Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3034489156', 'doi': 'https://doi.org/10.1073/pnas.1920109117', 'title': 'The AAA+ ATPase Msp1 is a processive protein translocase with robust unfoldase activity', 'display_name': 'The AAA+ ATPase Msp1 is a processive protein translocase with robust unfoldase activity', 'publication_year': 2020, 'publication_date': '2020-06-15', 'ids': {'openalex': 'https://openalex.org/W3034489156', 'doi': 'https://doi.org/10.1073/pnas.1920109117', 'mag': '3034489156', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32541053', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7334508'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1920109117', 'pdf_url': 'https://www.pnas.org/content/pnas/117/26/14970.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.pnas.org/content/pnas/117/26/14970.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5084313216', 'display_name': 'Dominic T. Castanzo', 'orcid': 'https://orcid.org/0009-0005-2974-4737'}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}, {'id': 'https://openalex.org/I103922791', 'display_name': 'QB3', 'ror': 'https://ror.org/04n1n3n22', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I103922791', 'https://openalex.org/I180670191', 'https://openalex.org/I185103710', 'https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dominic T. Castanzo', 'raw_affiliation_strings': ['California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720;', 'Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;', 'institution_ids': ['https://openalex.org/I95457486']}, {'raw_affiliation_string': 'California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720;', 'institution_ids': ['https://openalex.org/I95457486', 'https://openalex.org/I103922791']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053372977', 'display_name': 'Benjamin LaFrance', 'orcid': 'https://orcid.org/0000-0003-0229-5255'}, 'institutions': [{'id': 'https://openalex.org/I103922791', 'display_name': 'QB3', 'ror': 'https://ror.org/04n1n3n22', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I103922791', 'https://openalex.org/I180670191', 'https://openalex.org/I185103710', 'https://openalex.org/I95457486']}, {'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Benjamin LaFrance', 'raw_affiliation_strings': ['California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720;', 'Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;'], 'affiliations': [{'raw_affiliation_string': 'California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720;', 'institution_ids': ['https://openalex.org/I103922791', 'https://openalex.org/I95457486']}, {'raw_affiliation_string': 'Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;', 'institution_ids': ['https://openalex.org/I95457486']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5050274752', 'display_name': 'Andreas Martin', 'orcid': 'https://orcid.org/0000-0003-0923-3284'}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}, {'id': 'https://openalex.org/I103922791', 'display_name': 'QB3', 'ror': 'https://ror.org/04n1n3n22', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I103922791', 'https://openalex.org/I180670191', 'https://openalex.org/I185103710', 'https://openalex.org/I95457486']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Andreas Martin', 'raw_affiliation_strings': ['California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720;', 'Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;', 'Howard Hughes Medical Institute, University of California, Berkeley, CA 94720'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;', 'institution_ids': ['https://openalex.org/I95457486']}, {'raw_affiliation_string': 'California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720;', 'institution_ids': ['https://openalex.org/I103922791', 'https://openalex.org/I95457486']}, {'raw_affiliation_string': 'Howard Hughes Medical Institute, University of California, Berkeley, CA 94720', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I95457486']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5050274752'], 'corresponding_institution_ids': ['https://openalex.org/I95457486', 'https://openalex.org/I103922791', 'https://openalex.org/I1344073410'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.575, 'has_fulltext': False, 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.999982, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '117', 'issue': '26', 'first_page': '14970', 'last_page': '14977'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11072', 'display_name': 'Peroxisome Proliferator-Activated Receptors', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/random-hexamer', 'display_name': 'Random hexamer', 'score': 0.9620203}, {'id': 'https://openalex.org/keywords/aaa-proteins', 'display_name': 'AAA proteins', 'score': 0.9161354}, {'id': 'https://openalex.org/keywords/translocase', 'display_name': 'Translocase', 'score': 0.7485814}], 'concepts': [{'id': 'https://openalex.org/C189754071', 'wikidata': 'https://www.wikidata.org/wiki/Q7291972', 'display_name': 'Random hexamer', 'level': 2, 'score': 0.9620203}, {'id': 'https://openalex.org/C101635128', 'wikidata': 'https://www.wikidata.org/wiki/Q4649768', 'display_name': 'AAA proteins', 'level': 4, 'score': 0.9161354}, {'id': 'https://openalex.org/C113035283', 'wikidata': 'https://www.wikidata.org/wiki/Q909555', 'display_name': 'Translocase', 'level': 4, 'score': 0.7485814}, {'id': 'https://openalex.org/C23265538', 'wikidata': 'https://www.wikidata.org/wiki/Q300033', 'display_name': 'ATPase', 'level': 3, 'score': 0.6385344}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.57935464}, {'id': 'https://openalex.org/C127078168', 