Publication Information

{'id': 'https://openalex.org/W3083140303', 'doi': 'https://doi.org/10.1158/1538-7445.am2020-4188', 'title': 'Abstract 4188: The ERK1/2 inhibitor, JSI-1187, demonstrates preclinical efficacy in tumor models with MAPK pathway mutations', 'display_name': 'Abstract 4188: The ERK1/2 inhibitor, JSI-1187, demonstrates preclinical efficacy in tumor models with MAPK pathway mutations', 'publication_year': 2020, 'publication_date': '2020-08-15', 'ids': {'openalex': 'https://openalex.org/W3083140303', 'doi': 'https://doi.org/10.1158/1538-7445.am2020-4188', 'mag': '3083140303'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2020-4188', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100359727', 'display_name': 'Ao Li', 'orcid': 'https://orcid.org/0000-0001-7861-6313'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ao Li', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005960916', 'display_name': 'Shanzhong Jian', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shanzhong Jian', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091196162', 'display_name': 'Yuan Xia', 'orcid': 'https://orcid.org/0000-0002-8061-4955'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xia Yuan', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085355499', 'display_name': 'Fengge Song', 'orcid': 'https://orcid.org/0000-0003-2296-4225'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fengge Song', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111982858', 'display_name': 'Sheng‐Wei Yang', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shengwei Yang', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052572536', 'display_name': 'Chengyi Du', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chengyi Du', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109758403', 'display_name': 'Yue Tao', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yue Tao', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050400550', 'display_name': 'Liucheng Wang', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liucheng Wang', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052721144', 'display_name': 'Mingming Pan', 'orcid': 'https://orcid.org/0000-0001-7565-3418'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Mingming Pan', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036728493', 'display_name': 'Penghui Dong', 'orcid': 'https://orcid.org/0000-0003-1963-0152'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Penghui Dong', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009698535', 'display_name': 'jiajun Zhou', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'jiajun Zhou', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087040586', 'display_name': 'Zhengkang Ge', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhengkang Ge', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100547859', 'display_name': 'Qinghong Zhu', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qinghong Zhu', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029369861', 'display_name': 'Wenshan Hao', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenshan Hao', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039780672', 'display_name': 'Wen Xu', 'orcid': 'https://orcid.org/0000-0002-5182-6692'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wen Xu', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100412772', 'display_name': 'Jintao Zhang', 'orcid': 'https://orcid.org/0000-0002-1029-3404'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jintao Zhang', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100426174', 'display_name': 'Qun Li', 'orcid': 'https://orcid.org/0000-0002-0549-1852'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qun Li', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100667760', 'display_name': 'Shaohui Wang', 'orcid': 'https://orcid.org/0000-0002-4203-4941'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shaohui Wang', 'raw_affiliation_strings': ['JS InnoPharm, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': 'JS InnoPharm, Shanghai, China.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.394, 'has_fulltext': False, 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.444549, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 81}, 'biblio': {'volume': '80', 'issue': '16_Supplement', 'first_page': '4188', 'last_page': '4188'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11533', 'display_name': 'Melanoma and MAPK Pathways', 'score': 0.977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11533', 'display_name': 'Melanoma and MAPK Pathways', 'score': 0.977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.76572335}, {'id': 'https://openalex.org/C2781187634', 'wikidata': 'https://www.wikidata.org/wiki/Q20969980', 'display_name': 'KRAS', 'level': 4, 'score': 0.6383255}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.54972863}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5426133}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.53927183}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.5296687}, {'id': 'https://openalex.org/C2781249067', 'wikidata': 'https://www.wikidata.org/wiki/Q17142288', 'display_name': 'MEK inhibitor', 'level': 4, 'score': 0.43897027}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4183483}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.38778135}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3174604}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.31590867}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.27261}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14103562}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.06182289}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2020-4188', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.74}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4318612407', 