Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3034262391', 'doi': 'https://doi.org/10.3389/fbioe.2020.00601', 'title': 'A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency', 'display_name': 'A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency', 'publication_year': 2020, 'publication_date': '2020-06-10', 'ids': {'openalex': 'https://openalex.org/W3034262391', 'doi': 'https://doi.org/10.3389/fbioe.2020.00601', 'mag': '3034262391', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32656194', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7326002'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fbioe.2020.00601', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fbioe.2020.00601/pdf', 'source': {'id': 'https://openalex.org/S2595131146', 'display_name': 'Frontiers in Bioengineering and Biotechnology', 'issn_l': '2296-4185', 'issn': ['2296-4185'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.frontiersin.org/articles/10.3389/fbioe.2020.00601/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034332883', 'display_name': 'S. M. Naqvi', 'orcid': 'https://orcid.org/0000-0002-0492-3801'}, 'institutions': [{'id': 'https://openalex.org/I188760350', 'display_name': 'Ollscoil na Gaillimhe – University of Galway', 'ror': 'https://ror.org/03bea9k73', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I188760350']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Syeda Masooma Naqvi', 'raw_affiliation_strings': ['Mechanobiology and Medical Device Research Group, Department of Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Mechanobiology and Medical Device Research Group, Department of Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland', 'institution_ids': ['https://openalex.org/I188760350']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027165903', 'display_name': 'Juan Alberto Panadero Pérez', 'orcid': 'https://orcid.org/0000-0002-3296-642X'}, 'institutions': [{'id': 'https://openalex.org/I188760350', 'display_name': 'Ollscoil na Gaillimhe – University of Galway', 'ror': 'https://ror.org/03bea9k73', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I188760350']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Juan Alberto Panadero Pérez', 'raw_affiliation_strings': ['Mechanobiology and Medical Device Research Group, Department of Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Mechanobiology and Medical Device Research Group, Department of Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland', 'institution_ids': ['https://openalex.org/I188760350']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018501569', 'display_name': 'Vatsal Kumar', 'orcid': 'https://orcid.org/0000-0003-1302-328X'}, 'institutions': [{'id': 'https://openalex.org/I188760350', 'display_name': 'Ollscoil na Gaillimhe – University of Galway', 'ror': 'https://ror.org/03bea9k73', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I188760350']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Vatsal Kumar', 'raw_affiliation_strings': ['Mechanobiology and Medical Device Research Group, Department of Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Mechanobiology and Medical Device Research Group, Department of Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland', 'institution_ids': ['https://openalex.org/I188760350']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058588353', 'display_name': 'Anneke S.K. Verbruggen', 'orcid': 'https://orcid.org/0000-0002-1805-2453'}, 'institutions': [{'id': 'https://openalex.org/I188760350', 'display_name': 'Ollscoil na Gaillimhe – University of Galway', 'ror': 'https://ror.org/03bea9k73', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I188760350']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Anneke S. K. Verbruggen', 'raw_affiliation_strings': ['Mechanobiology and Medical Device Research Group, Department of Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Mechanobiology and Medical Device Research Group, Department of Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland', 'institution_ids': ['https://openalex.org/I188760350']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5020169130', 'display_name': 'Laoise M. McNamara', 'orcid': 'https://orcid.org/0000-0002-5050-9230'}, 'institutions': [{'id': 'https://openalex.org/I188760350', 'display_name': 'Ollscoil na Gaillimhe – University of Galway', 'ror': 'https://ror.org/03bea9k73', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I188760350']}], 'countries': ['IE'], 'is_corresponding': True, 'raw_author_name': 'Laoise M. McNamara', 'raw_affiliation_strings': ['Mechanobiology and Medical Device Research Group, Department of Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Mechanobiology and Medical Device Research Group, Department of Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland', 