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[198], 'may': [199, 910, 1047, 1184, 2093, 2240], 'like': [200, 2301], 'refer': [202], 'recent': [205, 297, 1043, 1394], 'update': [206], 'topic': [209, 2116, 2217], 'more': [211, 1686, 1712, 1966], 'information.23': [213], 'Suffice': [214], 'say': [217], 'clinical': [221, 514, 571, 1810], 'practice': [222], 'adverse': [223, 1384, 1491, 1513, 1614, 1633, 1641], 'effects': [224], 'are': [227, 1181, 1353, 1372, 1524, 2273], 'generally': [228], 'minor': [229], 'easily': [231], 'manageable.4': [232], 'In': [233, 382, 541, 932, 963, 1291, 1964], 'context': [235], 'LD-MTX,': [241], 'shows': [245, 1716], 'features': [246, 719, 1305, 2135], 'ILD': [248, 510, 581, 696, 1077, 1119, 1140, 1151, 1496, 1535, 1690, 1889, 1910, 2012, 2100], 'common': [251], '“blame”': [253], 'promptly': [256], '“ban”': [258], 'forever.': [260], 'Consequently,': [261], 'challenging': [264], 'without': [269, 679], 'LD-MTX.': [270, 1388], 'essential': [274], 'examine': [276], 'evidence': [278, 298, 680, 1085, 2089], 'favor': [280], 'against': [282, 613, 1425, 1725], 'involvement': [284, 306, 1427, 1563], 'causation': [289, 1432], 'disease,': [293], 'namely': [294], 'ILD.': [295, 311, 587, 898], 'Emerging': [296], 'challenged': [300], 'long-held': [302], 'view': [303], 'RA-associated': [310], 'first': [313, 666, 999, 1436], 'report': [314, 353], 'toxicity': [317, 765], 'was': [318, 348, 413, 431, 491, 499, 554, 597, 692, 745, 752, 829, 926, 948, 1301, 1551, 1643, 1659, 1833, 1896, 1911, 1946, 1985, 2014, 2065], 'presented': [319, 2088], 'Albert': [321], 'M.': [322, 326], 'Clarysse': [323], 'from': [324, 551, 642, 890, 1154, 1194, 1755, 1764, 1771, 1779, 2163, 2168, 2195], 'Maxwell': [325], "Wintrobe's": [327], 'hematology': [328, 409], 'group': [329, 1550], '(in': [330], 'Denver,': [331], 'Colorado,': [332], 'USA)': [333], 'at': [334, 1817, 1820, 1977, 2041], 'XII': [336], 'Congress': [337], 'International': [339], 'Society': [340], 'Hematology,': [342], 'New': [343, 2318], 'York,': [344], '196824': [346], 'which': [347, 443, 537, 604, 1018, 1081, 1274], 'published': [349, 943, 1704, 2170], '1969.25': [351], 'included': [354, 720, 1438, 1578, 1792, 1806], '7': [355, 403, 421, 424, 485, 1579], 'consecutive': [356], 'acute': [359, 439, 721, 741, 1314, 2124], 'lymphoblastic': [360], 'leukemia': [361], 'who': [362, 766, 1451, 1887, 1925, 1971], 'were': [363, 407, 460, 690, 794, 807, 819, 1010, 1596, 1800, 1847, 1972], 'treated': [364, 622, 1574], 'intermittently': [365], '13.3-20': [367], 'mg': [368], 'MTX': [369, 593, 657, 764, 799, 824, 879, 946, 1097, 1138, 1255, 1275, 1363, 1429, 1454, 1468, 1509, 1598, 1619, 1676, 1759, 1839, 1874, 1894, 1944, 1983, 2063, 2092, 2219, 2287], 'per': [370], 'square': [371], 'meter': [372], 'body': [373], 'surface': [374], 'after': [375, 488, 852, 1017, 1296, 1930], 'induction': [376], 'remission': [378], 'prednisone': [380], 'therapy.': [381], "authors'": [383], 'words': [384], '“A': [385], 'respiratory': [386, 465, 1383, 1613], 'illness': [387, 412, 442, 502], 'characterized': [388], 'fever,': [390], 