Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages

Name: Work Video:
Duration: 3 min 30 s
Weihua Guo; Yashan Li; Wei Pang; Hong Shen
{'id': 'https://openalex.org/W3034921165', 'doi': 'https://doi.org/10.1016/j.ymthe.2020.06.003', 'title': 'Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages', 'display_name': 'Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages', 'publication_year': 2020, 'publication_date': '2020-06-11', 'ids': {'openalex': 'https://openalex.org/W3034921165', 'doi': 'https://doi.org/10.1016/j.ymthe.2020.06.003', 'mag': '3034921165', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32563274', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7474264'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ymthe.2020.06.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S51596929', 'display_name': 'Molecular Therapy', 'issn_l': '1525-0016', 'issn': ['1525-0016', '1525-0024'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.ymthe.2020.06.003', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102763028', 'display_name': 'Weihua Guo', 'orcid': 'https://orcid.org/0000-0002-2380-9270'}, 'institutions': [{'id': 'https://openalex.org/I4210159865', 'display_name': 'Xiangya Hospital Central South University', 'ror': 'https://ror.org/05c1yfj14', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210159865']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weihua Guo', 'raw_affiliation_strings': ['Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'institution_ids': ['https://openalex.org/I4210159865', 'https://openalex.org/I139660479']}, {'raw_affiliation_string': 'Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'institution_ids': ['https://openalex.org/I4210159865', 'https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086311045', 'display_name': 'Yashan Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210159865', 'display_name': 'Xiangya Hospital Central South University', 'ror': 'https://ror.org/05c1yfj14', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210159865']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yashan Li', 'raw_affiliation_strings': ['Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'institution_ids': ['https://openalex.org/I4210159865', 'https://openalex.org/I139660479']}, {'raw_affiliation_string': 'Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'institution_ids': ['https://openalex.org/I4210159865', 'https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102354197', 'display_name': 'Wei Pang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}, {'id': 'https://openalex.org/I4210159865', 'display_name': 'Xiangya Hospital Central South University', 'ror': 'https://ror.org/05c1yfj14', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210159865']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Pang', 'raw_affiliation_strings': ['Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'institution_ids': ['https://openalex.org/I139660479', 'https://openalex.org/I4210159865']}, {'raw_affiliation_string': 'National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'institution_ids': ['https://openalex.org/I4210159865', 'https://openalex.org/I139660479']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001027254', 'display_name': 'Hong Shen', 'orcid': 'https://orcid.org/0000-0002-6456-8231'}, 'institutions': [{'id': 'https://openalex.org/I4210159865', 'display_name': 'Xiangya Hospital Central South University', 'ror': 'https://ror.org/05c1yfj14', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210159865']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Hong Shen', 'raw_affiliation_strings': ['Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'institution_ids': ['https://openalex.org/I4210159865', 'https://openalex.org/I139660479']}, {'raw_affiliation_string': 'Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'institution_ids': ['https://openalex.org/I4210159865', 'https://openalex.org/I139660479']}, {'raw_affiliation_string': 'National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China', 'institution_ids': ['https://openalex.org/I4210159865', 'https://openalex.org/I139660479']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5001027254'], 'corresponding_institution_ids': ['https://openalex.org/I4210159865', 'https://openalex.org/I139660479'], 'apc_list': {'value': 3900, 'currency': 'USD', 'value_usd': 3900, 'provenance': 'doaj'}, 'apc_paid': {'value': 3900, 'currency': 'USD', 'value_usd': 3900, 'provenance': 'doaj'}, 'fwci': 1.156, 'has_fulltext': False, 'cited_by_count': 53, 'citation_normalized_percentile': {'value': 0.999775, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '28', 'issue': '9', 'first_page': '1953', 'last_page': '1964'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10773', 'display_name': 'Extracellular vesicles in disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10773', 'display_name': 'Extracellular vesicles in disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.9895, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11313', 'display_name': 'Immune cells in cancer', 'score': 0.9836, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/exosome', 'display_name': 'Exosome', 'score': 0.42316586}], 'concepts': [{'id': 'https://openalex.org/C20518536', 'wikidata': 'https://www.wikidata.org/wiki/Q6840469', 'display_name': 'Microvesicles', 'level': 4, 'score': 0.9422332}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.75715387}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6019992}, {'id': 'https://openalex.org/C2779244956', 'wikidata': 'https://www.wikidata.org/wiki/Q184204', 'display_name': 'Macrophage', 'level': 3, 'score': 0.56045234}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.46251288}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.4519758}, {'id': 'https://openalex.org/C2781261824', 'wikidata': 'https://www.wikidata.org/wiki/Q903634', 'display_name': 'Exosome', 'level': 5, 'score': 0.42316586}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.41216433}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.37808207}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34589136}, {'id': 'https://openalex.org/C3020616263', 'wikidata': 'https://www.wikidata.org/wiki/Q1216998', 'display_name': 'Tumor cells', 'level': 2, 'score': 0.3016163}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.24854985}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.23629707}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.22651449}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.07459104}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.050694197}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002450', 'descriptor_name': 'Cell Communication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D059016', 'descriptor_name': 'Tumor Microenvironment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000084582', 'descriptor_name': 'Tumor-Associated Macrophages', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016764', 'descriptor_name': 'Cell Polarity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016764', 'descriptor_name': 'Cell Polarity', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016764', 'descriptor_name': 'Cell Polarity', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019139', 'descriptor_name': 'Tumor Escape', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000084582', 'descriptor_name': 'Tumor-Associated Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000084582', 'descriptor_name': 'Tumor-Associated Macrophages', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ymthe.2020.06.