Publication Information

{'id': 'https://openalex.org/W3041343166', 'doi': 'https://doi.org/10.1111/bjh.17003', 'title': 'Effect of low or high doses of low‐molecular‐weight heparin on thrombin generation and other haemostasis parameters in critically ill patients with COVID‐19', 'display_name': 'Effect of low or high doses of low‐molecular‐weight heparin on thrombin generation and other haemostasis parameters in critically ill patients with COVID‐19', 'publication_year': 2020, 'publication_date': '2020-07-06', 'ids': {'openalex': 'https://openalex.org/W3041343166', 'doi': 'https://doi.org/10.1111/bjh.17003', 'mag': '3041343166', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32779783', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7361613'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/bjh.17003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S153015021', 'display_name': 'British Journal of Haematology', 'issn_l': '0007-1048', 'issn': ['0007-1048', '1365-2141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1111/bjh.17003', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087623314', 'display_name': 'Antonio Chistolini', 'orcid': 'https://orcid.org/0000-0002-2593-1376'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Antonio Chistolini', 'raw_affiliation_strings': ['Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013393156', 'display_name': 'Franco Ruberto', 'orcid': 'https://orcid.org/0000-0001-7282-9457'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Franco Ruberto', 'raw_affiliation_strings': ['Department of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019162611', 'display_name': 'Francesco Alessandri', 'orcid': 'https://orcid.org/0000-0003-3989-4964'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Alessandri', 'raw_affiliation_strings': ['Department of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066768069', 'display_name': 'Cristina Santoro', 'orcid': 'https://orcid.org/0000-0002-7181-447X'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Cristina Santoro', 'raw_affiliation_strings': ['Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042160207', 'display_name': 'F. Barone', 'orcid': 'https://orcid.org/0000-0002-9761-8303'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Barone', 'raw_affiliation_strings': ['Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068945120', 'display_name': 'Maria Cristina Puzzolo', 'orcid': 'https://orcid.org/0000-0002-1948-8515'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Maria Cristina Puzzolo', 'raw_affiliation_strings': ['Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041821046', 'display_name': 'Giancarlo Ceccarelli', 'orcid': 'https://orcid.org/0000-0001-5921-3180'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giancarlo Ceccarelli', 'raw_affiliation_strings': ['Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087760329', 'display_name': 'Maria Lucia De Luca', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Maria L. De Luca', 'raw_affiliation_strings': ['Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103056564', 'display_name': 'Massimo Mancone', 'orcid': 'https://orcid.org/0000-0002-9602-0684'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Massimo Mancone', 'raw_affiliation_strings': ['Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081350888', 'display_name': 'Domenico Alvaro', 'orcid': 'https://orcid.org/0000-0003-3771-9644'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Domenico Alvaro', 'raw_affiliation_strings': ['Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016447523', 'display_name': 'Fabio M. Pulcinelli', 'orcid': 'https://orcid.org/0000-0003-2595-396X'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Fabio