Title: The Asymmetry of Membranes and its Implications for Membrane Biogenesis
Abstract: The fluid mosaic model of membrane structure is now accepted as a general scheme for the organization of the proteins and lipids of membranes. In this model, there are two classes of proteins associated with membranes, peripheral and integral. The integral proteins are postulated to be globular amphipathic molecules which, either singly or as subunit aggregates are embedded by their hydrophobic ends into a fluid matrix of lipid bilayer. The molecule may be embedded only part way through the bilayer, or if it has the appropriate size and structure, it may span the membrane with two different hydrophilic ends protruding from the two membrane surfaces, and a hydrophobic middle region embedded in the membrane interior. It is proposed that peripheral proteins are bound to the membrane at the exposed portions of specific integral proteins. Examples of each of these types of membrane proteins are known.
Publication Year: 1974
Publication Date: 1974-08-15
Language: en
Type: article
Indexed In: ['crossref']
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