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S51596929', 'display_name': 'Molecular Therapy', 'issn_l': '1525-0016', 'issn': ['1525-0016', '1525-0024'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474264', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32563274', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ymthe.2020.06.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S51596929', 'display_name': 'Molecular Therapy', 'issn_l': '1525-0016', 'issn': ['1525-0016', '1525-0024'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.42, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': None}, {'funder': 'https://openalex.org/F4320322843', 'funder_display_name': 'Natural Science Foundation of\xa0Hunan Province', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 125, 'referenced_works': ['https://openalex.org/W1570971207', 'https://openalex.org/W1601681275', 'https://openalex.org/W1608022280', 'https://openalex.org/W1916893403', 'https://openalex.org/W1950118853', 'https://openalex.org/W1970433764', 'https://openalex.org/W1970847274', 'https://openalex.org/W1973893754', 'https://openalex.org/W1985727076', 'https://openalex.org/W1992118957', 'https://openalex.org/W1995483790', 'https://openalex.org/W2002811765', 'https://openalex.org/W2016024700', 'https://openalex.org/W2024903578', 'https://openalex.org/W2029790299', 'https://openalex.org/W2031273578', 'https://openalex.org/W2033598310', 'https://openalex.org/W2037393136', 'https://openalex.org/W2040207921', 'https://openalex.org/W2046448712', 'https://openalex.org/W2047411188', 'https://openalex.org/W2047529648', 'https://openalex.org/W2051298779', 'https://openalex.org/W2059266855', 'https://openalex.org/W2061386923', 'https://openalex.org/W2063632665', 'https://openalex.org/W2065165253', 'https://openalex.org/W2067843805', 'https://openalex.org/W2068335734', 'https://openalex.org/W2073586533', 'https://openalex.org/W2081550278', 'https://openalex.org/W2087369559', 'https://openalex.org/W2095813909', 'https://openalex.org/W2098259366', 'https://openalex.org/W2115713194', 'https://openalex.org/W2124105964', 'https://openalex.org/W2126302500', 'https://openalex.org/W2132099454', 'https://openalex.org/W2141037581', 'https://openalex.org/W2142755954', 'https://openalex.org/W2157778803', 'https://openalex.org/W2159241628', 'https://openalex.org/W2164193797', 'https://openalex.org/W2176918495', 'https://openalex.org/W2283284501', 'https://openalex.org/W2345920029', 'https://openalex.org/W2417740873', 'https://openalex.org/W2460370136', 'https://openalex.org/W2480563847', 'https://openalex.org/W2490028389', 'https://openalex.org/W2512650293', 'https://openalex.org/W2512867860', 'https://openalex.org/W2515939346', 'https://openalex.org/W2582393724', 'https://openalex.org/W2584114288', 'https://openalex.org/W2586097538', 'https://openalex.org/W2588525419', 'https://openalex.org/W2588576443', 'https://openalex.org/W2589694509', 'https://openalex.org/W2594400638', 'https://openalex.org/W2594465601', 'https://openalex.org/W2596133050', 'https://openalex.org/W2605544924', 'https://openalex.org/W2615301036', 'https://openalex.org/W2617691667', 'https://openalex.org/W2617743720', 'https://openalex.org/W2622881601', 'https://openalex.org/W2624402790', 'https://openalex.org/W2649656222', 'https://openalex.org/W2740134922', 'https://openalex.org/W2771490038', 'https://openalex.org/W2774491730', 'https://openalex.org/W2775006908', 'https://openalex.org/W2783471328', 'https://openalex.org/W2790358993', 'https://openalex.org/W2791100847', 'https://openalex.org/W2792578813', 'https://openalex.org/W2796841059', 'https://openalex.org/W2797968797', 'https://openalex.org/W2800494230', 'https://openalex.org/W2800584789', 'https://openalex.org/W2801850195', 'https://openalex.org/W2803834684', 'https://openalex.org/W2806738650', 'https://openalex.org/W2810664676', 'https://openalex.org/W2827119614', 'https://openalex.org/W2867022353', 'https://openalex.org/W2883884612', 'https://openalex.org/W2887549163', 'https://openalex.org/W2888236179', 'https://openalex.org/W2888664067', 'https://openalex.org/W2890159310', 'https://openalex.org/W2895126364', 'https://openalex.org/W2898415660', 'https://openalex.org/W2899013745', 'https://openalex.org/W2899232187', 'https://openalex.org/W2899559547', 'https://openalex.org/W2900276526', 'https://openalex.org/W2900760949', 'https://openalex.org/W2904678682', 'https://openalex.org/W2909641414', 'https://openalex.org/W2914311347', 'https://openalex.org/W2914357704', 'https://openalex.org/W2916430222', 'https://openalex.org/W2916462873', 'https://openalex.org/W2917523924', 'https://openalex.org/W2922474621', 'https://openalex.org/W2923494869', 'https://openalex.org/W2935758727', 'https://openalex.org/W2936849225', 'https://openalex.org/W2939331939', 'https://openalex.org/W2945116833', 'https://openalex.org/W2945559305', 'https://openalex.org/W2946155588', 'https://openalex.org/W2946585494', 'https://openalex.org/W2947403474', 'https://openalex.org/W2948443239', 'https://openalex.org/W2952644505', 'https://openalex.org/W2952956569', 'https://openalex.org/W2954219563', 'https://openalex.org/W2956337168', 'https://openalex.org/W2995128645', 'https://openalex.org/W3013471626', 'https://openalex.org/W4213245349', 'https://openalex.org/W4249579699'], 'related_works': ['https://openalex.org/W4387637728', 'https://openalex.org/W4386033707', 'https://openalex.org/W4378085118', 'https://openalex.org/W3008588181', 'https://openalex.org/W2983860615', 'https://openalex.org/W2896759930', 'https://openalex.org/W2529223554', 'https://openalex.org/W2111545764', 'https://openalex.org/W2067275497', 'https://openalex.org/W1970650594'], 'abstract_inverted_index': {'Exosomes': [0, 142, 284, 360, 1420, 1580, 1664, 1893, 2650, 4017], 'comprise': [1, 143], 'extracellular': [2, 144, 288, 446, 564, 580, 1842, 2739], 'vesicles': [3, 145, 289, 472, 2740], '(EVs)': [4, 146, 290], 'with': [5, 65, 68, 147, 207, 210, 291, 485, 543, 553, 733, 735, 893, 1116, 1753, 1822, 3525, 3819, 3914], 'diameters': [6, 148, 292], 'between': [7, 30, 96, 116, 134, 149, 172, 238, 258, 276, 293, 306, 1359, 1458, 1476, 3573], '30': [8, 150, 294], 'and': [9, 16, 43, 71, 99, 109, 119, 121, 137, 151, 158, 185, 213, 241, 251, 261, 263, 279, 295, 298, 342, 364, 366, 372, 398, 420, 426, 445, 448, 483, 535, 573, 578, 601, 635, 683, 692, 705, 738, 763, 809, 869, 884, 889, 898, 918, 920, 1038, 1052, 1080, 1112, 1187, 1247, 1249, 1280, 1361, 1406, 1432, 1451, 1461, 1479, 1502, 1627, 1751, 1870, 1880, 1889, 1914, 1994, 2098, 2176, 2463, 2628, 2947, 2973, 2991, 3018, 3036, 3145, 3163, 3240, 3267, 3291, 3296, 3350, 3379, 3467, 3478, 3543, 3565, 3575, 3587, 3717, 3728, 3794, 3825, 3834, 3895, 3909, 3952, 4029, 4086, 4131], '150': [10, 152, 296], 'nm.': [11, 153], 'They': [12, 154], 'transfer': [13, 155, 2992], 'proteins,': [14, 156, 380, 384, 387, 391, 395, 533, 3924], 'RNA,': [15, 157], 'other': [17, 