M. Pulcinelli', 'raw_affiliation_strings': ['Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027162158', 'display_name': 'Maurizio Martelli', 'orcid': 'https://orcid.org/0000-0003-1007-0339'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Maurizio Martelli', 'raw_affiliation_strings': ['Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009431453', 'display_name': 'Robin Foà', 'orcid': 'https://orcid.org/0000-0002-5021-3026'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Robin Foà', 'raw_affiliation_strings': ['Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5004595193', 'display_name': 'Francesco Pugliese', 'orcid': 'https://orcid.org/0000-0002-8076-1250'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Pugliese', 'raw_affiliation_strings': ['Department of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Sapienza University of Rome, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Sapienza University of Rome, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5087623314'], 'corresponding_institution_ids': ['https://openalex.org/I861853513'], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.999264, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '190', 'issue': '4', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10041', 'display_name': 'COVID-19 Clinical Research Studies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10041', 'display_name': 'COVID-19 Clinical Research Studies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10285', 'display_name': 'Venous Thromboembolism Diagnosis and Management', 'score': 0.9846, 'subfield': {'id': 'https://openalex.org/subfields/2724', 'display_name': 'Internal Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11296', 'display_name': 'COVID-19 and healthcare impacts', 'score': 0.9808, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.88219076}, {'id': 'https://openalex.org/C2779936836', 'wikidata': 'https://www.wikidata.org/wiki/Q890200', 'display_name': 'Coagulopathy', 'level': 2, 'score': 0.84275705}, {'id': 'https://openalex.org/C2778734968', 'wikidata': 'https://www.wikidata.org/wiki/Q823027', 'display_name': 'Disseminated intravascular coagulation', 'level': 2, 'score': 0.70520824}, {'id': 'https://openalex.org/C2777557582', 'wikidata': 'https://www.wikidata.org/wiki/Q190016', 'display_name': 'Heparin', 'level': 2, 'score': 0.6153114}, {'id': 'https://openalex.org/C2778589496', 'wikidata': 'https://www.wikidata.org/wiki/Q487937', 'display_name': 'Hemostasis', 'level': 2, 'score': 0.5494135}, {'id': 'https://openalex.org/C2780868729', 'wikidata': 'https://www.wikidata.org/wiki/Q261327', 'display_name': 'Thrombosis', 'level': 2, 'score': 0.5280605}, {'id': 'https://openalex.org/C2776884760', 'wikidata': 'https://www.wikidata.org/wiki/Q2750727', 'display_name': 'Low molecular weight heparin', 'level': 3, 'score': 0.492683}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.46679765}, {'id': 'https://openalex.org/C2778205648', 'wikidata': 'https://www.wikidata.org/wiki/Q215118', 'display_name': 'Anticoagulant', 'level': 2, 'score': 0.42286628}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.41854697}], 'mesh': [{'descriptor_ui': 'D000086382', 'descriptor_name': 'COVID-19', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000086382', 'descriptor_name': 'COVID-19', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D006487', 'descriptor_name': 'Hemostasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006495', 'descriptor_name': 'Heparin, Low-Molecular-Weight', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000086402', 'descriptor_name': 'SARS-CoV-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013917', 'descriptor_name': 'Thrombin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000086382', 