Multiomics Evaluation of Gastrointestinal and Other Clinical Characteristics of COVID-19

Name: Work Video:
Duration: 3 min 30 s
Mulong Du; Guoshuai Cai; Feng Chen; David C. Christiani; Zhengdong Zhang; Meilin Wang
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2206, 2250], 'extracted': [626, 1481, 1633, 2058], 'genome-wide': [627, 2202], 'summary': [630, 2219, 2388], 'statistics': [631, 2220], '3000': [635], 'single-nucleotide': [636], 'polymorphisms': [637], 'assigned': [638], '33': [640, 1646, 2015, 2757], 'genes': [641, 1570, 2016, 2056, 2619], 'pathway': [645, 671, 1062, 2041, 2178, 2362], '3).': [657, 696, 715, 2050], 'pathway-based': [660], 'level,': [661, 701], 'modest': [677], 'performance': [678, 2378], 'prediction': [681, 2382], 'model': [682], 'nephrotic': [684, 735, 2262], '(area': [686], 'under': [687, 2836, 2862], 'receiver': [689, 2838, 2864], 'operating': [690, 2839, 2865], 'characteristic': [691, 2840, 2866], 'curve,': [692], '0.607)': [693], 'Partitioned': [697], 'gene-based': [700], 'joint': [704], 'effect': [705, 2174], 'each': [707, 1753, 1825, 2084, 2233, 2506, 2585], 'extended': [709], 'different': [711], 'disorders': [718], 'excretory': [723, 1121, 2270], 'systems,': [724], 'TGFB1': [725], 'associated': [727], 'colorectal': [729, 2260], 'cancer,': [730, 2261], 'ACE': [731], 'MAPK3': [733], 'syndrome,': [736, 2263], 'KLK1': [738], 'KNG1': [740], 'urolithiasis.': [742], 'Similarly,': [743], 'blood': [746, 1542, 2278], 'parameters,': [748, 2280], 'along': [750, 2086], 'ENPEP,': [752, 1067], 'only': [757], 'Alb.': [759], 'On': [760], 'basis': [762], 'prior': [764], 'evidence': [765, 992], 'suggesting': [766], 'that': [767, 795, 830, 890, 956, 982, 1049, 1981, 2189], 'entry': [771, 1093], 'into': [774, 904, 1096, 1571, 1722, 2358, 2460], 'cells,2Hoffmann': [775], 'previously': [793], 'smokers': [802], 'nonsmokers,': [805], 'especially': [806, 970], 'distinct': [808], 'types.7Cai': [811], 'G.': [812], 'al.Am': [814], 'J': [815, 857, 1032], 'Respir': [816], 'Crit': [817], 'Care': [818], 'Med.': [819, 858, 934, 1033], 'This': [823], 'corroborated': [825], 'observation': [829], 'cases': [835, 1416, 1432, 1439, 1454], 'likely': [840], 'smoking': [844], 'history': [845], '(22.1%)': [846], 'nonsevere': [850], '(13.1%).1Guan': [852], 'W.J.': [853, 1028], 'al.N': [855, 1030], 'Engl': [856, 1031], '382:': [860, 1035], '1708-1720Crossref': [861, 1036], '(20562)': [864, 1039], 'confirmed': [872, 1431], 'tract;': [882], 'therefore,': [883], 'mutual': [885], 'interaction': [886], 'potentially': [887], 'occurred': [888], 'such': [889], 'disrupted': [892], 'activity,': [894], 'infected': [895], 'epithelium': [898], 'cytotoxicity,': [901], 'shed': [903], 'feces,': [905], 'resulting': [906], 'manifestations': [909], 'and/or': [910], 'stool.4Xiao': [914], 'Scholar,8Xu': [930], 'Y.': [931], 'al.Nat': [933], '26:': [936], '502-505Crossref': [937], '(1078)': [940], 'Considering': [943, 1980], 'physiologic': [945], 'renewal': [946], 