Publication Information

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1925, 1931, 2104, 2112, 2124, 2183, 2193, 2240, 2242, 2340, 2378, 2384, 2426, 2454, 2464, 2486, 2496, 2510, 2525, 2537, 2574, 2596, 2631, 2661, 2683, 2724, 2731, 2758, 2765, 2781, 2831, 2877, 2886, 2909, 2935, 2963, 3051, 3088, 3094, 3115, 3132, 3135, 3151, 3154, 3179, 3233, 3301, 3320, 3345, 3353, 3401, 3459, 3555, 3600, 3621, 3647, 3660, 3692, 3699, 3744, 3758, 3802, 3917, 3935, 3957, 4077, 4105, 4126, 4197, 4246, 4267, 4338, 4365], 'pain': [16, 49, 76, 95, 205, 504, 524, 553, 580, 2807, 2828, 2878, 2936, 3187, 3346, 3531, 3642, 4043], 'insensitivity,4,19': [17], 'and': [18, 107, 149, 162, 169, 214, 414, 419, 472, 477, 489, 493, 552, 590, 674, 697, 736, 743, 762, 781, 800, 871, 893, 925, 954, 1041, 1199, 1235, 1256, 1290, 1300, 1311, 1436, 1445, 1449, 1487, 1519, 1539, 1582, 1592, 1620, 1744, 1751, 1754, 1812, 1826, 1879, 1940, 1952, 1960, 1992, 2046, 2162, 2169, 2236, 2300, 2313, 2326, 2346, 2412, 2418, 2448, 2461, 2533, 2586, 2605, 2620, 2669, 2786, 2793, 2803, 2809, 2847, 2893, 2937, 2952, 3053, 3056, 3079, 3141, 3166, 3191, 3193, 3220, 3249, 3276, 3363, 3398, 3504, 3521, 3561, 3585, 3628, 3638, 3676, 3707, 3720, 3781, 3823, 3841, 3854, 3949, 4094, 4116, 4140, 4149, 4186, 4235, 4276, 4333, 4368, 4444, 4451], 'such': [19, 623, 741, 938, 2323, 2380, 2747, 3527, 4081, 4108], 'cases': [20], 'have': [21, 44, 232, 344, 432, 1774, 2404, 2473, 2562, 2755, 2984, 2994, 3089, 3657, 4015, 4161], 'been': [22, 133, 555, 875, 1090, 1526, 1775, 1907, 1923, 2139, 2155, 2691, 3658, 4265, 4304], 'instrumental': [23], 'driving': [25], 'drug': [26, 599], 'discovery': [27, 1779], 'programs': [28], 'for': [29, 85, 103, 118, 243, 347, 576, 734, 755, 791, 810, 1587, 1662, 1784, 2196, 2545, 2640, 2948, 2966, 3015, 3026, 3542, 3569, 3970, 4279, 4340, 4441], 'new': [30, 1060, 1723, 2163], 'analgesics.75': [31], 'A': [32, 1481, 2434, 2597, 2637], 'less': [33, 3874, 3903], 'frequently': [34], 'trodden': [35], 'track': [36], 'is': [37, 98, 122, 157, 180, 215, 247, 260, 331, 387, 532, 600, 653, 662, 739, 753, 854, 904, 973, 986, 998, 1003, 1318, 1341, 1351, 1380, 1460, 1490, 1782, 1913, 2087, 2180, 2202, 2238, 2295, 2383, 2395, 2445, 2452, 2558, 2571, 2600, 2607, 2648, 2695, 2716, 2839, 2870, 2906, 2940, 3043, 3216, 3231, 3335, 3571, 3634, 3670, 3734, 3756, 3872, 3902, 3930, 4009, 4228, 4277, 4286, 4384, 4409, 4420], 'the': [38, 60, 70, 153, 163, 170, 174, 255, 263, 292, 296, 317, 334, 337, 388, 391, 398, 404, 417, 485, 518, 533, 537, 541, 545, 548, 577, 614, 657, 670, 678, 688, 707, 716, 756, 794, 798, 808, 834, 866, 878, 883, 889, 898, 911, 918, 940, 963, 981, 999, 1013, 1021, 1037, 1050, 1059, 1079, 1082, 1107, 1112, 1123, 1131, 1136, 1142, 1150, 1213, 1219, 1245, 1263, 1277, 1285, 1304, 1313, 1324, 1342, 1358, 1362, 1366, 1374, 1396, 1401, 1409, 1497, 1502, 1508, 1556, 1564, 1616, 1644, 1654, 1681, 1687, 1738, 1745, 1769, 1778, 1824, 1841, 1857, 1862, 1961, 1970, 1974, 1986, 1995, 2011, 2017, 2036, 2058, 2061, 2065, 2075, 2095, 2114, 2132, 2143, 2175, 2197, 2203, 2211, 2222, 2229, 2248, 2258, 2283, 2288, 2330, 2336, 2356, 2360, 2372, 2386, 2406, 2449, 2497, 2511, 2513, 2517, 2531, 2569, 2603, 2617, 2641, 2708, 2722, 2782, 2811, 2821, 2844, 2849, 2865, 2921, 2924, 2971, 2976, 2997, 3013, 3060, 3083, 3121, 3126, 3142, 3167, 3238, 3271, 3289, 3318, 3354, 3359, 3374, 3382, 3386, 3415, 3426, 3441, 3447, 3488, 3497, 3519, 3539, 3550, 3575, 3580, 3594, 3662, 3686, 3704, 3760, 3790, 3842, 3867, 3884, 3888, 3921, 3940, 3958, 3962, 3971, 3977, 3982, 3987, 3991, 4003, 4019, 4023, 4028, 4049, 4060, 4066, 4088, 4098, 4110, 4129, 4138, 4146, 4199, 4202, 4222, 4241, 4247, 4253, 4280, 4297, 4299, 4324, 4354, 4377, 4381, 4395, 4398, 4403, 4433, 4447], 'examination': [39, 2278], 'why': [41, 490, 3476], 'some': [42, 2902], 'animals': [43, 148, 410, 3192], 'evolved': [45, 233, 253, 515, 2563], 'specific': [46, 92, 3199, 3235], 'types': [47, 93, 502], 'insensitivity.': [50], 'In': [51, 275, 390, 479, 540, 797, 1010, 2131, 2303, 2500, 2686, 3309, 3424, 3645], 'this': [52, 127, 303, 351, 480, 527, 852, 1140, 1200, 1241, 1450, 1761, 2055, 2237, 2291, 2364, 2368, 2443, 2542, 2580, 2606, 2959, 3324, 4008, 4389, 4423], 'review,': [53, 481], 'I': [54, 482, 684, 4191], 'will': [55, 483, 625, 685], 'focus': [56], 'on': [57, 184, 291, 333, 725, 732, 789, 1421, 1501, 1560, 2233, 2257], 'insights': [58], 'that': [59, 100, 111, 135, 172, 262, 279, 302, 316, 330, 371, 408, 438, 521, 606, 746, 751, 770, 778, 819, 823, 851, 877, 902, 913, 959, 1056, 1081, 1088, 1096, 1114, 1163, 1223, 1253, 1350, 1364, 1408, 1476, 1491, 1522, 1524, 1627, 1676, 1736, 1749, 1773, 1780, 1791, 1822, 1829, 1865, 1893, 1917, 2060, 2063, 2073, 2080, 2085, 2101, 2121, 2127, 2146, 2166, 2191, 2287, 2421, 2492, 2541, 2560, 2583, 2649, 2693, 2748, 2763, 2771, 2800, 2882, 2978, 2996, 3111, 3184, 3212, 3291, 3337, 3370, 3431, 3511, 3607, 3633, 3673, 3748, 3774, 3820, 3864, 3883, 3895, 3946, 3954, 4038, 4123, 4169, 4201, 4230, 4344, 4353, 4388], 'biology': [61, 549, 2783], 'African': [63, 88, 497, 4157, 4335], 'mole-rats': [64, 343, 363, 431, 2274, 2472, 2647, 2797, 2826, 2983, 3107, 3644, 3929], 'has': [65, 131, 358, 554, 873, 1900, 1905, 1921, 2138, 2153, 2690, 2858, 3776, 4264, 4292, 4303, 4358, 4425], 'given': [66], 'us': [67, 1104, 1548, 2485, 4125], 'understanding': [69, 