'non-productive': [391], 'cough,': [392], 'severe': [393, 414], 'dyspnea,': [394, 727], 'cyanosis,': [395], 'bilateral': [397], 'pulmonary': [398, 1212, 2277], 'infiltrates': [399], 'developed': [400, 1888, 1926], 'all': [402, 484, 2111], 'while': [405, 1767, 1904, 2267], 'they': [406, 1082], 'remission.': [410], 'life-threatening': [416], '6': [418], 'patients.': [422, 749, 931, 1918], 'All': [423], 'recovered”.': [425], 'authors': [427, 649, 689, 840, 1090, 2080], 'had': [428, 504, 1025], 'noted': [429, 663, 831], 'there': [430, 1131, 1352, 1390, 1658], 'marked': [432], 'eosinophilia': [433, 735], 'these': [435, 458, 525, 552, 837, 900, 930, 1019, 1418, 2077, 2272], 'during': [437, 739, 1890], 'phase': [440], 'made': [444], 'physicians': [447, 1136], 'suspect': [448], 'acute/subacute': [449, 501], 'hypersensitivity': [450, 760, 1146], 'pneumonitis': [451, 674, 1147], '(HP)': [452], 'due': [453], 'environmental': [455, 1160, 1219], 'exposures.': [456], 'painstakingly': [461], 'investigated': [462], 'different': [464, 700], 'exposures': [466], 'including': [467, 1224, 1318, 2038], 'blastomycosis,': [468], 'coccidioidomycosis,': [469], 'histoplasmosis,': [470], 'tuberculosis': [471], 'any': [473, 583, 833, 1506, 1855, 1934, 2225], 'exposure': [474, 1158, 1213, 1840, 1875, 1895, 1945, 1984], 'birds.': [476], 'Finally,': [477], 'interesting': [480], 'note': [482], 'recovered': [487], 'discontinued.': [492], 'can': [494, 875], 'clearly': [496, 916, 1094], 'seen': [497, 511, 569, 928, 949, 1120], 'an': [500, 698, 1150, 1465, 2069, 2123, 2327], 'resemblance': [506, 561, 584, 2141], 'chronic': [509, 531, 565, 580, 694, 897], 'day-to-day': [513], 'practice.': [515, 572], 'Certainly,': [516], 'pulmonologist': [518], 'will': [519], 'confuse': [520], 'typical': [521, 556, 2136], 'HP': [522, 558, 789, 844, 921, 947, 957, 975, 1009, 1114, 2138], 'described': [523, 2122], 'ILD,': [529, 567], 'idiopathic': [532, 566, 586, 695], 'progressive': [533, 726], 'fibrotic': [534], 'reduces': [538], 'survival.': [540], 'hindsight,': [542], 'histopathological': [545, 786, 2134], 'finding': [546], 'biopsy': [550, 744], 'rather': [555, 1481, 1691], 'None': [573], 'above': [576], 'progressed': [578], 'into': [579, 1448], 'next': [589], 'major': [590], 'publication': [591], 'Kremer': [599, 615, 708], 'et': [600, 616, 709, 984, 1037, 1068, 1409], 'al': [601, 617, 710, 985, 1038, 1069], '1997': [603], 'also': [605, 915, 1039, 1537], 'reviewed': [606], 'literature': [608, 1245, 1298, 2107, 2214], 'topic.': [611], 'As': [612], 'cancer,': [614], 'studied': [618], 'MTX.26': [624], 'Six': [625], 'academic': [626], 'institutions': [627], 'private': [629], 'practices': [630], 'participated': [631], 'study': [634, 1502, 1607, 1731, 1747, 1832, 1853, 1882, 2026, 2060], 'collected': [636, 1801], 'information': [637], 'July': [643], '1981': [644], 'June': [646], '1993.': [647], 'selected': [650], 'Searles-McKendry': [654], 'criteria': [655], 'pneumonitis.27': [658], 'point': [667, 1064, 1125], '“Major': [670], 'criteria”': [671], 'states': [672], '“Hypersensitivity': [673], 