'descriptor_name': 'COVID-19', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016638', 'descriptor_name': 'Critical Illness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006495', 'descriptor_name': 'Heparin, Low-Molecular-Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013917', 'descriptor_name': 'Thrombin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/bjh.17003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S153015021', 'display_name': 'British Journal of Haematology', 'issn_l': '0007-1048', 'issn': ['0007-1048', '1365-2141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11573/1514004', 'pdf_url': 'https://iris.uniroma1.it/bitstream/11573/1514004/1/Chistolini_Low-high-Heparin_2020.pdf', 'source': {'id': 'https://openalex.org/S4377196107', 'display_name': 'IRIS Research product catalog (Sapienza University of Rome)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11573/1433401', 'pdf_url': 'https://iris.uniroma1.it/bitstream/11573/1514004.3/1/Chistolini_Low-high-Heparin_2020.pdf', 'source': {'id': 'https://openalex.org/S4377196107', 'display_name': 'IRIS Research product catalog (Sapienza University of Rome)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361613', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32779783', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/bjh.17003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S153015021', 'display_name': 'British Journal of Haematology', 'issn_l': '0007-1048', 'issn': ['0007-1048', '1365-2141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.62, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W2135492318', 'https://openalex.org/W2293439019', 'https://openalex.org/W2950662079', 'https://openalex.org/W3001118548', 'https://openalex.org/W3008461878', 'https://openalex.org/W3013730242', 'https://openalex.org/W3015656121', 'https://openalex.org/W3015863623', 'https://openalex.org/W3016965546', 'https://openalex.org/W3017014626', 'https://openalex.org/W3018573533', 'https://openalex.org/W3019046211', 'https://openalex.org/W3025306809'], 'related_works': ['https://openalex.org/W4381516419', 'https://openalex.org/W4283316082', 'https://openalex.org/W3137661440', 'https://openalex.org/W3029338190', 'https://openalex.org/W2963387556', 'https://openalex.org/W2890694160', 'https://openalex.org/W2773766728', 'https://openalex.org/W2031395992', 'https://openalex.org/W1977086340', 'https://openalex.org/W1505891614'], 'abstract_inverted_index': {'The': [0, 130, 167, 227, 243, 258, 350, 455, 833, 865, 1209, 1317], 'clinical': [1, 1015, 1235], 'picture': [2], 'of': [3, 43, 51, 81, 93, 96, 102, 122, 132, 141, 146, 154, 161, 169, 177, 219, 235, 239, 255, 270, 276, 306, 317, 329, 361, 416, 421, 429, 513, 543, 549, 554, 560, 605, 621, 692, 747, 759, 766, 812, 845, 868, 900, 915, 924, 948, 957, 961, 975, 993, 997, 1005, 1026, 1029, 1043, 1052, 1327], 'the': [4, 48, 76, 79, 90, 100, 139, 144, 159, 175, 200, 232, 236, 268, 271, 274, 285, 292, 302, 324, 330, 339, 359, 362, 413, 426, 437, 460, 465, 490, 498, 595, 662, 678, 684, 693, 713, 718, 748, 756, 764, 773, 787, 813, 836, 854, 860, 863, 880, 895, 913, 955, 967, 972, 991, 1003, 1022, 1041, 1227, 1234, 1241, 1252, 1279, 1290, 1293, 1296, 1304, 1323, 1333, 1345, 1349], 'severe': [5, 1034], 'acute': [6, 14, 374, 822], 'respiratory': [7, 15, 375], 'syndrome': [8, 16], 'coronavirus-2': [9], '(SARS-CoV-2)/coronavirus': [10], 'disease': [11], '2019': [12], '(COVID-19)-related': [13], 'is': [17, 105, 116, 136, 184, 245, 447, 800, 876, 951, 1319], 'often': [18], 'associated': [19, 117, 660], 'with': [20, 29, 35, 118, 209, 216, 320, 398, 406, 571, 588, 602, 661, 835, 911, 943, 978, 1033, 1058, 1307], 'a': [21, 38, 82, 151, 246, 252, 314, 419, 478, 546, 582, 