2158], 'molecular': [71, 2144, 2176, 4074], 'basis': [72, 690, 1411, 2177], 'naturally': [74, 136, 2697], 'occurring': [75, 137, 2698, 3684], 'insensitivity.27,89,91,114': [77], 'Many': [78, 2402], 'millions': [79], 'years': [81, 4058], 'ago,': [82, 4059], 'evolution': [83, 101], 'selected': [84, 102], 'changes': [86, 104, 516, 1641, 2093, 2117, 3648, 3980], 'mole-rat': [89, 298, 319, 422, 498, 514, 2285, 2358, 2490, 2515, 2753, 2817, 3128, 3169, 3260, 3293, 3449, 3499, 3582, 3688, 3706, 3740, 3754, 3771, 3785, 3811, 3831, 3839, 3844, 3852, 3869, 3942, 3960, 4001, 4025, 4051, 4061, 4148, 4158, 4224, 4243, 4326, 4356], 'producing': [91, 1713, 3877], 'insensitivity.27': [96], 'It': [97, 130, 246, 738, 776, 1689, 1912, 2557, 4227], 'striking': [99, 453, 1077], 'signal': [108], 'transduction': [109], 'pathways': [110], 'were': [112, 270, 1533, 1870, 2338, 3103, 3112, 3170], 'subsequently': [113], 'identified': [114], 'as': [115, 193, 195, 198, 583, 585, 642, 832, 939, 1320, 1797, 1799, 2324, 2429, 2433, 2568, 2599, 3023, 3025, 3029, 3045, 3264, 3451, 3462, 3909, 4082, 4109, 4175, 4177, 4312, 4314], 'being': [116, 228], 'critical': [117, 4020], 'human': [119, 1858, 1919, 2675], 'nociception,': [120, 3651], 'which': [121, 231, 728, 805, 997, 1251, 1585, 2001, 2040, 2179, 2394, 2483, 2920, 3071, 3080, 3230, 3408, 3419, 3682, 3746, 4207, 4291, 4302], 'major': [124, 226, 563, 1902, 3039], 'theme': [125], 'short': [128], 'review.': [129], 'long': [132, 459, 874], 'known': [134, 818, 831], 'chemical': [138, 1022], 'substances,': [139], 'called': [140], 'algogens,': [141], 'evoke': [142, 3302, 3556, 3629, 3700], 'painful': [143], 'sensations': [144, 211], 'or': [145, 1335, 1464, 1478, 1808, 1955, 2913, 3202, 4217], 'avoidance': [146], 'humans.': [150], 'One': [151, 2051, 2189, 2376], 'best': [154], 'characterized': [155], 'algogens': [156], 'capsaicin,': [158, 185, 3298, 3745], 'natural': [160], 'substance': [161, 171, 200, 922, 1989, 3672], 'active': [164], 'ingredient': [165], 'chili': [167], 'peppers,': [168], 'confers': [173], 'burn': [175], 'hot': [177], 'peppers.11,12': [178], 'There': [179, 558, 4383], 'huge': [182, 1189, 1289], 'literature': [183], 'characterizing': [186], 'its': [187, 196, 984, 2787, 2914, 3234], 'neurotoxic': [188], 'effects': [189, 1208, 1557, 1930], 'neonatal': [191], 'animals,': [192, 1012], 'well': [194, 556, 887, 1798, 3024, 4176, 4313], 'use': [197, 1694], 'produce': [202, 2044, 3186], 'acute': [203, 3650, 3675], 'experimental': [204], 'humans.41,124': [207], 'Capsaicin': [208, 3215, 3256], 'causes': [209, 3315], 'burning': [210], 'thought': [216, 1381, 2239], 'induce': [218, 1794, 3803], 'similar': [220, 3709], 'sensation': [221, 3188], 'most': [223, 452, 2304, 2662], 'vertebrates,': [224], 'one': [225, 3138, 3390, 3994], 'exception': [227], 'all': [229, 676, 820, 977, 1643, 2610, 2614, 4163], 'birds,': [230, 266], 'insensitivity': [234, 252, 525, 2829, 2876, 2934], 'capsaicin': [236, 251, 280, 1495, 3314, 3338, 3400, 3477, 3547, 3592, 3697, 3782], 'likely': [237, 2559, 3968], 'because': [238, 288, 350, 629, 1361, 1600, 3364], 'they': [239, 2650, 3057, 4039], 'are': [240, 364, 424, 559, 771, 1763, 2069, 2423, 2493, 2658, 2666, 2776, 3069, 3072, 3182, 3295, 3367, 3371, 3377, 3422, 3432, 3438, 3457, 3463, 3689, 3955, 3967, 4084], 'seed': [241], 'carriers': [242], 'capsicum': [244], 'plants.49': [245], 'not': [248, 282, 620, 855, 1352, 2462, 2589, 3004, 3130, 3328, 3343, 4011, 4143], 'clear': [249, 621, 850, 1407, 4229], 'when': [250, 1205, 3173, 3221, 3534, 3813, 3824], 'bird': [256], 'lineage,': [257], 'but': [258, 846, 983, 1466, 2740, 3445, 3485, 3738, 3794, 4007, 4151, 4418], 'it': [259, 618, 661, 816, 847, 872, 903, 1403, 2689, 3299, 3336, 3775, 4419], 'possible': [261], 'ancestors': [264], 'ie,': [267], 'nonavian': [268], 'dinosaurs,': [269], 'already': [271, 900, 957, 4063], 'insensitive': [272, 309], 'capsaicin.': [274], '2008,': [276], 'we': [277, 439, 747, 1161, 1789, 1796, 3174, 4014, 4322], 'discovered': [278, 4065], 'was': [281, 307, 403, 619, 817, 848, 942, 1034, 1045, 1074, 1078, 1202, 1218, 1404, 1415, 1660, 1667, 1678, 1707, 1728, 2057, 2084, 2516, 2543, 2928, 3012, 3536, 3552, 3618, 3714, 3725], 'universal': [284], 'irritant': [285], 'mammals': [287, 370, 2561, 2611, 2625, 4367], 'our': [289, 1567, 2991, 4318], 'studies': [290, 1283, 2993], 'nociceptive': [293, 907, 1561, 1746, 2270, 2891, 3021, 3351, 4400], 'system': [294, 2271, 4401], 'naked': [297, 318, 421, 491, 513, 2273, 2284, 2331, 2357, 2441, 2471, 2498, 2514, 2618, 2646, 2668, 2745, 2752, 2816, 2825, 2982, 3106, 3127, 3168, 3259, 3292, 3307, 3331, 3448, 3489, 3498, 3540, 3581, 3626, 3667, 3687, 3705, 3739, 3753, 3770, 3810, 3830, 3838, 3843, 3851, 3860, 3868, 3928, 3941, 3959, 3992, 4000, 4024, 4050, 4111, 4147, 4223, 4242, 4325, 4355, 4404, 4452], '(Heterocephalus': [299], 'glaber)': [300], 'revealed': [301, 315], 'unusual': [304, 4399], 'subterranean': [305, 2489], 'mammal': [306], 'completely': [308, 2841], 'capsaicin.91': [311], 'Further': [312], 'experiments': [313, 742, 1029, 3849], 'also': [314, 830, 849, 1468, 1871, 1922, 2154, 2678, 2930, 2941, 3326, 3378, 3619, 3788, 4102, 4152, 4255], 'displays': [320], 'no': [321], 'nerve': [322, 1033, 1044, 1064, 1683, 1976, 3017, 3036], 'growth': [323, 508, 530, 859, 1309, 1981, 3730], 'factor': [324, 531, 860, 1117, 1226, 1259, 