'every': [950, 1605], '4–5': [951], 'days,': [952], 'our': [953], 'results': [954], 'warn': [955], 'attention': [958], 'must': [959], 'given': [961], 'possibility': [964, 1130], 'SARS-CoV-2,': [969], 'carriers.': [973], 'indicated': [981], 'viral': [983], 'shedding': [984], 'urine': [987], 'feasible;': [989], 'actual': [995], 'urine.4Xiao': [1001], 'Nevertheless,': [1018], 'impairment': [1020], 'COVID-19,1Guan': [1027], 'damaged': [1051], 'tubular': [1053], 'induced': [1056], 'disruption': [1058], 'referring': [1063], 'ACE,': [1066], 'TGFB1,': [1068], 'THOP1,': [1069], 'MAS1,': [1070], 'NLN': [1072], 'involved': [1073], 'dysfunction.': [1076], 'summary,': [1078], 'kidney—more': [1086], 'specifically,': [1087], 'epithelium—could': [1090], 'mediate': [1091], 'accumulate': [1099], 'cause': [1101], 'cytotoxicity': [1102], 'does': [1104], 'respond': [1106], 'nonsteroidal': [1108], 'anti-inflammatory': [1109], 'drugs.': [1110], 'It': [1111], 'reasonable': [1113], 'emphasize': [1115], 'monitoring': [1117], 'system': [1122, 2271], 'complications': [1123], 'individuals': [1139], 'suspected': [1141], '4).': [1148], 'authors': [1150, 1179, 1218], 'acknowledge': [1151], 'Professor': [1152], 'David': [1153, 1350], 'C.': [1154, 1351], 'Christiani': [1155], '(Departments': [1156], 'Environmental': [1158, 1232], 'Health': [1159], 'Department': [1161], 'Epidemiology,': [1163, 1259], 'Harvard': [1164, 1193], 'T.H.': [1165, 1194], 'Chan': [1166, 1195], 'School': [1167, 1196, 1295], 'Public': [1169, 1198, 1297], 'Health)': [1170, 1199], 'as': [1171, 2294], 'senior': [1173], 'author': [1174], 'study.': [1177], 'would': [1180, 1219], 'like': [1181, 1220], 'thank': [1183, 1222], 'Dr': [1184], 'Duo': [1185], 'Peng': [1186, 1255], '(Department': [1187, 1230, 1257, 1272, 1288], 'Immunology': [1189], 'Infectious': [1191, 1263], 'Diseases,': [1192, 1264], 'his': [1201], 'helpful': [1202], 'advice': [1203], 'comments': [1205], 'notion': [1208], 'project': [1211, 1581, 1600, 1764], 'editing': [1213], 'manuscript.': [1216], 'Junyi': [1223], 'Xin,': [1224], 'Shuai': [1225], 'Ben,': [1226], 'Silu': [1228], 'Chen': [1229], 'Genomics,': [1233], 'Jiangsu': [1234], 'Key': [1235, 1260], 'Laboratory': [1236, 1261], 'Cancer': [1238, 1247, 1617, 1642, 1736, 1760], 'Biomarkers,': [1239], 'Prevention': [1240], 'Treatment,': [1242], 'Collaborative': [1243], 'Innovation': [1244], 'Center': [1245, 1291, 2062], 'Personalized': [1248], 'Medicine,': [1249], 'Nanjing': [1250, 1265, 1280, 1299, 2427], 'Medical': [1251, 1266, 1281, 1300, 2428], 'University,': [1252, 1267, 1282, 1301], 'Nanjing,': [1253, 1268, 1283, 1302], 'China),': [1254, 1269, 1284], 'Huang': [1256], 'Qiang': [1270], 'Cao': [1271], 'Urology,': [1274], 'First': [1276], 'Affiliated': [1277], 'Hospital': [1278], 'Lijuan': [1286], 'Lin': [1287], 'Biostatistics,': [1290], 'Global': [1293], 'Health,': [1294, 1298], 'China)': [1303], 'their': [1305], 'invaluable': [1306], 'contributions': [1307], 'article.': [1310], 