Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3042631053', 'doi': 'https://doi.org/10.1002/1878-0261.12765', 'title': 'Exosomal miR‐1255b‐5p targets human telomerase reverse transcriptase in colorectal cancer cells to suppress epithelial‐to‐mesenchymal transition', 'display_name': 'Exosomal miR‐1255b‐5p targets human telomerase reverse transcriptase in colorectal cancer cells to suppress epithelial‐to‐mesenchymal transition', 'publication_year': 2020, 'publication_date': '2020-07-17', 'ids': {'openalex': 'https://openalex.org/W3042631053', 'doi': 'https://doi.org/10.1002/1878-0261.12765', 'mag': '3042631053', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32679610', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7530775'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/1878-0261.12765', 'pdf_url': 'https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.12765', 'source': {'id': 'https://openalex.org/S80282989', 'display_name': 'Molecular Oncology', 'issn_l': '1574-7891', 'issn': ['1574-7891', '1878-0261'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.12765', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100445843', 'display_name': 'Xue Zhang', 'orcid': 'https://orcid.org/0000-0002-3856-5053'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210120234', 'display_name': 'Zhongnan Hospital of Wuhan University', 'ror': 'https://ror.org/01v5mqw79', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120234']}, {'id': 'https://openalex.org/I4210160841', 'display_name': 'Hubei Cancer Hospital', 'ror': 'https://ror.org/05p38yh32', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160841']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xue Zhang', 'raw_affiliation_strings': ['Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'Hubei Cancer Clinical Study Center, Wuhan, China', 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210120234']}, {'raw_affiliation_string': 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}, {'raw_affiliation_string': 'Hubei Cancer Clinical Study Center, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022214161', 'display_name': 'Jian Bai', 'orcid': 'https://orcid.org/0000-0002-6358-2496'}, 'institutions': [{'id': 'https://openalex.org/I4210160841', 'display_name': 'Hubei Cancer Hospital', 'ror': 'https://ror.org/05p38yh32', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160841']}, {'id': 'https://openalex.org/I4210120234', 'display_name': 'Zhongnan Hospital of Wuhan University', 'ror': 'https://ror.org/01v5mqw79', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120234']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian Bai', 'raw_affiliation_strings': ['Department of Gastrointestinal Surgery & Department of Gastric and Colorectal Surgical Oncology Zhongnan Hospital of Wuhan University Wuhan China', 'Hubei Cancer Clinical Study Center, Wuhan, China', 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}, {'raw_affiliation_string': 'Hubei Cancer Clinical Study Center, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}, {'raw_affiliation_string': 'Department of Gastrointestinal Surgery & Department of Gastric and Colorectal Surgical Oncology Zhongnan Hospital of Wuhan University Wuhan China', 'institution_ids': ['https://openalex.org/I4210120234', 'https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030742167', 'display_name': 'Hang Yin', 'orcid': 'https://orcid.org/0000-0002-0260-9130'}, 'institutions': [{'id': 'https://openalex.org/I4210120234', 'display_name': 'Zhongnan Hospital of Wuhan University', 'ror': 'https://ror.org/01v5mqw79', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120234']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210160841', 'display_name': 'Hubei Cancer Hospital', 'ror': 'https://ror.org/05p38yh32', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160841']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hang Yin', 'raw_affiliation_strings': ['Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'Hubei Cancer Clinical Study Center, Wuhan, China', 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210120234', 'https://openalex.org/I37461747']}, {'raw_affiliation_string': 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}, {'raw_affiliation_string': 'Hubei Cancer Clinical Study Center, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003827115', 'display_name': 'Long Long', 'orcid': 'https://orcid.org/0000-0002-0497-9493'}, 'institutions': [{'id': 'https://openalex.org/I4210120234', 'display_name': 'Zhongnan Hospital of Wuhan University', 'ror': 'https://ror.org/01v5mqw79', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120234']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210160841', 'display_name': 'Hubei Cancer Hospital', 'ror': 'https://ror.org/05p38yh32', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160841']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Long