Title: Applying Quantitative Immunogold Labeling Distributions of Cellular Compartments in Immunoelectron Microscopy Images to the Study of EGFR Intracellular Signaling
Abstract: Immunoelectron microscopy has been shown to be a useful tool for quantifying distributions of relevant proteins across cellular compartments. This methodology has been recently applied to study the biological response of Heberprot-P in humans, an epidermal growth factor (EGF)-based therapeutic product that enhances healing of chronic wounds in patients with diabetic foot ulcers (DFU) safely and efficaciously.