Publication Information

{'id': 'https://openalex.org/W3039408246', 'doi': 'https://doi.org/10.3760/cma.j.cn112140-20200209-00067', 'title': '[Infection rate and clinical characteristics of toxigenic Clostridium difficile in children with inflammatory bowel disease].', 'display_name': '[Infection rate and clinical characteristics of toxigenic Clostridium difficile in children with inflammatory bowel disease].', 'publication_year': 2020, 'publication_date': '2020-07-02', 'ids': {'openalex': 'https://openalex.org/W3039408246', 'doi': 'https://doi.org/10.3760/cma.j.cn112140-20200209-00067', 'mag': '3039408246', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32605340'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32605340', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 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'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'D Li', 'raw_affiliation_strings': ["Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045,China."], 'affiliations': [{'raw_affiliation_string': "Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045,China.", 'institution_ids': ['https://openalex.org/I4210144404', 'https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103013859', 'display_name': 'S Guo', 'orcid': 'https://orcid.org/0009-0000-0231-0182'}, 'institutions': [{'id': 'https://openalex.org/I4210144404', 'display_name': 'Beijing Children’s Hospital', 'ror': 'https://ror.org/04skmn292', 'country_code': 'CN', 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'https://orcid.org/0000-0003-2985-5566'}, 'institutions': [{'id': 'https://openalex.org/I4210144404', 'display_name': 'Beijing Children’s Hospital', 'ror': 'https://ror.org/04skmn292', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144404']}, {'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'D X Guan', 'raw_affiliation_strings': ["Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045,China."], 'affiliations': [{'raw_affiliation_string': "Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045,China.", 'institution_ids': ['https://openalex.org/I4210144404', 'https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049651632', 'display_name': 'Chunna Zhao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144404', 'display_name': 'Beijing Children’s Hospital', 'ror': 'https://ror.org/04skmn292', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144404']}, {'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'C N Zhao', 'raw_affiliation_strings': ["Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045,China."], 'affiliations': [{'raw_affiliation_string': "Department of Gastroenterology, 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Capital Medical University, National Center for Children's Health, Beijing 100045,China."], 'affiliations': [{'raw_affiliation_string': "Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045,China.", 'institution_ids': ['https://openalex.org/I4210144404', 'https://openalex.org/I183519381']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.077, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.529355, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 73, 'max': 76}, 'biblio': {'volume': '58', 'issue': '7', 'first_page': '564', 'last_page': '569'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11288', 'display_name': 'Clostridium difficile and Clostridium perfringens research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11288', 'display_name': 'Clostridium difficile and Clostridium perfringens research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10066', 'display_name': 'Gut microbiota and health', 'score': 0.9415, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 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['https://openalex.org/W2391380478', 'https://openalex.org/W2168577476', 'https://openalex.org/W2162304219', 'https://openalex.org/W2154165794', 'https://openalex.org/W2150489142', 'https://openalex.org/W2111416182', 'https://openalex.org/W2096350108', 'https://openalex.org/W2070258913', 'https://openalex.org/W18255195', 'https://openalex.org/W1781399623'], 'abstract_inverted_index': {'Objective:': [0], 'To': [1], 'explore': [2], 'the': [3, 27, 51, 62, 90, 96, 115, 155, 211, 241, 260, 271, 342], 'infection': [4, 180, 242, 347, 396], 'rate': [5, 181, 243, 348], 'and': [6, 30, 53, 72, 107, 122, 150, 227, 267, 270, 288, 337, 369], 'clinical': [7, 31, 73, 375, 404], 'characteristics': [8, 74, 309], 'of': [9, 33, 40, 55, 67, 75, 130, 163, 182, 244, 259, 310, 349, 385, 392], 'toxigenic': [10, 131, 164, 183, 245, 311, 350, 386, 393], 'Clostridium': [11, 68, 132, 140, 145, 165, 184, 204, 246, 312, 351, 387, 394], 'difficile': [12, 69, 133, 141, 146, 166, 185, 205, 247, 313, 352, 388, 395], 'in': [13, 61, 102, 