Long', 'raw_affiliation_strings': ['Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'Hubei Cancer Clinical Study Center, Wuhan, China', 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210120234', 'https://openalex.org/I37461747']}, {'raw_affiliation_string': 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}, {'raw_affiliation_string': 'Hubei Cancer Clinical Study Center, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036413704', 'display_name': 'Zhewen Zheng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210120234', 'display_name': 'Zhongnan Hospital of Wuhan University', 'ror': 'https://ror.org/01v5mqw79', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120234']}, {'id': 'https://openalex.org/I4210160841', 'display_name': 'Hubei Cancer Hospital', 'ror': 'https://ror.org/05p38yh32', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160841']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhewen Zheng', 'raw_affiliation_strings': ['Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'Hubei Cancer Clinical Study Center, Wuhan, China', 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210120234', 'https://openalex.org/I37461747']}, {'raw_affiliation_string': 'Hubei Cancer Clinical Study Center, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}, {'raw_affiliation_string': 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100638423', 'display_name': 'Qingqing Wang', 'orcid': 'https://orcid.org/0000-0002-5846-2801'}, 'institutions': [{'id': 'https://openalex.org/I4210120234', 'display_name': 'Zhongnan Hospital of Wuhan University', 'ror': 'https://ror.org/01v5mqw79', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120234']}, {'id': 'https://openalex.org/I4210160841', 'display_name': 'Hubei Cancer Hospital', 'ror': 'https://ror.org/05p38yh32', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160841']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qingqing Wang', 'raw_affiliation_strings': ['Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'Hubei Cancer Clinical Study Center, Wuhan, China', 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210120234', 'https://openalex.org/I37461747']}, {'raw_affiliation_string': 'Hubei Cancer Clinical Study Center, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}, {'raw_affiliation_string': 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008624746', 'display_name': 'Fengxia Chen', 'orcid': 'https://orcid.org/0009-0001-9187-0452'}, 'institutions': [{'id': 'https://openalex.org/I4210160841', 'display_name': 'Hubei Cancer Hospital', 'ror': 'https://ror.org/05p38yh32', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160841']}, {'id': 'https://openalex.org/I4210120234', 'display_name': 'Zhongnan Hospital of Wuhan University', 'ror': 'https://ror.org/01v5mqw79', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120234']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fengxia Chen', 'raw_affiliation_strings': ['Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'Hubei Cancer Clinical Study Center, Wuhan, China', 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Hubei Cancer Clinical Study Center, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}, {'raw_affiliation_string': 'Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210120234', 'https://openalex.org/I37461747']}, {'raw_affiliation_string': 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100695163', 'display_name': 'Xiaoyan Yu', 'orcid': 'https://orcid.org/0000-0003-0351-8393'}, 'institutions': [{'id': 'https://openalex.org/I4210160841', 'display_name': 'Hubei Cancer Hospital', 'ror': 'https://ror.org/05p38yh32', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160841']}, {'id': 'https://openalex.org/I4210120234', 'display_name': 'Zhongnan Hospital of Wuhan University', 'ror': 'https://ror.org/01v5mqw79', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120234']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoyan Yu', 'raw_affiliation_strings': ['Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'Hubei Cancer Clinical Study Center, Wuhan, China', 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Hubei Cancer Clinical Study Center, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}, {'raw_affiliation_string': 'Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210120234', 'https://openalex.org/I37461747']}, {'raw_affiliation_string': 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5090499433', 'display_name': 'Yunfeng Zhou', 'orcid': 'https://orcid.org/0000-0003-4328-6646'}, 'institutions': [{'id': 'https://openalex.org/I4210160841', 'display_name': 'Hubei Cancer Hospital', 'ror': 'https://ror.org/05p38yh32', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160841']}, {'id': 'https://openalex.org/I4210120234', 'display_name': 