159, 579, 1053], 'molecules': [18, 44, 160, 186, 682, 1862, 2968], 'from': [19, 161, 490, 1312, 1422, 1746, 1859, 2237, 2438, 2652, 2887, 3054, 3311, 3659, 4019], 'cell': [20, 162, 1549, 1591, 1737, 1787, 1837, 2316, 2420, 2556, 2583, 2617, 2825, 2870, 2885, 3021, 3178, 3814, 3850, 4114], 'to': [21, 39, 60, 74, 88, 130, 139, 163, 181, 202, 216, 230, 272, 281, 537, 663, 728, 741, 896, 916, 950, 1005, 1067, 1400, 1430, 1472, 1481, 1512, 1524, 1545, 1761, 1765, 1812, 1990, 2159, 2367, 2601, 2896, 2975, 2996, 3181, 3346, 3412, 3569, 3922, 3981, 3997, 4027, 4049, 4082], 'cell,': [22, 164], 'playing': [23, 165], 'an': [24, 47, 62, 166, 189, 204, 300, 665, 730, 756, 876, 906, 1062, 1365, 1521, 3059, 3315, 3757], 'important': [25, 48, 63, 167, 190, 205, 301, 666, 731, 757, 1366, 3138], 'role': [26, 92, 168, 234, 302, 758, 1221, 1367, 3688], 'in': [27, 93, 102, 113, 169, 235, 244, 255, 303, 701, 708, 759, 773, 850, 875, 905, 971, 1119, 1224, 1368, 1380, 1455, 1488, 1588, 1665, 1693, 1743, 1864, 1949, 2001, 2082, 2205, 2406, 2468, 2535, 2604, 2608, 2619, 2625, 2644, 2698, 2822, 2867, 2950, 3012, 3237, 3263, 3299, 3357, 3521, 3616, 3632, 3689, 3798, 3933, 3959, 3993, 4053, 4093, 4156], 'the': [28, 54, 94, 107, 114, 122, 132, 170, 196, 236, 249, 256, 264, 274, 286, 304, 463, 486, 492, 517, 527, 554, 563, 602, 656, 702, 722, 778, 793, 944, 999, 1069, 1078, 1089, 1094, 1103, 1107, 1357, 1369, 1449, 1456, 1466, 1474, 1510, 1514, 1757, 1813, 1817, 1865, 1868, 2206, 2541, 2742, 2845, 2848, 2888, 2916, 2998, 3115, 3128, 3131, 3137, 3150, 3154, 3264, 3270, 3381, 3428, 3552, 3556, 3628, 3831, 3889, 3893, 3901, 3905, 3910, 3915, 3918, 4110], 'interactions': [29, 171, 305, 575], 'cells.': [31, 173], 'The': [32, 174, 438, 510, 671, 2231, 2839, 3653, 3874], 'tumor': [33, 51, 66, 81, 97, 117, 135, 175, 193, 208, 223, 239, 259, 277, 657, 669, 676, 687, 748, 1110, 1243, 1251, 1362, 1407, 1459, 1477, 1525, 1688, 1838, 2368, 2892, 3111], 'microenvironment': [34, 176, 658, 704, 3266], '(TME)': [35, 177, 659], 'has': [36, 178, 660], 'been': [37, 58, 86, 179, 200, 228, 661, 726, 1398], 'found': [38, 59, 87, 180, 201, 229, 662, 727, 904, 1399], 'contain': [40, 182, 362], 'various': [41, 183], 'cells': [42, 98, 118, 136, 184, 240, 260, 278, 684, 753, 777, 974, 1033, 1111, 1363, 1427, 1460, 1478, 1689, 1989, 2110, 2443, 2654, 2913, 2966, 3057, 3112, 3313, 3345, 3879, 3980, 4024, 4045, 4081], 'that': [45, 187, 471, 685, 746, 754, 940, 996, 1058, 1469, 1681, 2702, 2798, 2983, 3065, 3106, 3127, 3302, 3432, 3682, 3760], 'have': [46, 57, 61, 85, 188, 199, 203, 227, 664, 725, 729, 865, 938, 994, 1055, 1397, 1485, 1679, 2796, 2981, 3104, 3125], 'impact': [49, 191, 667], 'on': [50, 192, 607, 668, 1756, 1789, 1816, 1894, 2245, 2844, 3667], 'development.': [52, 82, 194, 224, 670, 749], 'In': [53, 195, 653, 721, 1074, 1088, 1393, 1444, 2664, 2900, 3008, 3048, 3284, 3367, 3625, 3811, 3985, 4041, 4103], 'TME,': [55, 197, 723], 'macrophages': [56, 73, 77, 120, 138, 198, 215, 219, 262, 280, 724, 740, 744, 772, 797, 835, 873, 902, 1037, 1146, 1184, 1223, 1277, 1314, 1360, 1405, 1431, 1462, 1480, 1760, 1855, 1869, 1948, 2116, 2282, 2366, 2370, 2659, 2814, 2859, 2995, 3118, 3303, 3477, 3523, 3727, 4028, 4155], 'relationship': [64, 206, 732], 'cells,': [67, 209, 677, 1518, 1861], 'tumors': [69, 211, 736, 2987], 'recruiting': [70, 212, 737], 'inducing': [72, 214, 739, 2587, 3640], 'become': [75, 217, 742], 'tumor-associated': [76, 218, 743, 1313, 1947, 2037, 2115, 2813, 2858, 3092, 4154], '(TAMs),': [78, 220], 'which': [79, 126, 221, 268, 476, 491, 545, 557, 796, 947, 1002, 1098, 3764, 3877], 'promote': [80, 222, 686, 747, 1006, 1242, 1546, 2111, 2160, 2319, 2819, 2864, 3015, 3182, 3413, 3853, 3978, 3998], 'Recently,': [83, 225], 'exosomes': [84, 112, 127, 226, 254, 269, 493, 577, 1396, 1454, 1471, 1505, 1539, 1685, 1744, 1763, 1788, 1857, 1866, 2200, 2235, 2318, 2401, 2667, 2693, 2777, 2800, 2895, 2905, 2984, 3004, 3013, 3309, 3634, 3657, 3818, 3852, 3996], 'play': [89, 231, 299, 755], 'a': [90, 232, 679, 1085, 1434, 1489, 1694, 2241, 2465, 2645, 3120, 3571, 3663, 3686, 4031], 'critical': [91, 233, 1220, 1912, 3034, 3687], 'interaction': [95, 115, 237, 257, 1358, 1457], 'macrophages.': [100, 242, 3001], 'Thus,': [101, 243, 3579], 'this': [103, 245, 1445, 3585], 'review,': [104, 246, 1446], 'we': [105, 247, 1447], 'summarize': [106, 248, 1448], 'roles': [108, 250, 1450], 'mechanisms': [110, 252, 1452], 'of': [111, 253, 348, 418, 440, 465, 519, 521, 576, 641, 681, 802, 1077, 1082, 1109, 1144, 1226, 1343, 1371, 1453, 1491, 1516, 1543, 1584, 1684, 1696, 1759, 1784, 1819, 1825, 1891, 1939, 2036, 2114, 2234, 2279, 2543, 2615, 2744, 2847, 2891, 3000, 3062, 3091, 3117, 3122, 3130, 3156, 3185, 3210, 3272, 3470, 3476, 3483, 3527, 3558, 3581, 3656, 3720, 3726, 3733, 3892, 3900, 3904, 3917, 3955, 3975, 4112, 4116, 4146], 'potential': [123, 265, 1467], 'methods': [124, 266, 1468], 'by': [125, 267, 675, 795, 880, 909, 1030, 1106, 1147, 1182, 1275, 1630, 1687, 1808, 1840, 1945, 2117, 2285, 2325, 2658, 2816, 2861, 2907, 2986, 3110, 3308, 3376, 3563, 3567, 3792, 3859, 3876, 3885, 4152], 'are': [128, 270, 285, 494, 560, 751, 775, 798, 890, 903, 1100, 1113, 3306], 'used': [129, 271], 'target': [131, 273, 1473, 1915, 3037, 3823], 'communication': [133, 275, 1475], 'treat': [140, 282, 1482], 'cancer.': [141, 283, 1483], 'smallest': [287], 'nm': [297], 'cells.1Pegtel': [307], 'D.M.': [308, 401, 496], 'Gould': [309, 402, 497], 'S.J.': [310, 403, 498], 'Exosomes.Annu.': [311, 404, 499], 'Rev.': [312, 405, 500, 582, 711, 780, 817, 926, 1346, 1382, 3936], 'Biochem.': [313, 406, 501, 3275], '2019;': [314, 407, 502, 1920, 1951, 2003, 2332, 2411, 2449, 2591, 2957, 3042, 3193, 3276, 3359, 3866, 4095], '88:': [315, 408, 503], '487-514Crossref': [316, 409, 504], 'PubMed': [317, 355, 410, 457, 505, 589, 648, 716, 785, 822, 858, 931, 987, 1047, 1154, 1193, 1234, 1286, 1330, 1351, 1388, 1441, 1555, 1601, 1637, 1672, 1729, 1796, 1849, 1923, 1954, 2006, 2042, 2093, 2124, 2168, 2213, 2252, 2298, 2335, 2378, 2414, 2452, 2475, 2507, 2550, 2594, 2638, 2709, 2752, 2788, 2834, 2879, 2960, 3045, 3097, 3196, 3219, 3247, 3279, 3362, 3421, 3500, 3533, 3622, 3674, 3750, 3806, 3869, 3941, 3969, 4038, 4098], 'Scopus': [318, 356, 411, 458, 506, 590, 649, 717, 786, 823, 859, 932, 988, 1048, 1155, 1194, 1235, 1287, 1331, 1352, 1389, 1556, 1602, 1638, 1673, 1730, 1797, 1850, 1955, 2007, 2043, 2094, 2125, 2169, 2214, 2253, 2299, 2336, 2379, 2415, 2453, 2476, 2508, 2551, 2595, 2710, 2753, 2789, 2835, 2880, 2961, 3098, 3197, 3220, 3248, 3280, 3363, 3422, 3501, 3534, 3675, 3751, 3807, 3870, 3942, 3970, 4099], '(80)': [319, 412, 507], 'Google': [320, 358, 413, 460, 508, 592, 651, 719, 788, 825, 861, 934, 990, 1050, 1157, 1196, 1237, 1289, 1333, 1354, 1391, 1442, 1558, 1604, 1640, 1675, 1732, 1799, 1852, 1924, 1957, 2009, 2045, 2096, 2127, 2171, 2216, 2255, 2301, 2338, 2381, 2417, 2455, 2478, 2510, 2553, 2597, 2639, 2712, 2755, 2791, 2837, 2882, 2963, 3046, 3100, 3199, 3222, 3250, 3282, 3365, 3424, 3503, 3536, 3623, 3677, 3753, 3809, 3872, 3944, 3972, 4039, 4101], 'Scholar,2Farooqi': [321], 'A.A.': [322, 615, 1567], 'Desai': [323, 616], 'N.N.': [324, 617], 'Qureshi': [325, 618], 'M.Z.': [326, 619], 'Librelotto': [327, 620], 'D.R.N.': [328, 621], 'Gasparri': [329, 622], 