Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3043523186', 'doi': 'https://doi.org/10.3390/ijms21144966', 'title': 'Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson’s Disease', 'display_name': 'Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson’s Disease', 'publication_year': 2020, 'publication_date': '2020-07-14', 'ids': {'openalex': 'https://openalex.org/W3043523186', 'doi': 'https://doi.org/10.3390/ijms21144966', 'mag': '3043523186', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32674335', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7404170'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms21144966', 'pdf_url': 'https://www.mdpi.com/1422-0067/21/14/4966/pdf?version=1594721931', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1422-0067/21/14/4966/pdf?version=1594721931', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029705182', 'display_name': 'Shani Blumenreich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Shani Blumenreich', 'raw_affiliation_strings': ['Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029122273', 'display_name': 'Or B. Barav', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Or B. Barav', 'raw_affiliation_strings': ['Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087735454', 'display_name': 'Bethan J. Jenkins', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139319', 'display_name': 'Max Planck Institute of Neurobiology', 'ror': 'https://ror.org/03ap2av50', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210139319']}, {'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['DE', 'IL'], 'is_corresponding': False, 'raw_author_name': 'Bethan J. Jenkins', 'raw_affiliation_strings': ['Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel', 'Department of Neurobiology, Max Planck Institute of Neurobiology, 82152 Planegg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, Max Planck Institute of Neurobiology, 82152 Planegg, Germany', 'institution_ids': ['https://openalex.org/I4210139319']}, {'raw_affiliation_string': 'Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5021535678', 'display_name': 'Anthony H. Futerman', 'orcid': 'https://orcid.org/0000-0003-0013-0115'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': True, 'raw_author_name': 'Anthony H. Futerman', 'raw_affiliation_strings': ['Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5021535678'], 'corresponding_institution_ids': ['https://openalex.org/I53964585'], 'apc_list': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'fwci': 0.766, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 25, 'citation_normalized_percentile': {'value': 0.999394, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '21', 'issue': '14', 'first_page': '4966', 'last_page': '4966'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders in Human Health and Disease', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders in Human Health and Disease', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10085', 'display_name': "Pathophysiology of Parkinson's Disease", 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Mechanisms of Intracellular Membrane Trafficking', 'score': 0.9846, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lysosomal-storage-disease', 'display_name': 'Lysosomal storage disease', 'score': 0.76086015}, {'id': 'https://openalex.org/keywords/lysosomal-storage-disorders', 'display_name': 'Lysosomal Storage Disorders', 'score': 0.624678}, {'id': 'https://openalex.org/keywords/tfeb', 'display_name': 'TFEB', 'score': 0.5269595}, {'id': 'https://openalex.org/keywords/lysosome-biogenesis', 'display_name': 'Lysosome Biogenesis', 'score': 0.526695}], 'concepts': [{'id': 'https://openalex.org/C2780216420', 'wikidata': 'https://www.wikidata.org/wiki/Q83330', 'display_name': 'Lysosome', 'level': 3, 'score': 0.9333371}, {'id': 'https://openalex.org/C2778264360', 'wikidata': 'https://www.wikidata.org/wiki/Q675010', 'display_name': 'Lysosomal storage disease', 'level': 3, 'score': 0.76086015}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.5702262}, {'id': 'https://openalex.org/C2908579795', 'wikidata': 'https://www.wikidata.org/wiki/Q675010', 'display_name': 'Lysosomal storage disorders', 'level': 3, 'score': 0.5664296}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.5400435}, {'id': 'https://openalex.org/C2780674200', 'wikidata': 'https://www.wikidata.org/wiki/Q420038', 