Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3080198030', 'doi': 'https://doi.org/10.1073/pnas.2010214117', 'title': 'Next-generation gene drive for population modification of the malaria vector mosquito, <i>Anopheles gambiae</i>', 'display_name': 'Next-generation gene drive for population modification of the malaria vector mosquito, <i>Anopheles gambiae</i>', 'publication_year': 2020, 'publication_date': '2020-08-24', 'ids': {'openalex': 'https://openalex.org/W3080198030', 'doi': 'https://doi.org/10.1073/pnas.2010214117', 'mag': '3080198030', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32839345', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7502704'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.2010214117', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1073/pnas.2010214117', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023910888', 'display_name': 'Rebeca Carballar‐Lejarazú', 'orcid': 'https://orcid.org/0000-0002-9338-8774'}, 'institutions': [{'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rebeca Carballar-Lejarazú', 'raw_affiliation_strings': ['Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;', 'institution_ids': ['https://openalex.org/I204250578']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059812399', 'display_name': 'Christian Ogaugwu', 'orcid': 'https://orcid.org/0000-0002-7010-0512'}, 'institutions': [{'id': 'https://openalex.org/I43427933', 'display_name': 'Federal University Oye Ekiti', 'ror': 'https://ror.org/02q5h6807', 'country_code': 'NG', 'type': 'education', 'lineage': ['https://openalex.org/I43427933']}, {'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}], 'countries': ['NG', 'US'], 'is_corresponding': False, 'raw_author_name': 'Christian Ogaugwu', 'raw_affiliation_strings': ['Department of Animal and Environmental Biology, Federal University Oye-Ekiti, Oye-Ekiti 371010, Ekiti State, Nigeria;', 'Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;'], 'affiliations': [{'raw_affiliation_string': 'Department of Animal and Environmental Biology, Federal University Oye-Ekiti, Oye-Ekiti 371010, Ekiti State, Nigeria;', 'institution_ids': ['https://openalex.org/I43427933']}, {'raw_affiliation_string': 'Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;', 'institution_ids': ['https://openalex.org/I204250578']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061953795', 'display_name': 'Taylor Tushar', 'orcid': 'https://orcid.org/0000-0001-6982-3249'}, 'institutions': [{'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Taylor Tushar', 'raw_affiliation_strings': ['Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;', 'institution_ids': ['https://openalex.org/I204250578']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050538366', 'display_name': 'Adam Kelsey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Adam Kelsey', 'raw_affiliation_strings': ['Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;', 'institution_ids': ['https://openalex.org/I204250578']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038171896', 'display_name': 'Thai Binh Pham', 'orcid': 'https://orcid.org/0000-0001-7661-0495'}, 'institutions': [{'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thai Binh Pham', 'raw_affiliation_strings': ['Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;', 'institution_ids': ['https://openalex.org/I204250578']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012296449', 'display_name': 'Jazmin Murphy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jazmin Murphy', 'raw_affiliation_strings': ['Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;', 'institution_ids': ['https://openalex.org/I204250578']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089682736', 'display_name': 'Hanno Schmidt', 'orcid': 'https://orcid.org/0000-0001-8915-891X'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hanno Schmidt', 'raw_affiliation_strings': ['Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616;'], 'affiliations': [{'raw_affiliation_string': 'Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616;', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012656146', 'display_name': 'Yoosook Lee', 'orcid': 'https://orcid.org/0000-0002-1392-7177'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yoosook Lee', 'raw_affiliation_strings': ['Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616;'], 'affiliations': [{'raw_affiliation_string': 'Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616;', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087190416', 'display_name': 'Gregory C. Lanzaro', 'orcid': 'https://orcid.org/0000-0003-1190-9810'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gregory C. Lanzaro', 'raw_affiliation_strings': ['Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616;'], 'affiliations': [{'raw_affiliation_string': 'Vector Genetics Laboratory, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616;', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039756363', 'display_name': 'Anthony A. James', 'orcid': 