Antagonism of interferon signaling by fibroblast growth factors promotes viral replication

Name: Work Video:
Duration: 3 min 30 s
Luigi Maddaluno; Corinne Urwyler; Theresa Rauschendorfer; Michaël Meyer; D Stefanova; Roman Spörri; Mateusz S. Wietecha; Luca Ferrarese; Diana Stoycheva; Daniela Bender; Nick Li; Gerhard E. Strittmatter; Khondokar Nasirujjaman; Hans‐Dietmar Beer; Peter Staeheli; Eberhard Hildt; Annette Oxenius; Sabine Werner
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1145, 1150, 1159, 1176, 1192, 1223, 1260, 1280, 1299, 1315, 1345, 1404, 1412, 1417, 1471, 1483, 1530, 1533, 1549, 1552, 1620, 1629, 1652, 1690, 1729, 1734, 1738, 1762, 1800, 1810, 1843, 1895, 1901, 1916, 1925, 1945, 1955, 1961, 1966, 1983, 1985, 1988, 2051, 2081, 2087, 2104, 2111, 2121, 2125, 2134, 2468, 2492, 2508, 2514, 2526, 2544, 2565, 2579, 2600, 2607, 2620, 2631, 2641, 2654, 2664, 2713, 2849, 2872, 2882, 2884, 2902, 2930, 3015, 3029, 3040, 3048, 3117, 3130, 3226, 3237, 3240, 3264, 3268, 3270, 3277, 3280, 3288, 3309, 3323, 3337, 3362, 3368, 3408, 3475, 3504, 3516, 3527, 3575, 3649, 3682, 3714, 3876, 3908, 4058, 4066, 4069, 4073, 4075, 4113, 4270], 'Biotechnology,': [317, 743, 953], 'Rajshahi,': [320, 321, 746, 747, 956, 957], 'Bangladesh': [322, 748, 958], 'Hans-Dietmar': [330, 332, 756, 758, 899], 'Beer': [331, 333, 757, 759], 'orcid.org/0000-0002-8085-713X': [334, 760], 'Peter': [351, 353, 777, 779, 901], 'Staeheli': [352, 354, 778, 780], 'Freiburg,': [360, 361, 368, 369, 786, 787, 794, 795, 964, 965, 972, 973], 'Faculty': [363, 789], 'Medicine,': [365, 791, 969], 'Eberhard': [378, 380, 804, 806, 903], 'Hildt': [379, 381, 805, 807], 'Annette': [395, 397, 821, 823, 905], 'Oxenius': [396, 398, 822, 824], 'Sabine': [416, 420, 842, 846, 908], 'Werner': [417, 421, 843, 847, 909], 'orcid.org/0000-0001-7397-8710': [424, 850], 'Information': [871], '*,1,‡,': [874], 'Urwyler1,‡,': [876], 'Rauschendorfer1,‡,': [878], 'Meyer1,': [880], 'Stefanova1,': [882], 'Spörri2,': [884], 'Wietecha1,': [886], 'Ferrarese1,': [888], 'Stoycheva2,': [890], 'Bender3,': [892], 'Li1,4,': [894], 'Strittmatter4,': [896], 'Nasirujjaman1,5,': [898], 'Beer4,': [900], 'Staeheli6,7,': [902], 'Hildt3,': [904], 'Oxenius2': [906], '*,1': [910], '1Department': [911], '2Department': [923], '3Department': [933], '4Department': [939], '5Department': [948], '6Institute': [959], '7Faculty': [967], '‡These': [975], 'authors': [976, 984], 'contributed': [977], 'equally': [978], 'to': [979, 1035, 1038, 1127, 1157, 1339, 1420, 1477, 1490, 1578, 1617, 1717, 1919, 2114, 2231, 2247, 2478, 2552, 2568, 2590, 2610, 2667, 2711, 2717, 2731, 3397, 3449, 3478, 3530, 3562, 3652, 3678, 3696, 3709, 3862, 3911, 3940, 3959, 3967, 4054, 4135, 4154, 4290], 'work': [981], 'as': [982, 1243, 1507, 1509, 1648, 1859, 4036], 'first': [983], '*Corresponding': [985, 995], 'author.': [986, 996], 'Tel:': [987, 997], '+41': [988, 998], '44': [989, 999, 2418], '633': [990, 1000], '3941;': [991, 1001], 'E-mail:': [992, 1002], 'EMBO': [1005], 'Mol': [1006], 'Med': [1007], '(2020)12:e11793https://doi.org/10.15252/emmm.201911793': [1008], 'PDFDownload': [1009], 'PDF': [1010], 'article': [1012], 'text': [1013], 'main': [1015], 'figures.': [1016], 'Peer': [1017], 'ReviewDownload': [1018], 'a': [1019, 1336, 1348, 1386, 1452, 1520, 1768, 1787, 2772, 2945, 3151, 3179, 3229, 3318, 3386, 3604, 3632, 3726, 3752, 4086, 4309], 'summary': [1020], 'the': [1022, 1056, 1063, 1082, 1098, 1142, 1165, 1198, 1205, 1219, 1233, 1237, 1251, 1270, 1276, 1283, 1289, 1351, 1370, 1376, 1401, 1406, 1431, 1438, 1445, 1464, 1478, 1492, 1541, 1589, 1642, 1654, 1672, 1699, 1719, 1725, 1730, 1745, 1760, 1790, 1798, 1818, 1827, 1882, 1920, 1932, 1949, 1956, 1969, 1976, 1994, 2013, 2016, 2045, 2049, 2115, 2118, 2128, 2132, 2152, 2157, 2333, 2537, 2553, 2679, 2688, 2833, 2845, 2853, 2875, 2895, 2914, 2933, 2998, 3011, 3025, 3034, 3070, 3089, 3099, 3155, 3196, 3214, 3249, 3259, 3332, 3355, 3379, 3411, 3445, 3589, 3618, 3684, 3712, 4082, 4089, 4096, 4105, 4180, 4185, 4271, 4281], 'editorial': [1023, 1027], 'decision': [1024, 1028], 'including': [1026, 1547, 2055, 3115], 'letters,': [1029], 'reviewer': [1030], 'comments': [1031], 'responses': [1034], 'feedback.': [1036], 'ToolsAdd': [1037], 