'M.L.': [330, 623], 'Bishayee': [331, 624], 'A.': [332, 625, 841, 1698, 1706, 1716, 2190, 2192, 2724, 2764, 2774, 2935], 'Nabavi': [333, 626], 'S.M.': [334, 627, 1619], 'Curti': [335, 628], 'V.': [336, 629, 1132, 1561, 3607], 'Daglia': [337, 630], 'M.': [338, 566, 631, 843, 961, 1336, 1573, 1577, 1657, 1709, 1779, 1830, 2056, 2228, 2459, 2517, 2519, 2524, 2733, 2805, 2850, 3169, 3650], 'Exosome': [339, 632], 'biogenesis,': [340, 633], 'bioactivities': [341, 634], 'functions': [343, 636, 1081], 'as': [344, 424, 514, 637, 913, 1061, 1402, 1463, 1465, 1494, 2970, 3160, 4120], 'new': [345, 638, 2646], 'delivery': [346, 639], 'systems': [347, 640], 'natural': [349, 642], 'compounds.Biotechnol.': [350, 643], 'Adv.': [351, 644], '2018;': [352, 645, 782, 984, 1385, 1438, 1552, 1634, 1669, 1793, 2085, 2121, 2165, 2249, 2375, 2504, 2706, 2785, 2831, 2876, 3418, 3492, 3671, 3742, 4035], '36:': [353, 646], '328-334Crossref': [354, 647], '(49)': [357, 650], 'Scholar': [359, 414, 461, 509, 593, 652, 720, 789, 826, 862, 935, 991, 1051, 1238, 1355, 1392, 1443, 1676, 1733, 1800, 1853, 2792, 2838, 2883, 2964, 3047, 3101, 3283, 3366, 3425, 3537, 3624, 3678, 3754, 3810, 3873, 3973, 4040, 4102], 'mainly': [361], 'proteins': [363, 375, 2974], 'RNAs': [365, 416, 422, 429, 444], 'can': [367, 828, 942, 1241, 1506, 1690, 2655, 2801, 2988, 3014, 3113, 3765, 3977, 4108], 'also': [368, 1056], 'include': [369, 376], 'glycoconjugates,': [370], 'lipids,': [371, 534], 'DNAs.': [373], 'Exosomal': [374, 415], 'integral': [377], 'exosomal': [378, 396, 1622, 1940, 1992, 2032, 2151, 2372, 2500, 2578, 3051, 3087, 3107, 3286, 3316, 3348, 3371, 3404, 3881, 3983, 4047, 4084, 4117, 4147], 'membrane': [379, 383, 390, 394, 488, 530], 'lipid-anchored': [381, 388], 'outer': [382], 'peripheral': [385, 393], 'surface': [386, 1758, 1818], 'inner': [389, 392], 'enzymes,': [397], 'soluble': [399], 'proteins.1Pegtel': [400], 'consist': [417], 'mRNA': [419], 'noncoding': [421, 428], 'such': [423, 912, 1493, 2969, 3159, 4119], 'microRNAs': [425, 1429, 2971, 4026], 'long': [427], '(lncRNAs).3Sato-Kuwabara': [430], 'Y.': [431, 953, 955, 1293, 1417, 1617, 1643, 1655, 1905, 1971, 1981, 2390, 2392, 2436, 2675, 2677, 2691, 3027, 3327, 3337, 3599, 4014, 4063, 4073], 'Melo': [432], 'S.A.': [433], 'Soares': [434], 'F.A.': [435], 'Calin': [436], 'G.A.': [437, 1773], 'fusion': [439], 'two': [441, 803], 'worlds:': [442], 'non-coding': [443], 'vesicles—diagnostic': [447], 'therapeutic': [449, 1378], 'implications': [450], '(Review).Int.': [451], 'J.': [452, 959, 965, 1018, 1291, 1301, 1411, 1647, 1771, 1909, 1936, 1963, 1969, 2138, 2230, 2248, 2267, 2305, 2328, 2353, 2398, 2409, 2490, 2494, 2683, 2716, 2747, 2807, 2852, 3031, 3175, 3319, 3325, 3391, 3457, 3487, 3597, 3652, 3670, 3707, 3737, 3839, 3862, 4008, 4055, 4061, 4143], 'Oncol.': [453, 3489, 3739], '2015;': [454, 855, 1044, 1726, 2210, 2749], '46:': [455], '17-27Crossref': [456], '(0)': [459, 989, 1851, 2095, 2711, 3502, 3752, 3808], 'Regarding': [462], 'biogenesis': [464], 'exosomes,': [466, 2464], 'it': [467], 'is': [468, 513, 673, 792, 948, 1003, 1084, 1741, 2283, 3058, 3136, 3427, 3561, 3680, 3790, 3883, 3907], 'generally': [469], 'thought': [470], 'bud': [473], 'into': [474, 479, 524, 562, 800, 831, 1102, 1509, 2994, 3212, 3551], 'endosomes,': [475, 526], 'then': [477, 3292], 'mature': [478], 'multivesicular': [480], 'bodies': [481], '(MVBs)': [482], 'fuse': [484, 542, 552], 'plasma': [487], '(PM),': [489], 'released.1Pegtel': [495], 'specific': [511, 532, 807], 'process': [512, 518, 794, 3875, 4111], 'follows.': [515], 'During': [516], 'maturation': [520], 'early': [522, 528, 1090], 'endosomes': [523, 595], 'late': [525], 'endosomal': [529, 608], 'encapsulates': [531], 'cytosol': [536], 'form': [538, 596], 'MVBs.': [539], 'Most': [540], 'MVBs': [541, 551, 597], 'lysosomes,': [544], 'degrade': [546], 'their': [547, 558, 706, 1872], 'contents,': [548], 'while': [549, 992, 1801, 2793, 3143, 3437], 'some': [550, 2794, 3896, 4105], 'PM,': [555], 'through': [556, 598, 2540, 2586, 3119, 3187], 'contents': [559], 'released': [561, 1807], 'environment.4Colombo': [565], 'Raposo': [567], 'G.': [568, 1166, 1259, 1704, 2134, 3165, 3387], 'Théry': [569], 'C.': [570, 847, 1295, 1907, 1926, 2060, 2140, 2226, 2496, 2530, 2566, 2939, 3029, 3202, 3233, 3393, 3453, 3648, 3703, 3771, 4133], 'Biogenesis,': [571], 'secretion,': [572], 'intercellular': [574, 1736], 'vesicles.Annu.': [581], 'Cell': [583, 1042, 2208, 2330, 3864], 'Dev.': [584], 'Biol.': [585, 1043, 2209, 2293, 3490, 3740], '2014;': [586, 1151, 2295], '30:': [587], '255-289Crossref': [588], '(1869)': [591], 'Early': [594], 'many': [599, 3886], 'pathways,': [600], 'most': [603, 2665, 3629], 'common': [604], 'pathway': [605, 3135, 3206, 3236], 'depends': [606], 'sorting': [609], 'complexes': [610], 'required': [611], 'for': [612, 1222, 1916, 2903, 3038, 3140], 'transport': [613], '(ESCRT).2Farooqi': [614], 'recent': [654, 1394], 'years,': [655, 1395], 'TME': [672, 1511, 3894, 3906, 3912], 'generated': [674], 'containing': [678], 'variety': [680, 1490, 3121], 'metastasis,': [688, 1244, 1876], 'angiogenesis,': [689, 1877], 'drug': [690, 1878], 'resistance,': [691, 1246, 1879], 'so': [693], 'on.5Nagarsheth': [694], 'N.': [695, 1134, 2309, 2311, 3843, 3845], 'Wicha': [696], 'M.S.': [697], 'Zou': [698], 'W.': [699, 957, 1008, 1014, 1205, 1537, 2313, 2685, 2809, 2811, 2854, 2856, 3847], 'Chemokines': [700], 'cancer': [703, 709, 973, 1317, 1426, 1548, 1590, 1786, 1860, 1917, 1988, 2109, 2162, 2199, 2400, 2469, 2653, 2701, 2910, 2954, 3039, 3056, 3067, 3177, 3344, 3415, 3878, 3934, 3979, 3988, 4023, 4080, 4113], 'relevance': [707], 'immunotherapy.Nat.': [710], 'Immunol.': [712, 781, 1230, 2784, 3243], '2017;': [713, 819, 928, 1190, 1283, 1348, 1846, 2472, 2547, 3244, 3530, 3961], '17:': [714, 1045, 1349, 1386, 1553, 2211], '559-572Crossref': [715], '(359)': [718], 'tumors,': [734], '(TAMs)': [745], 'Macrophages': [750, 827], 'immune': [752, 894, 914, 1881, 1899, 1918, 1961, 2558, 3040], 'tissue': [760, 771], 'hemostasis,': [761], 'inflammation,': [762], 'pathology.6Lee': [764], 'C.Z.W.': [765], 'Kozaki': [766], 'T.': [767, 1128, 1769, 1777, 2142, 2343, 2355, 2576, 3395, 3605], 'Ginhoux': [768], 'F.': [769, 1297, 1307, 1975, 2671, 3171, 3331, 3783, 4067], 'Studying': [770], 'vitro:': [774], 'iPSC-derived': [776], 'answer?.Nat.': [779], '18:': [783], '716-725Crossref': [784], '(17)': [787, 2477], 'Macrophage': [790, 815, 848, 924], 'polarization': [791, 849, 978, 1143, 1542, 2035, 2113, 2156, 2323, 2780, 2840, 2999, 3017, 3064, 3090, 3116, 3184, 3209, 3262, 3375, 3409, 3475, 3520, 3550, 3725, 3857, 4001], 'activated': [799, 833, 838, 2815, 2860], 'one': [801], 'different': [804, 866, 870, 2626, 2894, 3006], 'phenotypes': [805, 864, 1079], 'at': [806], 'times': [808], 'locations': [810], 'via': [811, 979, 1319, 2077, 2157, 2371, 2781, 3314, 3410, 4002], 'multiple': [812], 'signals.7Murray': [813], 'P.J.': [814, 923, 1775], 'polarization.Annu.': [816, 925], 'Physiol.': [818, 927, 2329, 2331, 3863, 3865], '79:': [820, 929], '541-566Crossref': [821, 930], '(381)': [824, 933], 'be': [829, 1507, 1691, 2656], 'polarized': [830], 'classically': [832], 'M1': [834, 872, 945, 976, 1070, 1095, 2605, 2627, 2803, 3434, 3518, 3553], 'or': [836, 1071, 2606], 