Title: Colonization with <scp><i>Staphylococcus aureus</i></scp> in patients with hand eczema: Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization
Abstract: Contact DermatitisVolume 83, Issue 6 p. 442-449 ORIGINAL ARTICLE Colonization with Staphylococcus aureus in patients with hand eczema: Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization Line B. Nørreslet, Corresponding Author Line B. Nørreslet [email protected] orcid.org/0000-0002-3702-1409 Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark Correspondence Miss Line B. Nørreslet, Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark. Email: [email protected] for more papers by this authorSofie M. Edslev, Sofie M. Edslev Department of Bacteria, Parasites, and Fungi, Statens Serum Institute, Copenhagen, DenmarkSearch for more papers by this authorPaal S. Andersen, Paal S. Andersen Department of Bacteria, Parasites, and Fungi, Statens Serum Institute, Copenhagen, DenmarkSearch for more papers by this authorFrederik Plum, Frederik Plum Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorJette Holt, Jette Holt Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institute, Copenhagen, DenmarkSearch for more papers by this authorAnne Kjerulf, Anne Kjerulf Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institute, Copenhagen, DenmarkSearch for more papers by this authorNiels E. Ebbehøj, Niels E. Ebbehøj Department of Occupational and Environmental Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorMaja-Lisa Clausen, Maja-Lisa Clausen Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorEsben M. Flachs, Esben M. Flachs Department of Occupational and Environmental Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorTove Agner, Tove Agner Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this author Line B. Nørreslet, Corresponding Author Line B. Nørreslet [email protected] orcid.org/0000-0002-3702-1409 Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark Correspondence Miss Line B. Nørreslet, Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark. Email: [email protected] for more papers by this authorSofie M. Edslev, Sofie M. Edslev Department of Bacteria, Parasites, and Fungi, Statens Serum Institute, Copenhagen, DenmarkSearch for more papers by this authorPaal S. Andersen, Paal S. Andersen Department of Bacteria, Parasites, and Fungi, Statens Serum Institute, Copenhagen, DenmarkSearch for more papers by this authorFrederik Plum, Frederik Plum Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorJette Holt, Jette Holt Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institute, Copenhagen, DenmarkSearch for more papers by this authorAnne Kjerulf, Anne Kjerulf Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institute, Copenhagen, DenmarkSearch for more papers by this authorNiels E. Ebbehøj, Niels E. Ebbehøj Department of Occupational and Environmental Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorMaja-Lisa Clausen, Maja-Lisa Clausen Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorEsben M. Flachs, Esben M. Flachs Department of Occupational and Environmental Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorTove Agner, Tove Agner Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this author First published: 27 July 2020 https://doi.org/10.1111/cod.13679Citations: 3 Funding information: Aage Bangs Fond; Augustinus Fonden; Bispebjerg and Frederiksberg Hospital; The Danish Working Environment Fund, Grant/Award Number: 20185100823 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Background While Staphylococcus aureus (S. aureus) colonization has been thoroughly studied in atopic dermatitis (AD), where S. aureus is related to flares and considered a trigger factor, S. aureus colonization in hand eczema (HE) has only been sparsely studied. Objectives To examine the 1-week prevalence of S. aureus colonization in HE patients, and its association with severity, HE subtype, AD, and nasal S. aureus colonization compared with healthy controls. Methods In a case-control study of 50 adult HE patients and 50 healthy controls, bacterial swabs from lesional skin (patients only), non-lesional skin (dorsal hand), and the nasal cavity were sampled for culturing of S. aureus on days 1, 3, 5 and 8. Participants were characterized by demographics, AD, HE subtype, filaggrin gene mutation status, and HE severity. Results Twenty-seven HE patients (54%) were colonized with S. aureus on the hand compared to one control (2%) (P < .01). Nasal S. aureus colonization was found in 72% of patients and 22% of controls (P < .01). For patients, S. aureus colonization on the hands was associated with an atopic HE subtype and HE severity (P = .01 and P < .01, respectively). Conclusions Both hand and nasal S. aureus colonization were highly prevalent among HE-patients and may have an impact on the persistence of HE. CONFLICT OF INTEREST The authors declare no conflicts of interest. Citing Literature Volume83, Issue6December 2020Pages 442-449 RelatedInformation
Publication Year: 2020
Publication Date: 2020-09-21
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 15
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