Title: Cognitive impairment in major depressive disorder and severedepressive episode with psychotic symptoms
Abstract: Introduction Cognitive impairment in patients with depressive
disorder is a subject of intensive research. Objectives This
study deals with the cognitive impairment in patients with
severe depressive episode with psychotic symptoms and patients
with major depressive disorder during the acute state of
illness. Aims The aim was to define domains and the level of
cognitive impairment in both groups of patients. The next aim
was to compare profiles of cognitive impairment in both groups
of patients. The last aim was to find out a relationship
between cognitive performance and severity of depressive
episode during the acute state of illness. Methods We have used
neuropsychological test battery (Auditory–Verbal Learning Test,
Rey-Osterrieth Complex Figure Test, Logical Memory, Digit span
test, Trail making test, Verbal Fluency Test, Block Design and
Benton Visual Retention Test) for the evaluation of the
cognitive functions in patients with severe depressive episode
with psychotic symptoms (n = 5) and patients with major
depressive disorder (n = 8). Results We found cognitive
impairment in all examined domains in both groups of patients.
More profound cognitive impairment was found in patients with
severe depressive episode with psychotic symptoms, particularly
in visual memory, visuo-constructive abilities, speed of
cognitive processing and executive functions. We found no
correlation between cognitive performance and severity of
depressive episodes. Conclusions Our findings suggest a strong
correlation between psychotic symptoms in depression and
cognitive performance.
Publication Year: 2017
Publication Date: 2017-01-04
Language: en
Type: article
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