109, 120, 124, 176, 186, 194, 240, 250, 282, 353, 361, 397, 403], 'children': [14, 36, 58, 76, 354, 399], 'with': [15, 77, 292, 355, 366], 'inflammatory': [16], 'bowel': [17], 'disease': [18, 111], '(IBD).': [19], 'Methods:': [20], 'From': [21], 'July': [22], '2015': [23], 'to': [24, 38, 88, 334], 'October': [25], '2016,': [26], 'fecal': [28], 'samples': [29], 'data': [32, 54], '30': [34, 56, 97], 'IBD': [35, 98, 116, 187, 356, 398], 'admitted': [37], 'Department': [39], 'Gastroenterology,': [41], 'Beijing': [42], "Children's": [43], 'Hospital,': [44], 'Capital': [45], 'Medical': [46], 'University,': [47], 'as': [48, 50, 316], 'well': [49], 'specimens': [52], 'healthy': [57, 156, 195, 362], 'were': [59, 81, 101, 138, 230, 237, 263, 332], 'collected': [60], 'meantime.': [63], 'The': [64, 179, 256, 346, 364, 390], 'toxin': [65, 79, 139, 172, 206, 220, 284], 'gene': [66, 80, 173, 207, 221, 285], 'was': [70, 86, 152, 169, 174, 189, 208, 217, 274, 280, 306], 'detected': [71, 209, 281], 'positive': [78, 128, 161, 218, 286], 'analyzed': [82], 'retrospectively.': [83], 'χ(2)': [84], 'test': [85], 'used': [87], 'compare': [89], 'variables': [91], 'between': [92, 248], 'groups.': [93, 178], 'Results:': [94], 'Among': [95], 'patients,': [99], '15': [100, 108], 'ulcerative': [103], 'colitis': [104, 314], '(UC)': [105], 'group': [106, 188, 197], "Crohn's": [110], '(CD)': [112], 'group.': [113], 'In': [114, 154, 200], 'group,': [117, 157, 202], '6': [118, 261, 330], '(3': [119], 'UC': [121, 201], '3': [123], 'CD': [125], 'group)': [126], 'had': [127, 160, 294, 302, 325], 'result': [129, 162], '(20%),': [134], 'among': [135], 'whom': [136], '5': [137], 'A': [142], '(tcdA)': [143], '+toxin': [144], 'B': [147], '(tcdB)': [148], '-,': [149], '1': [151, 289], 'tcdA+tcdB+.': [153], 'only': [158], 'one': [159, 215], '(3%),': [167], 'which': [168], 'tcdA+tcdB-.': [170], 'Binary': [171], 'negative': [175], 'both': [177, 367], 'significantly': [190], 'higher': [191, 358], 'than': [192, 359], 'that': [193, 360], 'control': [196], '(χ(2)=4.043,': [198], 'P=0.044).': [199], 'no': [203, 307], 'during': [210, 223, 232, 341], 'remission': [212], 'period': [213, 253], '(0/1),': [214], 'case': [216, 273, 290], 'for': [219], '(1/11)': [222], 'mild': [224], 'active': [225, 234, 252], 'period,': [226], '2': [228], 'cases': [229, 262, 301, 324, 331], '(2/3)': [231], 'moderately': [233], 'period.': [235], 'There': [236], 'significant': [238], 'differences': [239], 'patients': [249, 365], 'different': [251], '(χ(2)=4.000,': [254], 'P=0.046).': [255], 'main': [257], 'manifestations': [258], 'diarrhea,': [264], 'abdominal': [265], 'pain': [266], 'bloody': [268, 297], 'stool,': [269], 'relapsed': [272], 'characterized': [275], 'by': [276], 'sudden': [277], 'aggravation.': [278], 'TcdA': [279], 'all': [283], 'samples,': [287], 'combined': [291], 'tcdB': [293, 370], 'more': [295, 373], 'serious': [296, 374], 'mucopurulent': [298], 'stool.': [299], 'Five': [300], 'colonoscopy,': [303], 'but': [304], 'there': [305, 378], 'obvious': [308], 'such': [315], 'yellow': [317], 'white': [318], 'plaques': [319], 'or': [320], 'pseudomembranous': [321], 'spot.': [322], 'Three': [323], 'antibiotic': [326], 'exposure': [327], 'history.': [328], 'All': [329], 'sensitive': [333], 'metronidazole': [335], 'treatment,': [336], 'stable': [338], 'without': [339], 'relapse': [340], '3-month': [343], 'follow-up.': [344], 'Conclusions:': [345], 'is': [357], 'children.': [363], 'tcdA': [368], 'could': [371], 'have': [372], 'symptoms,': [376], 'although': [377], 'may': [379], 'not': [380], 'be': [381, 401], 'specific': [382], 'pathological': [383], 'changes': [384], 'colitis.': [389], 'recognition': [391], 'should': [400], 'strengthened': [402], 'work.目的：': [405], '了解炎症性肠病（IBD）患儿产毒型艰难梭菌的感染率及阳性患儿的临床特点。': [406], '方法：': [407], '回顾性研究。收集2015年7月至2016年10月首都医科大学附属北京儿童医院消化科收治的30例IBD患儿及同医院健康体检的30名对照儿童的粪便标本及临床资料，检测其艰难梭菌毒素基因，并分析毒素基因阳性患儿的临床特征。组间比较采用χ(2)检验。': [408], '结果：': [409], 'IBD组30例（UC组、CD组各15例），艰难梭菌毒素基因阳性6例（UC': [410], '3例、CD': [411], '3例），产毒型艰难梭菌感染率为20%。基因型为艰难梭菌毒素A（tcdA）+艰难梭菌毒素B（tcdB）-5例，tcdA+tcdB+1例；健康对照组30名，产毒型艰难梭菌感染1例，感染率为3%，基因型为tcdA+tcdB-。两组儿童均未检测到二元毒素基因。IBD组粪便标本产毒型艰难梭菌感染率明显高于健康对照组，差异有统计学意义（χ(2)=4.043，P=0.044）。UC组缓解期未检测出艰难梭菌毒素基因（0/1），轻度活动期中艰难梭菌毒素基因阳性1例（1/11），中度活动期阳性2例（2/3），不同疾病活动度之间产毒型艰难梭菌感染率差异有统计学意义（χ(2)=4.000，P=0.046）。6例艰难梭菌毒素基因阳性患儿主要表现为腹泻、腹痛及便血，复发型者有突然加重的特点；所有阳性标本均检测到tcdA，1例合并tcdB+者黏液脓血便表现更重；5例完善结肠镜检查，未发现黄白色隆起或伪膜斑等艰难梭菌肠炎特异性表现；3例有抗菌药物暴露史；6例均对甲硝唑抗艰难梭菌治疗敏感；随访3个月，6例患儿均病情平稳，未复发。': [412], '结论：': [413], 'IBD患儿较健康儿童产毒型艰难梭菌感染率高。tcdA+tcdB+者临床表现更重。结肠镜检查无特异性表现。临床上应加强对IBD患儿产毒型艰难梭菌感染检测的认识。.': [414]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3039408246', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}], 'updated_date': '2025-01-14T16:36:48.450157', 'created_date': '2020-07-10'}