'institution_ids': ['https://openalex.org/I188760350']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5020169130'], 'corresponding_institution_ids': ['https://openalex.org/I188760350'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 2.832, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.999915, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '8', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12110', 'display_name': 'Role of Osteopontin in Biomineralization and Inflammation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12110', 'display_name': 'Role of Osteopontin in Biomineralization and Inflammation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11219', 'display_name': 'Molecular Mechanisms of Osteoclast Differentiation and Bone Remodeling', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10071', 'display_name': 'Osteoporosis', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2732', 'display_name': 'Orthopedics and Sports Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/osteocyte', 'display_name': 'Osteocyte', 'score': 0.8269472}, {'id': 'https://openalex.org/keywords/osteoblast-differentiation', 'display_name': 'Osteoblast Differentiation', 'score': 0.582494}, {'id': 'https://openalex.org/keywords/osteoclast-differentiation', 'display_name': 'Osteoclast Differentiation', 'score': 0.547714}], 'concepts': [{'id': 'https://openalex.org/C7876069', 'wikidata': 'https://www.wikidata.org/wiki/Q14873666', 'display_name': 'Paracrine signalling', 'level': 3, 'score': 0.85563004}, {'id': 'https://openalex.org/C2780973866', 'wikidata': 'https://www.wikidata.org/wiki/Q913236', 'display_name': 'Osteocyte', 'level': 4, 'score': 0.8269472}, {'id': 'https://openalex.org/C2778260815', 'wikidata': 'https://www.wikidata.org/wiki/Q917177', 'display_name': 'Osteoblast', 'level': 3, 'score': 0.6811378}, {'id': 'https://openalex.org/C2777164284', 'wikidata': 'https://www.wikidata.org/wiki/Q277954', 'display_name': 'Estrogen', 'level': 2, 'score': 0.5158369}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5105925}, {'id': 'https://openalex.org/C111696902', 'wikidata': 'https://www.wikidata.org/wiki/Q6864413', 'display_name': 'Mineralization (soil science)', 'level': 3, 'score': 0.4801304}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4516607}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.35235673}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.33733463}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26413548}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.13703614}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1113728}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10552716}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C537208039', 'wikidata': 'https://www.wikidata.org/wiki/Q627', 'display_name': 'Nitrogen', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fbioe.2020.00601', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fbioe.2020.00601/pdf', 'source': {'id': 'https://openalex.org/S2595131146', 'display_name': 'Frontiers in Bioengineering and Biotechnology', 'issn_l': '2296-4185', 'issn': ['2296-4185'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/b5430d5764a74684b69ae9a52e9b9fd6', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7326002', 'pdf_url': 'https://europepmc.org/articles/pmc7326002?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10147/630331', 'pdf_url': 'https://www.lenus.ie/bitstream/10147/630331/1/fbioe-08-00601.pdf', 'source': {'id': 'https://openalex.org/S4306401756', 'display_name': 'Lenus, The Irish Health Repository (Dr Steevens Hospital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32656194', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fbioe.2020.00601', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fbioe.2020.00601/pdf', 'source': {'id': 'https://openalex.org/S2595131146', 'display_name': 'Frontiers in Bioengineering and Biotechnology', 'issn_l': '2296-4185', 'issn': ['2296-4185'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6', 'score': 0.81}], 'grants': [{'funder': 'https://openalex.org/F4320320847', 'funder_display_name': 'Science Foundation Ireland', 'award_id': None}, {'funder': 'https://openalex.org/F4320321056', 'funder_display_name': 'Irish Research Council', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 158, 'referenced_works': ['https://openalex.org/W148120292', 'https://openalex.org/W1511542029', 'https://openalex.org/W1530300192', 'https://openalex.org/W1531951748', 'https://openalex.org/W1580813094', 'https://openalex.org/W1784605649', 'https://openalex.org/W1791004502', 'https://openalex.org/W1920644532', 'https://openalex.org/W1963803769', 'https://openalex.org/W1965470981', 'https://openalex.org/W1967072141', 'https://openalex.org/W1967879663', 'https://openalex.org/W1968344552', 'https://openalex.org/W1970779600', 