'histopathologic': [676, 803], 'examination': [677], '(and': [678], 'pathogenic': [682], 'organisms)”.': [683], 'definition,': [686], 'what': [687], 'describing': [691], 'not': [693, 830, 862, 927, 1112, 1348, 1674, 1947, 2066], 'but': [697, 1677], 'entirely': [699, 2275], 'condition': [702], 'namely,': [703, 1743], 'HP.': [704, 777, 912, 1665, 2152], 'For': [705], 'their': [706, 987, 998], 'study,': [707], 'identified': [711], '27': [712], 'cases': [713, 793, 806, 1055, 1909, 1924], 'met': [715], 'criteria.26': [717], 'Clinical': [718], 'subacute': [723, 1316, 2126], 'onset': [724, 2043, 2098], 'mostly': [728], 'dry': [729], 'cough': [730], 'fever': [732], 'mild': [734], 'majority': [738], 'phase.': [742], 'Lung': [743], 'available': [746, 2233], '20': [748], 'histopathology': [751], 'evaluated': [753], 'experts': [755], 'long': [757], 'experience': [758], 'could': [767, 1668, 1722, 1883, 2257], 'make': [768], 'distinction': [770, 787, 919, 1191], 'between': [771, 788, 920, 1311], 'MTX-related': [776, 843, 956, 974, 1008, 1664], 'paper': [779, 934], 'describes': [780], 'minute': [782], 'details': [783], 'RA-ILD.': [791, 1261, 1434, 1845, 2230], 'Twenty': [792], 'classified': [795], 'having': [797], 'definite': [798], 'injury': [801, 881, 2120], 'evaluation.': [804], 'Four': [805, 815], 'categorized': [808], 'probable,': [810], '3': [812, 1393, 1848], 'possible.': [814], 'specimens': [818], 'judged': [820], 'injury.': [826], 'Rheumatoid': [827], 'patient.': [834], 'Based': [835, 2075], 'upon': [836, 870, 2076], 'characteristics': [838], 'conclude': [841], 'toxic': [847], 'reaction': [848], 'usually': [850], 'occurs': [851], 'relatively': [854], 'short': [855], 'duration': [856], 'cumulative': [866], 'dose.': [867], 'Thus,': [868, 1243, 1666], 'based': [869], 'seminal': [872, 902], 'paper,': [873], 'summarized': [877, 1412], 'form': [884], 'HP,': [886], 'distinct': [889, 2276], 'RA-ILD': [891, 1272, 1736, 1859, 1879, 1923, 1953, 1976, 1994, 2037, 2073, 2143, 2266, 2290], 'garden': [894], 'variety': [895, 1216], 'Considering': [899], '2': [901, 1397, 1416, 1449, 1738, 2203, 2274], 'earlier': [903], 'papers,': [904], 'obvious': [907], 'cause': [911], 'These': [913, 1089], 'papers': [914, 1093, 2113], 'mention': [917], 'RA-ILD;': [923], 'latter': [925, 1124], 'long-term': [937], '2009,': [945], 'only': [950, 1373, 1929], '0.43%.28': [952], 'issue': [954], 'been': [959, 1026, 1116, 1392, 1538], 'recently': [960], 'revisited.22,': [961], '23': [962, 1772], 'his': [964], '2018': [965], 'review,': [966], 'Balk23': [967], 'quotes': [968], 'figures': [970, 1006, 1020, 2166, 2181], '1%-8%': [972, 2169], '1': [977, 1660, 2206, 2210], 'exceptionally': [978], 'high': [979, 1005], 'figure': [980, 1046], '33%.': [982], 'Fragoulis': [983, 1036, 1067, 1408], 'subject': [993], '2019,22': [995], 'came': [996], 'conclusion': [1000], 'most': [1002], 'reported': [1011, 1027, 1056, 1539, 2165], 'publications': [1013, 1395, 2194, 2201], 'before': [1014, 2171], '1990s': [1016], 'fell': [1021], '0.43%': [1023, 2186], 'Salliot': [1029], 'van': [1031], 'der': [1032], 'Heijde': [1033], '2009.28': [1035], 