'alternatively': [837], 'M2': [839, 901, 1000, 1035, 1072, 1104, 1897, 1946, 1959, 2012, 2047, 2101, 2130, 2154, 2220, 2257, 2303, 2320, 2341, 2424, 2629, 2669, 2918, 3016, 3063, 3141, 3183, 3213, 3260, 3374, 3407, 3440, 3474, 3589, 3642, 3691, 3724, 3836, 3854, 3999, 4153], 'macrophages.8Sica': [840], 'Erreni': [842], 'Allavena': [844], 'P.': [845, 963, 1533, 2052, 2526, 2681, 3781, 3785], 'Porta': [846], 'pathology.Cell.': [851], 'Mol.': [852], 'Life': [853], 'Sci.': [854], '72:': [856], '4111-4126Crossref': [857], '(208)': [860], 'These': [863], 'molecular': [867], 'characteristics': [868], 'functions.': [871], 'appear': [874], 'inflammatory': [877, 2945, 3484, 3734], 'environment': [878, 907, 1522], 'dominated': [879, 908], 'Toll-like': [881], 'receptors': [882], '(TLRs)': [883], 'interferon': [885], '(IFN)': [886], 'signaling': [887, 1587, 3235, 3383, 3542, 3684], 'pathways': [888], 'often': [891], 'associated': [892, 1115, 3524], 'responses': [895, 915], 'bacterial': [897], 'intracellular': [899], 'pathogens.': [900], 'TH2': [910], 'responses,': [911], 'worms': [917], 'asthma-': [919], 'allergy-inducing': [921], 'pathogens.7Murray': [922], 'Some': [936], 'studies': [937, 1054, 1678, 2795, 2980, 3103], 'observed': [939, 995, 1057], 'TAMs': [941, 997, 1059, 1083, 1092, 1240], 'present': [943, 998, 1093], 'phenotype,': [946, 1001, 1096], 'shown': [949, 1004, 1486, 1680, 2982, 3105], 'inhibit': [951, 1250, 3019], 'tumorigenesis,9Cheng': [952], 'Zhu': [954, 2019, 3074], 'Xu': [956, 958, 1536, 1929, 3598, 4136], 'Yang': [960, 2106, 2682, 3174], 'Chen': [962, 1300, 2025, 2686, 2808, 2810, 2853, 2855, 3080, 3166, 3172], 'Zhao': [964, 1902, 1933, 2676, 3024, 4140], 'Geng': [966], 'L.': [967, 1020, 1309, 1373, 1563, 1645, 1651, 1828, 1965, 2024, 2146, 2492, 2679, 2726, 3079, 3173, 3253, 3321, 3399, 4057], 'Gong': [968, 1294], 'S.': [969, 1299, 1653, 1713, 1718, 2184, 2222, 2224, 2461, 2515, 2758, 2768, 3167, 3451, 3644, 3646, 3701, 3777], 'PKCα': [970], 'colon': [972], 'promotes': [975, 1039, 1315, 1628, 2580, 2703, 3066, 3269, 3373, 3439, 3588], 'macrophage': [977, 1682, 1823, 2080, 2155, 2322, 2445, 2630, 2696, 2779, 2898, 2977, 3238, 3261, 3408, 3435, 3441, 3519, 3549, 3641, 3837, 3856, 4000], 'MKK3/6-P38': [980], 'MAPK': [981], 'pathway.Mol.': [982], 'Carcinog.': [983], '57:': [985], '1017-1029Crossref': [986], 'others': [993], 'tumorigenesis,10Zhou': [1007], 'Ke': [1009], 'S.Q.': [1010], 'Huang': [1011, 2139, 3392], 'Z.': [1012, 2148, 2394, 2484, 2568, 2689, 3401], 'Flavahan': [1013], 'Fang': [1015, 2391], 'X.': [1016, 1026, 1409, 1413, 1415, 1419, 1527, 1531, 1934, 1977, 2014, 2018, 2022, 2026, 2028, 2070, 2132, 2396, 2486, 3069, 3073, 3077, 3081, 3083, 3255, 3333, 3385, 3591, 4006, 4010, 4012, 4016, 4069, 4141], 'Paul': [1017], 'Wu': [1019, 2015, 2017, 3070, 3072], 'Sloan': [1021], 'A.E.': [1022], 'McLendon': [1023], 'R.E.': [1024], 'Li': [1025, 1412, 1976, 1980, 2393, 2489, 2493, 2567, 2672, 2690, 3170, 3254, 3332, 3336, 3508, 4009, 4068, 4072], 'et': [1027, 1141, 1179, 1218, 1272, 1310, 1719, 1982, 2071, 2197, 2737, 2940, 3338, 3610, 4074], 'al.Periostin': [1028], 'secreted': [1029, 1508, 1686, 2236, 2906, 2985, 3109, 3658], 'glioblastoma': [1031], 'stem': [1032], 'recruits': [1034], 'tumour-associated': [1036, 1145, 1183, 1276], 'malignant': [1040, 2820, 2865], 'growth.Nat.': [1041], '170-182Crossref': [1046], '(305)': [1049], 'behave': [1060], 'intermediate': [1063], 'state': [1064], 'not': [1065], 'committed': [1066], 'either': [1068], 'phenotype.': [1073], 'fact,': [1075], 'evolution': [1076], 'dynamic': [1086], 'process.': [1087], 'stage,': [1091], 'after': [1097], 'they': [1099, 2661], 'reprogrammed': [1101], 'phenotype': [1105, 2743, 2946], 'regulation': [1108, 1342], 'significantly': [1114, 3635], 'poor': [1117], 'prognosis': [1118], 'human': [1120, 2699], 'cancer.11Colegio': [1121], 'O.R.': [1122], 'Chu': [1123, 1127], 'N.Q.': [1124], 'Szabo': [1125], 'A.L.': [1126, 1215], 'Rhebergen': [1129], 'A.M.': [1130, 1565], 'Jairam': [1131], 'Cyrus': [1133], 'Brokowski': [1135], 'C.E.': [1136], 'Eisenbarth': [1137], 'S.C.': [1138], 'Phillips': [1139], 'G.M.': [1140], 'al.Functional': [1142], 'tumour-derived': [1148], 'lactic': [1149], 'acid.Nature.': [1150], '513:': [1152], '559-563Crossref': [1153], '(775)': [1156], 'Scholar,': [1158, 1197, 1559, 1605, 1641, 2713, 2756, 3200, 3223, 3251], '12Gordon': [1159], 'S.R.': [1160, 1253, 3595], 'Maute': [1161, 1254], 'R.L.': [1162, 1255], 'Dulken': [1163, 1256], 'B.W.': [1164, 1257], 'Hutter': [1165, 1258], 'George': [1167, 1260], 'B.M.': [1168, 1261], 'McCracken': [1169, 1262], 'M.N.': [1170, 1263], 'Gupta': [1171, 1264], 'R.': [1172, 1176, 1199, 1265, 1269, 2054, 2064, 2532, 2722, 2930, 2932, 3449, 3699], 'Tsai': [1173, 1266], 'J.M.': [1174, 1267, 3459, 3709], 'Sinha': [1175, 1268], 'Corey': [1177, 1270], 'D.': [1178, 1271, 1338, 1661, 1834, 1930, 1973, 3329, 3455, 3705, 4065, 4137], 'al.PD-1': [1180, 1273], 'expression': [1181, 1274, 2000, 3290, 3298, 3356, 3557, 3797, 4052, 4092], 'inhibits': [1185, 1278, 3149], 'phagocytosis': [1186, 1279], 'tumour': [1188, 1281, 1344], 'immunity.Nature.': [1189, 1282], '545:': [1191, 1284], '495-499Crossref': [1192, 1285], '(418)': [1195, 1288], '13Zaynagetdinov': [1198], 'Sherrill': [1200], 'T.P.': [1201], 'Polosukhin': [1202], 'V.V.': [1203], 'Han': [1204, 1927, 4134], 'Ausborn': [1206], 'J.A.': [1207], 'McLoed': [1208], 'A.G.': [1209], 'McMahon': [1210], 'F.G.': [1211], 'Gleaves': [1212], 'L.A.': [1213], 'Degryse': [1214], 'Stathopoulos': [1216], 'G.T.': [1217], 'al.A': [1219], 'promotion': [1225], 'urethane-induced': [1227], 'lung': [1228], 'carcinogenesis.J.': [1229], '2011;': [1231, 1322, 3938], '187:': [1232], '5703-5711Crossref': [1233], '(84)': [1236], 'M2-like': [1239, 2112], 'treatment': [1245], 'angiogenesis': [1248], 'immunity.12Gordon': [1252], 'Scholar,14Chen': [1290], 'Yao': [1292], 'Yu': [1296, 1966, 3322, 4058], 'Su': [1298, 1656, 2145, 3398], 'Liu': [1302, 1978, 2143, 2427, 2433, 2485, 3334, 3396, 4070], 'B.': [1303, 1700, 1932, 2062, 2144, 2178, 2307, 2388, 2560, 2673, 3397, 3841, 4139], 'Deng': [1304], 'H.': [1305, 1529, 1535, 1649, 1659, 1711, 1903, 1967, 2186, 2196, 2275, 2430, 2488, 2687, 2924, 3025, 3323, 3779, 4059], 'Wang': [1306, 1414, 1418, 1648, 1658, 1974, 2021, 2027, 2429, 2431, 2487, 2563, 2678, 3076, 3082, 3330, 3506, 3510, 3512, 4011, 4015, 4066], 'Lin': [1308, 1416, 1614, 1646, 2310, 2569, 3844, 4013], 'al.CCL18': [1311], 'breast': [1316, 1497, 1589, 3485, 3735], 'metastasis': [1318, 1629], 'PITPNM3.Cancer': [1320], 'Cell.': [1321, 3274], '19:': [1323], '541-555Abstract': [1324], 'Full': [1325, 1327, 1596, 1598, 2088, 2090, 3495, 3497, 3745, 3747, 3964, 3966], 'Text': [1326, 1328, 1597, 1599, 2089, 2091, 3496, 3498, 3746, 3748, 3965, 3967], 'PDF': [1329, 1600, 2092, 3499, 3749, 3968], '(289)': [1332], 'Scholar,15De': [1334], 'Palma': [1335], 'Biziato': [1337], 'Petrova': [1339], 'T.V.': [1340], 'Microenvironmental': [1341], 'angiogenesis.Nat.': [1345], 'Cancer.': [1347, 1551, 1668, 2410, 2748, 3937], '457-474Crossref': [1350], '(374)': [1353], 'Therefore,': [1356], 'plays': [1364, 3685], 'development': [1370], 'tumors.16Cassetta': [1372], 'Pollard': [1374], 'J.W.': [1375], 'Targeting': [1376, 3931], 'macrophages:': [1377], 'approaches': [1379], 