'display_name': 'Glucocerebrosidase', 'level': 3, 'score': 0.5321799}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.5273672}, {'id': 'https://openalex.org/C132647116', 'wikidata': 'https://www.wikidata.org/wiki/Q18032677', 'display_name': 'TFEB', 'level': 4, 'score': 0.5269595}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.4989829}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.47879085}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.3635584}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.35041943}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.3320536}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.320153}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2986887}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.18327376}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12616321}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.118135124}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016464', 'descriptor_name': 'Lysosomal Storage Diseases', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': True}, {'descriptor_ui': 'D016464', 'descriptor_name': 'Lysosomal Storage Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005962', 'descriptor_name': 'Glucosylceramidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005962', 'descriptor_name': 'Glucosylceramidase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005962', 'descriptor_name': 'Glucosylceramidase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016464', 'descriptor_name': 'Lysosomal Storage Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016464', 'descriptor_name': 'Lysosomal Storage Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms21144966', 'pdf_url': 'https://www.mdpi.com/1422-0067/21/14/4966/pdf?version=1594721931', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/953b814297e84e0e8328846ec0fce44a', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/21.11116/0000-0007-3291-C', 'pdf_url': 'https://pure.mpg.de/pubman/item/item_3247938_3/component/file_3247939/ijms-21-04966.pdf', 'source': {'id': 'https://openalex.org/S4306400655', 'display_name': 'MPG.PuRe (Max Planck Society)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I149899117', 'host_organization_name': 'Max Planck Society', 'host_organization_lineage': ['https://openalex.org/I149899117'], 'host_organization_lineage_names': ['Max Planck Society'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404170', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32674335', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms21144966', 'pdf_url': 'https://www.mdpi.com/1422-0067/21/14/4966/pdf?version=1594721931', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.62, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 92, 'referenced_works': ['https://openalex.org/W1509821238', 'https://openalex.org/W1558432922', 'https://openalex.org/W1581438400', 'https://openalex.org/W1780178978', 'https://openalex.org/W1866238768', 'https://openalex.org/W1968822375', 'https://openalex.org/W1970661950', 'https://openalex.org/W1973656222', 'https://openalex.org/W1975932268', 'https://openalex.org/W1979659124', 'https://openalex.org/W1980898435', 'https://openalex.org/W1981336920', 'https://openalex.org/W1982224533', 'https://openalex.org/W1993095877', 'https://openalex.org/W1997604339', 'https://openalex.org/W2004893995', 'https://openalex.org/W2015816621', 'https://openalex.org/W2020579700', 'https://openalex.org/W2029028848', 'https://openalex.org/W2040383487', 'https://openalex.org/W2042710439', 'https://openalex.org/W2046755890', 'https://openalex.org/W2052594340', 'https://openalex.org/W2068292276', 'https://openalex.org/W2069274491', 'https://openalex.org/W2076107153', 'https://openalex.org/W2076743021', 'https://openalex.org/W2079378641', 'https://openalex.org/W2084420014', 'https://openalex.org/W2089522371', 'https://openalex.org/W2095706874', 'https://openalex.org/W2102600433', 'https://openalex.org/W2104557299', 'https://openalex.org/W2104706512', 'https://openalex.org/W2107766190', 'https://openalex.org/W2108018538', 'https://openalex.org/W2114723455', 'https://openalex.org/W2118598201', 'https://openalex.org/W2118664033', 'https://openalex.org/W2120668700', 'https://openalex.org/W2123431154', 'https://openalex.org/W2130361709', 'https://openalex.org/W2131476886', 'https://openalex.org/W2144037754', 'https://openalex.org/W2144140825', 