'suggested': [1040, 2090], 'years': [1044], 'fallen': [1049], 'even': [1050, 1339, 1711], '0.28%': [1053], '(13': [1054], '4544': [1059], 'MTX-treated': [1060], 'patients).22': [1061], 'second': [1063, 1545], 'discussed': [1065, 1288], 'occurrence': [1074, 1951, 2247], 'MTX-induced': [1076, 1357, 2118], 'found': [1083, 1608, 1973], 'literature.22': [1088], 'quote': [1091], 'establishing': [1095], 'role': [1101], 'causing': [1103, 1364, 2255], 'disease.': [1106], 'seems': [1108, 1503, 2158], 'reasons': [1111], 'clear,': [1113], 'confused': [1117, 1270], 'RA.': [1122, 1144, 1798, 2104], 'requires': [1126], 'critical': [1127], 'appraisal': [1128], 'mainly': [1129], 'because': [1130, 1178, 1200, 1714], 'widespread': [1133, 2251], 'misbelief': [1134, 2252], 'among': [1135], 'causes': [1139], 'Chronic': [1145], '(CHP)': [1148], 'results': [1153, 1414, 1463], 'recurrent': [1155], 'long-standing': [1157], 'antigens': [1161], 'carries': [1163], 'poor': [1165], 'prognosis': [1166], '5-year': [1168], 'survival': [1169], 'low': [1171], '25%-30%.29': [1173], 'Diagnosing': [1174], 'CHP': [1175, 1193, 1207, 1248, 1263, 1307, 1312, 1346, 1365], 'difficult': [1177, 1338], 'manifestations': [1180], 'nonspecific': [1182, 1332], 'mimic': [1185], 'IPF': [1186, 1195], 'NSIP.30': [1188], 'Yet,': [1189], 'NSIP': [1197], 'important': [1199, 1699], 'each': [1201, 2283], 'managed': [1204], 'differently.30': [1205], 'Because': [1206], 'repeated': [1211], 'ubiquitous': [1218], 'small': [1220], 'organic': [1221], 'particles': [1222], '(antigens)': [1223], 'fungi,': [1225], 'animal': [1226], 'proteins,': [1227], 'insects': [1228], 'occasionally': [1230], 'chemical': [1231], 'compounds,31': [1232], 'avoidance': [1233], 'inciting': [1236], 'antigen': [1237], 'key': [1239], 'management.32': [1242], 'gives': [1249], 'possible': [1251, 1661, 1856], 'clue': [1252], 'why': [1254], 'getting': [1257, 1277], 'blame': [1259], 'Could': [1262], 'being': [1269, 1497, 2265], 'blame?': [1279], 'thought': [1283], 'needs': [1285], 'pulmonologists.': [1290], 'pulmonologists': [1294], 'search,33': [1299], 'evident': [1302], 'especially': [1308], 'differential': [1309], 'diagnosis': [1310, 1843, 1979, 2013], 'ILDs': [1317], 'diffuse': [1319], 'alveolar': [1320], 'damage,': [1321], 'organizing': [1322], 'pneumonia,': [1323, 1329], 'eosinophilic': [1324], 'pneumonia': [1325, 1334], '(EP),': [1326], 'lymphocytic': [1327], 'interstitial': [1328, 1333], 'cellular': [1331], '(NSIP)': [1335], 'often': [1337], 'specialists.': [1341], 'Moreover,': [1342, 2231], 'epidemiology': [1344], 'well': [1349, 1525], 'known.': [1350], 'reports': [1355], 'CHP.': [1358], 'possibility': [1361], 'would': [1366, 2291, 2300], 'remain': [1367], 'research': [1369], 'agenda.': [1370], 'There': [1371, 1846], 'few': [1375], 'high-quality': [1376], 'studies': [1377, 1580], 'suitable': [1378], 'analyze': [1382], 'events': [1385, 1615, 1642], 'Fortunately,': [1389], 'well-performed': [1398], 'meta-analyses': [1399], 'multivariate': [1402, 1702, 2207], 'analysis': [1403, 1921, 1968], 'issue.34-36': [1406], 