Title: Changes of choroidal thickness in patients with retinitis pigmentosa and its effect on visual function
Abstract:Objective
To investigate the changes of choroidal thickness in patients with retinitis pigmentosa(RP) and its effect on visual function.
Methods
37 patients with RP(62 eyes) and 30 healthy volu...Objective
To investigate the changes of choroidal thickness in patients with retinitis pigmentosa(RP) and its effect on visual function.
Methods
37 patients with RP(62 eyes) and 30 healthy volunteers(60 eyes) as the control group were selected.The subfoveal choroidal thickness(SFCT) of eyes was detected by using optical coherence tomography(OCT) technology for enhanced depth imaging(EDI). The full-field ERG was performed, and the waveform changes of ERG were recorded.According to T32 or LVC program, the visual fields of RP eyes were examined, the mean sensitivity (MS), mean defect degree (MD) and loss variance (LV) were recorded.The correlations between variables were analyzed by using Pearson correlation analysis.
Results
The SFCT of RP patients was (218.7±62.8)μm, which of the control group was (291.5±54.1)μm, covariance analysis showed that there was no interaction between age and group(F=1.574, P=0.213), compared the two groups, the difference was statistically significant(t=7.347, P 0.05). The dark adaptation response waveform of 23 eyes reduced, 39 eyes had no waveform, there was no difference between SFCT in the waveform reduced and no waveform(P>0.05).24 eyes accepted T32 program examined, the MD, MS, LV and SFCT were (19.6±6.1)dB, (10.3±5.2)dB, (33.9±14.9)dB2 and (212.9±69.8)μm, respectively.Pearson correlation analysis showed that the SFCT of eyes was negatively correlated with MD and LV(r=-0.502 and -0.687, all P<0.05), while was positively correlated with MS (r=0.551, P=0.005).38 eyes accepted LVC program examined, the MS and SFCT were (7.4±4.9)dB and (229.3±64.7)μm.Pearson correlation analysis showed that the SFCT of eyes was not correlated with MS (r=0.108, P=0.519).
Conclusion
The SFCT of RP patients is significantly reduced.But it is not related with the changes of full-field ERG waveform.The correlation with visual field examination is affected by eye condition of central vision.When central vision has less damage, SFCT can reflect central visual photographic ability.
Key words:
Retinitis, pigmentosa; Choroid; Vision TestRead More
Publication Year: 2017
Publication Date: 2017-03-01
Language: en
Type: article
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