'https://openalex.org/W4307910990', 'https://openalex.org/W4281763928', 'https://openalex.org/W4226207639', 'https://openalex.org/W3005630266', 'https://openalex.org/W2487850446', 'https://openalex.org/W2320994390', 'https://openalex.org/W2110980999', 'https://openalex.org/W2109132296', 'https://openalex.org/W1990511191'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1, 382], 'MAPK': [2, 92, 341, 393], 'pathway,': [3, 93], 'via': [4], 'RAS-RAF-MEK-ERK,': [5], 'is': [6], 'one': [7], 'of': [8, 40, 60, 71, 80, 123, 134, 167, 190, 221, 240, 338, 399, 403], 'the': [9, 69, 73, 91, 138, 149, 171, 180, 188, 191, 218, 229, 238, 245, 256, 273, 309, 314, 400, 404], 'most': [10], 'important': [11], 'pathways': [12], 'for': [13, 20, 42, 336, 407], 'relaying': [14], 'signals': [15], 'from': [16], 'cell': [17, 21, 142, 153, 158, 173, 182, 197], 'surface': [18], 'receptors': [19], 'survival,': [22], 'proliferation,': [23], 'and': [24, 33, 54, 145, 176, 226, 249, 262, 280, 320, 414], 'differentiation.': [25], 'Many': [26], 'mutations': [27, 89, 395], 'were': [28, 253, 282], 'identified': [29], 'in': [30, 37, 76, 87, 90, 99, 137, 148, 170, 179, 195, 212, 217, 272, 278, 289, 306, 313, 325, 389], 'this': [31, 77], 'pathway': [32, 342, 394], 'intensely': [34], 'studied,': [35], 'resulting': [36], 'a': [38, 109, 121, 213], 'number': [39], 'therapeutics': [41, 64], 'various': [43, 88], 'cancers': [44], '(for': [45], 'example,': [46], 'EGFR': [47], 'mutant': [48, 52], 'inhibitors,': [49], 'BRAF': [50, 139, 150, 310], 'V600': [51], 'inhibitors': [53], 'MEK': [55], 'inhibitors).': [56], 'A': [57, 291], 'common': [58], 'mechanism': [59], 'resistance': [61], 'to': [62, 67, 298], 'these': [63, 196], 'has': [65], 'emerged': [66], 'be': [68, 85, 333], 'reactivation': [70], 'ERK1/2,': [72], 'terminal': [74], 'kinase': [75], 'pathway.': [78], 'Inhibition': [79], 'ERK1/2': [81, 111, 383], 'activity': [82], 'could': [83], 'therefore': [84], 'instrumental': [86], 'either': [94], 'as': [95, 284, 286], 'single': [96], 'therapy': [97], 'or': [98], 'combination': [100, 307], 'with': [101, 120, 160, 255, 308, 340, 392], 'other': [102], 'compounds.': [103], 'Through': [104], 'internal': [105], 'effort,': [106], 'we': [107], 'discovered': [108], 'novel': [110], 'small': [112], 'molecule': [113], 'inhibitor,': [114, 384], 'JSI-1187,': [115, 385], 'which': [116], 'reversibly': [117], 'inhibited': [118, 187], 'ERK2': [119], 'Ki': [122], 'less': [124], 'than': [125], '1': [126], 'nM.': [127], 'In': [128, 228, 244, 296, 329], 'anti-proliferation': [129, 165], 'assays,': [130], 'JSI-1187': [131, 163, 186, 202, 207, 233, 276, 302, 319, 331], 'had': [132, 164], 'IC50': [133, 166], '37': [135], 'NM': [136, 147, 169, 178], 'V600E': [140, 151], 'melanonma': [141], 'line': [143, 154, 174, 183], 'A375': [144], '48': [146], 'CRC': [152, 172], 'COLO': [155, 223, 230, 315], '205.': [156], 'For': [157], 'lines': [159], 'KRAS': [161], 'mutations,': [162], '130': [168], 'HCT116': [175, 274], '150': [177], 'NSCLC': [181], 'Calu-6.': [184, 227], 'Furthermore,': [185], 'phosphorylation': [189], 'ERK': [192], 'substrate': [193], 'RSK1': [194], 'lines.': [198], 'We': [199], 'also': [200, 304], 'tested': [201, 300, 305], 'using': [203], 'mouse': [204], 'CDX': [205], 'models.': [206], 'showed': [208], 'tumor': [209, 235, 268, 281, 326, 390], 'growth': [210, 269, 327], 'inhibition': [211], 'dose': [214, 239], 'dependent': [215], 'manner': [216], 'xenograft': [219, 267, 317], 'models': [220, 391], 'A375,': [222], '205,': [224], 'HCT116,': [225], '205': [231, 316], 'model,': [232, 247, 275], 'caused': [234], 'regression': [236], 'at': [237], '20': [241, 263], 'mg/kg': [242, 260, 264], 'QD.': [243], 'Calu-6': [246], 'BID': [248, 261], 'QD': [250, 265], 'dosing': [251], 'schedules': [252], 'compared,': [254], 'result': [257], 'that': [258], '10': [259], 'inhibit': [266], 'similarly.': [270], 'Moreover,': [271], 'concentrations': [277], 'plasma': [279], 'measured,': [283], 'well': [285], 'phopspho-RSK1': [287], 'levels': [288], 'tumor.': [290], 'PK/PD': [292], 'correlation': [293], 'was': [294, 303], 'observed.': [295], 'addition': [297], 'being': [299], 'alone,': [301], 'inhibitor': [311], 'dabrafenib': [312, 321], 'model.': [318], 'demonstrated': [322], 'synergistic': [323], 'efficacy': [324, 388], 'inhibition.': [328], 'conclusion,': [330], 'can': [332], 'potentially': [334], 'used': [335], 'treatment': [337], 'cancer': [339], 'mutations.': [343], 'Citation': [344], 'Format:': [345], 'Ao': [346], 'Li,': [347, 379], 'Shanzhong': [348], 'Jian,': [349], 'Xia': [350], 'Yuan,': [351], 'Fengge': [352], 'Song,': [353], 'Shengwei': [354], 'Yang,': [355], 'Chengyi': [356], 'Du,': [357], 'Yue': [358], 'Tao,': [359], 'Liucheng': [360], 'Wang,': [361], 'Mingming': [362], 'Pan,': [363], 'Penghui': [364], 'Dong,': [365], 'jiajun': [366], 'Zhou,': [367], 'Zhengkang': [368], 'Ge,': [369], 'Qinghong': [370], 'Zhu,': [371], 'Wenshan': [372], 'Hao,': [373], 'Wen': [374], 'Xu,': [375], 'Jintao': [376], 'Zhang,': [377], 'Qun': [378], 'Shaohui': [380], 'Wang.': [381], 'demonstrates': [386], 'preclinical': [387], '[abstract].': [396], 'In:': [397], 'Proceedings': [398], 'Annual': [401], 'Meeting': [402], 'American': [405], 'Association': [406], 'Cancer': [408, 420], 'Research': [409], '2020;': [410], '2020': [411], 'Apr': [412], '27-28': [413], 'Jun': [415], '22-24.': [416], 'Philadelphia': [417], '(PA):': [418], 'AACR;': [419], 'Res': [421], '2020;80(16': [422], 'Suppl):Abstract': [423], 'nr': [424], '4188.': [425]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3083140303', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}], 'updated_date': '2024-12-14T20:11:40.768940', 'created_date': '2020-09-11'}