'aging-related': [1764], 'deficiencies': [1765], 'cardiovascular': [1776], 'disorders': [1777, 1918], 'In': [1832, 2320, 3026], 'contrast,': [1833], 'overactivity': [1834], 'also': [1839], 'overactive': [1846], '(11Hetz': [1856], '25Hughes': [1880], 'Mallucci': [1882], 'G.R.': [1883], 'disorders—therapeutic': [1890], 'modulation': [1891], 'pathway.FEBS': [1895], '286': [1898], '(29476642):': [1899], '342-35510.1111/febs.14422Crossref': [1900], '(46)': [1903], '26Remondelli': [1906], 'Renna': [1908], 'its': [1920, 3467], 'potential': [1921, 2274, 2339], 'significance.Front.': [1923], '10': [1927], '(28670265):': [1928], '18710.3389/fnmol.2017.00187Crossref': [1929], '(71)': [1932], 'IRE1': [1937, 1968, 2355, 2400, 2443, 2542, 2726, 2730, 2826, 2844, 2852, 2870, 2969, 3033, 3061, 3075, 3080, 3186, 3196, 3202, 3241, 3362, 3374, 3435, 3455, 3531, 3618, 3625, 3760], 'activity': [1938, 2036, 2574], 'atherosclerosis': [1942], 'mouse': [1944], '(27Tufanli': [1946], 'O.': [1947], 'Telkoparan': [1948], 'Akillilar': [1949], 'Kocaturk': [1953], 'B.': [1954, 2100], 'Onat': [1955], 'U.I.': [1956], 'Hamid': [1957], 'S.M.': [1958, 3871], 'Çimen': [1959], 'Weber': [1963], 'Erbay': [1965], 'Targeting': [1967], 'small': [1970], 'molecules': [1971], 'counteracts': [1972], 'progression': [1973], 'atherosclerosis.Proc.': [1975], 'Natl.': [1976, 2125, 2694, 2798, 3141, 3440], 'Acad.': [1977, 2126, 2695, 2799, 3142, 3441], 'U.': [1979, 2128, 2697, 2801, 3144, 3443], '114': [1983, 2132], '(28137856):': [1984], 'E1395-EE40410.1073/pnas.1621188114Crossref': [1985], '(20)': [1988], 'either': [1992, 2031, 2258], 'too': [1993, 1996], 'much': [1994], 'little': [1997], 'effect': [2013], 'may': [2014], 'best': [2016], 'demonstrated': [2017], 'hereditary': [2020], 'vision': [2021], 'disorder': [2022], 'achromatopsia,': [2023], 'where': [2024], 'ATF6': [2028, 2035, 2080, 2123, 2201, 3756], 'gene': [2029], 'decrease': [2034], 'causatively': [2039], 'impaired': [2043], 'retinal': [2044], '(28Ansar': [2050], 'Santos-Cortez': [2052], 'Saqib': [2054], 'M.A.': [2055, 2635], 'Zulfiqar': [2056], 'Lee': [2058, 3099], 'Ashraf': [2060], 'Ullah': [2062], 'X.': [2065, 2578, 3839], 'Sajid': [2066], 'Khan': [2068], 'F.S.': [2069], 'Amin-Ud-Din': [2070], 'University': [2072], 'Washington': [2074], 'Center': [2075], 'Mendelian': [2077], 'GenomicsMutation': [2078], 'causes': [2081], 'autosomal': [2082], 'recessive': [2083], 'achromatopsia.Hum.': [2084], '134': [2087], '(26063662):': [2088], '941-95010.1007/s00439-015-1571-4Crossref': [2089], '(42)': [2092], '29Chiang': [2095], 'W.-C.': [2096], 'Wissinger': [2099], 'Vincent': [2101], 'Skorczyk-Werner': [2103], 'Krawczyński': [2105], 'M.R.': [2106], 'Tsang': [2109], 'Héon': [2111], 'Kohl': [2113], 'Achromatopsia': [2117], 'target': [2119, 2289], 'sequential': [2120], 'steps': [2121], 'activation.Proc.': [2124], '(28028229):': [2133], '400-40510.1073/pnas.1606387114Crossref': [2134], '(23)': [2137], 'altered': [2143], 'makes': [2152], 'targets': [2156], '(9Plate': [2160], '30Glembotski': [2192], 'C.C.': [2193], 'Rosarda': [2194], 'beyond:': [2200], 'disease.Trends': [2204], '(31078432):': [2209], '538-55010.1016/j.molmed.2019.03.005Abstract': [2210], '(14)': [2218], '31Hetz': [2221], 