'Mulong': [1311], 'Du,': [1312], 'PhD': [1313, 1325, 1339, 1364, 1371], '(Conceptualization:': [1314, 1365, 1372], 'Equal;': [1315, 1330, 1355, 1366, 1373, 1376], 'Methodology:': [1316], 'Lead;': [1317, 1328], 'Writing': [1318, 1331, 1344, 1356], '–': [1319, 1332, 1345, 1357], 'original': [1320, 2414], 'draft:': [1321], 'Lead);': [1322, 1368], 'Guoshuai': [1323], 'Cai,': [1324], '(Formal': [1326], 'analysis:': [1327], 'Investigation:': [1329], 'review': [1333, 1346, 1358, 2424], '&': [1334, 1347, 1359], 'editing:': [1335, 1348, 1360], 'Supporting);': [1336, 1349, 1361], 'Feng': [1337], 'Chen,': [1338], '(Supervision:': [1340, 1354], 'Supporting;': [1341, 1343], 'Visualization:': [1342], 'Christiani,': [1352], 'MD': [1353], 'Zhengdong': [1362], 'Zhang,': [1363], 'Supervision:': [1367, 1377], 'Meilin': [1369], 'Wang,': [1370], 'Funding': [1374], 'acquisition:': [1375], 'Supporting)': [1378], 'resource': [1394], '(https://tinyurl.com/s6gsq5y),1Xu': [1395], '(169)': [1411], 'including': [1414, 1676, 1768, 2281], '26,357': [1415], 'worldwide.': [1417], 'analyzed': [1419], 'downloaded': [1423], 'Feb': [1425], '23,': [1426], '2020,': [1427], 'enrolled': [1429, 1536], '14,729': [1430], 'Hubei,': [1434], 'Wuhan': [1435], 'province,': [1436], '11,628': [1438], 'around': [1445], 'world.': [1447], 'built': [1457], 'using': [1458, 1734, 1755, 1845, 2045, 2334], 'plotly': [1459], 'shiny': [1461], 'packages': [1462], 'R': [1465], 'library': [1466], '(R': [1467], 'Core': [1468], 'Team,': [1469], 'Vienna,': [1470], 'Austria).': [1471], 'consensus': [1473], 'normalized': [1474], 'value': [1476, 2117], 'combined': [1484], 'transcriptomics': [1485], 'Human': [1489, 1547], 'Protein': [1490, 1548], 'Atlas,2Uhlen': [1491], 'al.Science.': [1494], '2015;': [1495, 1527, 1710, 2151, 2347], '347:': [1496], '1260419Crossref': [1497], '(9189)': [1500], 'Genotype': [1503, 1578], 'Tissue': [1504, 1579], 'Expression,3Nat': [1505], 'Genet.': [1506], '2013;': [1507], '45:': [1508, 1664], '580-585Crossref': [1509], '(5350)': [1512], 'Functional': [1516, 1594], 'Annotation': [1517, 1595, 2339], 'Mammalian': [1520, 1598], 'Genome,4Yu': [1521], 'N.Y.': [1522], 'al.Nucleic': [1524, 1660], 'Acids': [1525, 1661], 'Res.': [1526, 1662], '43:': [1528], '6787-6798Crossref': [1529], '(81)': [1532], '55': [1537], 'types': [1539, 1648], '6': [1541], 'types.': [1544], 'Briefly,': [1545, 1833], 'Atlas': [1549, 1619, 1809], 'provided': [1550, 1765, 2079], 'profiles': [1554, 1627], 'approximately': [1556], '40': [1557], 'kinds': [1558], 'cells,': [1560], 'tissues,': [1561], 'human': [1566, 1607, 2405, 2512, 2589], 'body': [1567], 'grouped': [1569, 1720, 2518], 'categories': [1572], 'describing': [1573], 'specificity.': [1576], 'Expression': [1580, 1622, 1653, 1674, 1808], 'samples': [1583], '54': [1585], 'nondiseased': [1586], 'sites': [1588], 'nearly': [1590], '1000': [1591, 2074], 'individuals.': [1592], 'Genome': [1599, 1618, 1643], 'major': [1606, 1677], 'organ': [1608], '200': [1612, 