'cancer.Nat.': [1381], 'Drug': [1383], 'Discov.': [1384], '887-904Crossref': [1387], '(158)': [1390], 'act': [1401], 'bridges': [1403], 'connecting': [1404], 'cells.17Chen': [1408], 'Zhou': [1410, 2389, 4007], 'derived': [1421, 1745, 1858, 2651, 3053, 3310, 4018], 'hypoxic': [1423, 4020], 'epithelial': [1424, 3986, 4021], 'ovarian': [1425, 2030, 2083, 3049, 3055, 3085, 3987, 4022], 'deliver': [1428, 2967, 4025], 'elicit': [1433, 4030], 'tumor-promoted': [1435, 4032], 'phenotype.Cancer': [1436, 4033], 'Lett.': [1437, 4034], '435:': [1439, 4036], '80-91Crossref': [1440, 4037], 'well': [1464], 'use': [1470], 'Studies': [1484], 'that,': [1487], 'cancers,': [1492], 'gastric': [1495, 1547, 2700], 'cancer,': [1496, 1498, 2902, 3050, 3369, 3627], 'hepatocellular': [1499], 'carcinoma': [1500, 2584, 3815], '(HCC),': [1501], 'nasopharyngeal': [1503, 1666], 'carcinoma,': [1504], 'regulate': [1513, 1871, 2662, 2976, 2997, 3114], 'function': [1515, 1839], 'neighboring': [1517], 'thus': [1519], 'creating': [1520], 'conducive': [1523], 'development.18Zhang': [1526], 'Shi': [1528], 'Yuan': [1530, 1616], 'Jiang': [1532, 1904, 2023, 2141, 3026, 3078, 3394], 'Qian': [1534], 'Tumor-derived': [1538, 2577, 2692], 'induce': [1540, 2402, 2602, 2668, 2694, 2802, 2915], 'N2': [1541], 'neutrophils': [1544], 'migration.Mol.': [1550], '146Crossref': [1554], '(6)': [1557], '19Luga': [1560], 'Zhang': [1562, 1608, 1908, 1935, 1968, 2069, 2135, 2185, 2680, 2806, 2851, 3030, 3324, 3388, 3454, 3704, 4060, 4142], 'Viloria-Petit': [1564], 'Ogunjimi': [1566], 'Inanlou': [1568], 'M.R.': [1569], 'Chiu': [1570], 'E.': [1571, 2068, 2357, 3225, 3227], 'Buchanan': [1572], 'Hosein': [1574], 'A.N.': [1575], 'Basik': [1576], 'Wrana': [1578], 'J.L.': [1579, 1832, 2611], 'mediate': [1581, 1762], 'stromal': [1582], 'mobilization': [1583], 'autocrine': [1585], 'Wnt-PCP': [1586], 'migration.Cell.': [1592], '2012;': [1593], '151:': [1594], '1542-1556Abstract': [1595], '(670)': [1603], '20Fang': [1606], 'J.H.': [1607, 3509], 'Z.J.': [1609], 'Shang': [1610], 'L.R.': [1611], 'Luo': [1612, 2133, 3386], 'Y.W.': [1613, 2265], 'Y.F.': [1615], 'Zhuang': [1618], 'Hepatoma': [1620], 'cell-secreted': [1621], 'microRNA-103': [1623], 'increases': [1624, 3614], 'vascular': [1625], 'permeability': [1626], 'targeting': [1631, 2078, 3257], 'junction': [1632], 'proteins.Hepatology.': [1633], '68:': [1635], '1459-1475Crossref': [1636], '(70)': [1639], '21Zhou': [1642], 'Xia': [1644], 'Oyang': [1650], 'Tan': [1652], 'Tian': [1654], 'Cao': [1660, 2137, 3390], 'Liao': [1662, 1770], 'Q.': [1663, 1901, 1928, 1979, 2016, 2020, 3023, 3071, 3075, 3335, 4071, 4135], 'carcinoma.J.': [1667, 2826, 2871], '9:': [1670, 2376, 2473, 2786], '767-777Crossref': [1671], '(12)': [1674], 'Recent': [1677], 'uptake': [1683, 1824], 'regulated': [1692, 3307, 3791, 3884], 'number': [1695], 'ways.22Hoshino': [1697], 'Costa-Silva': [1699], 'Shen': [1701], 'T.L.': [1702], 'Rodrigues': [1703], 'Hashimoto': [1705], 'Tesic': [1707], 'Mark': [1708, 2193], 'Molina': [1710, 2195], 'Kohsaka': [1712], 'Di': [1714, 2520], 'Giannatale': [1715], 'Ceder': [1717], 'al.Tumour': [1720], 'exosome': [1721, 2613], 'integrins': [1722], 'determine': [1723], 'organotropic': [1724], 'metastasis.Nature.': [1725], '527:': [1727], '329-335Crossref': [1728], '(1541)': [1731], 'For': [1734], 'example,': [1735, 2904], 'adhesion': [1738], 'molecule-1': [1739], '(ICAM-1)': [1740], 'enriched': [1742, 1863], 'pancreatic': [1747, 1785, 2161, 3368, 3414], 'ductal': [1748], 'adenocarcinoma': [1749, 2498], '(PDAC)': [1750], 'interacts': [1752], 'CD11c': [1754], 'exposed': [1755, 1815], 'docking': [1764], 'macrophages,23Linton': [1766], 'S.S.': [1767], 'Abraham': [1768], 'Clawson': [1772], 'Butler': [1774], 'Fox': [1776, 3602], 'Kester': [1778], 'Matters': [1780], 'G.L.': [1781], 'Tumor-promoting': [1782], 'effects': [1783, 2233, 3655, 3954], 'THP-1-derived': [1790], 'macrophages.PLoS': [1791, 3214], 'ONE.': [1792, 3215], '13:': [1794], 'e0206759Crossref': [1795], '(9)': [1798], 'regenerating': [1802], 'islet-derived': [1803], 'protein': [1804], '3β': [1805], '(REG3β),': [1806], 'paracarcinoma': [1809], 'tissue,': [1810], 'binds': [1811], 'glycoproteins': [1814], 'EVs,': [1820], 'interfering': [1821], 'these': [1826], 'EVs.24Bonjoch': [1827], 'Gironella': [1829], 'Iovanna': [1831], 'Closa': [1833], 'REG3β': [1835], 'modifies': [1836], 'impairing': [1841], 'vesicle': [1843], 'uptake.Sci.': [1844], 'Rep.': [1845, 2546], '7:': [1847, 2040, 2548, 2707, 3095], '3143Crossref': [1848], 'After': [1854], 'internalize': [1856], 'enter': [1867], 'polarization,': [1873, 1898, 1960, 2048, 3142, 3436], 'thereby': [1874, 3547, 3829], 'influencing': [1875], 'evasion': [1882], '(Figure': [1883], '1;': [1884], 'Table': [1885], '1).Table': [1886], '1The': [1887], 'Functions': [1888], 'Mechanisms': [1890], 'Cancer-Derived': [1892], 'MacrophagesCancerMoleculeMechanismFunctionReferencesHepatocellular': [1895], 'carcinomamiR-146a–promoting': [1896], 'evasion25Han': [1900], 'Yin': [1906, 2565, 3028], 'HCC-derived': [1910, 3032], 'exosomes:': [1911, 3033], 'player': [1913, 3035], 'escape.Cells.': [1919, 3041], '8:': [1921, 1952, 2592, 2958, 3043, 3217], 'E558Crossref': [1922, 3044], 'Scholar,26Yin': [1925], 'Zheng': [1931, 4138], 'SALL4-mediated': [1937, 4144], 'upregulation': [1938, 3155, 4145], 'miR-146a-5p': [1941, 4148], 'drives': [1942, 4149], 'T-cell': [1943, 4150], 'exhaustion': [1944, 4151], 'HCC.OncoImmunology.': [1950], '1601479Crossref': [1953], '(3)': [1956, 2254, 3676], 'ScholarmiR-23a-3pPTEN/PI3Kpromoting': [1958], 'evasion27Liu': [1962], 'Fan': [1964, 3320, 4056], 'He': [1970, 2312, 2684, 3326, 3846, 4062], 'Feng': [1972, 2573, 3328, 4064], 'al.Endoplasmic': [1983, 3339, 4075], 'reticulum': [1984, 3340, 3920, 3957, 4076], 'stress': [1985, 3341, 3958, 4077], 'causes': [1986, 3342, 4078], 'liver': [1987, 2457, 3343, 4079], 'release': [1991, 3347, 4046, 4083], 'miR-23a-3p': [1993, 3287, 3349, 4048, 4085], 'up-regulate': [1995, 3351, 4087], 'programmed': [1996, 3352, 4088], 'death': [1997, 3353, 4089], 'ligand': [1998, 3354, 4090], '1': [1999, 3355, 4091], 'macrophages.Hepatology.': [2002, 3358, 4094], '70:': [2004, 3360, 4096], '241-258Crossref': [2005, 3361, 4097], '(223)': [2008, 3364, 4100], 'ScholarOvarian': [2010], 'cancermiR-222-3p–promoting': [2011], 'polarization28Ying': [2013], 'Epithelial': [2029, 3084], 'cancer-secreted': [2031, 3086], 'miR-222-3p': [2033, 3052, 3088], 'induces': [2034, 2537, 3089, 3761, 3991], 'macrophages.Oncotarget.': [2038, 3093], '2016;': [2039, 2635, 3094, 3619], '43076-43087Crossref': [2041, 3096], '(102)': [2044, 3099], 'ScholarmiR-1246Cav1/p-gppromoting': [2046], 'resistance': [2049, 2076], 'against': [2050, 3480, 3730], 'paclitaxel29Kanlikilicer': [2051], 'Bayraktar': [2053, 2067], 'Denizli': [2055], 'Rashed': [2057], 'M.H.': [2058, 2107, 3601], 'Ivan': [2059], 'Aslan': [2061], 'Mitra': [2063], 'Karagoz': [2065], 'K.': [2066, 2136, 2273, 3229, 3231, 3389, 3609, 3773, 3787], 'al.Exosomal': [2072], 'miRNA': [2073, 2246, 3668], 'confers': [2074], 'chemo': [2075], 'Cav1/p-gp/M2-type': [2079], 'axis': [2081], 'cancer.EBioMedicine.': [2084], '38:': [2086], '100-112Abstract': [2087], 'ScholarHead': [2097], 'neck': [2099], 'cancermiR-21–promoting': [2100], 'polarization30Hsieh': [2102], 