1310, 1982], '(NGF)-induced': [325], 'thermal': [326, 3054, 3563, 3631, 3701, 3712, 3732, 3764, 3925], 'hyperalgesia,66,91': [327], 'phenomenon': [329, 1423, 3325], 'dependent': [332, 1420], 'presence': [335, 3595], 'capsaicin-activated': [338], 'ion': [339, 1967, 3200, 3251], 'channel': [340, 3244, 3252], 'TRPV1.17': [341], 'Naked': [342, 362, 430, 3784], 'fascinated': [345], 'biologists': [346, 803], 'several': [348, 1588], 'decades': [349], 'underground-dwelling': [352], 'species': [353, 2294, 2365, 2491, 2508, 2519, 4174, 4337], 'native': [354], 'East': [356], 'Africa': [357], 'unique': [360, 3956, 4218, 4347, 4372], 'biology.': [361], '1': [365, 3243, 3948], 'only': [367, 1164, 2518, 3074, 3572, 4144], '2': [368, 1819, 3100, 4231, 4334, 4370], 'eusocial': [369], 'live': [372], 'very': [374, 631, 886, 1165, 1203, 1220, 4119], 'large': [375, 764, 1204, 1418, 4120], 'colonies': [376, 423], '(up': [377], '300': [379, 2856], 'individuals)': [380], 'with': [381, 888, 1270, 1642, 1883, 1927, 2398, 2520, 2579, 2704, 2854, 2874, 2904, 2943, 3020, 3108, 3270, 3418, 3826, 4002, 4018, 4033], 'single': [383, 1570, 1629], 'breeding': [384], 'female': [385], 'who': [386], 'queen.42,43': [389], 'late': [392, 3677], '1970s,': [393], 'Dr': [394], 'Jenny': [395], 'Jarvis': [396], 'from': [397, 1156, 1174, 1244, 1394, 1948, 1956, 1994, 2071, 2210, 2221, 2506, 2727, 3007, 3280, 3394, 3818, 4022, 4137, 4317, 4459], 'University': [399], 'Cape': [401], 'Town': [402], 'first': [405, 594, 1108, 1221, 1609, 1710, 1818, 2276], 'show': [407, 1700, 2679, 2805, 4040, 4214, 4237], 'these': [409, 1168, 1282, 2437, 3001, 3099, 3147, 4034, 4164, 4193], 'could': [411, 1016, 1118, 1793, 1806, 1837, 2043, 3525], 'be': [412, 863, 945, 1017, 1370, 1383, 1469, 1597, 1838, 1874, 2173, 2184, 2194, 2309, 2341, 2964, 3133, 3152, 4103, 4184, 4268, 4346, 4392], 'kept': [413], 'bred': [415], 'laboratory,': [418], 'today': [420], 'maintained': [425], 'many': [427, 434, 1910, 2430, 3452], 'laboratories': [428], 'worldwide.': [429], 'so': [433, 4168], 'extreme': [435, 475], 'physiological': [436, 454, 2992], 'features': [437, 1759], 'would': [440, 3995], 'need': [441], 'an': [442, 457, 597, 649, 1233, 1321, 1333, 1336, 1347, 1702, 2081, 2455, 2553, 3032, 3410], 'entire': [443], 'review': [444, 687, 2256], 'detail': [446], 'them': [447, 2103], 'all.': [448], 'Some': [449], 'their': [451, 786, 1192, 2318, 3155, 3176], 'adaptations': [455], 'include': [456], 'extraordinarily': [458], 'maximum': [460], 'life': [461], 'span': [462], 'at': [464, 560, 1439, 1622, 3373, 3381, 3876, 4296], 'least': [465, 561], '36': [466], 'years,100': [467], 'apparent': [468, 1611], 'resistance': [469, 473], 'cancer,': [471], 'hypercapnia': [476], 'hypoxia.92': [478], 'examine': [484, 2379, 3661, 4198], 'questions': [486], 'how': [488, 666, 692, 1296], 'mole-rats,': [492, 2442, 2746], 'more': [494, 1076, 1237, 1535, 1552, 2254, 2741, 3171, 4054], 'recently': [495, 2736, 4114], 'other': [496, 1800, 2479, 2663, 2946, 3118, 3164, 4155, 4366], 'species,': [499], 'lost': [500, 2367], 'certain': [501], 'sensitivity.': [505], '2.': [506], 'Nerve': [507, 529, 858, 1308, 1980, 3729], 'factor:': [509], 'recent': [510], 'history': [511], 'The': [512, 593, 700, 993, 1625, 1757, 1817, 1890, 2269, 2275, 2349, 2769, 2835, 2896, 3038, 3066, 3158, 3348, 3565, 4073, 4261, 4406], 'NGF': [519, 551, 575, 609, 650, 667, 693, 711, 720, 733, 752, 790, 838, 843, 881, 960, 1134, 1148, 1505, 1532, 1559, 1574, 1659, 1677, 1706, 1731, 1781, 1792, 1869, 1920, 2042, 2086, 2785, 2912, 2925, 2972, 3791, 3800, 3808, 3896, 4071], 'signaling': [520, 651, 1984, 3908, 3973], 'probably': [522], 'underlies': [523], 'species.89,91': [528], 'founding': [534], 'member': [535], 'neurotrophin': [538], 'family.': [539], 'past': [542, 2133], '20': [543, 2134], 'years,': [544, 2135], 'link': [546, 1741], 'between': [547, 1441, 1742, 3163, 3514, 3947, 4145], 'established.35,60,73,95': [557], '5': [562], 'pharmaceutical': [564], 'companies': [565], 'running': [566], 'clinical': [567], 'trials': [568], 'humanized': [570, 603], 'antibodies': [571, 1696, 1805], 'designed': [572], 'sequester': [574], 'treatment': [578], 'conditions': [582, 1899], 'varied': [584], 'osteoarthritis,': [586], 'lower': [587], 'back': [588], 'pain,': [589, 660], 'interstitial': [591], 'cystitis.8,14,28,52,57,106': [592], 'example': [595, 1483, 3543], 'NGF-sequestering': [598], 'tanezumab,': [601], 'monoclonal': [604], 'antibody': [605, 703], 'potently': [607, 3208], 'binds': [608], 'developed': [610], 'by': [611, 1145, 1373, 1840, 2297, 2546, 2872, 3075, 3196, 3205, 3254, 3266, 3297, 3435, 3591, 3727, 3911], 'Rinat/Pfizer.57': [612], 'At': [613], 'time': [615, 1274], 'writing,': [617], 'whether': [622, 1658, 1701, 1803, 2363, 2824], 'drugs': [624], 'gain': [626], 'regulatory': [627], 'approval': [628], 'percentage': [633], 'treated': [635], 'patients': [636], 'had': [637, 956, 1068, 1089, 1525, 2366, 4062], 'experienced': [638], 'severe': [639], 'joint': [640], 'damage': [641], 'side': [644], 'effect': [645, 1904], 'treatment.106': [647], 'Because': [648], 'axis': [652], 'undoubtedly': [654], 'important': [655, 663, 1291, 1914, 2082, 2195, 4278], 'etiology': [658], 'understand': [665], 'functions': [668, 694], 'context': [671, 679], 'nociception': [673, 696], 'above': [675], 'inflammatory': [681, 1337, 1663, 1726, 