'Axten': [2223], 'J.M.': [2224], 'Patterson': [2225], 'J.B.': [2226], 'Pharmacological': [2227], 'intervention.Nat.': [2236], '15': [2240, 2768, 3233, 3349], '(31320759):': [2241], '764-77510.1038/s41589-019-0326-2Crossref': [2242], '(70)': [2245], 'activate': [2259, 3623], 'inhibit': [2261], 'select': [2262], 'provide': [2267], 'individual': [2290], 'pathways,': [2292], 'how': [2295], 'they': [2296], 'were': [2297], 'discovered,': [2298], 'described': [2300, 3366], 'action,': [2303], 'applicability': [2306], 'studying': [2308], 'models.': [2319], 'addition,': [2321], 'summarize': [2323], 'UPR-modulating': [2329], 'confer': [2336], 'increased': [2337], 'guide': [2347], 'future': [2349], 'next-generation': [2352], 'compounds.': [2353], 'highly': [2361, 3769], 'conserved': [2362, 3463, 3551], 'arm': [2363, 2818], 'UPR,': [2366, 2821], 'found': [2367, 3072], 'organisms': [2370], 'yeast': [2372, 3528], 'humans': [2374], '(20Hollien': [2377], '32Nikawa': [2396], 'Yamashita': [2398], 'putative': [2403, 3069], 'containing': [2406], 'membrane-spanning': [2408], 'domain': [2409, 2466, 2872, 3010, 3035, 3470, 3678], 'required': [2412], 'inositol': [2414], 'phototrophy': [2415], 'Saccharomyces': [2417], 'cerevisiae.Mol.': [2418], 'Microbiol.': [2419], '1992;': [2420], '(1625574):': [2422], '1441-144610.1111/j.1365-2958.1992.tb00864.xCrossref': [2423], 'Notably,': [2427], 'was': [2429], 'first': [2431], 'identified': [2436], 'likely': [2439], 'well-studied.': [2442], 'I': [2447], 'comprising': [2451], 'domains:': [2453], 'luminal': [2456, 2845, 2871, 3009, 3034, 3076], 'domain,': [2457, 2461, 3077, 3620], 'cytosolic': [2459, 2464, 3468, 3619], 'RNase': [2465, 3206, 3626, 3677], '2,': [2468], 'A': [2469, 2478, 2962, 3840], 'B)': [2471], '(33Tirasophon': [2472], 'W.': [2473, 3492, 3580, 3646], 'Welihinda': [2474], 'A.A.': [2475, 3392], 'nucleus': [2488], 'requires': [2489, 2522], 'novel': [2491], 'bifunctional': [2492], 'kinase/endoribonuclease': [2494], '(Ire1p)': [2495], 'mammalian': [2497, 3111, 3808, 3846], 'cells.Genes': [2498], '1998;': [2500], '(9637683):': [2502], '1812-182410.1101/gad.12.12.1812Crossref': [2503], '34Cox': [2507], 'J.S.': [2508, 3123], 'Shamu': [2509], 'C.E.': [2510, 2746, 3211, 3327], 'Transcriptional': [2513], 'induction': [2514], 'genes': [2516], 'resident': [2520], 'kinase.Cell.': [2526], '1993;': [2527], '73:': [2528], '1197-120610.1016/0092-8674(93)90648-AAbstract': [2529], '(845)': [2535], 'Mammals': [2538], 'encode': [2539], 'two': [2540], 'isoforms:': [2543], 'IRE1α': [2544, 2547, 2573, 2645, 2720, 3003], 'IRE1β.': [2546], 'isoform': [2551, 2721], 'types,': [2559], 'whereas': [2560], 'IRE1β': [2561, 2642, 2687], 'appears': [2562, 3370], 'primarily': [2564, 2716], 'tissue-specific': [2567], 'mechanisms': [2568], 'and/or': [2569], '(35Bertolotti': [2575], 'Novoa': [2579], 'Jungreis': [2581], 'Schlessinger': [2583], 'Cho': [2585], 'West': [2587], 'A.B.': [2588], 'Increased': [2591], 'sensitivity': [2592], 'dextran': [2594], 'sodium': [2595], 'sulfate': [2596], 'colitis': [2597], 'IRE1β-deficient': [2599], 'mice.J.': [2600], 'Clin.': [2601], 'Invest.': [2602], '2001;': [2603, 