2196], 'cancer': [1613, 1647], 'Gene': [1621, 1652, 1673], 'Omnibus': [1623], 'also': [1624, 2372], 'normal': [1637], 'Atlas,': [1644], 'spanning': [1645], 'Profiling': [1654], 'Interactive': [1655, 1813], 'Analysis': [1656, 2336, 2776], 'platform,5Tang': [1657], 'Z.': [1658, 1692], '2017;': [1663, 1925], 'W98-W102Crossref': [1665], '(6435)': [1668], 'Omnibus,': [1675], '(GSE2361,6Ge': [1679], 'X.': [1680, 2038], 'al.Genomics.': [1682], '2005;': [1683], '86:': [1684], '127-141Crossref': [1685], '(215)': [1688], 'GSE7905,7Dezso': [1691], 'al.BMC': [1694], 'Biol.': [1695, 2346], '2008;': [1696], '6:': [1697, 1711, 2152], '49Crossref': [1698], '(158)': [1701], 'GSE715718Thomas': [1705], 'S.S.': [1706, 2147], 'al.Genom': [1708, 2149], 'Data.': [1709, 2150], '154-158Crossref': [1712, 2153], '(7)': [1715, 2156], 'Scholar).': [1717, 1954], 'subtypes': [1724], 'intestine,': [1725], 'kidney,': [1726], 'according': [1729], 'progenitor': [1733], 'Cell': [1737, 1761, 1807], 'Line': [1738, 1762], 'Encyclopedia': [1739, 1763, 1965, 2141, 2210], 'differential': [1744], 'subgroup': [1754, 2587], 'test.': [1758], 'data,': [1767], 'transcriptome9Barretina': [1769], 'al.Nature.': [1772, 1924, 2161], '2012;': [1773, 2162], '483:': [1774, 2163], '603-607Crossref': [1775, 2164], '(5504)': [1778, 2167], 'proteome,10Nusinow': [1782], 'D.P.': [1783], '180:': [1787], '387-402Abstract': [1788], '(475)': [1796], 'covering': [1799], '1100': [1800], 'used': [1804, 2131, 2259, 2373], 'Single': [1806], '(https://www.ebi.ac.uk/gxa/sc/home)': [1810], 'Kidney': [1812], 'Transcriptomics': [1814], '(http://humphreyslab.com/SingleCell/)': [1815], 'visualize': [1817], 'cluster': [1827], 'kidney.': [1832, 2447, 2577], 'sequencing': [1836, 2435], 'InDrop,': [1847], 'DropSeq,': [1848], 'or': [1849, 2198, 2225, 2361], '10×': [1850], 'Chromium': [1851], 'platforms,': [1852], 'distribution': [1855], 'subgroups': [1863, 2504], '(including': [1868, 1915], '4524': [1869], 'nuclei': [1870, 1895, 1937], 'complete': [1872], 'tissues11Wu': [1874], 'al.Cell': [1877], 'Stem': [1878], 'Cell.': [1879], '2018;': [1880, 1905], '23:': [1881], '869-881Abstract': [1882], '(362)': [1890], '4259': [1894], 'epithelia12Wu': [1898], 'al.J': [1901, 1943], 'Am': [1902, 1944], 'Soc': [1903, 1945], 'Nephrol.': [1904, 1946], '29:': [1906], '2069-2080Crossref': [1907], '(255)': [1910], 'Scholar)': [1912], '1522': [1916], 'epithelia13Haber': [1921], 'A.L.': [1922], '551:': [1926], '333-339Crossref': [1927], '(954)': [1930], '11,395': [1934], 'epithelia14Wu': [1940], '2019;': [1947, 2393], '30:': [1948], '23-32Crossref': [1949], '(386)': [1952], 'key': [1956], 'pathways': [1957], 'containing': [1958], 'Kyoto': [1964], 'Genes': [1967, 2758], 'Genomes': [1969, 2075], '(Renin-angiotensin': [1970], 'system;': [1971], 'hsa04614)': [1972], 'PathCards': [1974], '(ACE': [1975], 'Inhibitor': [1976], 'Pathway,': [1977], 'Pharmacodynamics': [1978], 'SuperPath).': [1979], 'TMPRSS2': [1982], 'cooperate': [1984], 