589, 603, 609, 612, 623, 632, 637, 644, 736, 753, 846, 921, 946, 979, 994], 'coagulopathy.1': [22], 'An': [23], 'elevated': [24], 'D-dimer': [25, 500], 'has': [26], 'been': [27], 'linked': [28], 'an': [30, 119, 190, 378, 495, 561, 577, 743, 964, 1009], 'unfavourable': [31], 'prognosis': [32], 'in': [33, 68, 85, 89, 143, 198, 205, 334, 338, 497, 569, 608, 619, 630, 635, 641, 648, 668, 735, 755, 763, 776, 810, 872, 894, 907, 920, 983, 1011, 1031, 1045, 1049, 1054, 1303], 'patients': [34, 44, 69, 208, 319, 365, 385, 394, 570, 670, 767, 777, 815, 828, 875, 884, 910, 942, 984, 1032, 1055, 1306], 'COVID-19.': [36], 'In': [37, 72, 391, 739, 933, 988], 'recent': [39, 74], 'cohort': [40], 'study,': [41], '71%': [42], 'who': [45, 70], 'died': [46], 'matched': [47], 'International': [49], 'Society': [50], 'Thrombosis': [52], 'and': [53, 125, 150, 180, 211, 311, 345, 380, 388, 403, 464, 481, 523, 534, 551, 556, 643, 706, 750, 752, 761, 820, 897, 1024, 1225, 1236, 1239, 1250, 1266], 'Hemostasis': [54], '(ISTH)': [55], 'criteria': [56], 'for': [57, 369, 971, 1322, 1348], 'disseminated': [58], 'intravascular': [59], 'coagulation': [60, 196, 248, 566], '(DIC)2,': [61], 'while': [62], 'this': [63, 103, 113], 'percentage': [64], 'was': [65, 229, 354, 469, 617, 666, 716, 786, 791, 838, 851], 'only': [66, 607, 788, 929, 982], '0·6%': [67], 'survived.3': [71], 'two': [73, 451, 817], 'studies,': [75], 'authors': [77, 1210, 1294], 'described': [78], 'presence': [80], 'hypercoagulability': [83, 550, 949], 'state': [84, 947], 'COVID-19': [86, 210, 321, 572, 912, 944, 1035, 1059, 1087, 1308], 'affected': [87, 372, 1057], 'patients,': [88, 622], 'absence': [91, 145], 'however': [92], 'pathognomonic': [94], 'signs': [95], 'DIC.4,': [97], '5': [98, 470, 1073], 'Thus,': [99], 'nature': [101], 'coagulopathy': [104, 115], 'not': [106, 918, 1320], 'fully': [107], 'understood.': [108], 'Clinical': [109], 'evidence': [110, 428], 'suggests': [111], 'that': [112, 250, 266, 655, 790, 882, 898, 939, 950], 'COVID-19-related': [114], 'increased': [120, 552, 689, 744, 793], 'risk': [121, 923, 1051], 'both': [123], 'venous': [124], 'arterial': [126], 'thrombotic': [127, 431, 807, 1006], 'events.6,': [128], '7': [129], 'management': [131], 'these': [133, 214, 225, 656], 'thromboembolic': [134, 382, 869, 1000], 'complications': [135, 870, 1007], 'based': [137, 424], 'on': [138, 425, 477, 768, 778, 830, 840, 903, 966, 1040], 'use': [140, 914, 992], 'heparin': [142, 162, 221, 663, 916], 'contraindications': [147], '(active': [148], 'bleeding': [149, 925, 1012], 'platelet': [152, 646], 'count': [153, 647], '<30': [155], '×': [156, 1074], '109/l).8': [157], 'However,': [158], 'efficacy': [160, 1023], 'remains': [163], 'to': [164, 193, 212, 224, 280, 284, 323, 435, 441, 502, 576, 581, 677, 683, 772, 853, 879, 1019, 1081, 1344], 'be': [165, 574, 659, 1342], 'validated.': [166], 'benefit/risk': [168], 'using': [170], 'heparin,': [171], 'as': [172, 174, 510, 512, 889, 891, 999], 'well': [173, 511], 'timing': [176], 'starting': [178, 489], 'anti-coagulants': [179], 'at': [181, 418, 672], 'which': [182, 665], 'dose,': [183], 'controversial.9,': [185], '10': [186, 346], 'We': [187, 493, 652], 'carried': [188], 'out': [189], 'observational': [191], 'study': [192, 228], 'investigate': [194], 'different': [195, 217, 1027], 'parameters,': [197], 'particular': [199], 'thrombin': [201, 277, 287, 289, 294, 297, 307, 976, 1046], 'generation': [202, 1047], 'assay': [203], '(TGA),': [204], 'critically': [206, 940], 'ill': [207, 941], 'correlate': [213], 'results': [215, 657, 937], 'doses': [218, 960, 1028], 'low-molecular-weight': [220], '(LMWH)': [222], 'administered': [223], 'patients.': [226], 'approved': [230], 'by': [231, 373, 732, 803, 1065, 1332], 