3773], '107': [2604, 3447, 3774], '(11238559):': [2605], '585-59310.1172/JCI11476Crossref': [2606], '36Grey': [2610], 'M.J.': [2611, 2953, 3873], 'Cloots': [2612], 'Simpson': [2614], 'M.S.': [2615], 'LeDuc': [2616], 'Serebrenik': [2618], 'Y.V.': [2619], 'De': [2620, 2623], 'Luca': [2621], 'H.': [2622, 2679, 3423, 3742], 'Sutter': [2624], 'Luong': [2626], 'Thiagarajah': [2628], 'J.R.': [2629, 3879], 'Paton': [2630, 2632], 'Seeliger': [2634], 'Eyckerman': [2636], 'Janssens': [2638], 'Lencer': [2640], 'W.I.': [2641], 'negatively': [2643], 'regulates': [2644], 'stress.J.': [2652], '219': [2656], '(31985747):': [2657], 'e20190404810.1083/jcb.201904048Crossref': [2658], '(2)': [2661], '37Tsuru': [2664], 'Fujimoto': [2666], 'Takahashi': [2668], 'Saito': [2670], 'Nakamura': [2672], 'Iwano': [2674], 'Iwawaki': [2676], 'Kadokura': [2678], 'Kohno': [2682], 'Negative': [2684], 'feedback': [2685], 'optimizes': [2688], 'mucin': [2689], 'goblet': [2692], 'cells.Proc.': [2693], '110': [2701, 2805], '(23386727):': [2702], '2864-286910.1073/pnas.1212484110Crossref': [2703], '(86)': [2706], 'purposes': [2711], 'review,': [2714], 'focus': [2717], '(herein': [2722], 'referred': [2723], 'unless': [2727], 'otherwise': [2728], 'noted).': [2729], 'insults,': [2738], '(38Shamu': [2745, 3210], 'Oligomerization': [2749, 3214, 3330], 'phosphorylation': [2751, 3216, 3332], 'Ire1p': [2754, 3219, 3335, 3713], 'intracellular': [2757, 3222, 3338], 'nucleus.EMBO': [2765, 3230, 3346], '1996;': [2767, 3232, 3348], '(8670804):': [2769, 3234, 3350], '3028-303910.1002/j.1460-2075.1996.tb00666.xCrossref': [2770, 3235, 3351], '(416)': [2773, 3238, 3354], '39Volmer': [2776], 'der': [2779], 'Ploeg': [2780], 'saturation': [2786], 'activates': [2787, 3110], 'transducers': [2793, 2932], 'domains.Proc.': [2797], '(23487760):': [2806], '4628-463310.1073/pnas.1217611110Crossref': [2807], '(310)': [2810], 'Despite': [2813], 'being': [2814, 3190], 'well-studied': [2817], 'molecular': [2823], 'remains': [2828], 'somewhat': [2829], 'controversial,': [2830], 'proposed': [2833], 'models,': [2834], 'involve': [2838, 3201], 'sensing': [2841, 3134], 'domain.': [2846], 'prominent': [2848], 'model': [2849, 3058], 'suggests': [2850], 'detects': [2853], 'dynamic': [2857, 3438], 'interactions': [2858, 3545], 'HSP70': [2862], 'chaperone': [2863], 'binding': [2864, 3684], 'immunoglobulin': [2865], '(BiP)': [2867], 'process': [2875], 'regulated': [2876], 'BiP': [2878, 2928, 2966, 3029], 'co-chaperones,': [2879], 'such': [2880], 'DNA': [2883], 'J': [2884], 'domain–containing': [2885], '4': [2887], '(ERdj4)': [2888], '(19Preissler': [2889], '40Bertolotti': [2915], 'Y.': [2918, 2995, 3835], 'Hendershot': [2919], 'L.M.': [2920], 'Harding': [2921, 2958], 'H.P.': [2922, 2959], 'Dynamic': [2925], 'interaction': [2926], 'unfolded-protein': [2935], '(10854322):': [2941], '326-33210.1038/35014014Crossref': [2942], '(1828)': [2945], '41Amin-Wetzel': [2948], 'Saunders': [2950], 'R.A.': [2951], 'Kamphuis': [2952], 'Rato': [2954], 'Preissler': [2956], 'J-protein': [2963], 'co-chaperone': [2964], 'recruits': [2965], 'monomerize': [2968], 'repress': [2971], 'response.Cell.': [2975, 