'favoritesDownload': [1039], 'CitationsTrack': [1040], 'CitationsPermissions': [1041], 'ShareFacebookTwitterLinked': [1042], 'InMendeleyWechatReddit': [1043], 'Figures': [1044], '&': [1045, 1555, 1559, 1601, 1668, 1705, 3164, 3314], 'Info': [1046], 'Abstract': [1047], 'Fibroblast': [1048, 1514], '(FGFs)': [1051, 1394], 'play': [1052], 'key': [1053], 'roles': [1054], 'in': [1055, 1095, 1106, 1109, 1125, 1188, 1193, 1258, 1318, 1327, 1395, 1418, 1460, 1499, 1502, 1510, 1535, 1540, 1588, 1688, 1695, 1744, 1757, 1778, 1784, 1789, 1826, 1841, 1875, 1881, 1897, 1999, 2011, 2048, 2156, 2332, 2464, 2524, 2548, 2687, 2703, 2726, 2807, 2832, 2844, 2894, 2908, 2935, 2953, 2982, 3006, 3024, 3049, 3069, 3098, 3128, 3223, 3290, 3310, 3371, 3395, 3414, 3588, 3665, 3683, 3691, 3701, 3711, 3765, 3839, 3873, 3953, 4007, 4081, 4148, 4241, 4274, 4304], 'pathogenesis': [1057, 1542], 'different': [1059, 1467, 1596, 1659, 1849, 2475, 2562, 2773, 3727, 3753, 4034, 4097], 'human': [1060, 1190, 1340, 1505, 1545, 3078, 3230, 3250], 'diseases,': [1061, 1546], 'but': [1062, 1355, 1613], 'cross-talk': [1064, 1497, 1731], 'between': [1065, 1732], 'FGFs': [1066, 1080, 1163, 1398, 1482, 1563, 1607, 1637, 1678, 1733, 1840, 3124, 3398], 'other': [1068, 1504, 1673, 1735, 3169], 'cytokines': [1069], 'remains': [1070], 'largely': [1071], 'unexplored.': [1072], 'We': [1073, 1384], 'identified': [1074, 1385, 1942, 2047], 'an': [1075, 1244, 3571], 'unexpected': [1076, 1496], 'antagonistic': [1077], 'effect': [1078, 1265, 2988, 3320, 3326, 3828, 4235, 4264], 'on': [1081, 1269, 2992, 3160, 4104, 4267], '(IFN)': [1084], 'pathway.': [1086], 'or': [1088, 1113, 1129, 1423, 1567, 1679, 1754, 2486, 2488, 2685, 2706, 3357, 3428, 3435, 3462, 3541, 3591, 3625, 3639, 3673, 3822, 3892, 3937, 4033, 4226], 'pharmacological': [1089], 'inhibition': [1090, 1181, 1322, 1429, 3110], 'FGF': [1092, 1147, 1230, 1240, 1248, 1267, 1277, 1286, 1303, 1320, 1427, 1441, 1536, 1575, 1742, 1824, 1856, 1879, 3138, 3388, 3868, 4311], 'receptor': [1093, 1148, 1241, 1278, 1321, 1428, 1442, 1571, 1576, 1857, 3704], 'keratinocytes': [1096, 1117, 1158, 1191, 1259, 1758, 1842, 1876, 1898, 2465, 2528, 2576, 2596, 2616, 2638, 2673, 2851, 2912, 2956, 2973, 3008, 3057, 3080, 3129, 3148, 3161, 3177, 3212, 3225, 3415, 3420, 3454, 3483, 3513, 3536, 3566, 3611, 3875, 3884, 4024, 4110], 'promoted': [1097, 1164, 3111], 'expression': [1099, 1120, 1253, 1407, 1676, 1833, 1871, 2470, 2701, 2724, 2829, 2876, 2904, 2943, 2994, 2999, 3023, 3074, 3112, 3127, 3181, 3198, 3260, 3348, 3380, 3663, 3689, 3699, 3872, 3951, 4020, 4146, 4269, 4276, 4298], 'interferon-stimulated': [1101, 3118], 'genes': [1102, 1257, 1411, 1874, 1935, 1973, 1995, 2024, 2046, 2136, 3003], '(ISG)': [1103], 'proteins': [1105, 1413], 'vitro': [1107], 'vivo.': [1110], 'Conversely,': [1111], 'FGF7': [1112, 3190, 3255, 3328, 3353, 3367, 3407, 3432, 3461, 3490, 3550, 3594, 3636, 3672, 3827, 3891, 3923, 4016, 4028, 4119, 4234, 4266, 4291, 4303], 'FGF10': [1114, 3369, 3409, 3463, 3893], 'treatment': [1115, 1206, 1293, 1377, 1422, 1446, 1465, 1700, 2787, 3370, 3634, 3785, 3795], 'suppressed': [1118, 1838, 3195, 3351], 'ISG': [1119, 1133, 2469, 2942, 2993, 3022, 3073, 3126, 3142, 3286, 3871, 4019, 4268], 'under': [1121, 1414, 1610], 'homeostatic': [1122, 1611], 'conditions': [1123, 1416], 'response': [1126, 1222, 1256, 1272, 1291, 1403, 1419, 2057, 2230, 2240, 2246, 3396, 3413], 'IFN': [1128, 1138, 2056, 2467, 3294, 3412, 3703], 'poly(I:C)': [1130], 'treatment.': [1131], 'FGF-mediated': [1132], 'suppression': [1134, 3071], 'was': [1135, 2031, 2095, 2839, 2905, 2925, 2950, 2965, 2995, 3031, 3075, 3208, 3329, 3349, 3374, 4047, 4091, 4277, 4299, 4308], 'independent': [1136, 4162], 'receptors,': [1139], 'occurred': [1140], 'at': [1141, 1282, 1782, 1911, 1989, 2098, 2107, 2338, 2583, 2889, 2928, 3033, 3213, 3331, 3354], 'transcriptional': [1143, 1284], 'level,': [1144], 'required': [1146], 'kinase': [1149, 1202, 1279, 3091], 'proteasomal': [1151], 'activity.': [1152], 'It': [1153], 'is': [1154, 1273, 1381, 1451, 1582, 1608, 1623, 1685, 1715, 1837, 2151, 2541, 2545, 2944, 3392, 4102, 4288], 'not': [1155, 3350, 4300], 'restricted': [1156], 'functionally': [1160], 'relevant,': [1161], 'since': [1162, 