Publication Information

{'id': 'https://openalex.org/W3032381152', 'doi': 'https://doi.org/10.3760/cma.j.issn.2095-0160.2016.01.007', 'title': 'The protactive effects and mechanisms of cx3cr1 antibody on retinal neuron in rats with ischemia reperfusion injury by intravitreal injection', 'display_name': 'The protactive effects and mechanisms of cx3cr1 antibody on retinal neuron in rats with ischemia reperfusion injury by intravitreal injection', 'publication_year': 2016, 'publication_date': '2016-01-10', 'ids': {'openalex': 'https://openalex.org/W3032381152', 'doi': 'https://doi.org/10.3760/cma.j.issn.2095-0160.2016.01.007', 'mag': '3032381152'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://rs.yiigle.com/CN115989201601/863510.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764489546', 'display_name': 'Zhonghua shiyan yanke zazhi', 'issn_l': '2095-0160', 'issn': ['2095-0160'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 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'Kunming Medical University', 'ror': 'https://ror.org/038c3w259', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I26080491']}, {'id': 'https://openalex.org/I4210120169', 'display_name': 'First Affiliated Hospital of Kunming Medical University', 'ror': 'https://ror.org/02g01ht84', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120169']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhiwei Tang', 'raw_affiliation_strings': ['Department of Neurosurgery, Affiliated First Hospital, Kunming Medical University, Kunming 650032, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosurgery, Affiliated First Hospital, Kunming Medical University, Kunming 650032, China', 'institution_ids': ['https://openalex.org/I26080491', 'https://openalex.org/I4210120169']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 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'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11597', 'display_name': 'Neutrophil, Myeloperoxidase and Oxidative Mechanisms', 'score': 0.9857, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10170', 'display_name': 'Retinal Diseases and Treatments', 'score': 0.9844, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health 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'score': 0.1913318}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.0958384}, {'id': 'https://openalex.org/C12823836', 'wikidata': 'https://www.wikidata.org/wiki/Q24720618', 'display_name': 'Chemokine receptor', 'level': 4, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://rs.yiigle.com/CN115989201601/863510.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764489546', 'display_name': 'Zhonghua shiyan yanke zazhi', 'issn_l': '2095-0160', 'issn': ['2095-0160'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.8, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3045025803', 'https://openalex.org/W3032593046', 'https://openalex.org/W3032474110', 'https://openalex.org/W3032305401', 'https://openalex.org/W3031290628', 'https://openalex.org/W3031076771', 'https://openalex.org/W3031059972', 'https://openalex.org/W3030824595', 'https://openalex.org/W3030525475', 'https://openalex.org/W3029957996', 'https://openalex.org/W3029583730', 'https://openalex.org/W3029393518', 'https://openalex.org/W3028808900', 'https://openalex.org/W2983640126', 'https://openalex.org/W2411881052', 'https://openalex.org/W2381823966', 'https://openalex.org/W2350060614', 'https://openalex.org/W2347301899', 'https://openalex.org/W2177608351', 'https://openalex.org/W1977781630'], 'abstract_inverted_index': {'Background\r\nStudy': [0], 'confirmed': [1], 'that': [2], 'the': [3, 32, 51, 86, 100, 104, 111, 118, 132, 135, 158, 162, 169, 192, 209, 223, 235, 262, 270, 287, 309, 313, 347, 353, 392, 397, 421, 426, 448, 454, 460, 467], 'active': [4], 'microglia': [5], 'may': [6, 41], 'injure': [7], 'retinal': [8, 13, 58, 153, 184, 451, 468], 'ganglion': [9], 'cells': [10, 186, 255], '(RGCs)': [11], 'in': [12, 26, 44, 60, 99, 103, 131, 182, 208, 227, 234, 256, 261, 269, 286, 340, 346, 352, 386, 391, 417, 443, 472], 'ischemia': [14], 'reperfusion': [15], 'injury': [16], '(IRI),': [17], 'and': [18, 29, 117, 125, 139, 150, 168, 191, 204, 225, 229, 284, 299, 312, 362, 383, 403, 425, 464, 480], 'increased': [19], 'cx3cr1': [20, 35, 55, 89, 113, 120, 197, 272, 292, 301, 318, 324, 358, 364, 379, 399, 405, 428, 437, 441, 477], 'expression': [21, 33, 179, 194, 335, 376], 'is': [22, 478], 'an': [23], 'important': [24], 'factor': [25], 'microglial': [27, 38, 185, 254], 'activation,': [28, 39], 'thus': [30], 'blocking': [31], 'of': [34, 54, 91, 134, 152, 164, 171, 180, 196, 220, 238, 248, 277, 338, 378, 436, 450, 456, 462, 476], 'can': [36, 445], 'inhibit': [37, 447], 'which': [40], 'be': [42], 'useful': [43], 'neuronal': [45], 'protection.