1785, 1898, 3655, 4042], 'hyperalgesia.': [682, 1458, 1664, 1714, 1786, 2151, 3765], 'Here,': [683, 4190], 'briefly': [686], 'mechanistic': [689, 2033], 'chronic': [698], 'pain.': [699, 3214], 'availability': [701], 'tools': [704, 4075], 'manipulate': [706], 'endogenous': [708, 1868], 'levels': [709, 879, 1132, 4131, 4179, 4440], 'allowed': [712], 'researchers': [713], 'address': [715], 'functional': [717, 1640, 3085, 3139], 'consequences': [718], 'sequestration.': [721], 'Initially,': [722], 'efforts': [723], 'focused': [724], 'identifying': [726], 'precisely': [727], 'neuronal': [729], 'populations': [730, 3102], 'depend': [731], 'survival': [735, 757, 792, 811], 'when.': [737], 'through': [740, 2245, 3544], 'later': [744], 'genetics': [745], 'got': [748], 'know': [750], 'required': [754, 807], 'sympathetic': [759, 780, 892], 'ganglion': [760], 'neurons': [761, 769, 783, 806, 822, 909, 932, 1169, 1198, 1444, 1748, 2008, 2354, 2703, 3002, 3366, 3397, 3417, 3430, 3456, 3464, 3742, 3787, 3817, 4415], 'proportion': [765], 'embryonic': [767, 840], 'sensory': [768, 782, 821, 894, 908, 931, 968, 1025, 1443, 1747, 1999, 2280, 2353, 2369, 2656, 2702, 3210, 3741, 3786, 3816, 4414], 'destined': [772], 'become': [774], 'nociceptors.23,101,102': [775], 'seems': [777, 2192, 2962, 3150], 'both': [779, 1254, 1823, 2167, 2298, 3050, 3502, 3635], 'largely': [784, 2292, 2651], 'lose': [785], 'absolute': [787, 2456], 'dependency': [788], 'postnatal': [795, 2710, 2749], 'period.101,102': [796], '1980s': [799, 899], '1990s,': [801], 'developmental': [802, 2968, 4271], 'asked': [804], 'neurotrophins': [809, 1297], 'during': [812, 839], 'development.59': [813], 'For': [814, 2252], 'example,': [815, 2949], 'express': [824, 3789], 'TrkA': [825, 970, 995, 1854, 2927, 3828, 3853, 3857, 3870, 3900, 3936, 3943, 3966, 3983, 4005], '(tropomyosin': [826], 'receptor': [827, 836, 971, 2231, 2250, 2788, 2915, 2926, 2973, 2998, 3109, 3240, 3567, 3792, 3871], 'kinase': [828, 3963, 3984], 'A,': [829], 'NTRK1),': [833], 'main': [835], 'development,': [841], 'require': [842, 2113], 'survive,': [845], 'population': [853, 2370, 3042, 3068, 3086], 'phenotypically': [856], 'homogenous.23,74': [857], 'continues': [861], 'synthesized': [864], 'peripheral': [867, 1014, 1355, 1939, 1975, 2096, 2148, 2170, 2392, 3375], 'targets': [868], 'into': [869, 1149, 1634, 2311, 3223, 3538, 3549, 4027], 'adulthood': [870], 'noted': [876, 1521], 'target': [884], 'correlate': [885], 'density': [890], 'innervation.54,59,109': [895], 'Studies': [896], 'showed': [901, 1187, 1252, 1821, 3863], 'primarily': [905, 921, 3933], 'neuropeptide-containing': [906], 'adults': [912], 'respond': [914, 3743], 'NGF.59': [916], 'Thus': [917], 'neuropeptide': [919, 2321], 'content,': [920], 'P': [923], '(SP)': [924], 'calcitonin': [926, 2028], 'gene-related': [927, 2029], 'peptide': [928], '(CGRP),': [929], 'innervating': [933, 1065, 1176, 1212], 'tissues': [934, 949], 'high': [935, 946, 1070, 2591], 'NGF,': [937, 1183, 1631, 3721], 'skin,': [941, 1049], 'observed': [943, 2339, 2420, 2692, 2737, 2900, 3715, 3989], 'compared': [947, 1206, 3093, 3691, 3916, 4245, 4364], 'low': [950, 2450, 2522], 'NGF.78': [952], 'Lindsay': [953], 'Harmar': [955], 'demonstrated': [958, 2286, 2871, 3773, 3894], 'directly': [961, 1371, 3185, 3197, 4127, 4305], 'upregulates': [962], 'SP': [964, 1051, 1071, 2345, 2804, 3535, 3570, 3598, 3617], 'content': [965, 1052], 'adult': [967, 4413], 'neurons.69': [969], 'expression': [972, 985, 1959, 2120, 2319, 2969, 4130, 4178, 4216, 4239, 4258], 'feature': [975, 2053], 'developing': [978], 'nociceptors': [979, 1007, 1431, 1512, 2215, 2227, 2460, 2477, 2818, 2838, 2869, 2899, 3028, 3294, 3341, 3421, 3437, 3461, 3473, 3495, 3590], 'embryo,': [982], 'extinguished': [987], 'postnatal,': [989], 'small-diameter,': [990], 'nonpeptidergic': [991, 2314], 'nociceptors.83': [992], 'high-affinity': [994], 'receptor,': [996, 1002], 'primary': [1000, 1359, 1442], 'NGF-signaling': [1001, 1896], 'coexpressed': [1004, 3825], 'neuropeptide-positive': [1006, 2352], 'adults.': [1009, 2734], 'mature': [1011], 'tissue': [1015], 'shown': [1018, 1764, 1872, 2995, 3620, 3910, 4266], 'influence': [1020], 'composition': [1023], 'afferents.': [1026], 'Thus,': [1027, 1427, 2470, 3120, 3491, 3920, 4047], 'where': [1030, 1730], 'cutaneous': [1032, 2416, 2476, 2523, 2565, 2642, 2676, 2979], 'rerouted': [1035, 1046], 'NGF-poor': [1038], 'skeletal': [1039, 1137, 1177, 1184], 'muscle': [1040, 1043, 1063, 1086, 1185, 1210, 2585, 2635], 'NGF-rich': [1048], 'changed': [1053], 'match': [1055], 'characteristic': [1057], 'target,': [1061], 'eg,': [1062], 'skin': [1066, 1093, 1099, 1472, 2289, 2337, 2570, 2604, 3035], 'now': [1067, 1094, 1906], 'content.77,78': [1072], 'What': [1073], 'even': [1075, 2848, 3795], 'fact': [1080, 1626, 2977, 3290], 'central': [1083, 1388, 1425, 1941, 1996, 2021, 2125, 2168, 2200, 2212, 2223, 2262], 'connectivity': [1084, 3470], 'afferents': [1087, 1175, 1186, 1211, 1363], 'redirected': [1091], 'resembled': [1095], 'normal': [1098, 2687, 2967, 3777], 'afferents.62': [1100], 'These': [1101, 1545], 'results': [1102, 3833, 4032], 'led': [1103, 1547], 'conduct': [1106], 'serious': [1109], 'test': [1110], 'idea': [1113, 1242, 2059, 4200], 'neurotrophic': [1116, 1225, 1258, 2025], 'regulate': [1119, 1298], 'synaptic': [1120, 1172, 1229, 1301, 