1455, 2948, 2997], 'herpes': [1168], 'simplex': [1169, 1309], 'virus': [1170, 1310, 1314, 1317], 'I': [1171, 1978, 2148, 2880], '(HSV-1),': [1172], 'lymphocytic': [1173, 1312], 'choriomeningitis': [1174, 1313], 'virus,': [1175], 'Zika': [1177, 1316], 'virus.': [1178], 'Most': [1179, 1562], 'importantly,': [1180], 'FGFR': [1183, 1201, 1592, 1683, 1691, 1868, 2462, 2680, 3067, 3090, 3109], 'blocked': [1185], 'HSV-1': [1186], 'cultured': [1189, 2954], 'mice.': [1194, 2495, 2531, 2602, 2623, 2899], 'These': [1195, 1765, 1853], 'results': [1196, 1781, 1854, 3759], 'suggest': [1197], 'use': [1199, 1238, 1439], 'inhibitors': [1203, 1242, 1443, 1457, 1692, 1858, 3620], 'infections.': [1209, 1449], 'Synopsis': [1210], 'The': [1211, 1264, 1329, 2532, 2863, 3063, 3325, 3364, 3758, 4078, 4177, 4262], 'study': [1212, 1436, 1491, 1501, 1741], 'demonstrates': [1213], 'that': [1214, 1832, 1947, 1996, 2323, 2976, 3202, 3245, 3391], 'suppress': [1218, 1400, 3125, 3410], 'cellular': [1220], 'thereby': [1224], 'promote': [1225], 'replication.': [1227], 'Inhibition': [1228, 1866, 2460], 'has': [1232, 1323, 1430], 'opposite': [1234, 1432], 'effect,': [1235, 2947], 'suggesting': [1236, 2975], 'antiviral': [1245, 1325, 1396, 1410, 1863, 2316], 'defense': [1246], 'strategy.': [1247], 'suppresses': [1250, 1288, 3870, 4017], 'basal': [1252, 1415, 2525, 2848], 'intestinal': [1261, 3131], 'epithelial': [1262, 3132], 'cells.': [1263, 3251], 'mediated': [1274], 'via': [1275, 2183, 2271], 'occurs': [1281], 'level.': [1285], 'upon': [1292, 1300, 1615], 'cells': [1295, 2937, 2981, 3133, 3188, 3693, 3706, 3880, 3916, 4199], 'with': [1296, 1595, 1773, 1845, 2003, 2074, 2127, 2385, 2517, 2678, 2870, 2920, 2969, 3088, 3149, 3189, 3210, 3232, 3248, 3431, 3460, 3489, 3549, 3570, 3617, 3635, 3671, 3760, 3830, 3890, 3922, 4027, 4118, 4198, 4219, 4228, 4280], 'interferons,': [1297, 1484], 'interferon-inducers,': [1298], 'infection.': [1302], 'Herpes': [1308], 'I,': [1311], 'keratinocytes.': [1319, 1328], 'strong': [1324, 2533, 2842], 'activities': [1326, 1480, 1711], 'paper': [1330], 'explained': [1331], 'Problem': [1332], 'Viral': [1333], 'infections': [1334, 1344, 1380], 'are': [1335, 1363, 1458, 1472, 1525, 1538, 1638, 1693, 1814, 1972, 2021, 2324, 2720, 2805, 2812, 3285, 3837, 3844, 4005, 4239, 4246], 'major': [1337, 1409, 1544, 3152], 'threat': [1338], 'health.': [1341], 'Combating': [1342], 'such': [1343, 1456, 1647], 'prevention': [1346], 'pandemic': [1349], 'requires': [1350], 'development': [1352, 1371, 1529, 1921, 2116, 2224], 'vaccines,': [1354], 'also': [1356, 1487, 2951, 3221, 3241, 3306, 3342, 4278], 'efficient': [1358, 1626], 'therapeutics.': [1359], 'Unfortunately,': [1360], 'many': [1361, 3168], 'therapeutics': [1362], 'virus-specific': [1364], 'and/or': [1365, 1681, 4039, 4122], 'have': [1366, 3228], 'high': [1367], 'toxicity.': [1368], 'Therefore,': [1369, 1635], 'novel': [1373], 'approaches': [1374], 'essential.': [1382], 'Results': [1383, 1865], 'previously': [1387, 1748], 'uncharacterized': [1388], 'role': [1389, 3065], 'defense.': [1397], 'efficiently': [1399], 'thus': [1405, 1917, 2112, 2931], 'infections,': [1425], 'while': [1426, 3698], 'effect.': [1433, 2986], 'Impact': [1434], 'Our': [1435], 'suggests': [1437], 'This': [1450, 2924, 3207], 'promising': [1453, 1860], 'approach,': [1454], 'already': [1459, 2096, 2926], 'clinical': [1461, 1696], 'trials': [1462, 1697], 'types': [1468, 1660, 1850, 3171], 'cancers': [1470], 'relatively': [1473], 'well': [1474, 1508], 'tolerated.': [1475], 'Due': [1476], 'widespread': [1479], 'it': [1485, 1714, 2949, 2964], 'will': [1486], 'be': [1488], 'important': [1489, 1710, 3064], 'relevance': [1493], 'their': [1495], 'described': [1498], 'various': [1503, 1618, 1702, 1835, 3183], 'diseases': [1506, 1551], 'tissue': [1511, 1531, 1627, 1645], 'repair.': [1512], 'Introduction': [1513], '(FGFs),': [1517], 'which': [1518, 1622, 1780, 2868, 3103, 3219, 3227, 3284, 3305, 4287], 'comprise': [1519], 'family': [1521], '22': [1523], 'proteins,': [1524], 'master': [1526], 'regulators': [1527], 'repair,': [1532, 1646], 'abnormalities': [1534, 1951, 2124], 'involved': [1539, 3289], 'developmental': [1548], 'inflammatory': [1550, 1770], 'cancer': [1553, 3879, 