\r\n\r\n\r\nObjective\r\nThis': [46], 'study': [47], 'was': [48, 96, 129, 155, 166, 174, 187, 240, 280], 'to': [49, 73, 439], 'analyze': [50], 'protective': [52], 'effects': [53], 'antibody': [56, 90, 114, 121, 273, 293, 302, 319, 325, 359, 365, 400, 406, 429, 438], 'on': [57], 'neuron': [59], 'rat': [61, 341, 387], 'eyes': [62, 102], 'with': [63, 242, 396], 'IRI.\r\n\r\n\r\nMethods\r\nNinety': [64], 'SD': [65, 473], 'rats': [66, 106, 109, 133], 'were': [67, 78, 144, 211, 231, 259, 267, 343, 389, 415], 'divided': [68], 'into': [69, 85], '4': [70], 'groups': [71], 'according': [72], 'random': [74], 'number': [75, 170, 276], 'table.IRI': [76], 'models': [77], 'established': [79], 'by': [80, 176, 189, 213], 'perfusing': [81], 'normal': [82, 105, 136, 241, 288, 314, 354, 422], 'saline': [83], 'solution': [84], 'anterior': [87], 'chamber.The': [88], '1': [92], 'μl': [93], '(0.2': [94], 'μg/μl)': [95], 'intravitreally': [97], 'injected': [98, 115, 122, 130, 294, 303, 320, 326, 360, 366, 401, 407, 430], 'right': [101], 'or': [107, 322], 'model': [108, 119, 140, 263, 271, 296, 300, 310, 323, 348, 363, 393, 404], 'as': [110], 'only': [112, 291, 317, 357, 398, 427], 'group': [116, 138, 298, 311, 321, 327, 349, 361, 367, 394, 402, 408, 424, 431], 'group,': [123, 290, 295, 304, 316, 356], 'respectively,': [124], 'no': [126], 'any': [127], 'drug': [128], 'control': [137, 141, 289, 297, 315, 355, 423], 'group.Retinal': [142], 'sections': [143], 'prepared': [145], '48': [146], 'hours': [147], 'after': [148], 'modeling,': [149], 'apoptosis': [151, 461], 'neutron': [154], 'observed': [156, 416], 'under': [157], 'transmission': [159], 'electron': [160], 'microscope;': [161], 'morphology': [163], 'retinas': [165, 210, 342, 388, 444], 'exmined': [167], 'survival': [172, 278], 'RGCs': [173, 221, 279, 463], 'calculated': [175], 'histopathologic': [177], 'method.The': [178], 'CD68': [181, 339], 'activated': [183], 'detected': [188], 'immunochemistry,': [190], 'relative': [193, 375], 'levels': [195, 336, 377, 442], 'mRNA,': [198, 380], 'tumor': [199], 'necrosis': [200, 486], 'factor-α': [201], '(TNF-α)': [202], 'mRNA': [203, 207, 382, 385], 'interleukin-1β': [205], '(IL-1β)': [206], 'assayed': [212], 'real': [214], 'time': [215], 'quantitative': [216], 'PCR.\r\n\r\n\r\nResults\r\nThe': [217], 'cell': [218, 245], 'nucleus': [219], 'showed': [222], 'round': [224], 'ellipse': [226], 'shape': [228], 'there': [230], 'abundant': [232, 243], 'organelles': [233], 'cells.The': [236], 'mophology': [237], 'photoreceptors': [239], 'mitochondrions.Irregular': [244], 'shape,': [246], 'disrupture': [247], 'outer': [249], 'segment': [250], 'membranous': [251], 'disc,': [252], 'proliferative': [253], 'RGC': [257], 'layer': [258], 'seen': [260], 'group.However,': [264], 'these': [265, 418], 'findings': [266], 'mild': [268], 'group.The': [274], 'mean': [275], '(38.100±3.929),': [281], '(37.200±5.266),': [282], '(26.700±2.584)': [283], '(31.700±2.946)/field': [285], 'showing': [305], 'significant': [306, 413], 'differences': [307, 414], 'between': [308, 420], '(t=7.492,': [328], '6.125,': [329], '-4.607,': [330], 'all': [331], 'at': [332, 410, 433], 'P<0.01).': [333, 411], 'The': [334, 374], '(absorbance)': [337], 'significantly': [344], 'higher': [345], 'than': [350], 'those': [351], '(t=-3.397,': [368], 'P=0.008;': [369], 't=-6.207,': [370], 'P=0.000;': [371], 't=3.494,': [372], 'P=0.007).': [373], 'TNF-α': [381], 'IL-1β': [384], 'raised': [390], 'compared': [395], '(all': [409, 432], 'No': [412], 'indicators': [419], 'P<0.05).\r\n\r\n\r\nConclusions\r\nIntravitreal': [434], 'injection': [435, 475], 'neutralize': [440], 'effectively': [446], 'activation': [449], 'microglia,': [452], 'decrease': [453], 'release': [455], 'inflammatory': [457], 'factors,': [458], 'reduce': [459], 'thereby': [465], 'protect': [466], 'neutrons': [469], 'against': [470], 'IRI': [471], 'rats.Intravitreal': [474], 'safe': [479], 'feasible.\r\n\r\n\r\nKey': [481], 'words:': [482], '\r\nReceptors,': [483], 'CXCR3;\xa0Microglia/cytology;\xa0Neutralization;\xa0Retina/pathology;\xa0Reperfusion': [484], 'injury;\xa0Tumor': [485], 'factor-α;\xa0Interleukin-1β;\xa0Apoptosis;\xa0Rats,': [487], 'Sprague-Dawley': [488]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3032381152', 'counts_by_year': [], 'updated_date': '2024-12-06T10:16:17.200439', 'created_date': '2020-06-05'}