'Ethics': [233], 'Committee': [234], 'Sapienza': [237, 331], 'University': [238, 332], 'Rome': [240, 335], '(no.': [241], '109/2020).': [242], 'TGA': [244, 260], 'global': [247], 'test': [249], 'provides': [251], 'direct': [253], 'assessment': [254], 'plasma': [256], 'coagulability.11': [257], 'following': [259], 'parameters': [261, 567, 600, 729, 1048, 1302], 'were': [262, 336, 343, 348, 366, 371, 386, 396, 475, 485, 730, 829, 885, 902], 'evaluated:': [263], 'T-Lag,': [264], 'time': [265, 279, 283, 360, 458, 615, 628], 'follows': [267], 'addition': [269], 'trigger': [272], 'until': [273], 'initiation': [275], 'generation;': [278], 'peak': [281, 290], '(tt-Peak),': [282], 'highest': [286, 293], 'concentration;': [288, 295], '(Peak),': [291], 'endogenous': [296], 'potential': [298, 430], '(ETP),': [299], 'area': [300], 'under': [301], 'curve,': [303], 'total': [304, 973], 'amount': [305, 974], 'generation.': [308], 'Between': [309], 'April': [310], 'May': [312], '2020,': [313], 'consecutive': [315], 'series': [316], '27': [318, 814, 1305], 'admitted': [322], 'Intensive': [325], 'Care': [326], 'Unit': [327], '(ICU)': [328], 'Hospital': [333], 'included': [337], 'study;': [340], '17': [341], '(63%)': [342], 'males': [344], '(37%)': [347], 'females.': [349], 'mean': [351, 499, 690, 714, 745, 757], '(range)': [352, 457], 'age': [353], '66': [355], '(38–85)': [356], 'years.': [357], 'At': [358], 'sample': [363, 467], 'collection,': [364], 'swab-culture': [367], 'positive': [368], 'COVID-19,': [370], 'failure': [376], 'without': [377, 1008], 'active': [379, 578], 'diagnosed': [381], 'event.': [383, 932], 'All': [384, 728, 826, 1292], 'intubated': [387], 'mechanically': [389], 'ventilated.': [390], 'all,': [392], '14': [393], '(51·9%)': [395], 'treated': [397, 453], 'low-dose': [399, 779, 831, 855], 'LMWH': [400, 408, 417, 462, 491, 733, 770, 780, 804, 887, 962, 1030], '(100': [401, 409], 'iu/kg/day)': [402], '13': [404], '(48·1%)': [405], 'high-dose': [407, 769, 841, 904, 986], 'iu/kg/twice': [410], 'daily).': [411], 'After': [412], 'initial': [414], 'administration': [415, 463, 734, 956], 'dose': [420, 439, 996], '100': [422, 442], 'iu/kg,': [423], 'growing': [427], 'events': [432], 'we': [433, 449, 597, 686, 741, 927], 'decided': [434], 'increase': [436, 496, 1010], 'prophylactic': [438], 'up': [440], 'iu/kg': [443], 'twice': [444], 'daily.12': [445], 'This': [446], 'why': [448], 'observed': [450, 494, 568, 618, 687, 742, 775, 871, 928], 'differently': [452], 'populations.': [454], 'median': [456], 'from': [459, 671], 'first': [461], 'blood': [466, 483, 679], 'collection': [468], '(2–21)': [471], 'days;': [472], 'laboratory': [473, 599, 968], 'assays': [474], 'evaluated': [476], 'single': [479], 'occasion': [480], 'all': [482, 669, 883], 'samples': [484], 'collected': [486, 1233], 'just': [487], 'before': [488], 'administration.': [492], 'values': [501, 691], '4686·07': [503], 'ng/ml': [504], '[normal': [505], 'value': [506, 746, 758], '(n.v.)': [507], '<550': [508], 'ng/ml],': [509], 'factor': [514, 519], 'VIII': [515], '(FVIII),': [516], 'von': [517], 'Willebrand': [518], 'antigen': [520], 'level': [521], '(VWF:Ag)': [522], 'VWF': [524], 'ristocetin': [525], 'co-factor': [526], '(VWF:RCo):': [527], '209%': [528], '(n.v.': [529, 532, 536], '58–130%),': [530], '319·54%': [531], '50–160%)': [533], '310·60%': [535], '52–124%)': [537], 'respectively': [538], '(Table': [539, 650, 781], 'I).': [540, 651], 'Increased': [541], 'levels': [542, 553], 'FVIII': [544], 'are': [545, 558, 1017, 1060], 'potent': [547], 'sign': [548], 'VWF:Ag': [555], 'VWF:RCo': [557], 'indicative': [559], 'endothelial': [562], 'derangement.': [563], 'These': [564], 'altered': [565], 'could': [573], 'related': [575], 'response': [579], 