4284], '(Beenken': [1554], 'Mohammadi,': [1556], '2009;': [1557], 'Ornitz': [1558], 'Itoh,': [1560, 1602, 3165, 3315], '2015).': [1561, 1603, 2144, 3166], 'signal': [1564, 2079], 'through': [1565], 'one': [1566, 3737, 4169], 'four': [1570, 3730, 3779], 'tyrosine': [1572, 2217], 'kinases,': [1573], 'designated': [1574], '(FGFR)1': [1577], 'FGFR4.': [1579], 'Additional': [1580], 'complexity': [1581], 'achieved': [1583], 'alternative': [1585], 'splicing,': [1586], 'resulting': [1587], 'production': [1590, 2891], 'splice': [1593, 3157], 'variants': [1594], 'ligand': [1597, 3153], 'binding': [1598], 'specificities': [1599], '(Ornitz': [1600, 3163, 3313], 'Expression': [1604], 'most': [1606, 2017], 'low': [1609, 3105], 'conditions,': [1612], 'induced': [1614], 'injury': [1616], 'tissues': [1619, 1657], 'organs,': [1621], 'essential': [1624], 'repair': [1628], 'regeneration': [1630], '(Maddaluno': [1631], 'et': [1632, 1664, 1794, 1908, 2138, 2142, 3095, 3173, 3297, 3301, 3400, 4293], 'al,': [1633, 1665, 1795, 1909, 2139, 2143, 3096, 3174, 3298, 3302, 3401, 4294], '2017).': [1634], 'recombinant': [1636], 'clinically': [1639], 'used': [1640, 4183], 'promotion': [1643], 'cutaneous': [1649, 2123], 'wound': [1650], 'healing,': [1651], 'protection': [1655], 'from': [1658, 1786, 1891, 2039, 2216, 2483, 2503, 2572, 2594, 2614, 2635, 2671, 2771, 2913, 2957, 3010, 3058, 3421, 3509, 3514, 3537, 3725, 3729, 3736, 3751, 3755, 3773, 3797, 3965, 3974, 3982, 4160, 4168, 4174, 4195, 4200], 'damage': [1662], '(Nunes': [1663], '2016;': [1666], 'Zhang': [1667], 'Li,': [1669], '2016).': [1670, 1707], 'On': [1671], 'hand,': [1674], 'enhanced': [1675, 1846, 2890], 'FGFRs': [1680], 'abnormal': [1682], 'frequently': [1686], 'observed': [1687, 2952, 4279], 'cancer,': [1689], 'therefore': [1694], 'malignancies': [1703], '(Tanner': [1704], 'Grose,': [1706], 'Given': [1708], 'these': [1709, 3002, 3187, 3372, 4305], 'FGFs,': [1713, 1724], 'paramount': [1716], 'identify': [1718, 1855, 1878], 'mechanisms': [1720], 'action': [1722], 'responsible': [1726], 'target': [1727, 3389], 'genes,': [1728, 2020], 'cytokines.': [1739], 'To': [1740, 1877, 3134], 'function': [1743, 3234], 'skin,': [1746], 'we': [1747, 1830, 1884, 3144, 3203, 3246], 'generated': [1749], 'mice': [1750, 1766, 1813, 1892, 1903, 1954, 2041, 2161, 2337, 2510, 2550, 2582, 2643, 2705, 2728, 2737, 2744, 2761, 2838, 2855, 2960, 3017, 3060, 3423, 3518, 3543, 3762], 'lacking': [1751, 1893], 'FGFR1,': [1752], 'FGFR2,': [1753], 'both': [1755], 'receptors': [1756], 'epidermis': [1761, 2001, 2158, 2223, 2334, 2834, 2896, 2915, 3012], 'hair': [1763, 1959], 'follicles.': [1764], 'develop': [1767], 'progressive': [1769], 'skin': [1771, 1923, 2505], 'disease': [1772], 'features': [1774], 'resembling': [1775], 'atopic': [1776], 'dermatitis': [1777], 'humans,': [1779], 'least': [1783, 1990], 'part': [1785], 'defect': [1788, 2120], 'epidermal': [1791, 1799, 1889, 1926, 1950, 2037, 2481, 2501], 'barrier': [1792, 2119], '(Yang': [1793, 1907, 2137], '2010).': [1796], 'However,': [1797, 2963], 'immune': [1801, 2239, 2936, 2980], 'phenotype': [1802], 'only': [1803, 3192], 'develops': [1804], 'around': [1805], '3': [1806, 2200, 2299, 2453, 3278, 3427, 3742, 3783, 3968, 3975, 3981, 4256], 'weeks': [1807], 'after': [1808, 2101, 3579], 'birth,': [1809], 'therefore,': [1811], 'young': [1812], 'ideally': [1815], 'suited': [1816], 'identification': [1819], 'direct': [1821], 'targets': [1822, 1880], 'epidermis.': [1828], 'Here,': [1829], 'show': [1831, 2696, 3178, 3658, 3946, 4141], 'ISGs': [1836, 2030, 2094, 2322, 2476, 2588, 2606, 3201, 3244, 3447, 4052, 4133], 'correlates': [1844], 'viruses.': [1852], 'compounds': [1861], 'therapies.': [1864], 'IFN-stimulated': [1873, 2023, 2309], 'epidermis,': [1883], 'performed': [1885], 'microarray': [1886, 2050], 'analysis': [1887, 1930, 2035, 2627, 3045, 3377], 'RNA': [1890, 2038, 2181, 2269, 2482, 2571, 2593, 2613, 2670, 3215, 3356, 3438, 3467, 3507, 3553, 3641, 3897, 3926, 4046, 4126], 'FGFR1': [1894, 3028], 'FGFR2': [1896, 3030, 3156], '(K5-R1/R2': [1899], 'mice)': [1900], 'control': [1902, 2493, 2580], 'without': [1904], 'Cre': [1905, 2608, 2990], 'recombinase': [1906, 2991], '2010)': [1910], 'postnatal': [1912], 'day': [1913, 