'enable': [1988], 'enter': [1992], 'host': [1994], 'cells,15Hoffmann': [1995], '(13712)': [2009], 'ultimately': [2013], 'included': [2014], 'network': [2020, 2042, 2625], '2),': [2027], 'ATP6AP2,': [2031], 'AGTR2': [2033], 'located': [2035], 'chromosome': [2037], 'STRING': [2046, 2629], '(https://string-db.org/)': [2047, 2630], 'Genomic': [2051], 'information': [2052, 2082], 'candidate': [2055, 2267, 2359], 'National': [2061], 'Biotechnology': [2064], 'Information': [2065], 'assembly': [2066], 'GRCh': [2068], '37': [2069], '2).': [2072], 'Projects': [2076], '(phase': [2077], '3)': [2078], 'gene,': [2085], 'following': [2089], 'quality': [2090], 'control': [2091], 'criteria': [2092], 'selecting': [2094], 'variants': [2096, 2357], 'underlying': [2097, 2387], 'east': [2098], 'Asian': [2099, 2134], 'ancestry': [2100], '(CHB:': [2101], 'Han': [2102], 'Chinese': [2103], 'Beijing,': [2105], 'China;': [2106], 'JPT:': [2107], 'Japanese': [2108, 2140, 2209], 'Tokyo,': [2110], 'Japan):': [2111], 'minor': [2112], 'allele': [2113], 'frequency': [2114], '>0.01,': [2115], 'Hardy-Weinberg': [2119], 'equilibrium': [2120], '>1.0': [2121], '10–6,': [2123], 'genotyping': [2125], 'call': [2126], 'rate': [2127], '>95%.': [2128], 'initially': [2130], 'largest': [2133], 'database,': [2138], 'Genetic': [2143, 2212, 2780], 'Associations': [2144, 2213], 'Riken,8Thomas': [2146], 'Scholar,9Barretina': [2158], 'evaluate': [2171, 2365, 2376], 'process': [2188], 'occurs': [2190], 'ACE2-enriched': [2192], 'traits': [2197], 'diseases': [2199], 'Riken,': [2215], 'logistic': [2224], 'linear': [2226], 'regression': [2227], 'nucleotide': [2235, 2850, 2876], 'polymorphism': [2236], 'phenotypes.': [2238], 'When': [2239], 'mapping': [2240], 'set,': [2257], 'urolithiasis': [2265], 'diseases.': [2272], 'addition,': [2274], 'albumin/globulin': [2283], 'ratio': [2284], 'Albumin,': [2287], 'C-reactive': [2288], 'protein,': [2289], 'total': [2291], 'concentrations,': [2293], 'reflections': [2295], "patients'": [2297], 'health': [2298], 'conditions': [2299], 'terms': [2301], 'COVID-19.18Chen': [2307], 'N.': [2308], 'al.Lancet.': [2310], 'To': [2314], 'avoid': [2315], 'unexplainable': [2316], 'weak': [2318], 'effects': [2319], 'variant': [2324], 'phenotype,': [2327], 'thus': [2329], 'Multi-marker': [2335], 'genomic': [2338], '(MAGMA),19de': [2340], 'Leeuw': [2341], 'C.A.': [2342], 'al.PLoS': [2344], 'Comput': [2345], '11e1004219Crossref': [2348], '(1574)': [2351], 'aggregated': [2355], 'sets,': [2363], 'predict': [2367], 'susceptibility.': [2370], 'SummaryAUC': [2374], 'polygenic': [2380], 'risk': [2381], 'models': [2383], 'binary': [2385], 'outcomes': [2386], 'statistics.20Song': [2389], 'L.': [2390], 'al.Bioinformatics.': [2392], '35:': [2394], '4038-4044Crossref': [2395], '(11)': [2398], 'All': [2401], 'public': [2402], 'databases': [2403], 'involving': [2404], 'participants': [2406], 'approved': [2408, 2420], 'ethics': [2411], 'committees': [2412], 'studies,': [2415], 