3726], '171': [2977], '(29198525):': [2978], '1625-1637.e1310.1016/j.cell.2017.10.040Abstract': [2979], '(81)': [2987], '42Amin-Wetzel': [2990], 'Neidhardt': [2992], 'Yan': [2994], 'Mayer': [2996], 'M.P.': [2997], 'Unstructured': [3000], 'regions': [3001], 'specify': [3004], 'BiP-mediated': [3005], 'destabilisation': [3006], 'dimer': [3011, 3359], 'repression': [3013], 'UPR.Elife.': [3016], '8': [3018], '(31873072):': [3019], 'e5079310.7554/eLife.50793Crossref': [3020], '(6)': [3023], 'model,': [3028], 'dissociates': [3030], 'misfolded': [3042], 'lumen,': [3047], 'thus': [3048], '2A).': [3055], 'another': [3057], 'proposes': [3059], 'directly': [3062, 3081, 3166], 'binds': [3063], 'conformations': [3066], 'peptide-binding': [3070], 'groove': [3071], 'suggesting': [3078], 'senses': [3082], '2A)': [3092, 3209, 3263, 3705], '(43Karagöz': [3093], 'Nguyen': [3097], 'H.T.': [3098], 'C.P.': [3100], 'Chu': [3101], 'An': [3105], 'protein-induced': [3107], 'conformational': [3108, 3614], 'switch': [3109], 'IRE1.Elife.': [3112], '(28971800):': [3115], 'e3070010.7554/eLife.30700Crossref': [3116], '44Credle': [3120], 'Finer-Moore': [3122, 3393], 'Stroud': [3126, 3399], 'R.M.': [3127, 3400], 'On': [3130], 'reticulum.Proc.': [3140], '102': [3148], '(16365312):': [3149], '18773-1878410.1073/pnas.0509487102Crossref': [3150], '(358)': [3153], '45Gardner': [3156], 'B.M.': [3157], 'Unfolded': [3160], 'Ire1-activating': [3163], 'ligands': [3164], 'induce': [3167], 'response.Science.': [3171], '333': [3173], '(21852455):': [3174], '1891-189410.1126/science.1209126Crossref': [3175], '(401)': [3178], 'Whereas': [3181, 3357], 'precise': [3183], 'still': [3189], 'scrutinized,': [3191], 'well-established': [3199], 'oligomerization,': [3203], 'autophosphorylation,': [3204], 'exists': [3242], 'predominantly': [3243], 'monomer': [3246], 'undergoes': [3257], 'dimerization/oligomerization': [3258], 'subsequent': [3260], 'trans-autophosphorylation': [3261], '(18Karagöz': [3264], '38Shamu': [3326], 'higher-order': [3361, 3376], 'oligomers': [3363], 'have': [3364, 3532], 'vitro,': [3368], 'clustering': [3372], 'into': [3375], 'assemblies': [3377], 'parallels': [3378], 'maximal': [3379], 'measured': [3382], 'outputs': [3386], '(46Korennykh': [3387], 'A.V.': [3388, 3425], 'Egea': [3389], 'P.F.': [3390], 'Korostelev': [3391], 'Shokat': [3397], 'K.M.': [3398], 'signals': [3407, 3436], 'high-order': [3409], 'assembly': [3410], 'Ire1.Nature.': [3412], '457': [3414], '(19079236):': [3415], '687-69310.1038/nature07661Crossref': [3416], '(408)': [3419], '47Li': [3422], 'Korennykh': [3424], 'Behrman': [3426], 'S.L.': [3427, 3881], 'Mammalian': [3430], 'sensor': [3434], 'clustering.Proc.': [3439], '2010;': [3446], '(20798350):': [3448], '16113-1611810.1073/pnas.1010580107Crossref': [3449], '(204)': [3452], 'autophosphorylation': [3456, 3503, 3591, 3657], 'occurs': [3457], 'several': [3459], 'sites': [3460], '“activation': [3464], 'loop”': [3465], '2C)': [3472, 3560], '(48Ali': [3473, 3561, 3627], 'M.M.': [3474, 3562, 3628], 'Bagratuni': [3475, 3563, 3629], 'Davenport': [3477, 3565, 3631], 'E.L.': [3478, 3566, 3632], 'Nowak': [3479, 3567, 3633], 'P.R.': [3480, 3568, 3634], 'Silva-Santisteban': [3481, 3569, 3635], 'Hardcastle': [3483, 