2099], '18': [1914], '(P18)': [1915], 'prior': [1918, 2113], 'inflammation': [1924], 'thickening.': [1927], 'Functional': [1928], 'enrichment': [1929], 'differentially': [1933], 'regulated': [1934, 2019, 2154, 3222, 4301], '(log2(f.c.)': [1936, 2005, 2326], '>': [1937, 2006, 2327], '1.5,': [1938, 2007, 2328], 'P': [1939, 2008, 2329], '<': [1940, 2009, 2330, 3812, 3999, 4215], '0.05)': [1941, 2331], 'enriched': [1943], 'ontologies': [1944], 'pathways': [1946], 'reflect': [1948], 'K5-R1/R2': [1953, 2000, 2160, 2336, 2491, 2507, 2530, 2549, 2578, 2601, 2642, 2837, 2917, 2959, 3059], 'loss': [1957], 'follicles': [1960], 'associated': [1962, 2122], 'melanocytes': [1963], '(Table': [1964, 1981, 2026], '1A': [1965, 1982], 'B).': [1967], 'Remarkably,': [1968], 'top': [1970, 2153], 'hits': [1971], 'characteristic': [1974], '"Type': [1977], 'Interferon': [1979, 2287, 2294], 'Response"': [1980], 'B,': [1984, 3817], 'Dataset': [1986, 2808, 3840, 4008, 4242], 'EV1),': [1987], '15%': [1991], '(11/63)': [1992], 'were': [1997, 2709, 2729, 3004, 3083, 3220, 3424, 3440, 3455, 3469, 3484, 3495, 3519, 3544, 3555, 3567, 3585, 3601, 3612, 3643, 3676, 3694, 3707, 3763, 3885, 3899, 3917, 3928, 3957, 4025, 4111, 4128, 4152, 4182], 'upregulated': [1998, 2325, 3394], 'compared': [2002, 2968], 'controls': [2004, 2874], '0.05),': [2010], 'particular': [2012, 3050], 'majority': [2014], 'strongly': [2018, 3393], 'classical': [2022, 3387], '(ISGs)': [2025], '1C).': [2027], 'Upregulation': [2028, 2091, 2940, 3020], 'confirmed': [2032, 2840, 3032, 3076], 'qRT–PCR': [2034, 2473, 2560, 2586, 2604, 2661, 3443, 3472, 3522, 3558, 3646, 3902, 3931, 4050, 4131], 'adult': [2040, 2836], 'some': [2043, 2093], 'additional': [2053, 3243, 3767], 'ISGs,': [2054, 2563, 3114, 3218, 3978], 'factor': [2058], '7': [2059, 2236], '(Irf7),': [2060], 'radical': [2061], 'S-adenosyl': [2062, 2363, 2395, 2433], 'methionine': [2063, 2364, 2396, 2434], 'domain': [2064, 2365, 2397, 2435], 'containing': [2065, 2366, 2398, 2436], '2': [2066, 2070, 2190, 2293, 2367, 2399, 2437, 3615, 3854, 3966], '(Rsad2),': [2067], '2′-5′-oligoadenylate': [2068, 2443], 'synthetase-like': [2069], '(Oasl2),': [2071], 'IFN-induced': [2072, 4018], 'protein': [2073, 2355, 2384, 2407, 2417, 3035, 3333, 3358, 4059], 'tetratricopeptide': [2075, 2386], 'repeat': [2076], '1': [2077, 2085, 2174, 2286, 2374, 2388, 2822, 3236, 3276, 3710, 3983], '(Ifit1),': [2078], 'transducer': [2080], 'activator': [2082], 'transcription': [2084], '(Stat1),': [2086], 'Stat2': [2088], '(Fig': [2089, 2109, 2856, 2938, 2961, 3018, 3061, 3122, 3205, 3235, 3282, 3339], '1A).': [2090], 'significant': [2097, 4310], '5': [2100, 2221, 2314, 2760], 'birth': [2102], '(P5)': [2103], 'very': [2105], 'robust': [2106], 'P9': [2108], '1B)': [2110], 'concomitant': [2126, 4272], 'complete': [2129], 'deletion': [2130], 'Fgfr1': [2133], 'Fgfr2': [2135], '2010;': [2140], 'Sulcova': [2141], 'Table': [2145, 3238], '1.': [2146, 2459, 2732, 3679, 3960, 4155], 'Type': [2147], 'pathway': [2155], '(A)': [2162, 2485, 2733, 3719, 3961, 4156], 'Gene': [2163, 2342, 2345], 'Ontology': [2164], '(GO)': [2165], 'Biological': [2166], 'Process': [2167], '2017b': [2168], 'Index': [2169, 2281], 'Name': [2170, 2282], 'P-value': [2171, 2173, 2283, 2285, 2351], 'Adj': [2172, 2284], 'Negative': [2175, 2191, 2201, 2263], 'regulation': [2176, 2192, 2202, 2264, 3292], 'single': [2178, 2266], 'stranded': [2179, 2267], 'double-stranded': [2184, 2272], 'DNA': [2185, 2273], 'intermediate': [2186, 2274], '(GO:0045869)': [2187, 2275], '0.000008': [2188, 2276], '0.001836': [2189, 2199, 2277], 'genome': [2195, 2207], '(GO:0045071)': [2197], '0.000006': [2198], 'host': [2204], '(GO:0044828)': [2209], '0.000015': [2210], '0.002497': [2211], '4': [2212, 2305, 2356, 3774], 'Melanin': [2213], 'biosynthetic': [2214], '(GO:0006583)': [2218], '0.000000': [2219], '0.000315': [2220], 'Skin': [2222], '(GO:0098773)': [2225], '0.000171': [2226], '0.006386': [2227, 2235, 2243, 2253, 2261], '6': [2228, 3384, 3429, 3458, 3793, 3920, 4193], 'Defense': [2229, 2245], 'fungus': [2232, 2258], '(GO:0050832)': [2233], '0.000379': [2234, 2242, 2252, 2260], 'Antifungal': [2237], 'innate': [2238], '(GO:0061760)': [2241], '8': [2244, 2377], 