1454, 2014], 'strength': [1121, 1264, 1302, 1455], 'nervous': [1124, 1305], 'system.': [1125, 1306], 'We': [1126, 2078, 2735, 3509, 4113, 4160], 'decided': [1127], 'artificially': [1129], 'raise': [1130], 'muscle,': [1138, 1144], 'case': [1141, 3014], 'gastrocnemius': [1143], 'chronically': [1146], 'pumping': [1147], 'muscle.': [1151, 1178], 'By': [1152], 'making': [1153], 'extracellular': [1154], 'recordings': [1155, 3269, 3279, 3393], 'spinal': [1157, 2018, 2234, 3355, 3395, 3583, 3597, 4141], 'dorsal': [1158, 1196, 1446, 2019, 3282, 3361, 3387, 3443, 3454, 3506, 3523, 3577], 'horn': [1159, 1197, 1447, 3455, 3507, 3524, 3578], 'neurons,': [1160, 1448, 2000, 2857, 3799], 'knew': [1162], 'few': [1166], 'receive': [1170], 'strong': [1171, 1428], 'drive': [1173], 'However,': [1179, 2328, 2439, 3287, 3807, 4013, 4097], 'after': [1180, 1332, 1462, 1471, 1492, 1615, 1650, 1684, 1788, 2049, 3716], 'exposure': [1181], 'increase': [1190, 1201, 1262, 1322, 2205], 'ability': [1193], 'excite': [1195], 'contralateral,': [1214], 'untreated': [1215, 1543], 'muscle.68': [1216], 'This': [1217, 1376, 1665, 2712, 3011, 3468], 'demonstration': [1222], 'modulate': [1228], 'strength.': [1230], 'Shortly': [1231], 'afterwards,': [1232], 'elegant': [1234], 'perhaps': [1236], 'direct': [1238, 3267], 'proof': [1239], 'came': [1243], 'laboratory': [1246, 4079], 'Moo': [1248], 'Ming': [1249], 'Poo,': [1250], 'neurotrophin-3': [1255], 'brain-derived': [1257, 2024], '(BDNF)': [1260], 'neuromuscular': [1266], 'synapses': [1267, 1299, 1440], 'vitro,': [1269], 'surprisingly': [1272], 'fast': [1273], 'course': [1275, 2373], 'range': [1278, 2623], 'seconds.71': [1280], 'Together,': [1281], 'provided': [1284], 'foundation': [1286], 'area': [1292, 1343, 1349, 1368, 2539], 'study,': [1294], 'namely': [1295], '3.': [1307], 'hyperalgesia:': [1312], 'linchpin': [1314, 1734], 'theory': [1315], '1993': [1316], 'Hyperalgesia': [1317, 1459], 'defined': [1319], 'felt': [1325], 'intensity': [1326], 'noxious': [1329, 2105], 'stimulus,': [1330], 'usually': [1331], 'injury': [1334, 1398, 1463], 'process.': [1338], 'Secondary': [1339], 'hyperalgesia': [1340, 1379, 1414, 1489, 1594, 1602, 1608, 1647, 1727, 1814, 1828, 1881, 2048, 2068, 2161, 3632, 3665, 3702, 3713, 3724, 3733, 3926], 'hypersensitivity': [1345], 'surrounding': [1346], 'injured': [1348], 'due': [1353, 1384, 2453, 2463, 2830, 2885, 2908, 3134, 3232, 3934], 'sensitization': [1356, 1386, 1945, 2126, 2201, 3316, 3804], 'afferent': [1360, 1391], 'innervate': [1365, 2584], 'secondary': [1367, 1413], 'cannot': [1369], 'sensitized': [1372], 'injury.': [1375], 'type': [1377], 'circuits': [1389], 'input': [1392, 3352], 'coming': [1393], 'nearby': [1395], 'initial': [1397], 'site.65,80,124': [1399], 'During': [1400], '1980s,': [1402], 'becoming': [1405, 1618], 'increasingly': [1406], 'neurobiological': [1410], 'extent': [1419], 'termed': [1424], 'sensitization.20,79,127': [1426], 'activation': [1429, 3236, 3339, 3492, 3588, 3603, 3865, 3897], 'leads': [1432, 2123, 3599], 'rapid': [1435, 1639, 2092], 'long-lasting': [1437, 1451], 'plasticity': [1438, 2244], 'change': [1452], 'sustain': [1457, 1752], 'induced': [1461], 'inflammation,': [1465], 'produced': [1470, 1579], 'application': [1473, 1493], 'substances': [1475], 'activate': [1477, 3402], 'sensitize': [1479, 2002, 2102], 'nociceptors.': [1480], 'classic': [1482], 'algogen-induced': [1485], 'heat': [1486, 1540, 1581, 1591, 1601, 1753, 1811, 1825, 1878, 2045, 2067, 2106, 2150, 3321], 'mechanical': [1488, 1538, 1583, 1593, 1607, 1755, 1813, 1827, 1880, 2047, 2076, 2129, 2160, 3052, 3077, 3723], 'skin.56': [1498], 'While': [1499], 'working': [1500], 'role': [1503, 3978, 4427], 'determining': [1507], 'phenotypic': [1509], 'identity': [1510], 'Lorne': [1514], "Mendell's": [1515], 'laboratory,61,99': [1516], 'Amy': [1517], 'Ritter': [1518], 'myself': [1520], 'rats': [1523], 'exposed': [1527, 2573], 'daily': [1529], 'injections': [1530], 'behaviorally': [1534], 'sensitive': [1536], 'stimuli': [1541, 3078, 3656], 'than': [1542, 2478, 2552, 4055], 'animals.': [1544], 'observations': [1546], 'make': [1550, 3058, 3081, 3392, 3997], 'systematic': [1553], 'study': [1554, 2487, 2503, 4078], 'behaviors': [1562, 2795, 3162], 'rat.': [1565], 'To': [1566, 3975], 'surprise,': [1568], 'systemic': [1571], 'injection': [1572], '(1': [1575], 'mg/kg': [1576], 'body': [1577, 2672], 'weight)': [1578], 'profound': [1580], 'hyperalgesia,': [1584, 1795, 2109], 'lasted': [1586], 'days.': [1589], 'Interestingly,': [1590, 2958, 3098, 3533], 'seemed': [1595, 2111], 'mechanistically': [1598], 'distinct': [1599, 2070], 'appeared': [1603, 4053], 'within': [1604], 'minutes,': [1605], 'whereas': [1606, 3311], 'became': [1610, 1691], 'around': [1612], '7': [1613], 'hours': [1614], 'injection,': [1617, 3546], 'maximal': [1619], 'sustained': [1621], '24': [1623], 'hours.67': [1624], 'molecule,': [1630], 'set': [1633, 2861, 4122], 'motion': [1635], 'series': [1637], 'hallmarks': [1645], 'normally': [1648, 2396], 'seen': [1649, 1933, 2601], 'sterile': [1651], 'inflammation': [1652, 1685, 1743, 1836, 1886], 'raised': [1653, 2359, 2820], 'obvious': [1655, 1692], 'question': [1656, 1666, 2361, 2382, 2822], 'necessary': [1661, 1709, 1783, 2965], 'particularly': [1668], 'pertinent': [1669], 'light': [1671], 'data': [1673, 1718, 2164, 4121, 4165, 4196, 4456], 