'https://openalex.org/W1970864109', 'https://openalex.org/W1972568078', 'https://openalex.org/W1974660371', 'https://openalex.org/W1974706978', 'https://openalex.org/W1976319789', 'https://openalex.org/W1977577042', 'https://openalex.org/W1978413495', 'https://openalex.org/W1981298061', 'https://openalex.org/W1982395713', 'https://openalex.org/W1983425256', 'https://openalex.org/W1985564086', 'https://openalex.org/W1985848199', 'https://openalex.org/W1988406815', 'https://openalex.org/W1990526837', 'https://openalex.org/W1991128088', 'https://openalex.org/W1991334000', 'https://openalex.org/W1991919076', 'https://openalex.org/W1992607963', 'https://openalex.org/W1994398946', 'https://openalex.org/W1995849174', 'https://openalex.org/W1996161852', 'https://openalex.org/W1998837192', 'https://openalex.org/W2001069153', 'https://openalex.org/W2005074915', 'https://openalex.org/W2008698339', 'https://openalex.org/W2008763172', 'https://openalex.org/W2010827915', 'https://openalex.org/W2011828467', 'https://openalex.org/W2012246056', 'https://openalex.org/W2013293643', 'https://openalex.org/W2014225480', 'https://openalex.org/W2018560747', 'https://openalex.org/W2019196925', 'https://openalex.org/W2019582558', 'https://openalex.org/W2020300493', 'https://openalex.org/W2020392462', 'https://openalex.org/W2020852091', 'https://openalex.org/W2022641698', 'https://openalex.org/W2023237068', 'https://openalex.org/W2025592015', 'https://openalex.org/W2028794801', 'https://openalex.org/W2028910660', 'https://openalex.org/W2029859781', 'https://openalex.org/W2035170119', 'https://openalex.org/W2038050797', 'https://openalex.org/W2039223695', 'https://openalex.org/W2045497567', 'https://openalex.org/W2046832422', 'https://openalex.org/W2047978012', 'https://openalex.org/W2054218371', 'https://openalex.org/W2054958748', 'https://openalex.org/W2059153388', 'https://openalex.org/W2059668536', 'https://openalex.org/W2062638851', 'https://openalex.org/W2064282853', 'https://openalex.org/W2065115529', 'https://openalex.org/W2068014772', 'https://openalex.org/W2072128657', 'https://openalex.org/W2072893401', 'https://openalex.org/W2074028842', 'https://openalex.org/W2074898328', 'https://openalex.org/W2075562454', 'https://openalex.org/W2077411147', 'https://openalex.org/W2079088633', 'https://openalex.org/W2082234046', 'https://openalex.org/W2084152511', 'https://openalex.org/W2086511139', 'https://openalex.org/W2094003039', 'https://openalex.org/W2095599499', 'https://openalex.org/W2099923692', 'https://openalex.org/W2100323821', 'https://openalex.org/W2102124563', 'https://openalex.org/W2104192993', 'https://openalex.org/W2104440688', 'https://openalex.org/W2104779362', 'https://openalex.org/W2105240389', 'https://openalex.org/W2105502019', 'https://openalex.org/W2108244474', 'https://openalex.org/W2108704056', 'https://openalex.org/W2108910200', 'https://openalex.org/W2115238892', 'https://openalex.org/W2127385187', 'https://openalex.org/W2130447245', 'https://openalex.org/W2130804510', 'https://openalex.org/W2134670075', 'https://openalex.org/W2134880640', 'https://openalex.org/W2137080510', 'https://openalex.org/W2137191057', 'https://openalex.org/W2138889138', 'https://openalex.org/W2139088926', 'https://openalex.org/W2140683077', 'https://openalex.org/W2141783706', 'https://openalex.org/W2142475814', 'https://openalex.org/W2143956064', 'https://openalex.org/W2145430157', 'https://openalex.org/W2146728938', 'https://openalex.org/W2148595955', 'https://openalex.org/W2148785592', 'https://openalex.org/W2151072481', 'https://openalex.org/W2153738010', 'https://openalex.org/W2153753616', 'https://openalex.org/W2153971800', 'https://openalex.org/W2158815446', 'https://openalex.org/W2160287478', 'https://openalex.org/W2160726243', 'https://openalex.org/W2162236787', 'https://openalex.org/W2163120917', 'https://openalex.org/W2169386958', 'https://openalex.org/W2170034857', 'https://openalex.org/W2172224570', 'https://openalex.org/W2191751320', 'https://openalex.org/W2300220838', 'https://openalex.org/W2326648613', 'https://openalex.org/W2335702929', 'https://openalex.org/W2376475013', 'https://openalex.org/W2395258336', 'https://openalex.org/W2398680031', 'https://openalex.org/W2427479068', 'https://openalex.org/W2531652035', 'https://openalex.org/W2598044883', 'https://openalex.org/W2731310897', 'https://openalex.org/W2741282806', 'https://openalex.org/W2760850930', 'https://openalex.org/W2765810049', 'https://openalex.org/W2777939879', 'https://openalex.org/W2782854611', 'https://openalex.org/W2791290079', 'https://openalex.org/W2806705495', 'https://openalex.org/W2841068772', 'https://openalex.org/W2887425822', 'https://openalex.org/W2889686274', 'https://openalex.org/W2905495415', 'https://openalex.org/W2922256857', 'https://openalex.org/W2946942886', 