'Zhongnan Hospital of Wuhan University', 'ror': 'https://ror.org/01v5mqw79', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120234']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yunfeng Zhou', 'raw_affiliation_strings': ['Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'Hubei Cancer Clinical Study Center, Wuhan, China', 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Hubei Cancer Clinical Study Center, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}, {'raw_affiliation_string': 'Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210120234', 'https://openalex.org/I37461747']}, {'raw_affiliation_string': 'Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160841']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5090499433'], 'corresponding_institution_ids': ['https://openalex.org/I4210160841', 'https://openalex.org/I4210120234', 'https://openalex.org/I37461747'], 'apc_list': {'value': 3600, 'currency': 'USD', 'value_usd': 3600, 'provenance': 'doaj'}, 'apc_paid': {'value': 3600, 'currency': 'USD', 'value_usd': 3600, 'provenance': 'doaj'}, 'fwci': 3.071, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.999982, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '14', 'issue': '10', 'first_page': '2589', 'last_page': '2608'}, 'is_retracted': True, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10773', 'display_name': 'Extracellular vesicles in disease', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10773', 'display_name': 'Extracellular vesicles in disease', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/exosome', 'display_name': 'Exosome', 'score': 0.51492935}, {'id': 'https://openalex.org/keywords/tumor-progression', 'display_name': 'Tumor progression', 'score': 0.499516}], 'concepts': [{'id': 'https://openalex.org/C125593758', 'wikidata': 'https://www.wikidata.org/wiki/Q15315135', 'display_name': 'Telomerase reverse transcriptase', 'level': 4, 'score': 0.8595156}, {'id': 'https://openalex.org/C94581717', 'wikidata': 'https://www.wikidata.org/wiki/Q331839', 'display_name': 'Telomerase', 'level': 3, 'score': 0.81061846}, {'id': 'https://openalex.org/C20518536', 'wikidata': 'https://www.wikidata.org/wiki/Q6840469', 'display_name': 'Microvesicles', 'level': 4, 'score': 0.7749841}, {'id': 'https://openalex.org/C76419328', 'wikidata': 'https://www.wikidata.org/wiki/Q74419', 'display_name': 'Epithelial–mesenchymal transition', 'level': 4, 'score': 0.72706234}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.66981995}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6696883}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.6639509}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.542584}, {'id': 'https://openalex.org/C2781261824', 'wikidata': 'https://www.wikidata.org/wiki/Q903634', 'display_name': 'Exosome', 'level': 5, 'score': 0.51492935}, {'id': 'https://openalex.org/C2779256057', 'wikidata': 'https://www.wikidata.org/wiki/Q16909647', 'display_name': 'Tumor progression', 'level': 3, 'score': 0.499516}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.48302016}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.41127872}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.37148058}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.30826345}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.21268156}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0516738}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019098', 'descriptor_name': 'Telomerase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015687', 'descriptor_name': 'Cell Hypoxia', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015687', 'descriptor_name': 'Cell Hypoxia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005163', 'descriptor_name': 'Factor Analysis, Statistical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015999', 'descriptor_name': 'Multivariate Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019098', 'descriptor_name': 'Telomerase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/1878-0261.12765', 'pdf_url': 'https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.12765', 'source': {'id': 'https://openalex.org/S80282989', 'display_name': 'Molecular Oncology', 'issn_l': '1574-7891', 'issn': ['1574-7891', '1878-0261'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/1dca598b7c3242bbb41f2d3d7fd145f5', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530775', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32679610', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/1878-0261.12765', 'pdf_url': 'https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.12765', 'source': {'id': 'https://openalex.org/S80282989', 'display_name': 'Molecular Oncology', 'issn_l': '1574-7891', 'issn': ['1574-7891', '1878-0261'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.82}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81472799'}], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1611113373', 