'due': [580, 878], 'marked': [583], 'alveolar': [584], 'inflammatory': [585], 'cell': [586], 'infiltrate': [587], 'consequent': [590], 'systemic': [591], 'cytokine': [592], 'storm.': [593], 'On': [594], 'contrary,': [596], 'found': [598], 'compatible': [601], 'diagnosis': [604], 'DIC': [606], 'few': [610], 'patients:': [611], 'prolonged': [613, 624], 'prothrombin': [614], '(PT)': [616], '29·6%': [620], 'activated': [625], 'partial': [626], 'thromboplastin': [627], '(aPTT)': [629], '14·8%,': [631], 'reduced': [633, 638, 1002], 'fibrinogen': [634], '29·6%,': [636], 'antithrombin': [639], '(AT)': [640], '37%': [642], 'decreased': [645], '7·4%': [649], 'cannot': [653], 'exclude': [654], 'may': [658], 'administration,': [664], 'ongoing': [667], 'least': [673], '2': [674], 'days': [675, 858], 'prior': [676], 'collection.': [680], 'With': [681], 'regard': [682], 'TGA,': [685], 'overall': [688], 'T-Lag': [694, 749], '(7·70': [695], 'min;': [696, 709, 723], 'n.v.': [697, 703, 710, 724], '<4·3': [698], 'min),': [699], 'Peak': [700, 760], '(122·22': [701], 'nM;': [702], '<106·2': [704], 'nM)': [705], 'tt-Peak': [707], '(13·38': [708], '<9·8': [711], 'min);': [712], 'ETP': [715, 762, 785, 799], 'within': [717], 'normal': [719], 'range': [720], '(953·51': [721], 'nM': [722, 726], '<984·12': [725], 'min).': [727], 'influenced': [731, 801], 'dose-dependent': [737], 'manner.': [738], 'fact,': [740], 'tt-Peak,': [751], 'decrease': [754], 'group': [765], 'compared': [771], 'data': [774, 1238, 1265], 'I,': [782], 'Fig': [783], '1).': [784], 'parameter': [789], 'significantly': [792], '(P': [794], '=': [795], '0·046),': [796], 'probably': [797, 877], 'because': [798, 844], 'more': [802], 'dosing.': [805], 'A': [806], 'complication': [808], 'occurred': [809], 'three': [811, 827], '(11%):': [816], 'pulmonary': [818], 'embolisms': [819], 'one': [821, 930], 'myocardial': [823], 'ischaemia': [824], '(MI).': [825], 'LMWH.': [832, 905, 958], 'patient': [834, 861], 'MI': [837], 'previously': [839], 'LMWH,': [842, 998], 'but': [843], 'tracheostomy': [847], 'site': [848], 'bleed,': [849], 'he': [850], 'switched': [852], 'regimen:': [856], '3': [857], 'later': [859], 'experienced': [862], 'MI.': [864], 'low': [866], 'rate': [867], 'our': [873, 908, 935, 989], 'present': [874, 909, 936, 953], 'fact': [881], 'given': [886], 'prophylaxis': [888], 'soon': [890], 'they': [892], 'arrived': [893], 'ICU': [896], 'half': [899], 'them': [901], 'Moreover,': [906, 1037], 'did': [917], 'result': [919], 'higher': [922, 995], 'complications:': [926], 'haemorrhagic': [931], 'conclusion,': [934], 'suggest': [938], 'develop': [945], 'also': [952], 'during': [954], 'Different': [959], 'have': [963, 1211], 'influence': [965], 'results,': [969], 'especially': [970], 'generation,': [977], 'significant': [980], 'reduction': [981], 'receiving': [985], 'heparin.': [987], 'experience,': [990], 'prophylaxis,': [1001], 'incidence': [1004], 'events.': [1013], 'Randomised': [1014], 'trials': [1016], 'required': [1018], 'conclusively': [1020], 'define': [1021], 'safety': [1025], 'infection.': [1036], 'further': [1038], 'studies': [1039], 'utility': [1042], 'changes': [1044], 'predicting': [1050], 'thromboembolism': [1053], 'severely': [1056], 'required.': [1061], 'Work': [1062], 'partly': [1063], 'supported': [1064], 'Associazione': [1066], 'Italiana': [1067], 'Ricerca': [1068], 'sul': [1069], 'Cancro': [1070], '(AIRC),': [1071], 'Special': [1072], '1000': [1075], 'Program': [1076], 'Metastases': [1077], '(21198),': [1078], 'Milan': [1079], '(Italy)': [1080], 'Franco': [1082, 1191, 1217, 1270], 'Ruberto.': [1083], 'Policlinico': [1084], 'Umberto': [1085], 'I': [1086], 'Group:': [1088], 'Alida': [1089], 'Albante,': [1090], 'Francesco': [1091, 