Title: Effects of myricetin on testicular torsion‐detorsion injury in rats
Abstract: AndrologiaVolume 52, Issue 10 e13775 ORIGINAL ARTICLE Effects of myricetin on testicular torsion-detorsion injury in rats Esra Ekşi, Esra Ekşi Department of Pediatric Surgery of Gumushane Hospital, Gumushane, TurkeySearch for more papers by this authorHatice Sonay Yalçın Cömert, Corresponding Author Hatice Sonay Yalçın Cömert [email protected] orcid.org/0000-0002-5281-4933 Department of Pediatric Surgery, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey Correspondence Hatice Sonay Yalçın Cömert, Department of Pediatric Surgery, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. Email: [email protected]Search for more papers by this authorMustafa Imamoğlu, Mustafa Imamoğlu Department of Pediatric Surgery, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeySearch for more papers by this authorAhmet Alver, Ahmet Alver Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeySearch for more papers by this authorSevdegül Aydin Mungan, Sevdegül Aydin Mungan Department of Pathology, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeySearch for more papers by this authorHaluk Sarıhan, Haluk Sarıhan Department of Pediatric Surgery, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeySearch for more papers by this author Esra Ekşi, Esra Ekşi Department of Pediatric Surgery of Gumushane Hospital, Gumushane, TurkeySearch for more papers by this authorHatice Sonay Yalçın Cömert, Corresponding Author Hatice Sonay Yalçın Cömert [email protected] orcid.org/0000-0002-5281-4933 Department of Pediatric Surgery, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey Correspondence Hatice Sonay Yalçın Cömert, Department of Pediatric Surgery, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. Email: [email protected]Search for more papers by this authorMustafa Imamoğlu, Mustafa Imamoğlu Department of Pediatric Surgery, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeySearch for more papers by this authorAhmet Alver, Ahmet Alver Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeySearch for more papers by this authorSevdegül Aydin Mungan, Sevdegül Aydin Mungan Department of Pathology, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeySearch for more papers by this authorHaluk Sarıhan, Haluk Sarıhan Department of Pediatric Surgery, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeySearch for more papers by this author First published: 12 August 2020 https://doi.org/10.1111/and.13775Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Testicular torsion is an emergency, and unless there is an urgent intervention, irreversible ischaemic damage and gonad loss occur in the testicle. We aimed to investigate myricetin's antioxidant properties as well as its protective effect against ischaemia–reperfusion (I/R) damage in the testicular torsion model. A total of 18 rats were divided into three equal groups. Group 1 was the sham group. Group 2: testicular torsion was performed, and orchiectomy was done 2 hr after detorsion. Group 3: received torsion and 1 mg/kg intraperitoneal myricetin was given 30 min before detorsion, and orchiectomy was applied 2 hr after detorsion. We evaluated tissue malondialdehyde, superoxide dismutase, and catalase levels and Johnsen Testicular Biopsy Score to show its histopathological effect. There was a statistically significant decrease in MDA values in myricetin group compared to Group 2 (p < .017). There was no significant difference in the statistical analysis of SOD and CAT values (p = .337 and p = .025). There was a statistically significant difference in testicular I/R damage in the myricetin group compared to Group 1 and Group 2 (p < .017). Myricetin treatment significantly decreased testicular tissue damage compared to the torsion group but did not reach the values close to the control group. CONFLICT OF INTEREST All authors declare no conflict of interest. Citing Literature Volume52, Issue10November 2020e13775 RelatedInformation