'fungus,': [2248], 'incompatible': [2249], 'interaction': [2250], '(GO:0009817)': [2251], '9': [2254, 3582], 'Neutrophil-mediated': [2255], 'killing': [2256], '(GO:0070947)': [2259], '10': [2262, 2736, 3465], '(B)': [2278, 2490, 2740, 3732, 3970, 4164], 'Reactome': [2279], '2016': [2280], 'alpha/beta': [2288], 'signaling_Homo': [2289], 'sapiens_R-HSA-909733': [2290], '0.000017': [2291], '0.001495': [2292], 'Signaling_Homo': [2295], 'sapiens_R-HSA-913531': [2296], '0.000870': [2297], '0.039131': [2298], 'Glutathione': [2300], 'conjugation_Homo': [2301], 'sapiens_R-HSA-156590': [2302], '0.003484': [2303], '0.104528': [2304], 'Antiviral': [2306], 'mechanism': [2307], 'genes_Homo': [2310], 'sapiens_R-HSA-1169410': [2311], '0.011532': [2312, 2319], '0.207580': [2313, 2320], 'ISG15': [2315, 2424, 2665], 'mechanism-Homo': [2317], 'sapiens_R-HSA-1169408': [2318], '(C)': [2321, 2747, 3739, 4171], 'P18': [2339], '(microarray': [2340], 'data)': [2341], 'Symbol': [2343], 'Description': [2344], 'ID': [2346, 2349], 'Affy': [2347], 'Probe': [2348], 'Log2(f.c.)': [2350], 'Rtp4': [2352], 'Receptor': [2353], 'transporter': [2354], '67775': [2357], '1418580_at': [2358], '2.841': [2359], '0.003': [2360], 'Rsad2': [2361, 2393, 2431], 'Radical': [2362, 2394, 2432], '58185': [2368, 2400, 2438], '1421009_at': [2369], '2.824': [2370], '0.007': [2371], 'Il1f8': [2372], 'Interleukin': [2373], 'family,': [2375], 'member': [2376], '69677': [2378], '1425715_at': [2379], '2.652': [2380], '0.014': [2381, 2392], 'Ifit1': [2382], 'Interferon-induced': [2383, 2416], 'repeats': [2387], '15957': [2389], '1450783_at': [2390], '2.649': [2391], '1436058_at': [2401], '2.589': [2402], '0.021': [2403, 2414], 'Ifi27l2a': [2404], 'Interferon,': [2405], 'alpha-inducible': [2406], '27': [2408], 'like': [2409], '2A': [2410], '76933': [2411], '1426278_at': [2412], '2.506': [2413], 'Ifi44': [2415], '99899': [2419], '1423555_a_at': [2420], '2.493': [2421], '0.004': [2422], 'Isg15': [2423], 'ubiquitin-like': [2425], 'modifier': [2426], '100038882': [2427], '1431591_s_at': [2428], '2.027': [2429], '0.009': [2430, 2441], '1421008_at': [2439], '1.931': [2440], 'Oas1d': [2442], 'synthetase': [2444], '1D': [2445], '100535': [2446], '1416847_s_at': [2447], '1.879': [2448], '0.039': [2449], 'Defb3': [2450], 'Defensin': [2451], 'beta': [2452], '27358': [2454], '1421806_at': [2455], '1.56': [2456], '0.044': [2457], 'Figure': [2458, 2821, 3405, 3853, 3866, 4014, 4255], 'A,': [2471], 'B.': [2472, 3451, 3913], 'relative': [2477, 2567, 2589, 2609, 2666, 2716, 3448, 3477, 3529, 3561, 3651, 3910, 3939, 4053, 4134], 'Rps29': [2479, 2569, 2591, 2611], 'using': [2480, 2570, 2592, 2612, 2669, 3603], '8-week-old': [2484], '5-day-old': [2487], '9-day-old': [2489], '(CTRL)': [2494, 2581], 'C.': [2496, 3480], 'Confocal': [2497], 'microscopy': [2498], 'images': [2499, 2749], 'sheets': [2502], 'back': [2504], 'CTRL': [2509, 2599, 2640, 2704, 3666, 3954, 4149], 'stained': [2511], 'IRF7': [2513, 2522, 2831, 3474, 3648, 4297], 'K14,': [2515], 'counterstained': [2516], 'DAPI.': [2518], 'Arrows': [2519], 'denote': [2520], 'nuclear': [2521, 2632, 2864, 3052], '(red)': [2523], 'suprabasal': [2527, 2850], 'red': [2534, 2858], 'staining': [2535], 'stratum': [2538], 'corneum': [2539], '(sc)': [2540], 'unspecific': [2542], 'background': [2543], 'pronounced': [2547, 2967], 'due': [2551], 'increased': [2554, 2907], 'thickness': [2555], 'layer.': [2558], 'D.': [2559, 3506, 4107], 'Ifnb,': [2564], 'Ifnl3': [2566, 2903], 'freshly': [2573, 2909, 2971], 'isolated,': [2574, 2910], 'non-cultured': [2575, 2911], 'P7.': [2584], 'E.': [2585, 3532], 'primary': [2595, 2615, 2955, 3007, 3146, 3419, 3512, 3535, 4109], 'neonatal': [2598, 2618, 3538], 'F.': [2603, 3564], 'K5-Cre': [2619, 2727, 3016], 'wild-type': [2621, 3014], '(WT)': [2622], 'G.': [2624], 'Western': [2625, 3043, 3498, 4062], 'blot': [2626, 3044, 3499, 4063, 4084, 4173], 'total': [2629, 3047, 4065], '(L)': [2630], '(N)': [2633], 'lysates': [2634, 3053, 3494], 'immortalized': [2636, 3056, 3079], '(imm.)': [2637], 'IRF1,': [2645, 3038, 3501, 3904, 4071], 'IRF7,': [2646, 2867, 3039, 3262, 3933], 'IRF9,': [2647, 3503, 4072], 'Lamin': [2648], 'A/C': [2649], '(nuclear': [2650], 'marker,': [2651, 2657], 