Abstract: Common variable immunodeficiency (CVID) is the most common type of primary immunodeficiencies affecting both children and adults with the peak onset of symptoms during the first and third decades of life. It is characterized by a constellation of hypogammaglobulinemia, failure of specific antibody production, vulnerability to infections, and an array of comorbidities. CVID typically has a combination of decreased IgG, IgA, and/or IgM levels associated with poor vaccine response and prone to have bacterial infections. it consists of heterogeneous constituents of rare diseases considering numerous ways in impairment of antibody production, and therefore managing this disease poses a significant challenge for clinicians. Although CVID has been recognized since the 1950s, its underlying mechanisms remain not completely understood. The clinical heterogeneity suggests the involvement of multiple genetic and immunoregulatory defects with hypogammaglobulinemia as the final outcome.
Publication Year: 2020
Publication Date: 2020-04-16
Language: en
Type: article
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Cited By Count: 1
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