1103, 1134, 1141, 1183, 1222, 1229, 1243, 1274, 1287], 'Alessandri,': [1092, 1230, 1275], 'Domenico': [1093, 1285], 'Alvaro,': [1094, 1286], 'Guido': [1095], 'Antonelli,': [1096], 'Fabio': [1097, 1185, 1219], 'Araimo-Morselli,': [1098], 'Daniela': [1099], 'Auricchio,': [1100], 'Erminia': [1101], 'Baldacci,': [1102], 'Barone,': [1104, 1244], 'Federico': [1105], 'Bilotta,': [1106], 'Matteo': [1107], 'Brisciani,': [1108], 'Katia': [1109], 'Bruno,': [1110], 'Alessandro': [1111], 'Cappannoli,': [1112], 'Vincenzo': [1113], 'Cardinale,': [1114], 'Giancarlo': [1115, 1254], 'Ceccarelli,': [1116, 1255], 'Paola': [1117], 'Celli,': [1118], 'Antonio': [1119, 1215, 1272], 'Chistolini,': [1120, 1216, 1273], 'Stella': [1121], 'Consolo,': [1122], 'Claudia': [1123, 1189], 'Croce,': [1124], 'Beatrice': [1125], 'Crocitti,': [1126], 'Mariaignazia': [1127], 'Curreli,': [1128], 'Gabriella': [1129], "D'Ettorre,": [1130], 'De': [1131, 1135, 1139, 1260], 'Lauri': [1132], 'Daniela,': [1133], 'Lazzaro,': [1136], 'Maria': [1137, 1245, 1258], 'Lucia': [1138], 'Luca,': [1140], 'Fedele,': [1142], 'Antonietta': [1143], 'Ferretti,': [1144], 'Gioacchino': [1145], 'Galardo,': [1146], 'Lorena': [1147], 'Giannetti,': [1148], 'Stefano': [1149], 'Ianni,': [1150], 'Carmela': [1151], 'Imperiale,': [1152], 'Viviana': [1153], 'Maestrini,': [1154], 'Eugenia': [1155], 'Magnanimi,': [1156], 'Federica': [1157], 'Maldarelli,': [1158], 'Massimo': [1159, 1256, 1283], 'Mancone,': [1160, 1257, 1284], 'Maurizio': [1161], 'Martelli,': [1162, 1164], 'Sabina': [1163], 'Claudio': [1165], 'Mastroianni,': [1166], 'Teresa': [1167], 'Messina,': [1168], 'Sandra': [1169], 'Olivieri,': [1170], 'Agnese': [1171], 'Pallotta,': [1172], 'Elisa': [1173], 'Pattelli,': [1174], 'Filippo': [1175], 'Pecorari,': [1176], 'Serena': [1177], 'Perrella,': [1178], 'Mario': [1179], 'Piazzolla,': [1180], 'Monica': [1181], 'Portieri,': [1182], 'Pugliese,': [1184], 'Pulcinelli,': [1186, 1221], 'Fabiola': [1187], 'Ratini,': [1188], 'Ricci,': [1190], 'Ruberto,': [1192, 1218, 1271], 'Pietro': [1193], 'Santopietro,': [1194], 'Cristina': [1195, 1231, 1246, 1276], 'Santoro,': [1196], 'Alessandra': [1197], 'Serrao,': [1198], 'Guglielmo': [1199], 'Tellan,': [1200], 'Luca': [1201, 1261], 'Titi,': [1202], 'Paolo': [1203], 'Tordiglione,': [1204], 'Antonella': [1205], 'Tosi,': [1206], 'Fausto': [1207], 'Trigilia.': [1208], 'no': [1212], 'competing': [1213], 'interests.': [1214], 'M.': [1220], 'Pugliese': [1223, 1288], 'conceived': [1224], 'designed': [1226], 'study.': [1228], 'Santoro': [1232, 1277], 'epidemiological': [1237, 1264], 'analysed': [1240, 1251, 1262], 'results.': [1242], 'Puzzolo': [1247], 'performed': [1248, 1267], 'tests': [1249], 'data.': [1253], 'L.': [1259], 'clinical,': [1263], 'statistical': [1268], 'analyses.': [1269], 'wrote': [1278], 'manuscript.': [1280, 1291], 'Robin': [1281], 'Foà,': [1282], 'reviewed': [1289], 'revised': [1295], 'final': [1297], 'version.': [1298], 'Table': [1299], 'SI.': [1300], 'Coagulation': [1301], '(median': [1309], 'values).': [1310], 'Data': [1311], 'S1.': [1312], 'Supplementary': [1313], 'methods.': [1314], 'Please': [1315], 'note:': [1316], 'publisher': [1318], 'responsible': [1321], 'content': [1324], 'or': [1325], 'functionality': [1326], 'any': [1328], 'supporting': [1329], 'information': [1330], 'supplied': [1331], 'authors.': [1334], 'Any': [1335], 'queries': [1336], '(other': [1337], 'than': [1338], 'missing': [1339], 'content)': [1340], 'should': [1341], 'directed': [1343], 'corresponding': [1346], 'author': [1347], 'article.': [1350]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3041343166', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 3}], 'updated_date': '2025-01-08T03:06:44.469209', 'created_date': '2020-07-16'}