'institutional': [2423], 'board': [2425], 'University': [2429], '(NJMUIRB': [2430], '-2020-020).Supplementary': [2431], '2Single-cell': [2433], 'showing': [2437], '(A)': [2448], 'tSNE': [2449, 2500], 'plot': [2450, 2501], 'epithelial': [2454], 'subgroups.': [2456], 'Cells': [2457, 2485, 2510, 2561], 'partitioned': [2459], '9': [2461], 'groups:': [2462], 'early': [2463], 'enterocyte': [2464, 2468], 'progenitor,': [2465, 2469], 'enterocyte,': [2466], 'late': [2467], 'stem': [2470], 'cell,': [2471, 2473, 2475, 2477, 2479], 'tuft': [2472], 'endocrine': [2474], 'goblet': [2476], 'Paneth': [2478], 'transit': [2481], 'amplifying': [2482], 'cell.': [2483], '(B)': [2484], 'expressing': [2486, 2562], 'colored': [2490, 2565], 'blue,': [2491], 'indicating': [2492, 2567], 'enterocytes.': [2498], '(C)': [2499], 'set.': [2509], 'mouse': [2514, 2591], 'anatomy:': [2521], 'ascending': [2522], 'limb': [2523, 2537], '(AL),': [2524], 'collecting': [2525], 'duct–principal': [2526], '(CD-PC),': [2528], 'connecting': [2529], '(CNT),': [2531], 'distal': [2532], 'convoluted': [2533], '(DCT/DT),': [2535], 'descending': [2536], '(DL),': [2538], 'endothelial': [2539], '(EC),': [2541], 'intercalated': [2542], '(IC),': [2544], 'loop': [2545], 'Henle': [2547], '(LH),': [2548], 'mesangial': [2549], '(MC),': [2551], 'macrophage': [2552], '(MΦ),': [2553], 'podocyte': [2554], '(Pod/P),': [2555], '(PT).': [2559], '(D)': [2560], 'red,': [2566], '(E)': [2578], 'abundance': [2580], 'kidneys.': [2592], 'avg,': [2593], 'average;': [2594], 'exp,': [2595], 'expression;': [2596], 'CPM,': [2597], 'counts': [2598], 'per': [2599], 'million;': [2600], 'pct,': [2601], 'percent;': [2602], 'tSNE,': [2603], 't-distributed': [2604], 'stochastic': [2605], 'neighbor': [2606], 'embedding.View': [2607], 'Large': [2608, 2635, 2665], 'Image': [2609, 2636, 2666], 'ViewerDownload': [2611, 2638, 2668], 'Hi-res': [2612, 2639, 2669], 'image': [2613, 2640, 2670], 'Download': [2614, 2641, 2671], '(PPT)Supplementary': [2615, 2642, 2672], '3Network': [2617], 'default': [2633], 'parameters.View': [2634], '4Schematic': [2644], 'evaluating': [2650], 'infection,': [2652], 'accumulation,': [2653], 'hosts.': [2657], 'diagram': [2659], 'BioRender': [2663], '(https://biorender.com/).View': [2664], '1Clinical': [2674], 'Characteristics': [2675], 'Patients': [2677], 'Infected': [2678], 'With': [2679], 'SARS-CoV-2CharacteristicsPatients': [2680], 'HubeiPatients': [2682], 'Hubein': [2685], '39%n': [2687], '359%Age,': [2689], 'y': [2690], '<1800.00123.34': [2691], '18–2900.004412.26': [2692], '30–3912.567320.33': [2693], '40–4925.137320.33': [2694], '50–59410.266518.11': [2695], '60–691128.215615.60': [2696], '70–79923.08143.90': [2697], '≥801128.2151.39Sex': [2698], 'Male2666.6720155.99': [2699], 'Female1333.3314841.23Countries': [2700], 'Belgium10.28': [2701], 'Cambodia10.28': [2702], 'China25671.31': [2703], 'France30.84': [2704], 'Germany10.28': [2705], 'Italy10.28': [2706], 'Japan5214.48': [2707], 'Malaysia71.95': [2708], 