'loading': [2652, 2658], 'control),': [2653], 'GAPDH': [2655, 4076], '(cytosolic': [2656], 'control).': [2659], 'H.': [2660, 3609], 'RSAD2': [2663, 3116, 3476, 4074, 4083], 'RPLP0': [2668, 4055], 'HaCaT': [2672, 3211, 3253, 3453, 3482, 3565, 3610, 3874, 3883, 4023], 'treated': [2674, 3084, 3145, 3425, 3456, 3485, 3545, 3670, 3886, 3918, 4026, 4114], '48': [2676, 3086], 'h': [2677, 3087, 3194, 3430, 3459, 3488, 3548, 3578, 3616, 3889, 3921, 4117], 'inhibitor': [2681, 3092], 'BGJ398': [2682, 3093], '(3.5': [2683], 'μM)': [2684], 'vehicle': [2686, 3436], 'presence': [2689, 3100, 3590], 'serum.': [2691], 'Data': [2692, 2819, 3654, 3851, 3942, 4137, 4253], 'information:': [2693, 3655, 3943, 4138], 'Scatter': [2694, 3656, 3944, 4139], 'plots': [2695, 3657, 3945, 4140], 'mean': [2697, 3659, 3947, 4142], '±': [2698, 3660, 3948, 4143], 'SEM.': [2699, 3661, 3949, 4144], 'Mean': [2700, 3662, 3950, 4145], 'levels': [2702, 2715, 2725, 3000, 3106, 3664, 3690, 3700, 3952, 4147], 'cell': [2707, 3170, 3667, 3955, 4150, 4285], 'cultures': [2708, 2769, 3668, 3723, 3749, 3956, 4151], 'set': [2710, 2730, 3677, 3695, 3708, 3958, 4153], '1,': [2712, 3697], 'mRNA': [2714], 'value': [2719], 'shown.': [2721], 'In': [2722, 3252, 3680], '(F),': [2723], 'N': [2734, 2741, 2758, 2766, 2783, 3720, 3733, 3746, 3770, 3781, 3791, 3962, 3971, 3979, 4157, 4165, 4191], '=': [2735, 2742, 2759, 2767, 2784, 3721, 3734, 3747, 3771, 3782, 3792, 3963, 3972, 3980, 4100, 4158, 4166, 4188, 4192], 'per': [2738, 2745, 2762, 2775, 2786, 3784, 3794], 'genotype,': [2739], '6–14': [2743], 'genotype.': [2746, 2763, 2776], 'Representative': [2748, 2778, 3740, 3777, 4172], 'two': [2751, 3756, 3766, 3798, 4161, 4175, 4196, 4201], 'experiments.': [2752, 2781, 3731, 3743, 3757, 3768, 3775, 3799, 4163, 4176], 'Magnification': [2753], 'bar:': [2754], '20': [2755, 3598], 'μm.': [2756], '(D)': [2757, 3681, 4190], '(E,': [2764], 'F)': [2765], '4–7': [2768], '(each': [2770, 3464, 3724, 3750], 'mouse)': [2774, 3728, 3754], '(G)': [2777, 3624, 3776], 'three': [2780], '(H)': [2782, 3790], '6–9': [2785], 'group.': [2788], '*P': [2789, 3802, 3989, 4205], '≤': [2790, 2793, 2796, 2799, 3803, 3806, 3809, 3990, 3993, 3996, 4206, 4209, 4212], '0.05,': [2791, 3804, 3991, 4207], '**P': [2792, 3805, 3992, 4208], '0.01,': [2794, 3807, 3994, 4210], '***P': [2795, 3808, 3995, 4211], '0.001,': [2797, 3810, 3997, 4213], '****P': [2798, 3811, 3998, 4214], '0.0001': [2800, 3813, 4000, 4216], '(Mann–Whitney': [2801, 3814, 4001], 'U-test).': [2802, 4002], 'Exact': [2803, 3835, 4003, 4237], 'P-values': [2804, 3836, 4004, 4238], 'provided': [2806, 4006], 'EV2.': [2809, 3841, 4009, 4243], 'data': [2811, 3843, 4245], 'available': [2813, 3845, 4247], 'online': [2814, 3846, 4248], 'figure.': [2817, 3849, 3865, 4251], '[emmm201911793-sup-0005-SDataFig1.pdf]': [2823], 'Download': [2824, 2826, 3856, 3858, 4010, 4012, 4258, 4260], 'figure': [2825, 3857, 4011, 4259], 'PowerPoint': [2827, 3859, 4013, 4261], 'Elevated': [2828], 'immunostaining': [2843], 'nuclei': [2846], 'mutant': [2854], '1C,': [2857], 'dots': [2859], 'indicated': [2860, 3446, 4037], 'arrows).': [2862], 'localization': [2865], 'together': [2869], 'IRF3': [2871, 3347], 'NF-κB': [2873], 'interferons': [2878], 'type': [2879, 2885], '(IFN-α': [2881], 'IFN-β)': [2883], 'III': [2886], '(IFN-λ),': [2887], 'hints': [2888], 'IFNs': [2893, 2977], 'FGFR1/R2-deficient': [2898], 'Indeed,': [2900], 'Ifnb': [2901], 'significantly': [2906], 'mice,': [2918], 'concomitantly': [2919], 'all': [2921, 3200], 'tested': [2922, 3204, 3247], 'ISGs.': [2923, 3184], 'seen': [2927], 'P7': [2929], 'preceding': [2932], 'increase': [2934, 4273], '1D).': [2939], 'cell-autonomous': [2946], 'neonate': [2958], '1E).': [2962], 'less': [2966], 'non-cultured,': [2970], 'isolated': [2972, 3009], '(P7),': [2974], 'produced': [2978], 'vivo': [2983], 'potentiate': [2984], 'An': [2987], 'excluded,': [2996], 'similar': [3005, 3233, 3319], '1F).': [3019], 'absence': [3026, 3592], 'level': [3036, 3216, 3334, 3359], 'IRF9': [3041, 3338], 'spontaneously': [3055], '1G).': [3062], 'when': [3077], '(HaCaT': [3081], 'cells)': [3082], '(Guagnano': [3094], '2011)': [3097], 'serum,': [3102], 'contains': [3104], 'FGFs.': [3108], 'gene': [3119, 