'published': [1674, 4117], 'showing': [1675], 'upregulated': [1679], 'sciatic': [1682], 'skin.26': [1688], 'then': [1690, 3334], 'blocking': [1695], 'vivo': [1698, 3034, 3273], 'inflammation-dependent': [1703], 'rise': [1704], 'step': [1711], 'After': [1715], 'obtaining': [1716], 'preliminary': [1717], 'using': [1719, 3031, 3850, 4454], 'NGF-blocking': [1720, 1804, 1844], 'antibodies,': [1721], 'model': [1724, 1762, 1887, 2034, 2056], 'proposed': [1729, 2031], 'represents': [1732], 'molecule': [1735], 'provides': [1737], 'key': [1739, 1758, 1891, 2052, 4270], 'humoral': [1740], 'initiate': [1750, 3213], 'hyperalgesia.63': [1756], 'Figure': [1766], '1,': [1767], 'highlighting': [1768], 'areas': [1770], 'progress': [1772, 2137], 'made': [1776, 2140, 2156, 4162], 'since': [1777, 4048], 'Soon': [1787], 'reported': [1790], 'groups': [1801, 2403], 'tested': [1802], 'ameliorate': [1807], 'block': [1809], 'inflammation-associated': [1810], '(Fig.': [1815, 2216, 4225, 4249, 4259, 4348, 4416], '1A).': [1816, 4260], 'reports': [1820], 'follow': [1830], 'complete': [1832, 2888], "Freund's": [1833], 'adjuvant': [1834], '(CFA)-induced': [1835], 'ameliorated': [1839], 'administration': [1842, 3312, 3717], 'antibodies.67,128': [1845], 'Later': [1846], 'on,': [1847], 'trkA-IgG': [1848], 'fusion': [1849], 'proteins': [1850, 3369], '(extracellular': [1851, 3858], 'domain': [1852, 3964, 3985], 'fused': [1855], 'Fc': [1859], 'portion': [1860], 'immunoglobulin': [1863], 'G)': [1864], 'specifically': [1866], 'bind': [1867], 'capable': [1875, 2088], 'ameliorating': [1877], 'associated': [1882, 2942], 'carrageenan-evoked': [1885], 'rats.76': [1889], 'finding': [1892], 'blockade': [1894], 'analgesic': [1903, 4067], 'validated': [1908], 'models.47,95': [1911], 'note': [1916], 'recombinant': [1918], 'administered': [1924], 'almost': [1928, 2840, 3113, 3931], 'identical': [1929, 3114], 'those': [1932, 2072, 3116], 'animals.60,94,103Figure': [1935], '1.:': [1936], 'Mechanisms': [1937], 'sensitization.': [1942], '(A)': [1943, 4436], 'Peripheral': [1944], 'may': [1946, 2172, 3608, 4213, 4391], 'result': [1947], 'post-translational': [1949], 'modifications': [1950], '(top': [1951], 'middle': [1953], 'panel)': [1954], 'increased': [1957, 2041, 2465], 'gene': [1958, 2119, 2922, 4263, 4408], 'insertion': [1962], 'additional': [1964], 'mechanically': [1965], 'gated': [1966], 'channels': [1968, 3201], 'plasma': [1971], 'membrane': [1972], 'terminal': [1977, 3376, 3384], '(bottom).': [1978], '(B)': [1979], '(NGF)': [1983], 'induces': [1985], 'release': [1987, 2207], 'P,': [1990], 'BDNF,': [1991, 2023], 'CGRP': [1993, 2325, 2347, 2802], 'terminals': [1997, 2097, 2213, 2224, 3404], 'NMDA': [2003, 2249, 3636], 'receptors': [2004, 3047, 3203, 3211, 3901], 'second-order': [2006, 3416], 'projection': [2007], 'resulting': [2009], 'strengthening': [2012], 'transmission': [2015, 2399], 'horn—ie,': [2020], 'sensitization.56': [2022], 'factor;': [2026], 'CGRP,': [2027], 'peptide.We': [2030], 'illustrating': [2035], 'various': [2037], 'ways': [2038], 'inflammation.63': [2050], 'mechanisms': [2062, 2145, 2171, 2259], 'underlie': [2064, 2074, 2147], 'NGF-dependent': [2066, 2149, 2159], 'hyperalgesia.67,67': [2077, 2130], 'supposed': [2079], 'difference': [2083], 'inducing': [2090], 'extremely': [2091, 4085], 'C': [2099, 2431, 2594, 2894, 3063, 3096, 3148, 3262], '-fibers': [2100, 2432, 2435, 3019, 3064], 'stimuli.': [2107, 2577], 'Mechanical': [2108], 'however,': [2110, 2674], 'induction': [2115], 'eventually': [2122], 'maintains': [2128], 'much': [2136, 3873], 'elucidating': [2142], 'Progress': [2152], 'indicate': [2165, 4037], 'important,': [2174], 'just': [2181, 2446, 3450], 'beginning': [2182], 'unraveled,': [2185], 'reviewed': [2186], '60.': [2188], 'mechanism': [2190], 'maintenance': [2198], 'NGF-induced': [2204, 2261, 3763, 3878, 3924], 'BDNF': [2209, 2220, 2230], '1B).31,34,81': [2217], 'Release': [2218], 'TrkA-positive': [2226, 4283], 'activates': [2228, 3258, 3501], 'TrkB': [2232], 'interneurons': [2235, 3517], 'postsynaptic': [2243, 3412, 3429], 'phosphorylation': [2246], '(N-methyl-D-aspartate).': [2251], 'detailed': [2255, 2277], 'sensitization,': [2263, 3880], 'see': [2264], 'Refs.': [2265], '60,': [2266], '95.': [2267], '4.': [2268], 'anatomy': [2281], 'hairless': [2293], 'innervated': [2296], 'myelinated': [2299, 2409], 'unmyelinated': [2301, 2306, 2333, 2389, 2413, 2459], 'fibers.90': [2302], 'rodents,': [2305], 'fibers': [2307, 2315, 2334, 2595, 2598, 3149, 3263], 'subdivided': [2310], 'peptidergic': [2312], 'based': [2316], 'upon': [2317], 'neurotransmitters': [2322], 'SP.85,110,118': [2327], 'mole-rat,': [2332, 2619, 3541, 3993, 4453], 'virtually': [2342], 'devoid': [2343], 'immunostaining.': [2348], 'lack': [2350, 2652, 2670, 2801, 2931, 3143, 3821, 3922], 'evolution.': [2375], 'way': [2377], 'quantify': [2385], 'numbers': [2387, 2407, 2466, 2535], 'axons': [2390, 2706, 2715], 'nerves,': [2393], 'done': [2397], 'electron': [2400], 'microscopy.': [2401], 'quantified': [2405], '(A': [2410], '-fibers)': [2411], '(C-fibers)': [2414], 'nerves': [2417, 2505, 2582, 2677, 2980], 'consistently': [2419], 'there': [2422, 2694], 'always': [2424], '3': [2425, 2751, 3950], '4': [2427], 'times': [2428], 'nerves.115': [2438], 'ratio': [2444, 2451, 2633, 2726, 2760], '∼1.5:1': [2447], 'paucity': [2457, 2548], 