'Additionally,': [1407], 'al22': [1410], 'studies34,': [1419], '35': [1420, 2205], 'succinctly': [1421], 'argued': [1423, 2081], 'strongly': [1424], 'meta-analysis': [1437, 1546], '22': [1439], 'randomized': [1440], 'controlled': [1441], 'trials': [1442], '8584': [1444], 'patients,': [1445], 'equally': [1446], 'divided': [1447], 'groups': [1450], 'received': [1452], 'either': [1453], 'comparator': [1457], 'conventional': [1458, 1602], 'DMARD': [1460], '(csDMARD).34': [1461], 'indicated': [1464], 'association': [1466, 1507, 1837, 1857, 1872, 2226], 'increased': [1470, 2070], 'risk': [1471, 1475, 1991, 2033, 2071], 'infectious': [1473, 1630, 1638], '(relative': [1474], '[RR]': [1476], '1.11,': [1477], '95%': [1478, 1486, 1622, 1647, 1653, 1958, 1997, 2019], 'CI': [1479, 1487, 1623, 1648, 1654, 1959, 1998, 2020], '1.02-1.21),': [1480], 'than': [1482, 1531, 1692], 'non-infectious': [1483, 1499, 1511, 1632, 1640], '(RR': [1484, 1620, 1645], '1.02,': [1485, 1646], '0.65)': [1488], 'etiology': [1489], 'effect': [1492], 'lung.': [1495], 'condition,': [1500], 'negate': [1505], 'effects.': [1514], 'Higher': [1515], 'rates': [1516], 'infection': [1519], 'known.37,': [1526], '38': [1527], 'Similarly,': [1528], 'higher': [1530, 2039], 'normal': [1532], 'RA.39': [1543], 'carried': [1552], 'out': [1553], 'objective': [1556], 'evaluating': [1558], 'RR': [1560, 1651], 'psoriasis,': [1567, 1585], 'psoriatic': [1568, 1586], 'arthritis,': [1569], 'inflammatory': [1571, 1589], 'bowel': [1572, 1590], 'MTX.35': [1576], 'comprising': [1581], '1640': [1582], 'Of': [1592], 'these,': [1593], '818': [1594], 'taking': [1597, 1618], '812': [1600], 'other': [1601, 2031], 'DMARDs': [1604], '(csDMARDs).': [1605], 'increase': [1610, 1636], 'overall': [1612], '1.03,': [1621], '0.90-1.17).': [1624], 'On': [1625], 'separate': [1627], 'assessment': [1628], 'events,': [1634], 'observed': [1644], '0.88-1.19;': [1649], '1.07,': [1652], '0.58-1.96,': [1655], 'respectively).': [1656], 'However,': [1657], 'case': [1662], 'concluded': [1670, 2061], 'itself': [1681], 'makes': [1683], 'prone': [1687], 'developing': [1689, 2036], 'third': [1698], 'publication,': [1700], 'analysis,': [1703], 'middle': [1707], '2019': [1709], 'compelling': [1713], 'protective': [1724], 'development': [1727], 'ILD.36': [1729], 'assessed': [1732], 'predictive': [1733], 'factors': [1734, 1869, 2034], 'early': [1739, 1745, 1751], 'inception': [1741], 'cohorts,': [1742], '(ERAS)': [1748], 'network': [1753], '(ERAN),': [1754], 'standpoint': [1757], 'exposure.': [1760], 'ERAS': [1761], 'recruited': [1762, 1769], '9': [1765], 'centers': [1766, 1773], 'ERAN': [1768], 'England,': [1775], 'Wales': [1776], 'Ireland': [1778], '1986': [1780], '2012': [1782], 'follow-up': [1784, 1823], 'going': [1785], 'up': [1787], '25': [1789], 'years.': [1790], 'Participants': [1791], '2701': [1793], 'newly': [1796], 'diagnosed': [1797], 'Data': [1799], 'standardized': [1803], 'forms': [1804], 'demographics,': [1807], 'therapies,': [1809], 'outcomes': [1811, 1850], 'presence': [1814], 'RA-ILD,': [1816], 'baseline,': [1819], '3-6': [1821], 'months': [1822], 