3390], '15': [3120], '(ISG15)': [3121], '1H).': [3123], 'further': [3135], 'determine': [3136], 'whether': [3137], 'directly': [3140], 'regulates': [3141], 'expression,': [3143], 'murine': [3147], 'FGF7,': [3150], 'variant': [3158], 'expressed': [3159], '(FGFR2b)': [3162], 'Like': [3167], '(Gough': [3172], '2012),': [3175], 'mouse': [3176, 3224], 'tonic': [3180, 3197], 'Treatment': [3185], '3–6': [3193], '2A).': [3206], 'verified': [3209, 3330], 'orthologue': [3231], '1C)': [3239], 'cells,': [3254, 4306], 'suppressed,': [3256], 'example,': [3258], 'RSAD2,': [3263], 'IRF1': [3265, 3336, 3650], '(Figs': [3266, 3321, 3360], '2B': [3267, 3322], 'EV1A)': [3269], 'suppressor': [3272], 'cytokine': [3274], '(SOCS1': [3279], 'SOCS3)': [3281], 'EV1A),': [3283], 'products': [3287], 'negative': [3291], '(Blumer': [3296], '2017;': [3299], 'Michalska': [3300], '2018).': [3303], 'FGF10,': [3304], 'activates': [3307], 'FGFR2b': [3308], 'addition': [3311], 'FGFR1b': [3312], '2015),': [3316], 'had': [3317], 'EV1A).': [3324, 3404], '2C,': [3340], 'see': [3341], 'Fig': [3343, 3403], '3C).': [3344], 'By': [3345], 'contrast,': [3346], 'EV1A': [3361], '2C).': [3363], 'efficiency': [3365], 'experiments': [3373, 3976, 4197], 'validated': [3375], 'dual-specific': [3382], 'phosphatase': [3383], '(DUSP6),': [3385], '(Li': [3399], '2007;': [3402], '2.': [3406], 'A.': [3416, 3881], 'Growth': [3417, 3533], 'factor-starved': [3418, 3534], 'WT': [3422, 3515], '(10': [3433, 3491, 3551, 3595, 3622, 3637, 3894, 3924, 4029, 4120], 'ng/ml)': [3434, 3596, 3638, 4121], '(CTRL).': [3437], 'samples': [3439, 3468, 3508, 3554, 3642, 3898, 3927, 4060, 4127], 'analyzed': [3441, 3470, 3496, 3520, 3556, 3602, 3644, 3900, 3929, 4048, 4129], 'Rps29.': [3450, 3531, 3563], 'Serum-starved': [3452, 3481, 3882, 3914, 4022], 'ng/ml).': [3466, 3492, 3552, 3925], 'RPLP0.': [3479, 3653, 3912, 3941, 4136], '16': [3487, 3888], 'Protein': [3493], 'IRF3,': [3502, 3905], 'GAPDH.': [3505], 'untreated,': [3510], 'serum-starved': [3511], 'Ifnar1-KO': [3517, 3761], 'Irf7,': [3524], 'Rsad2,': [3525], 'Oasl2,': [3526], 'Ifnar1': [3528], 'WT,': [3539], 'Ifnar1-KO,': [3540], 'Ifnar1/Ifnlr1-KO': [3542], '24': [3547, 3577], 'Irf7': [3560], 'transiently': [3568], 'transfected': [3569], 'ISRE-Luciferase': [3572], 'reporter': [3573], 'construct': [3574], 'starved': [3576, 4112], 'transfection': [3580], 'h.': [3583, 3599, 4045], 'They': [3584], 'then': [3586], 'incubated': [3587], 'Lysates': [3600], 'DualGlo': [3605], 'Luciferase': [3606], 'Assay.': [3607], 'G,': [3608], 'pre-treated': [3613], 'proteasome': [3619], 'MG132': [3621], 'μm': [3623], 'epoxomicin': [3626], '(100': [3627], 'nM)': [3628], '(H),': [3629], 'followed': [3630], '20-h': [3633], 'vehicle.': [3640], '(not': [3669], 'any': [3674], 'inhibitor)': [3675], 'left': [3685], 'panel': [3686, 3716], '(E),': [3688], 'wt': [3692], 'untreated': [3702], 'knockout': [3705], 'middle': [3713], 'right': [3715], '(E).': [3718], '8–11': [3722], '3–5': [3735], 'experiment.': [3738, 3789, 4170], '(D,': [3744], 'E)': [3745], '5–11': [3748], 'reproduced': [3764], '(F)': [3769], '16–18': [3772], 'experiments,': [3780, 3969], 'group': [3786, 3796], 'each': [3788], 'ns:': [3800, 3987, 4203], 'non-significant,': [3801, 3988, 4204], 'U-test': [3815], '(A,': [3816, 4031, 4056, 4224], 'D,': [3818], 'E,': [3819], 'F,': [3820], 'H)': [3821], 't-test': [3823, 4227], 'assessment': [3825, 4232], '(G),': [3829], 'Welch': [3831, 4229], 'correction': [3832, 4230], 'IRF1.': [3834], 'shown': [3838, 4103, 4240], '[emmm201911793-sup-0006-SDataFig2.pdf]': [3855], 'Click': [3860], 'here': [3861], 'expand': [3863], 'EV1.': [3867], 'Caco-2': [3877, 3915, 4282], 'colon': [3878, 4283], 'ng/ml': [3895, 4030], 'each).': [3896], 'SOCS1,': 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'(C)).': [4236], '[emmm201911793-sup-0007-SDataFig3.pdf]': [4257], 'suppressive': [4263], 'line,': [4286], 'responsive': [4289], '(Visco': [4292], '2009).': [4295], 'While': [4296], 'there': [4307]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3045645539', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}], 'updated_date': '2024-12-31T10:35:38.118810', 'created_date': '2020-08-03'}
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