'https://openalex.org/W296442853', 'https://openalex.org/W2967126422', 'https://openalex.org/W2989054308', 'https://openalex.org/W2990020847', 'https://openalex.org/W3010765523', 'https://openalex.org/W4232934018', 'https://openalex.org/W4233274199', 'https://openalex.org/W4253903652', 'https://openalex.org/W570158762', 'https://openalex.org/W601907569'], 'related_works': ['https://openalex.org/W4200398779', 'https://openalex.org/W3201644517', 'https://openalex.org/W2507544731', 'https://openalex.org/W2284004751', 'https://openalex.org/W2166846841', 'https://openalex.org/W2081071444', 'https://openalex.org/W2070862472', 'https://openalex.org/W2041863225', 'https://openalex.org/W1970727713', 'https://openalex.org/W1543082153'], 'abstract_inverted_index': {'Recent': [0], 'in': [1, 32, 71, 90, 100, 104, 118, 140, 222, 247, 254, 286, 295], 'vitro': [2, 287], 'studies': [3, 27], 'have': [4], 'revealed': [5], 'that': [6, 155], 'the': [7, 37, 160, 252, 273, 291], 'mechanobiological': [8], 'responses': [9], 'of': [10, 39, 162, 210, 249, 263, 275], 'osteoblasts': [11, 264], 'and': [12, 51, 58, 78, 121, 127, 132, 164, 199, 225, 231, 239, 282], 'osteocytes': [13, 266], 'are': [14, 42], 'fundamentally': [15], 'impaired': [16], 'during': [17, 267], 'estrogen': [18, 66, 94, 107, 113, 179, 185, 223, 268, 276, 299], 'deficiency.': [19, 300], 'However,': [20], 'these': [21], 'two': [22], 'dimensional': [23, 48], '(2D)': [24], 'cell': [25, 124, 280], 'culture': [26, 103, 125], 'do': [28], 'not': [29], 'account': [30], 'for': [31, 166, 206], 'vivo': [33], 'biophysical': [34], 'cues.': [35], 'Thus,': [36], 'objectives': [38], 'this': [40, 61], 'study': [41], 'to': [43, 63, 69, 73, 182, 289], '(1)': [44, 105], 'develop': [45], 'a': [46, 56, 141, 245, 284], 'three': [47], '(3D)': [49], 'osteoblast': [50, 72], 'osteocyte': [52, 74, 156, 167], 'model': [53, 62, 288], 'integrated': [54], 'into': [55], 'bioreactor': [57, 146], '(2)': [59, 110], 'apply': [60], 'investigate': [64, 290], 'whether': [65], 'deficiency': [67, 277], 'leads': [68], 'changes': [70, 294], 'transition,': [75], 'mechanosensation,': [76], 'mineralisation': [77], 'paracrine': [79, 204], 'signaling': [80, 205, 256], 'associated': [81, 202], 'with': [82, 93, 203], 'bone': [83, 279, 296], 'resorption': [84], 'by': [85, 159, 260], 'osteoclasts.': [86], 'MC3T3-E1s': [87], 'were': [88, 98, 116, 136, 219, 233], 'expanded': [89], 'media': [91], 'supplemented': [92], '(17β-estradiol).': [95], 'These': [96, 134, 270], 'cells': [97, 297], 'encapsulated': [99], 'gelatin-mtgase': [101], 'before': [102], 'continued': [106], '(E)': [108], 'or': [109, 147, 265], 'no': [111], 'further': [112], 'supplementation.': [114], 'Constructs': [115], 'placed': [117], 'gas': [119], 'permeable': [120], 'water': [122], 'impermeable': [123], 'bags': [126, 135], 'maintained': [128, 148], 'at': [129, 236], '5%': [130], 'CO2': [131], '37ºC.': [133], 'either': [137], 'mechanically': [138, 226], 'stimulated': [139, 227], 'custom': [142], 'Hydrostatic': [143], 'Pressure': [144], '(HP)': [145], 'under': [149, 178, 183], 'static': [150], 'conditions': [151], '(control).': [152], 'We': [153], 'report': [154], 'differentiation,': [157], 'characterized': [158], 'presence': [161], 'dendrites': [163], 'staining': [165], 'marker': [168], 'dentin': [169], 'matrix': [170], 'acidic': [171], 'phosphoprotein': [172], '1': [173, 238], '(DMP1),': [174], 'was': [175], 'significantly': [176, 220], 'greater': [177], 'withdrawal': [180], 'compared': [181], 'continuous': [184], 'treatment': [186], '(day': [187], '21).': [188], 'Mineralization': [189], '(bone': [190], 'sialoprotein': [191], '(BSP),': [192], 'osteopontin': [193], '(OPN),': [194], 'alkaline': [195], 'phosphatase': [196], '(ALP),': [197], 'calcium': [198], 'gene': [200], 'expression': [201], 'osteoclastogenesis': [207], '(receptor': [208], 'activator': [209], 'nuclear': [211], 'factor': [212], 'kappa-β': [213], 'ligand': [214], '(RANKL)/': [215], 'osteoprotegerin': [216], 'OPG': [217], 'ratio)': [218], 'increased': [221, 235], 'deficient': [224], 'cells.': [228], 'Interestingly': [229], 'BSP': [230], 'DMP-1': [232], 'also': [234], 'day': [237, 240], '21': [241], 'respectively,': [242], 'which': [243], 'play': [244], 'role': [246], 'regulation': [248], 'biomineralization.': [250], 'Furthermore,': [251], 'increase': [253], 'pro-osteoclastogenic': [255], 'may': [257], 'be': [258], 'explained': [259], 'altered': [261], 'mechanoresponsiveness': [262], 'withdrawal.': [269], 'findings': [271], 'highlight': [272], 'impact': [274], 'on': [278], 'function': [281], 'provide': [283], 'novel': [285], 'mechanisms': [292], 'underpinning': [293], 'after': [298]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3034262391', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-09-13T03:46:25.715492', 'created_date': '2020-06-19'}