'https://openalex.org/W1963892864', 'https://openalex.org/W1964847767', 'https://openalex.org/W1968542304', 'https://openalex.org/W1993101945', 'https://openalex.org/W1998335196', 'https://openalex.org/W2037583144', 'https://openalex.org/W2039357236', 'https://openalex.org/W2042897772', 'https://openalex.org/W2053103314', 'https://openalex.org/W2058902552', 'https://openalex.org/W2068474690', 'https://openalex.org/W2075451769', 'https://openalex.org/W2081045797', 'https://openalex.org/W2089467855', 'https://openalex.org/W2093172415', 'https://openalex.org/W2094831008', 'https://openalex.org/W2095900421', 'https://openalex.org/W2098041070', 'https://openalex.org/W2104268053', 'https://openalex.org/W2118195139', 'https://openalex.org/W2122193579', 'https://openalex.org/W2137261276', 'https://openalex.org/W2138171776', 'https://openalex.org/W2144662794', 'https://openalex.org/W2144796426', 'https://openalex.org/W2157000380', 'https://openalex.org/W2204695292', 'https://openalex.org/W2527898319', 'https://openalex.org/W2586407709', 'https://openalex.org/W2603630537', 'https://openalex.org/W2610193187', 'https://openalex.org/W2623685580', 'https://openalex.org/W2768762463', 'https://openalex.org/W2770906567', 'https://openalex.org/W2773846169', 'https://openalex.org/W2781525129', 'https://openalex.org/W2782430302', 'https://openalex.org/W2789637558', 'https://openalex.org/W2798033749', 'https://openalex.org/W2908747018', 'https://openalex.org/W2908755714', 'https://openalex.org/W2947851506', 'https://openalex.org/W2966597246', 'https://openalex.org/W3143591677'], 'related_works': ['https://openalex.org/W3149534788', 'https://openalex.org/W2794306047', 'https://openalex.org/W2735616874', 'https://openalex.org/W2184345139', 'https://openalex.org/W2141515497', 'https://openalex.org/W2121324028', 'https://openalex.org/W2114551234', 'https://openalex.org/W2102536676', 'https://openalex.org/W2044473828', 'https://openalex.org/W1549402393'], 'abstract_inverted_index': {'Cancer': [0], 'cells': [1, 98], 'undergo': [2], 'epithelial‐to‐mesenchymal': [3], 'transition': [4], '(EMT)': [5], 'in': [6, 12, 61, 166], 'response': [7], 'to': [8, 132], 'hypoxia.': [9], 'Exosomes': [10], 'produced': [11], 'tumor': [13, 150], 'microenvironments': [14], 'carry': [15], 'microRNAs': [16], '(miRNAs)': [17], 'that': [18, 85, 174], 'affect': [19], 'proliferation,': [20], 'metastasis,': [21], 'and': [22, 33, 49, 80, 106, 135, 152, 163], 'EMT.': [23, 171], 'Hypoxic': [24], 'regulation': [25, 168, 176], 'of': [26, 58, 94, 161, 169, 177], 'EMT': [27, 66, 112, 134], 'is': [28, 179], 'associated': [29], 'with': [30], 'telomerase': [31, 51, 81, 107, 136, 178], 'content': [32], 'stability,': [34], 'but': [35], 'the': [36, 92, 158, 167], 'underlying': [37], 'mechanisms': [38], 'remain': [39], 'unclear.': [40], 'We': [41, 83, 172], 'identified': [42], 'a': [43, 139, 180], 'targeting': [44], 'relationship': [45], 'between': [46, 96], 'tumor‐suppressing': [47], 'miR‐1255b‐5p': [48, 70, 90, 110, 123, 147, 162], 'human': [50], 'reverse': [52], 'transcriptase': [53], '(hTERT)': [54], 'via': [55, 68, 117], 'clinical': [56], 'screening': [57], 'serum': [59], 'samples': [60], 'colorectal': [62], 'cancer': [63], '(CRC)': [64], 'patients.': [65], 'suppression': [67], 'exosomal': [69, 89, 122], 'delivery': [71, 93], 'was': [72], 'investigated': [73], 'by': [74, 113, 125], 'assessing': [75], 'hTERT': [76, 118, 130], 'expression,': [77, 105], 'Wnt/β‐catenin': [78, 115], 'signaling,': [79], 'activity.': [82, 137], 'revealed': [84], 'hypoxia': [86], 'directly': [87], 'affected': [88], 'content,': [91], 'which': [95], 'CRC': [97, 126, 141, 186], 'significantly': [99], 'impacted': [100], 'cell': [101], 'invasion,': [102], 'EMT‐related': [103], 'protein': [104], 'stability.': [108], 'Specifically,': [109], 'suppressed': [111], 'inhibiting': [114], 'activation': [116], 'inhibition.': [119], 'Hypoxia': [120], 'reduced': [121], 'secretion': [124], 'cells,': [127], 'thereby': [128], 'increasing': [129], 'expression': [131], 'enhance': [133], 'In': [138], 'mouse': [140], 'model,': [142], 'hypoxic': [143], 'exosomes': [144], 'containing': [145], 'overexpressed': [146], 'attenuated': [148], 'EMT,': [149], 'progression,': [151], 'liver': [153], 'metastasis.': [154], 'Our': [155], 'results': [156], 'suggest': [157], 'antitumor': [159], 'role': [160], 'its': [164], 'involvement': [165], 'hTERT‐mediated': [170], 'propose': [173], 'miRNA‐targeted': [175], 'promising': [181], 'therapeutic': [182], 'strategy': [183], 'for': [184], 'future': [185], 'treatment.': [187]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3042631053', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 3}], 'updated_date': '2024-12-24T07:02:59.390552', 'created_date': '2020-07-23'}