'wikidata': 'https://www.wikidata.org/wiki/Q138639', 'display_name': 'Peroxisome', 'level': 3, 'score': 0.4979601}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49472567}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.49404147}, {'id': 'https://openalex.org/C2777289219', 'wikidata': 'https://www.wikidata.org/wiki/Q7632154', 'display_name': 'Substrate (aquarium)', 'level': 2, 'score': 0.4261161}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.2845803}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.062117815}, {'id': 'https://openalex.org/C138626823', 'wikidata': 'https://www.wikidata.org/wiki/Q916504', 'display_name': 'Chromosomal translocation', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000251', 'descriptor_name': 'Adenosine Triphosphatases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000251', 'descriptor_name': 'Adenosine Triphosphatases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000251', 'descriptor_name': 'Adenosine Triphosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000251', 'descriptor_name': 'Adenosine Triphosphatases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020675', 'descriptor_name': 'Peroxisomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020675', 'descriptor_name': 'Peroxisomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020675', 'descriptor_name': 'Peroxisomes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000072417', 'descriptor_name': 'Protein Domains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1920109117', 'pdf_url': 'https://www.pnas.org/content/pnas/117/26/14970.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://escholarship.org/uc/item/2hw191r7', 'pdf_url': 'https://escholarship.org/content/qt2hw191r7/qt2hw191r7.pdf?t=rw0s9w', 'source': {'id': 'https://openalex.org/S4306400115', 'display_name': 'eScholarship (California Digital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2801248553', 'host_organization_name': 'California Digital Library', 'host_organization_lineage': ['https://openalex.org/I2801248553'], 'host_organization_lineage_names': ['California Digital Library'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334508', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32541053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1920109117', 'pdf_url': 'https://www.pnas.org/content/pnas/117/26/14970.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320306082', 'funder_display_name': 'Howard Hughes Medical Institute', 'award_id': '-'}, {'funder': 'https://openalex.org/F4320337354', 'funder_display_name': 'National Institute of General Medical Sciences', 'award_id': 'R01-GM094497'}], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1517653810', 'https://openalex.org/W1973872724', 'https://openalex.org/W2025221127', 'https://openalex.org/W2059029715', 'https://openalex.org/W2073158371', 'https://openalex.org/W2075824676', 'https://openalex.org/W2086356615', 'https://openalex.org/W2091634027', 'https://openalex.org/W2095083734', 'https://openalex.org/W2106728955', 'https://openalex.org/W2108920131', 'https://openalex.org/W2109283736', 'https://openalex.org/W2116568781', 'https://openalex.org/W2148306017', 'https://openalex.org/W2213968760', 'https://openalex.org/W2408373435', 'https://openalex.org/W2507744702', 'https://openalex.org/W2545780796', 'https://openalex.org/W2605050533', 'https://openalex.org/W2735420073', 'https://openalex.org/W2763915801', 'https://openalex.org/W2782500865', 'https://openalex.org/W2796883998', 'https://openalex.org/W2908579890', 'https://openalex.org/W2921659605', 'https://openalex.org/W2925591784', 'https://openalex.org/W2953320394', 'https://openalex.org/W2979976361', 'https://openalex.org/W69814808'], 'related_works': ['https://openalex.org/W4388540922', 'https://openalex.org/W4376646906', 'https://openalex.org/W4213274926', 'https://openalex.org/W3175319794', 'https://openalex.org/W3034489156', 'https://openalex.org/W3016409291', 'https://openalex.org/W2793719545', 'https://openalex.org/W2607322700', 'https://openalex.org/W2320129280', 'https://openalex.org/W2170866385'], 'abstract_inverted_index': {'Significance': [0], 'The': [1, 86], 'AAA+': [2, 101], 'ATPase': [3, 43, 77], 'Msp1': [4, 42, 58], 'has': [5], 'previously': [6], 'been': [7], 'shown': [8], 'to': [9, 36], 'function': [10], 'in': [11, 79], 'the': [12, 19, 38, 72, 76, 94, 100], 'quality': [13], 'control': [14], 'of': [15, 28, 41, 75], 'tail-anchored': [16], 'proteins': [17, 48], 'at': [18, 93], 'mitochondrial': [20], 'and': [21, 45, 67, 103], 'peroxisomal': [22, 87], 'membranes,': [23], 'yet': [24], 'its': [25, 69], 'detailed': [26], 'mechanisms': [27], 'substrate': [29, 53, 105], 'processing': [30], 'have': [31], 'remained': [32], 'unknown.': [33], 'Using': [34], 'scaffolds': [35], 'stabilize': [37], 'functional': [39], 'hexamer': [40, 78, 102], 'domains': [44], 'various': [46], 'model': [47], 'derived': [49], 'from': [50], 'Msp1’s': [51, 91], 'endogenous': [52], 'Pex15,': [54], 'we': [55], 'show': [56], 'that': [57, 64], 'is': [59], 'a': [60], 'promiscuous': [61], 'protein': [62, 88], 'translocase': [63], 'mechanically': [65], 'unfolds': [66], 'pulls': [68], 'substrates': [70], 'through': [71], 'central': [73], 'pore': [74], 'an': [80], 'N-to-C': [81], 'or': [82], 'C-to-N': [83], 'terminal': [84], 'direction.': [85], 'Pex3': [89], 'modulates': [90], 'activity': [92], 'peroxisome': [95], 'by': [96], 'directly': [97], 'interacting': [98], 'with': [99], 'inhibiting': [104], 'threading.': [106]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3034489156', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2025-01-10T08:05:45.945808', 'created_date': '2020-06-19'}