'A-fiber': [2468, 2526, 2532, 2632, 2684, 2725, 2759], 'axons.89,91,115': [2469], 'far': [2474], 'fewer': [2475], 'similarly': [2480], 'sized': [2481], 'mammals,': [2482, 2664], 'prompted': [2484], 'related': [2488, 2536, 4156], 'phylogenetic': [2494], 'neighbors': [2495], 'mole-rat.': [2499, 3490, 4112, 4405], 'comparative': [2502], '6': [2507, 4154], 'belonging': [2509], 'Bathyergidae,': [2512], 'markedly': [2521], 'C-fiber': [2524, 2534, 2630, 2643, 2682, 2705, 2723, 2757, 2989, 3027, 3040, 3101], 'ratio.115': [2527], 'An': [2528], 'analysis': [2529, 3768, 4351], 'surface': [2538], 'determined': [2540, 3265], 'accounted': [2544], 'C-fibers,': [2550, 3070], 'rather': [2551], 'overabundance': [2554], 'A-fibers.115': [2556], 'high-density': [2564], 'nociceptor': [2566, 2774, 2833, 2938, 3041, 4274, 4430], 'innervation': [2567], 'constantly': [2572], 'potentially': [2575, 3474], 'damaging': [2576], 'Consistent': [2578], 'idea,': [2581], 'joints': [2587], 'do': [2588, 3003], 'display': [2590, 2627, 2827], 'ratios': [2592], 'true': [2608], 'examined.': [2612], 'Indeed,': [2613, 2864, 3766, 3848], 'bathyergids,': [2615], 'including': [2616], 'wide': [2622], 'typically': [2626], '∼1:1': [2629, 2766], 'nerves.44–46,115': [2636], 'parsimonious': [2638], 'explanation': [2639], 'deficit': [2644, 3885], 'fur,': [2653], 'although': [2654, 3683, 3722], 'specialized': [2655], 'hairs': [2657], 'present.22': [2659], 'Compared': [2660], 'relatively': [2667, 4360], 'dense': [2671], 'hair;': [2673], '∼4:1': [2681, 2732], 'ratio.87': [2685], 'mice,': [2688, 3224, 3425, 3484], 'ongoing': [2696], 'cell': [2699], 'death': [2700], 'early': [2709], 'period.': [2711], 'loss': [2713, 2775, 2897, 2939, 3122, 3136, 3749], 'reflected': [2717], 'drop': [2720], '∼6:1': [2728, 2762], 'neonates': [2730], 'similar,': [2739], 'extreme,': [2742], 'process': [2743], 'day': [2750], 'pups': [2754], 'drops': [2764], 'adults.89': [2768], 'factors': [2770], 'might': [2772, 4345], 'cause': [2773, 4209], 'discussed': [2777, 3695], 'below': [2778], 'relation': [2780], 'TrkA.': [2789, 3919], '5.': [2790], 'Nociceptor': [2791], 'function': [2792, 3751], 'nocifensive': [2794, 3161, 3227, 3481, 3558, 3613, 3680], 'Transgenic': [2798], 'mice': [2799, 2918, 3819, 4017, 4035, 4083], 'diminished': [2806, 3690], 'behaviors10,105': [2808], 'thus': [2810, 3586, 3881, 4385], 'absence': [2812, 2889, 3710, 3761], 'neuropeptides': [2814, 3145], 'initially': [2819], 'reduced': [2832, 3912, 4041, 4070, 4215, 4238, 4257], 'function.': [2834], 'existence': [2836], 'ubiquitous': [2842], 'animal': [2845], 'kingdom': [2846], 'nematode': [2850], 'worm': [2851], 'Caenorhabditis': [2852], 'elegans,': [2853], 'approximately': [2855], 'dedicated': [2860], 'nociceptors.113,120': [2863], 'fundamental': [2866], 'importance': [2867], 'congenital': [2875], '(CIP),': [2879], 'syndrome': [2881], 'arise': [2884], 'Aδ-fibers': [2892], '-fibers.97,119': [2895], 'individuals': [2903], 'CIP': [2905, 4210, 4232], 'chiefly': [2907], 'TrkA.40': [2916], 'Consistently,': [2917], 'encoding': [2923], 'ablated': [2929], 'C-fibers.111': [2932], 'Congenital': [2933], 'genes,': [2947, 4233], 'PRDM12': [2950, 4203, 4262, 4327, 4407], '(PRDI-BF1': [2951], 'RIZ': [2953], 'homology': [2954], 'domain-containing': [2955], 'protein': [2956, 4390, 4424], '12).16': [2957], 'transcriptional': [2960], 'regulator': [2961, 4272], 'TrkA.25,86': [2974], 'Despite': [2975], 'depleted': [2986], 'number': [2987], 'nociceptors,': [2990, 3206, 3407], 'properties': [2999, 3092, 3110], 'differ': [3005], 'significantly': [3006], 'C-fibers': [3008, 3124], 'mice.91': [3010], 'saphenous': [3016], 'Aδ': [3018], 'properties,': [3022], 'measured': [3030], 'ex': [3033, 3272], 'preparation.82,84,126': [3037], 'classified': [3044], 'polymodal': [3046, 3095, 3261], '(ie,': [3048], 'responding': [3049], 'stimuli)': [3055], 'up': [3059, 3082], 'majority': [3061, 3349, 3427], '(60%-70%).30,53,64,65': [3065], 'second': [3067], 'activated': [3073, 3296], 'intense': [3076], 'remaining': [3084], 'seem': [3087, 3131], 'different': [3090], 'mechanosensitive': [3091], 'fibers.6,82': [3097], 'present': [3104, 3573], 'rodents.91': [3119], 'does': [3129, 3327, 3342], 'subpopulation': [3140], 'unrelated': [3153], 'receptive': [3156], 'properties.': [3157], 'differences': [3159], 'rodents': [3165, 4080], 'dramatic': [3172], 'examined': [3175], 'behavioral': [3177], 'response': [3178, 3319, 3482, 3560], 'algogens.': [3180], 'Algogens': [3181], 'chemicals': [3183], 'often': [3194], 'work': [3195], 'activating': [3198, 3209], 'expressed': [3204, 3253, 3372, 3380, 3814, 4411], 'thereby': [3207], 'prototypical': [3218], 'algogen': [3219], 'injected': [3222, 3548], 'evokes': [3225, 3674], 'licking': [3228, 3304, 3559], 'response,': [3229], 'transient': [3239], 'potential': [3241, 4068], 'vanilloid': [3242], '(TRPV1),': [3245], 'heat-,': [3247], 'capsaicin-,': [3248], 'acid-gated': [3250], 'nociceptors.12,13,124': [3255], 'robustly': [3257], 'electrophysiological': [3268], 'skin-nerve': [3274], 'preparation': [3275], 'patch': [3277], 'clamp': [3278], 'isolated': [3281], 'root': [3283], 'ganglia': [3284], '(DRG)': [3285], 'neurons.89,91,114': [3286], 'despite': [3288], 'fails': [3300, 3698, 3801], 'any': [3303], 'behavior': [3305], 'mole-rats.27,91': [3308], 'addition,': [3310, 4252], '(thermal': [3322], 'hyperalgesia),': [3323], 