'then': [1825, 2175], 'annually.': [1826], 'primary': [1828, 1920], 'outcome': [1829], 'evaluate': [1835], 'secondary': [1849], 'with:': [1860], '(a)': [1861], 'demographic': [1862], 'factors,': [1863], '(b)': [1864], 'comorbidities': [1865], '(c)': [1867], 'RA-specific': [1868], '(serology,': [1870], 'time': [1877, 2010], 'diagnosis).': [1880], 'find': [1884], '92': [1885], 'stated': [1892], 'period.': [1893], 'recorded': [1897, 1912], '39': [1899], '(2.5%)': [1900], '1578': [1902], 'non-MTX': [1907], 'exposed': [1908, 2006], '53': [1914], '(4.8%)': [1915], '1114': [1917], 'initiation': [1932], 'csDMARD': [1937], '(n': [1939, 1980], '=': [1940, 1962, 1981, 2001, 2023], '67)': [1941], 'showed': [1942], 'associated': [1948, 1986, 2067], '(odds': [1954], 'ratio': [1955], '[OR]': [1956], '0.85,': [1957], '0.49-1.49,': [1960], 'P': [1961, 2000, 2022], '.578).': [1963], 'comprehensive': [1967], '92),': [1982], 'significantly': [1989, 2015], 'reduced': [1990], 'incident': [1993], '(OR': [1995, 2017], '0.48,': [1996], '0.3-0.79,': [1999], '.004).': [2002, 2024], 'Also,': [2003, 2197], 'those': [2005], 'MTX,': [2008], 'longer': [2016], '0.41,': [2018], '0.23-0.75,': [2021], 'This': [2025], 'confirmed': [2027], 'known': [2032], 'age': [2040], 'RA,': [2045], 'smoking': [2046], '(current': [2047], 'past),': [2049], 'male': [2050], 'gender,': [2051], 'nodules': [2053], 'delay': [2055, 2096], 'appropriate': [2057], 'treatment.': [2058], 'diagnosis.': [2074], 'results,': [2078], 'that,': [2082], 'contrary': [2083], 'belief,': [2086], 'prevent': [2094], 'An': [2105], 'extensive': [2106], 'revealed': [2109], 'clinical,': [2131], 'radiographic': [2132], 'responds': [2146], 'standard': [2148], 'Mysteriously,': [2153], 'incidence': [2155], 'MH-pneumo': [2157, 2180, 2263], 'gone': [2161], 'down': [2162, 2184], 'varying': [2167], '2009.': [2172], 'Publications': [2173], 'since': [2174, 2198], 'shown': [2177], 'come': [2183], '200928': [2188], 'now,': [2190], '0.286%': [2191], '2019.22': [2196], '2014': [2199], 'meta-analyses,34,': [2204], 'analysis36': [2208], 'narrative': [2211], 'RA-ILD22': [2221], 'firmly': [2223], 'refuted': [2224], 'data': [2234], 'tend': [2235], 'indicate': [2237], 'actually': [2241], 'preventing': [2243], 'delaying': [2245], 'RA-ILD.36': [2249], 'regarding': [2253], '“MTX': [2254], 'ILD”': [2256], 'root': [2260], 'misinterpreting': [2262], 'fact': [2269], 'relationship': [2281], 'other.': [2284], 'discontinuing': [2286], 'appear': [2292], 'illogical': [2295], 'unreasonable.': [2297], 'author': [2299], 'acknowledge': [2303], 'Prof.': [2304], 'Kevin': [2305], 'Pile': [2306], 'Director': [2307], 'Rheumatology,': [2308], 'Campbelltown': [2309], 'Hospital': [2310], 'University': [2313], 'Western': [2315], 'Sydney|': [2316], 'Campbelltown,': [2317], 'South': [2319], 'Wales,': [2320], 'Australia,': [2321], 'encouraging': [2323], 'write': [2325], 'article.': [2328], 'None.': [2329]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3038124772', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-10T07:34:23.388813', 'created_date': '2020-07-02'}