'Nepal10.28': [2709], 'Philippines10.28': [2710], 'Russia20.56': [2711], 'Singapore92.51': [2712], 'South': [2713], 'Korea92.51': [2714], 'Thailand51.39': [2715], 'United': [2716], 'States30.84': [2717], 'Vietnam71.95Symptoms': [2718], 'Fever3179.4926674.09': [2719], 'Cough2153.8512835.65': [2720], 'Fatigue512.82164.46': [2721], 'Digestive': [2722], '(diarrhea,': [2723], 'nausea,': [2724], 'vomiting/emesis,': [2725], 'anorexia)25.13123.34': [2726], 'Asymptomatic00.006a3': [2727], 'Japan,': [2731, 2741], '3': [2733, 2737, 2743], 'Malaysia.1.67a': [2736], 'Malaysia.': [2746], 'Open': [2747, 2766, 2852], 'table': [2748, 2767, 2853], 'new': [2751, 2770, 2856], 'tab': [2752, 2771, 2857], '2Information': [2755], 'PathwayGene': [2762], 'nameGene': [2763], 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'identification.': [2765, 2859], '3Gene': [2774], 'Set': [2775], 'Evaluate': [2778], 'Effect': [2781], 'Pathway': [2785], 'PhenotypesSourcesPhenotypesPathway': [2789], 'nameNumber': [2790, 2819], 'genes/SNPsSample': [2792], 'size,': [2793], 'NPpathway': [2794], 'basedAUC': [2795], '(variance)DiseaseColorectal': [2796], 'cancerACE2': [2797], 'pathway33202,807.9200.542': [2798], '(1.21': [2799], '10-5)Nephrotic': [2801], 'syndromeACE2': [2802], 'pathway33212,453.9330.607': [2803], '(8.24': [2804], '10-5)UrolithiasisACE2': [2806], 'pathway33212,453.7430.537': [2807], '(1.29': [2808], '10-5)Blood': [2810], 'testAlbuminACE2': [2811], 'pathway33102,223.306NAAlbumin/globulin': [2812], 'ratioACE2': [2813], 'pathway3398,626.349C-reactive': [2814], 'proteinACE2': [2815, 2817], 'pathway3375,391.365Total': [2816], 'pathway33113,509.541Gene': [2818], 'SNPsDiseaseColorectal': [2821], 'cancerTGFB123202,807.028NANephrotic': [2822], 'syndromeACE37212,453.012Nephrotic': [2823], 'syndromeMAPK33212,453.012UrolithiasisKLK113212,453.001UrolithiasisKNG1146212,453.002Blood': [2824], 'testAlbuminENPEP130102,223.020NAAlbuminACE218102,223.029Albumin/globulin': [2825], 'ratioACE3398,626.012Albumin/globulin': [2826], 'ratioTGFB12398,626.013Albumin/globulin': [2827], 'ratioTHOP13698,626.020Albumin/globulin': [2828], 'ratioMAS11398,626.032Albumin/globulin': [2829], 'ratioNLN25398,626.037C-reactive': [2830], 'proteinNR3C262475,391.021Total': [2831], 'proteinMRGPRD1113,509.008Total': [2832], 'proteinCTSA16113,509.012Total': [2833], 'proteinTHOP136113,509.012AUC,': [2834], 'area': [2835, 2861], 'curve': [2841, 2867], '(calculated': [2842, 2868], 'SummaryAUC);': [2844, 2870], 'NA,': [2845, 2871], 'available;': [2847, 2873], 'SNP,': [2848, 2874], 'polymorphism.': [2851, 2877], 'ID,': [2858], 'AUC,': [2860]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3033835395', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 23}, {'year': 2022, 'cited_by_count': 28}, {'year': 2021, 'cited_by_count': 43}, {'year': 2020, 'cited_by_count': 37}], 'updated_date': '2025-01-09T14:19:16.298104', 'created_date': '2020-06-12'}
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