'C.H.': [2103], 'Tai': [2104], 'S.K.': [2105], 'Snail-overexpressing': [2108], 'delivering': [2118], 'miR-21-abundant': [2119], 'exosomes.Neoplasia.': [2120], '20:': [2122, 2250, 3672], '775-788Crossref': [2123], '(27)': [2126, 3535], 'ScholarPancreatic': [2128], 'cancermiR-301a-3pPTEN/PI3Kpromoting': [2129], 'polarization31Wang': [2131], 'Qiu': [2147, 3400], 'Hypoxic': [2149, 3402], 'tumor-derived': [2150, 3003, 3403], 'miR-301a': [2152, 3405], 'mediates': [2153, 3207, 3406], 'PTEN/PI3Kγ': [2158, 3411], 'metastasis.Cancer': [2163, 3416], 'Res.': [2164, 2448, 2830, 2875, 3191, 3417, 3618], '78:': [2166, 3419], '4586-4598Crossref': [2167, 3420], '(25)': [2170, 3423], 'ScholarMIF–promoting': [2172], 'pre-metastatic': [2173, 2202, 2620], 'niches': [2174], 'formation': [2175, 2204], 'metastasis32Costa-Silva': [2177], 'Aiello': [2179], 'N.M.': [2180], 'Ocean': [2181], 'A.J.': [2182, 2261], 'Singh': [2183, 2929], 'Thakur': [2187], 'B.K.': [2188], 'Becker': [2189], 'Hoshino': [2191], 'M.T.': [2194], 'al.Pancreatic': [2198], 'initiate': [2201], 'niche': [2203], 'liver.Nat.': [2207], '816-826Crossref': [2212], '(953)': [2215], 'ScholarProstate': [2217], 'cancer–integrin': [2218], 'signalingpromoting': [2219], 'polarization33Ferguson': [2221], 'Kim': [2223, 2264, 3645], 'Lee': [2225, 3647], 'Deci': [2227, 3649], 'Nguyen': [2229, 3651], 'phenotypic': [2232, 3654], 'distinct': [2238, 3660], 'cellular': [2239, 3661], 'sources:': [2240, 3662], 'comparative': [2242, 3664], 'study': [2243, 3665], 'based': [2244, 3666], 'composition.AAPS': [2247, 3669], '67Crossref': [2251, 3673], 'ScholarMFG-E8–promoting': [2256], 'polarization34Soki': [2258], 'F.N.': [2259], 'Koh': [2260], 'Jones': [2262], 'J.D.': [2263], 'Dai': [2266, 2491], 'Keller': [2268], 'E.T.': [2269], 'Pienta': [2270], 'K.J.': [2271], 'Atabai': [2272], 'Roca': [2274], 'McCauley': [2276], 'L.K.': [2277], 'Polarization': [2278], 'prostate': [2280, 2901, 2909, 2953, 3626], 'cancer-associated': [2281], 'induced': [2284, 2841], 'milk': [2286], 'fat': [2287], 'globule-EGF': [2288], 'factor': [2289, 3431, 4123], '8': [2290], '(MFG-E8)-mediated': [2291], 'efferocytosis.J.': [2292], 'Chem.': [2294], '289:': [2296], '24560-24572Crossref': [2297], '(79)': [2300], 'ScholarOSCCmiR-29a-3pSOCS1/STAT6promoting': [2302], 'polarization35Cai': [2304], 'Qiao': [2306, 3840], 'Gao': [2308, 3842], 'Oral': [2314, 3848], 'squamous': [2315, 2555, 2582, 2824, 2869, 3813, 3849], 'carcinoma-derived': [2317, 3851], 'subtype': [2321, 3855], 'mediated': [2324, 2631, 3858], 'exosome-enclosed': [2326, 3860], 'miR-29a-3p.Am.': [2327, 3861], '316:': [2333, 3867], 'C731-C740Crossref': [2334, 3868], '(7)': [2337, 2962, 3871], 'ScholarColon': [2339], 'cancermiR-1246–promoting': [2340], 'polarization36Cooks': [2342], 'Pateras': [2344], 'I.S.': [2345], 'Jenkins': [2346], 'L.M.': [2347], 'Patel': [2348], 'K.M.': [2349, 2720], 'Robles': [2350], 'A.I.': [2351], 'Morris': [2352], 'Forshew': [2354], 'Appella': [2356], 'Gorgoulis': [2358], 'V.G.': [2359], 'Harris': [2360], 'C.C.': [2361], 'Mutant': [2362], 'p53': [2363], 'cancers': [2364], 'reprogram': [2365], 'supporting': [2369], 'miR-1246.Nat.': [2373], 'Commun.': [2374], '771Crossref': [2377], '(92)': [2380], 'ScholarColorectal': [2382], 'cancerIRF-2inducing': [2383], 'macrophage-releasing': [2384], 'VEGFCpromoting': [2385], 'lymphatic': [2386, 2403], 'metastasis37Sun': [2387], 'Gu': [2395], 'Xiang': [2397, 3596], 'Colorectal': [2399], 'network': [2404], 'remodeling': [2405], 'lymph': [2407, 2621], 'nodes.Int.': [2408], '145:': [2412], '1648-1659Crossref': [2413], '(10)': [2416], 'ScholarLarge': [2418], 'B': [2419], 'lymphomaNSEinhibiting': [2421], 'NF-κB': [2422], 'activitypromoting': [2423], 'polarization38Zhu': [2425], 'M.Y.': [2426], 'W.J.': [2428], 'W.D.': [2432], 'N.W.': [2434], 'Lu': [2435], 'NSE': [2437], 'diffuse': [2439], 'large': [2440], 'B-cell': [2441, 3801], 'lymphoma': [2442], 'regulates': [2444, 3433], 'polarization.Cancer': [2446], 'Manag.': [2447], '11:': [2450, 3939], '4577-4595Crossref': [2451], '(1)': [2454], 'Scholaravβ5–promoting': [2456], 'metastasis39Paolillo': [2458], 'Schinelli': [2460], 'Integrins': [2462], 'dangerous': [2466], 'liaison': [2467], 'progression.Cancers': [2470], '(Basel).': [2471], 'E95Crossref': [2474], 'ScholarLung': [2479], 'adenocarcinomamiR-21targeting': [2480], 'Pdcd4promoting': [2481], 'bone': [2482, 2513], 'metastasis40Xu': [2483], 'Dong': [2495], 'Lung': [2497], 'cell-derived': [2499, 3995], 'miR-21': [2501], 'facilitates': [2502], 'osteoclastogenesis.Gene.': [2503], '666:': [2505], '116-122Crossref': [2506], '(19)': [2509], 'ScholarNSCLCAREGEGFR': [2511], 'pathwaypromoting': [2512], 'metastasis41Taverna': [2514], 'Pucci': [2516], 'Giallombardo': [2518], 'Bella': [2521], 'M.A.': [2522], 'Santarpia': [2523], 'Reclusa': [2525], 'Gil-Bazo': [2527], 'I.': [2528, 3775], 'Rolfo': [2529], 'Alessandro': [2531], 'Amphiregulin': [2533], 'contained': [2534], 'NSCLC-exosomes': [2536], 'osteoclast': [2538], 'differentiation': [2539], 'activation': [2542, 3129, 3239], 'EGFR': [2544], 'pathway.Sci.': [2545], '3170Crossref': [2549], '(39)': [2552], 'ScholarEsophageal': [2554], 'carcinomaHMGB1–promoting': [2557], 'evasion42Li': [2559], 'Song': [2561], 'T.N.': [2562], 'F.R.': [2564], 'J.P.': [2570], 'Meng': [2571], 'Y.Q.': [2572], 'H.M.': [2574], 'Jing': [2575], 'HMGB1': [2579], 'esophageal': [2581], 'progression': [2585, 3271], 'PD1+': [2588, 2695], 'TAM': [2589, 3186], 'expansion.Oncogenesis.': [2590], '17Crossref': [2593], '(15)': [2596], 'ScholarMelanoma–inducing': [2598], 'endothelial': [2599, 2616], 'GM-CSF': [2600, 2618], 'HIF-1α': [2603], 'HIF-2α': [2607], 'M2promoting': [2609], 'angiogenesis43Hood': [2610], 'Melanoma': [2612], 'induction': [2614], 'nodes': [2622], 'may': [2623, 2842], 'result': [2624], 'angiogenic': [2632], 'processes.Med.': [2633], 'Hypotheses.': [2634], '94:': [2636], '118-122Crossref': [2637], 'Scholar–,': [2640], 'unknown.': [2641, 2649], 'Open': [2642], 'table': [2643], 'tab': [2647], '–,': [2648], 'internalized': [2657], 'where': [2660], 'polarization.': [2663, 2899, 2978], 'cases,': [2666], 'polarization,44Wang': [2670], 'Wei': [2674], 'Jiao': [2688], 'population': [2697], 'disease': [2704], 'progression.Oncogenesis.': [2705], '41Crossref': [2708], '45de': [2714], 'Vrij': [2715], 'Maas': [2717], 'S.L.': [2718], 'Kwappenberg': [2719], 'Schnoor': [2721], 'Kleijn': [2723], 'Dekker': [2725], 'Luider': [2727], 'T.M.': [2728], 'de': [2729], 'Witte': [2730], 'L.D.': [2731], 'Litjens': [2732], 'van': [2734, 2933], 'Strien': [2735], 'M.E.': [2736], 'al.Glioblastoma-derived': [2738], 'modify': [2741], 'monocytic': [2745], 'cells.Int.': [2746], '137:': [2750], '1630-1642Crossref': [2751], '(82)': [2754], '46Ham': [2757], 'Lima': [2759], 'L.G.': [2760], 'Chai': [2761], 'E.P.Z.': [2762], 'Muller': [2763], 'Lobb': [2765], 'R.J.': [2766], 'Krumeich': [2767], 'Wen': [2769], 'S.W.': [2770], 'Wiegmans': [2771], 'A.P.': [2772], 'Möller': [2773, 3784], 'Breast': [2775], 'cancer-derived': [2776, 2799], 'alter': [2778], 'gp130/STAT3': [2782], 'signaling.Front.': [2783], '871Crossref': [2787], '(26)': [2790, 2836, 2881], 'confirmed': [2797], 'polarization.47Xiao': [2804], 'M1-like': [2812, 2857], 'exosome-transferred': [2817, 2862], 'THBS1': [2818, 2863], 