'https://openalex.org/W2147290689', 'https://openalex.org/W2152884293', 'https://openalex.org/W2153622855', 'https://openalex.org/W2170281382', 'https://openalex.org/W2174314139', 'https://openalex.org/W2337675431', 'https://openalex.org/W2337871602', 'https://openalex.org/W2338408645', 'https://openalex.org/W2471220893', 'https://openalex.org/W2495228129', 'https://openalex.org/W2518972237', 'https://openalex.org/W2519209874', 'https://openalex.org/W2522005098', 'https://openalex.org/W2523238466', 'https://openalex.org/W2532473127', 'https://openalex.org/W2559604477', 'https://openalex.org/W2575523348', 'https://openalex.org/W2604894269', 'https://openalex.org/W2727376740', 'https://openalex.org/W2745136677', 'https://openalex.org/W2746979715', 'https://openalex.org/W2752380554', 'https://openalex.org/W2754278602', 'https://openalex.org/W2767690268', 'https://openalex.org/W2768738386', 'https://openalex.org/W2773754127', 'https://openalex.org/W2774279504', 'https://openalex.org/W2779236324', 'https://openalex.org/W2781740238', 'https://openalex.org/W2782297377', 'https://openalex.org/W2786185614', 'https://openalex.org/W2792102607', 'https://openalex.org/W2795198244', 'https://openalex.org/W2796293593', 'https://openalex.org/W2802593879', 'https://openalex.org/W2803346396', 'https://openalex.org/W2803496847', 'https://openalex.org/W2804666066', 'https://openalex.org/W2805823081', 'https://openalex.org/W2809205023', 'https://openalex.org/W2884107989', 'https://openalex.org/W2888867513', 'https://openalex.org/W2892528940', 'https://openalex.org/W2899344105', 'https://openalex.org/W2912022330', 'https://openalex.org/W2973720548', 'https://openalex.org/W967812935'], 'related_works': ['https://openalex.org/W4387668351', 'https://openalex.org/W4306971719', 'https://openalex.org/W4252300778', 'https://openalex.org/W3114379697', 'https://openalex.org/W3043523186', 'https://openalex.org/W2809738004', 'https://openalex.org/W2562785312', 'https://openalex.org/W2130361709', 'https://openalex.org/W2061499894', 'https://openalex.org/W1138449060'], 'abstract_inverted_index': {'The': [0, 32], 'lysosome': [1, 33, 121], 'is': [2, 55, 87, 129], 'a': [3, 11, 20, 24, 44, 50, 94, 101, 110, 135], 'central': [4, 136], 'player': [5], 'in': [6, 23, 64, 90, 103, 138, 147, 156, 162], 'the': [7, 37, 67, 77, 116, 120, 152, 157, 163], 'cell,': [8], 'acting': [9], 'as': [10], 'clearing': [12], 'house': [13], 'for': [14, 72], 'macromolecular': [15], 'degradation,': [16], 'but': [17], 'also': [18], 'plays': [19, 134], 'critical': [21], 'role': [22, 137], 'variety': [25], 'of': [26, 39, 46, 85, 97, 154, 166], 'additional': [27], 'metabolic': [28], 'and': [29, 41, 61, 122], 'regulatory': [30], 'processes.': [31], 'has': [34], 'recently': [35], 'attracted': [36], 'attention': [38], 'neurobiologists': [40], 'neurologists': [42], 'since': [43, 93], 'number': [45], 'neurological': [47], 'diseases': [48], 'involve': [49], 'lysosomal': [51, 83, 111, 132, 142, 148], 'component.': [52], 'Among': [53], 'these': [54], 'Parkinson’s': [56], 'disease': [57, 113], '(PD).': [58], 'While': [59], 'heterozygous': [60], 'homozygous': [62], 'mutations': [63, 146], 'GBA1': [65], 'are': [66], 'highest': [68], 'genetic': [69], 'risk': [70], 'factor': [71], 'PD,': [73], 'studies': [74], 'performed': [75], 'over': [76], 'past': [78], 'decade': [79], 'have': [80, 100], 'suggested': [81], 'that': [82, 108, 131], 'loss': [84], 'function': [86], 'likely': [88], 'involved': [89], 'PD': [91, 98, 123, 139], 'pathology,': [92], 'significant': [95, 127], 'percent': [96], 'patients': [99], 'mutation': [102], 'one': [104], 'or': [105], 'more': [106], 'genes': [107], 'cause': [109], 'storage': [112], '(LSD).': [114], 'Although': [115], 'mechanistic': [117], 'connection': [118], 'between': [119], 'remains': [124], 'somewhat': [125], 'enigmatic,': [126], 'evidence': [128], 'accumulating': [130], 'dysfunction': [133], 'pathophysiology.': [140], 'Thus,': [141], 'dysfunction,': [143], 'resulting': [144], 'from': [145], 'genes,': [149], 'may': [150, 160], 'enhance': [151], 'accumulation': [153], 'α-synuclein': [155], 'brain,': [158], 'which': [159], 'result': [161], 'earlier': [164], 'development': [165], 'PD.': [167]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3043523186', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}], 'updated_date': '2024-09-01T08:34:11.386910', 'created_date': '2020-07-23'}