'https://orcid.org/0000-0001-5577-3308'}, 'institutions': [{'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204250578']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anthony A. James', 'raw_affiliation_strings': ['Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;', 'Department of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697-3900'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025;', 'institution_ids': ['https://openalex.org/I204250578']}, {'raw_affiliation_string': 'Department of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697-3900', 'institution_ids': ['https://openalex.org/I204250578']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 12.522, 'has_fulltext': False, 'cited_by_count': 184, 'citation_normalized_percentile': {'value': 0.999982, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '117', 'issue': '37', 'first_page': '22805', 'last_page': '22814'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11075', 'display_name': 'Insect Resistance and Genetics', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11075', 'display_name': 'Insect Resistance and Genetics', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12134', 'display_name': 'Insect symbiosis and bacterial influences', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/anopheles-gambiae', 'display_name': 'Anopheles gambiae', 'score': 0.94296193}, {'id': 'https://openalex.org/keywords/gene-drive', 'display_name': 'Gene drive', 'score': 0.6114227}], 'concepts': [{'id': 'https://openalex.org/C2776802408', 'wikidata': 'https://www.wikidata.org/wiki/Q135237', 'display_name': 'Anopheles gambiae', 'level': 3, 'score': 0.94296193}, {'id': 'https://openalex.org/C92087593', 'wikidata': 'https://www.wikidata.org/wiki/Q427389', 'display_name': 'Vector (molecular biology)', 'level': 4, 'score': 0.7710458}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.6733752}, {'id': 'https://openalex.org/C2781375639', 'wikidata': 'https://www.wikidata.org/wiki/Q158597', 'display_name': 'Anopheles', 'level': 3, 'score': 0.6331943}, {'id': 'https://openalex.org/C2778060650', 'wikidata': 'https://www.wikidata.org/wiki/Q22964789', 'display_name': 'Gene drive', 'level': 4, 'score': 0.6114227}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.563799}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.47530922}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.45777294}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.44315842}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.31613418}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.11469126}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.113838464}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.071453035}, {'id': 'https://openalex.org/C98108389', 'wikidata': 'https://www.wikidata.org/wiki/Q412563', 'display_name': 'CRISPR', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000852', 'descriptor_name': 'Anopheles', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000075423', 'descriptor_name': 'Gene Drive Technology', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D009032', 'descriptor_name': 'Mosquito Control', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000483', 'descriptor_name': 'Alleles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030801', 'descriptor_name': 'Animals, Genetically Modified', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D030801', 'descriptor_name': 'Animals, Genetically Modified', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000852', 'descriptor_name': 'Anopheles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064113', 'descriptor_name': 'CRISPR-Cas Systems', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D064113', 'descriptor_name': 'CRISPR-Cas Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000075423', 'descriptor_name': 'Gene Drive Technology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005828', 'descriptor_name': 'Genetics, Population', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D005828', 'descriptor_name': 'Genetics, Population', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059014', 'descriptor_name': 'High-Throughput Nucleotide Sequencing', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D059014', 'descriptor_name': 'High-Throughput Nucleotide Sequencing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009032', 'descriptor_name': 'Mosquito Control', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072138', 'descriptor_name': 'Mosquito Vectors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000072138', 'descriptor_name': 'Mosquito Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019076', 'descriptor_name': 'Transgenes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019076', 'descriptor_name': 'Transgenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.2010214117', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://escholarship.org/uc/item/33d7v04x', 'pdf_url': 'https://escholarship.org/content/qt33d7v04x/qt33d7v04x.pdf?t=qmgs2h', 'source': {'id': 'https://openalex.org/S4306400115', 