'migration': [2821, 2866], 'oral': [2823, 2868, 3812], 'Exp.': [2827, 2872], 'Clin.': [2828, 2873], 'Cancer': [2829, 2874, 2965, 3190], '37:': [2832, 2877], '143Crossref': [2833, 2878], 'depend': [2843], 'stage': [2846], 'cancer.47Xiao': [2849], 'Different': [2884, 3002], 'lines': [2886], 'same': [2889], 'type': [2890], 'secrete': [2893, 3880, 3982], 'activate': [2897], 'African-American': [2908], '(PCa)': [2911], 'e006aa-ht': [2912], 'strongly': [2914], 'pro-inflammatory': [2917], 'phenotype.48Panigrahi': [2919], 'G.K.': [2920], 'Praharaj': [2921], 'P.P.': [2922], 'Kittaka': [2923], 'Mridha': [2925], 'A.R.': [2926, 3445, 3695], 'Black': [2927], 'O.M.': [2928, 3443, 3693], 'Mercer': [2931], 'Bokhoven': [2934], 'Torkko': [2936], 'K.C.': [2937], 'Agarwal': [2938], 'al.Exosome': [2941], 'proteomic': [2942], 'analyses': [2943], 'identify': [2944], 'novel': [2948], 'biomarkers': [2949], 'African': [2951], 'American': [2952], 'patients.Cancer': [2955], 'Med.': [2956], '1110-1123Crossref': [2959], '(miRNAs)': [2972], 'Numerous': [2979], 'carry': [2989, 3005], 'miRNAs': [2990, 2993, 3108, 3631, 3882, 3992], 'miRNAs.': [3007, 3984], 'HCC,': [3009, 3285, 4042], 'miR-146a': [3010], 'enrichment': [3011], 'T': [3020], 'function.25Han': [3022], 'effective': [3060], 'regulator': [3061], 'development.28Ying': [3068], 'Further': [3102], 'pathways.': [3123], 'Researches': [3124], 'reported': [3126], 'phosphatidylinositol': [3132], '3-kinase': [3133], '(PI3K)/AKT': [3134], 'way': [3139], 'phosphatase': [3144], 'tensin': [3146], 'homolog': [3147], '(PTEN)': [3148], 'PI3K/AKT': [3151], 'pathway,': [3152], 'suppressing': [3153], 'M2-related': [3157], 'genes,': [3158], 'CD68,': [3161], 'CD204,': [3162], 'arginase-1.49Lian': [3164], 'Ouyang': [3168], 'Colon': [3176], 'secretes': [3179], 'EGF': [3180], 'EGFR/PI3K/AKT/mTOR': [3188], 'pathway.Technol.': [3189], 'Treat.': [3192], '18': [3194], '(1533033819849068)Crossref': [3195], '(4)': [3198], '50Rocher': [3201], 'Singla': [3203], 'D.K.': [3204], 'SMAD-PI3K-Akt-mTOR': [3205], 'BMP-7': [3208], 'monocytes': [3211], '2013;': [3216], 'e84009Crossref': [3218], '(64)': [3221], '51Vergadi': [3224], 'Ieronymaki': [3226], 'Lyroni': [3228], 'Vaporidi': [3230], 'Tsatsanis': [3232], 'Akt': [3234], 'M1/M2': [3241], 'polarization.J.': [3242], '198:': [3245], '1006-1014Crossref': [3246], '(156)': [3249], '52Bao': [3252], 'MicroRNA-32': [3256], 'PTEN': [3258, 3289, 3378], 'enhances': [3259], 'glioma': [3265], 'further': [3268], 'glioma.Mol.': [3273], '460:': [3277], '67-79Crossref': [3278], '(2)': [3281], 'downregulates': [3288], 'upregulates': [3293], 'phosphorylated': [3294], 'AKT': [3295], 'PD-L1': [3297, 3305, 4051], 'macrophages,': [3300], 'suggesting': [3301], 'expressing': [3304], 'HCC': [3312, 4044], 'miR-23a/PTEN/AKT': [3317], 'pathway.27Liu': [3318], 'hypoxia-related': [3370], 'miR-301a-3p': [3372], 'inhibiting': [3377], 'activating': [3380], 'PI3Kγ': [3382], 'pathway.31Wang': [3384], 'STAT1': [3426, 3541, 3568, 3574], 'main': [3429], 'transcriptional': [3430, 3897], 'STAT6': [3438, 3471, 3545, 3564, 3576, 3683, 3721, 3767, 3788, 3832], 'polarization.53Rahal': [3442, 3692], 'Wolfe': [3444, 3694], 'Mandal': [3446, 3696], 'P.K.': [3447, 3697], 'Larson': [3448, 3698], 'Tin': [3450, 3700], 'Jimenez': [3452, 3702], 'Horton': [3456, 3706], 'Reuben': [3458, 3708], 'McMurray': [3460, 3710], 'J.S.': [3461, 3711], 'Woodward': [3462, 3712], 'W.A.': [3463, 3713], 'Blocking': [3464, 3714], 'interleukin': [3465, 3715], '(IL)4-': [3466, 3716], 'IL13-mediated': [3468, 3718], 'phosphorylation': [3469, 3719], '(Tyr641)': [3472, 3722], 'decreases': [3473, 3723], 'protects': [3479, 3729], 'macrophage-mediated': [3481, 3731], 'radioresistance': [3482, 3732], 'cancer.Int.': [3486, 3736], 'Radiat.': [3488, 3738], 'Phys.': [3491, 3741], '100:': [3493, 3743], '1034-1043Abstract': [3494, 3744], 'Scholar,54Gan': [3504], 'Z.S.': [3505], 'Q.Q.': [3507], 'X.L.': [3511], 'Y.Z.': [3513], 'Du': [3514], 'H.H.': [3515], 'Iron': [3516], 'reduces': [3517], 'RAW264.7': [3522], 'inhibition': [3526], 'STAT1.Mediators': [3528], 'Inflamm.': [3529], '2017:': [3531], '8570818Crossref': [3532], 'Integrin': [3538], 'β3': [3539, 3560, 3583, 3613, 3638], 'activates': [3540], 'suppresses': [3544], 'signaling,': [3546], 'promoting': [3548, 3690, 3835], 'type.': [3554], 'However,': [3555], 'integrin': [3559, 3582, 3612, 3637], 'promoted': [3562], 'inhibited': [3566], 'maintain': [3570], 'balance': [3572, 3586], 'signal': [3577, 3833], 'transduction.': [3578], 'loss': [3580], 'disrupts': [3584], 'polarization.55Su': [3590], 'Esser': [3592], 'A.K.': [3593], 'Amend': [3594], 'Ross': [3600], 'G.C.': [3603], 'Kobayashi': [3604], 'Steri': [3606], 'Roomp': [3608], 'al.Antagonizing': [3611], 'immunosuppression': [3615], 'cancer.Cancer': [3617], '76:': [3620], '3484-3495Crossref': [3621], 'abundant': [3630], 'PC3': [3633], 'downregulate': [3636, 3826], 'expression,': [3639, 3828], 'polarization.33Ferguson': [3643], 'It': [3679], 'known': [3681], 'SOCS1': [3755, 3824], 'contains': [3756], 'SH2': [3758], 'domain': [3759], 'proteasomal': [3762], 'degradation,': [3763], 'suppress': [3766], 'signaling.56Ritz': [3768], 'O.': [3769], 'Guiter': [3770], 'Dorsch': [3772], 'Dusanter-Fourt': [3774], 'Wegener': [3776], 'Jouault': [3778], 'Gaulard': [3780], 'Castellano': [3782], 'Leroy': [3786], 'activity': [3789], 'SOCS-1': [3793], 'modulates': [3795], 'BCL-XL': [3796], 'primary': [3799], 'mediastinal': [3800], 'lymphoma.Leukemia.': [3802], '2008;': [3803], '22:': [3804], '2106-2110Crossref': [3805], '(OSCC),': [3816], 'OSCC-derived': [3817], 'captured': [3820], 'miR-29a-3p': [3821], 'directly': [3822], 'its': [3827], 'stimulating': [3830], 'polarization.35Cai': [3838], 'factors,': [3887], 'including': [3888], 'physicochemical': [3890, 3902], 'features': [3891, 3903], 'factors.': [3898], 'One': [3899], 'hypoxia,': [3908], 'harmful': [3911], 'interferes': [3913], 'ability': [3916], 'endoplasmic': [3919, 3956], '(ER)': [3921], 'fold': [3923], 'causing': [3925], 'ER': [3926], 'stress.57Wilson': [3927], 'W.R.': [3928], 'Hay': [3929], 'M.P.': [3930], 'hypoxia': [3932, 3990], 'therapy.Nat.': [3935], '393-410Crossref': [3940], '(1594)': [3943], 'Scholar,58Cubillos-Ruiz': [3945], 'J.R.': [3946], 'Bettigole': [3947], 'S.E.': [3948], 'Glimcher': [3949], 'L.H.': [3950], 'Tumorigenic': [3951], 'immunosuppressive': [3953], 'cancer.Cell.': [3960], '168:': [3962], '692-706Abstract': [3963], '(203)': [3971], 'Both': [3974], 'them': [3976], '(EOC),': [3989], 'EOC': [3994], 'hypoxia-inducible': [4003], 'factors': [4004, 4107, 4129], '(HIFs).17Chen': [4005], 'ER-stressed': [4043], 'upregulate': [4050], 'macrophages.27Liu': [4054], 'addition,': [4104], 'transcription': [4106, 4122, 4128], 'affect': [4109], 'secretion': [4115], 'miRNA,': [4118], 'spalt-like': [4121], '4': [4124], '(SALL4),': [4125], 'epithelial-to-mesenchymal': [4126], 'transition-activating': [4127], '(EMT-TFs),': [4130], 'p53.26Yin': [4132], 'HCC.OncoImmu': [4157]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3034921165', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 20}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 5}], 'updated_date': '2024-12-13T23:35:19.812523', 'created_date': '2020-06-19'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
