Publication Information

{'id': 'https://openalex.org/W3032449335', 'doi': 'https://doi.org/10.3760/cma.j.issn.1009-9921.2009.02.021', 'title': 'Progression of the FLT3 Inhibitor in acute myeloid leukemia', 'display_name': 'Progression of the FLT3 Inhibitor in acute myeloid leukemia', 'publication_year': 2009, 'publication_date': '2009-02-25', 'ids': {'openalex': 'https://openalex.org/W3032449335', 'doi': 'https://doi.org/10.3760/cma.j.issn.1009-9921.2009.02.021', 'mag': '3032449335'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN11535620091802/376714.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306555461', 'display_name': '白血病·淋巴瘤', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004863222', 'display_name': 'Jiazhuo Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}, {'id': 'https://openalex.org/I4210147887', 'display_name': 'Institute of Hematology & Blood Diseases Hospital', 'ror': 'https://ror.org/04n16t016', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147887']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jia-zhuo Liu', 'raw_affiliation_strings': ['State Key Laboratory of Experimental Hematology,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,300020,China)'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Experimental Hematology,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,300020,China)', 'institution_ids': ['https://openalex.org/I200296433', 'https://openalex.org/I4210147887']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5086214965', 'display_name': 'Jianxiang Wang', 'orcid': 'https://orcid.org/0000-0001-9437-9151'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}, {'id': 'https://openalex.org/I4210147887', 'display_name': 'Institute of Hematology & Blood Diseases Hospital', 'ror': 'https://ror.org/04n16t016', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147887']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian-xiang Wang', 'raw_affiliation_strings': ['State Key Laboratory of Experimental Hematology,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,300020,China)'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Experimental Hematology,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,300020,China)', 'institution_ids': ['https://openalex.org/I200296433', 'https://openalex.org/I4210147887']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 64}, 'biblio': {'volume': '18', 'issue': '02', 'first_page': '120', 'last_page': '122'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9734, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11215', 'display_name': 'Chronic Myeloid Leukemia Treatments', 'score': 0.9711, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cd135', 'display_name': 'CD135', 'score': 0.70421493}, {'id': 'https://openalex.org/keywords/protein-kinase-domain', 'display_name': 'Protein kinase domain', 'score': 0.43118232}], 'concepts': [{'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.76630163}, {'id': 'https://openalex.org/C41650920', 'wikidata': 'https://www.wikidata.org/wiki/Q14912399', 'display_name': 'CD135', 'level': 4, 'score': 0.70421493}, {'id': 'https://openalex.org/C2778820342', 'wikidata': 'https://www.wikidata.org/wiki/Q906415', 'display_name': 'Tyrosine-kinase inhibitor', 'level': 3, 'score': 0.6674898}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.64072496}, {'id': 'https://openalex.org/C2910954276', 'wikidata': 'https://www.wikidata.org/wiki/Q14912399', 'display_name': 'Fms-Like Tyrosine Kinase 3', 'level': 4, 'score': 0.6101314}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.60367197}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.596089}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.5612498}, {'id': 'https://openalex.org/C176944494', 'wikidata': 'https://www.wikidata.org/wiki/Q1415380', 'display_name': 'Point mutation', 'level': 4, 'score': 0.5527571}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.49013814}, {'id': 'https://openalex.org/C32619005', 'wikidata': 'https://www.wikidata.org/wiki/Q24768234', 'display_name': 'Protein kinase domain', 'level': 4, 'score': 0.43118232}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4217586}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4033775}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3011111}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.2895712}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.22513449}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20982301}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16653636}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.1026746}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.10256487}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN11535620091802/376714.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306555461', 'display_name': '白血病·淋巴瘤', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'No poverty', 'score': 0.57, 'id': 'https://metadata.un.org/sdg/1'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3204239799', 'https://openalex.org/W3179349718', 'https://openalex.org/W3135874072', 'https://openalex.org/W3092767555', 'https://openalex.org/W3080817366', 'https://openalex.org/W2998830459', 'https://openalex.org/W2997305509', 'https://openalex.org/W2966864098', 'https://openalex.org/W2740665501', 'https://openalex.org/W2617622088', 'https://openalex.org/W2570937751', 'https://openalex.org/W2414493062', 'https://openalex.org/W2208328515', 'https://openalex.org/W2163515240', 'https://openalex.org/W2043532370', 'https://openalex.org/W2010737710', 'https://openalex.org/W1996307710', 'https://openalex.org/W1984209370', 'https://openalex.org/W1893489279', 'https://openalex.org/W1486058293'], 'abstract_inverted_index': {'FLT3,': [0], 'a': [1, 43, 74], 'tyrosine': [2, 31], 'kinase': [3, 32], 'receptor,': [4], 'is': [5], 'the': [6, 22, 30, 50, 60, 81, 91, 99, 107, 110], 'most': [7], 'common': [8], 'mutation': [9], 'in': [10, 21, 29, 59, 80, 106], 'AML': [11, 35, 65], 'and': [12, 26, 62, 66, 76, 95, 104], 'has': [13], 'two': [14], 'classes': [15], 'of': [16, 52, 64, 90, 98, 109], 'mutations:': [17], 'internal': [18], 'tandem': [19], 'duplications': [20], 'juxtamembrane': [23], 'domain': [24, 33], '(FLT3-ITDs)': [25], 'point': [27], 'mutations': [28, 39, 54], '(FLT3-TKDs).': [34], 'patients': [36], 'with': [37], 'FLT3': [38, 53, 92, 100, 111], 'tend': [40], 'to': [41], 'have': [42, 67], 'poor': [44], 'prognosis.': [45], 'As': [46], 'an': [47, 56], 'independent': [48], 'factor,': [49], 'presences': [51], 'play': [55], 'important': [57], 'role': [58], 'origin': [61], 'development': [63], 'prognostic': [68], 'value.': [69], 'Molecular': [70], 'targeted': [71], 'therapy': [72], 'represents': [73], 'novel': [75], 'popular': [77], 'therapeutic': [78], 'approach': [79], 'world.': [82], 'In': [83], 'this': [84], 'review,': [85], 'we': [86], 'explain': [87], 'clinical': [88], 'value': [89], 'mutations,': [93], 'mechanism': [94], 'research': [96, 108], 'progression': [97], 'inhibitor;and': [101], 'discuss': [102], 'difficulties': [103], 'perspectives': [105], 'inhibitor.\r\n\r\nKey': [112], 'words:': [113], '\r\nReceptor': [114], 'protein-tyrosine': [115], 'kinases;\xa0Mutation;\xa0Inhibins;\xa0Leukemia,myelocytic,acute': [116]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3032449335', 'counts_by_year': [], 'updated_date': '2024-12-15T21:10:53.728460', 'created_date': '2020-06-05'}