3571, 3637], 'McAndrews': [3485, 3573, 3639], 'Rowlands': [3487, 3575, 3641], 'M.G.': [3488, 3576, 3642], 'Morgan': [3489, 3577, 3643], 'G.J.': [3490, 3578, 3644], 'Aherne': [3491, 3579, 3645], 'Collins': [3493, 3581, 3647], 'Davies': [3495, 3583, 3649], 'F.E.': [3496, 3584, 3650], 'Pearl': [3497, 3585, 3651], 'L.H.': [3498, 3586, 3652], 'Structure': [3499, 3587, 3653], 'Ire1': [3502, 3590, 3656], 'complex': [3504, 3592, 3658, 3811], 'response.EMBO': [3511, 3599, 3665], '30': [3514, 3602, 3668], '(21317875):': [3515, 3603, 3669], '894-90510.1038/emboj.2011.18Crossref': [3516, 3604, 3670], '(145)': [3519, 3607, 3673], 'Extensive': [3522], 'structural': [3523], 'biochemical': [3525], 'studies': [3526], 'characterized': [3533], 'displacement': [3535], 'loop': [3538], 'upon': [3539], 'ATP': [3540], 'binding,': [3541], 'due': [3542], 'direct': [3544], 'bound': [3547], 'ADP': [3548], 'DFG': [3552], 'motif': [3553], 'active': [3557, 3770], 'site': [3558], 'cause': [3612], 'coordinated': [3613], 'changes': [3615], 'allosterically': [3622], 'cleaves': [3679], 'mRNA': [3681, 3720, 3752, 3816], 'X-box': [3683], '(XBP1),': [3687], 'then': [3690], 're-ligated': [3691], 'RTCB': [3694], 'RNA': [3695, 3848, 3886], 'ligase,': [3696], 'resulting': [3697], 'frameshift': [3700], 'transcript': [3703], '(49Sidrauski': [3706], 'site-specific': [3716], 'endonuclease': [3717], 'initiates': [3719], 'splicing': [3721, 3813], '1997;': [3727], '90': [3728], '(9323131):': [3729], '1031-103910.1016/S0092-8674(00)80369-4Abstract': [3730], '(601)': [3738], '50Yoshida': [3741], 'Matsui': [3743], 'Yamamoto': [3745], 'Okada': [3747], 'Mori': [3749], 'XBP1': [3751, 3815], 'induced': [3754], 'spliced': [3758], 'produce': [3767], 'factor.Cell.': [3772], '(11779464):': [3775], '881-89110.1016/S0092-8674(01)00611-0Abstract': [3776], '(2617)': [3784], '51Jurkin': [3787], 'Henkel': [3789], 'Nielsen': [3791], 'A.F.': [3792], 'Minnich': [3793], 'Popow': [3795], 'Kaufmann': [3797], 'Heindl': [3799], 'Hoffmann': [3801], 'Busslinger': [3803], 'Martinez': [3805], 'tRNA': [3809], 'ligase': [3810, 3849], 'mediates': [3812], 'controls': [3818], 'antibody': [3819], 'secretion': [3820], 'plasma': [3822], 'cells.EMBO': [3823], '2014;': [3825, 3852], '33': [3826], '(25378478):': [3827], '2922-293610.15252/embj.201490332Crossref': [3828], '(79)': [3831], '52Lu': [3834], 'Liang': [3836], 'F.X.': [3837], 'synthetic': [3841], 'identifies': [3844], 'RtcB.Mol.': [3850], '55': [3853], '(25087875):': [3854], '758-77010.1016/j.molcel.2014.06.032Abstract': [3855], '(110)': [3863], '53Kosmaczewski': [3866], 'S.G.': [3867], 'Edwards': [3868], 'T.J.': [3869], 'Han': [3870], 'Eckwahl': [3872], 'Meyer': [3874], 'B.I.': [3875], 'Peach': [3876], 'Hesselberth': [3878], 'Wolin': [3880], 'Hammarlund': [3882], 'RtcB': [3885], 'lig': [3887]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3083466538', 'counts_by_year': [{'year': 2024, 'cited_by_count': 22}, {'year': 2023, 'cited_by_count': 28}, {'year': 2022, 'cited_by_count': 28}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 3}], 'updated_date': '2025-01-05T20:44:16.000629', 'created_date': '2020-09-11'}
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