'display_name': 'eScholarship (California Digital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2801248553', 'host_organization_name': 'California Digital Library', 'host_organization_lineage': ['https://openalex.org/I2801248553'], 'host_organization_lineage_names': ['California Digital Library'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502704', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32839345', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.2010214117', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320306137', 'funder_display_name': 'Bill and Melinda Gates Foundation', 'award_id': 'OPP1160739'}], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1596062789', 'https://openalex.org/W1901801915', 'https://openalex.org/W1968730525', 'https://openalex.org/W1969226149', 'https://openalex.org/W1990765375', 'https://openalex.org/W2008093264', 'https://openalex.org/W2062066670', 'https://openalex.org/W2087664746', 'https://openalex.org/W2101317489', 'https://openalex.org/W2112963066', 'https://openalex.org/W2144614846', 'https://openalex.org/W2170434008', 'https://openalex.org/W2172898214', 'https://openalex.org/W2175385506', 'https://openalex.org/W2180866616', 'https://openalex.org/W2190054909', 'https://openalex.org/W2517063877', 'https://openalex.org/W2557601429', 'https://openalex.org/W2562896996', 'https://openalex.org/W2583741452', 'https://openalex.org/W2728426457', 'https://openalex.org/W2768183859', 'https://openalex.org/W2794019234', 'https://openalex.org/W2891027664', 'https://openalex.org/W2925190684', 'https://openalex.org/W2938334149', 'https://openalex.org/W2949144539', 'https://openalex.org/W2949834184', 'https://openalex.org/W2950981781', 'https://openalex.org/W2976988014', 'https://openalex.org/W2994719674', 'https://openalex.org/W3006331632', 'https://openalex.org/W3011255407', 'https://openalex.org/W3012007369', 'https://openalex.org/W3012401804', 'https://openalex.org/W3014702683', 'https://openalex.org/W3046317109', 'https://openalex.org/W4245976088', 'https://openalex.org/W778596373'], 'related_works': ['https://openalex.org/W4392190524', 'https://openalex.org/W4386888352', 'https://openalex.org/W4381687487', 'https://openalex.org/W4280571146', 'https://openalex.org/W3080198030', 'https://openalex.org/W2436574078', 'https://openalex.org/W2343649896', 'https://openalex.org/W2249361275', 'https://openalex.org/W2022298477', 'https://openalex.org/W1968890548'], 'abstract_inverted_index': {'A': [0], 'Cas9/guide': [1, 115], 'RNA-based': [2], 'gene': [3, 27], 'drive': [4, 22, 72], 'strain,': [5], 'AgNosCd-1,': [6], 'was': [7, 45], 'developed': [8], 'to': [9, 14, 37, 53, 157], 'deliver': [10], 'antiparasite': [11], 'effector': [12], 'molecules': [13], 'the': [15, 25, 68, 75, 89, 94, 114], 'malaria': [16, 159], 'vector': [17], 'mosquito,': [18], 'Anopheles': [19], 'gambiae': [20], 'The': [21], 'system': [23], 'targets': [24], 'cardinal': [26], 'ortholog': [28], 'producing': [29], 'a': [30, 57, 83, 139, 146, 150], 'red-eye': [31], 'phenotype.': [32], 'Drive': [33], 'can': [34, 144], 'achieve': [35], '98': [36], '100%': [38], 'in': [39, 47, 74, 93, 99, 111, 125, 131], 'both': [40], 'sexes': [41], 'and': [42, 86, 103, 143], 'full': [43], 'introduction': [44], 'observed': [46, 130], 'small': [48], 'cage': [49], 'trials': [50], 'within': [51], '6': [52], '10': [54], 'generations': [55], 'following': [56], 'single': [58], 'release': [59], 'of': [60, 88, 101, 138, 149], 'gene-drive': [61], 'males.': [62], 'No': [63], 'genetic': [64], 'load': [65], 'resulting': [66], 'from': [67], 'integrated': [69], 'transgenes': [70], 'impaired': [71], 'performance': [73, 136], 'trials.': [76], 'Potential': [77], 'drive-resistant': [78], 'target-site': [79], 'alleles': [80], 'arise': [81], 'at': [82], 'frequency': [84], '<0.1,': [85], 'five': [87], 'most': [90], 'prevalent': [91], 'polymorphisms': [92], 'guide': [95], 'RNA': [96, 116], 'target': [97, 140], 'site': [98, 122], 'collections': [100], 'colonized': [102], 'wild-derived': [104], 'African': [105], 'mosquitoes': [106], 'do': [107], 'not': [108], 'prevent': [109], 'cleavage': [110], 'vitro': [112], 'by': [113], 'complex.': [117], 'Only': [118], 'one': [119], 'predicted': [120], 'off-target': [121], 'is': [123], 'cleavable': [124], 'vitro,': [126], 'with': [127], 'negligible': [128], 'deletions': [129], 'vivo.': [132], 'AgNosCd-1': [133], 'meets': [134], 'key': [135], 'criteria': [137], 'product': [141], 'profile': [142], 'be': [145], 'valuable': [147], 'component': [148], 'field-ready': [151], 'strain': [152], 'for': [153], 'mosquito': [154], 'population': [155], 'modification': [156], 'control': [158], 'transmission.': [160]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3080198030', 'counts_by_year': [{'year': 2024, 'cited_by_count': 24}, {'year': 2023, 'cited_by_count': 34}, {'year': 2022, 'cited_by_count': 59}, {'year': 2021, 'cited_by_count': 55}, {'year': 2020, 'cited_by_count': 10}], 'updated_date': '2024-12-13T06:02:46.651502', 'created_date': '2020-09-01'}