'occur': [3329], 'mole-rats.91': [3332], 'How': [3333], 'behavior?': [3347], 'cord': [3356, 3396, 3584], 'terminates': [3357], 'superficial': [3360, 3442, 3466, 3503, 3520, 3576, 3605], 'horn121,122': [3362], 'DRG': [3365, 3798, 4139, 4244, 4448], 'pseudounipolar,': [3368], 'commonly': [3379], 'presynaptic': [3383, 3403], 'horn.': [3388], 'Consequently,': [3389], 'apply': [3399], 'TRPV1-expressing': [3406], 'produces': [3409], 'excitatory': [3411], 'current': [3413], 'TRPV1-positive': [3420, 3436, 3472], 'connected.129': [3423], 'synaptically': [3433, 3515], 'driven': [3434, 3516], 'located': [3439], 'horn,': [3444], 'deep': [3453, 3505, 3522, 4092], 'coupled': [3458], 'capsaicin-sensitive': [3460, 3494], 'layers.91': [3467], 'altered': [3469], 'explains': [3475], 'elicits': [3478], 'robust': [3480], 'none': [3486], 'simultaneously': [3500], 'neurons.': [3508], 'speculate': [3510], 'reciprocal': [3512], 'connections': [3513], 'under': [3526], 'circumstances': [3528], 'negate': [3529], 'signal.': [3532], 'introduced': [3537], 'intrathecal': [3545], 'paw': [3551], 'newly': [3553], 'able': [3554], 'provoked': [3562], 'hyperalgesia.91': [3564], 'neurokinin-1': [3566], '(NK1R)': [3568], 'presumably': [3587], 'stronger': [3602], 'layers': [3606], 'allow': [3609], 'gating': [3610], 'response.91': [3614], 'Administration': [3615], '"rescue"': [3622], 'histamine-induced': [3623], 'itch': [3624], 'mole-rats112': [3627], 'receptor-': [3637], 'NK1R-dependent.7': [3639], '6.': [3640], 'Inflammatory': [3641], 'addition': [3646], 'variety': [3653], 'used': [3659, 4192], 'development': [3663, 4281, 4396], 'mole-rats.': [3668], 'Formalin': [3669], 'phases': [3678], 'behaviors,': [3681], 'mice.27,91': [3693], 'As': [3694], 'above,': [3696], 'CFA': [3719], 'evoked': [3726], 'CFA.91': [3728], 'factor–induced': [3731], 'TRPV1-dependent': [3736], 'process,17': [3737], 'suggests': [3747], 'TRPV1': [3755, 3772, 3812, 3822, 3840, 3879], 'unlikely': [3757], 'explain': [3759], 'subsequent': [3767], 'heat,': [3778], 'pH,': [3779], 'voltage,': [3780], 'sensitivity.114': [3783], 'TrkA,': [3793, 4236], 'cultured': [3797], 'TRPV1.89,91': [3806], 'sensitizes': [3809], 'rat': [3827, 3918], 'fibroblasts,': [3832], 'ruling': [3834], 'out': [3835], 'deficits': [3836], 'cellular': [3845], 'environment,': [3846], 'respectively.': [3847], 'chimeric': [3856, 3899], 'rat/intracellular': [3859], 'mole-rat)': [3861], 'further': [3862], 'efficient': [3875, 3904], 'indicating': [3882], 'lies': [3886], 'intracellular': [3889], 'domain.89': [3890], 'Furthermore,': [3891], 'quantitative': [3892], 'proteomics': [3893], 'engaging': [3906], 'downstream': [3907], 'abundance': [3913], 'phosphopeptides': [3915], 'certainly': [3932], 'hypofunctionality.89': [3937], 'Examination': [3938], 'sequence': [3944, 4170, 4219, 4328, 4357, 4363], 'shows': [3945, 4256], 'amino': [3951, 4341, 4373], 'acid': [3952, 4342, 4374], 'substitutions': [3953], 'responsible': [3969], 'hypofunctional': [3972], 'observed.89': [3974], 'confirm': [3976], 'underlying': [3986], 'phenotypes': [3988, 4044], 'ideally': [3996], 'transgenic': [3999], 'mouse': [4004, 4029, 4248, 4450], 'sequence,': [4006], 'currently': [4010], 'feasible.': [4012], 'generated': [4016, 4115], 'residues': [4021], 'reengineered': [4026], 'genome.': [4030], 'Initial': [4031, 4350], 'indeed': [4036], '(unpublished': [4045], 'results).': [4046], 'ancestor': [4052], '30': [4056], 'million': [4057], 'blindly': [4064], 'signaling.': [4072], 'available': [4076, 4167, 4195], 'powerful': [4086], 'modern': [4089], 'age': [4090], 'sequencing': [4093], 'single-cell': [4095], 'transcriptomics.32,125': [4096], 'same': [4099], 'methods': [4100], 'applied': [4104], 'non-model': [4106], 'organisms,': [4107], 'enabled': [4124], 'compare': [4128], 'nearly': [4133], '7000': [4134], 'orthologous': [4135, 4181], 'transcripts': [4136, 4182], 'cord,': [4142], 'mouse,': [4150, 4332], 'across': [4153, 4172], 'species.27': [4159], 'freely': [4166], 'variants': [4171, 4220, 4343, 4375], '8': [4173], 'accessed': [4185], 'analyzed': [4187], 'online': [4188], '(https://moleratexpress.mdc-berlin.de).': [4189], 'publicly': [4194], 'gene,': [4204], 'humans,': [4212], '2).': [4226], 'Prdm12': [4234], '1A);': [4250], 'Trpv1': [4254, 4445], 'differentiation': [4275], 'nociceptors.3,25,86': [4284], 'PRMD12': [4285], 'highly': [4288], 'conserved': [4289], 'protein,': [4290], 'polyalanine': [4294, 4362], 'stretch': [4295], 'C-terminus,': [4298], 'expansion': [4300], 'implicated': [4306], 'pathogenicity.16': [4308], 'Using': [4309], 'public': [4310], 'databases': [4311], 'transcriptomes': [4315], 'assembled': [4316], 'own': [4319], 'RNAseq': [4320, 4455], 'data,': [4321], 'aligned': [4323], 'against': [4329], 'human,': [4330], 'chimpanzee,': [4331], 'rodent': [4336], 'look': [4339], '2B).': [4349], 'indicates': [4352], 'expanded': [4361], 'possesses': [4369], 'seemingly': [4371], 'C-terminal': [4378], 'region': [4379], 'protein.': [4382], 'possibility': [4387], 'involved': [4393], 'still': [4410], '2),': [4417], 'unknown': [4421], 'if': [4422], 'maintaining': [4429], 'physiology': [4431], 'adult.Figure': [4434], '2.:': [4435], 'Comparison': [4437], 'mRNA': [4439], 'Prdm12,': [4442], 'Ntrk1,': [4443], 'sets': [4457], 'downloaded': [4458]}, 'cited_by_api_url': 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