Title: Analysis of adverse pregnancy outcomes of pregnant women with hypoproteinemia in the third trimester and its influencing factors
Abstract: Objective
To investigate adverse pregnancy outcomes of pregnant women with hypoproteinemia in the third trimester and its influencing factors.
Methods
A total of 86 cases of pregnant women who were diagnosed as hypoalbuminemia in the third trimester in the Tongzhou Maternal & Child Health Hospital from January 2011 to July 2014 were included into this study. All of those 86 cases of pregnant women were divided into severe hypoalbuminemia groups (Ⅰ group, n=39) and mild hypoalbuminemia group (Ⅱ group, n=47) according to serum albumin levels. At the same time, 50 cases of healthy pregnancy women in the third trimester were chosen as control group (n=50). There was no significant difference among three groups in the aspect of mean age (P>0.05). The adverse pregnant results, indexes of biochemical examination, and constituent ratio of main diseases of pregnant women with hypoalbuminemia during the third trimester were analyzed. Furthermore, correlation between eclampsism and hypoproteinemia, non-conditional multivariate logistic regression analysis were also analyzed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Tongzhou Maternal & Child Health Hospital. Informed consent was obtained from each patient.
Results
① The main disease of pregnant women with hypoalbuminemia during the third trimester was preeclampsia (53.5%), followed by liver diseases (12.8%) and multiple pregnancies (11.6%). There were significant differences among preeclampsia pregnant women, non-preeclampsia pregnant women and control group in serum total protein, albumin and prealbumin (PA) (P<0.05). ② There were significant differences among Ⅰgroup, Ⅱ group and control group in total protein, albumin, PA, uric acid, alamine aminotransferase (ALT), lactate dehydrogenase (LDH), serum creatinine, blood urea nitrogen (BUN), Mg2+ , triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) (P<0.05). And the incidence rates of preterm birth, fetal growth restriction, placental abruption and other adverse pregnancy outcomes inⅠ group were higher than those in Ⅱ group and control group, with significant differences (P<0.05). ③Non-conditional multivariable logistic regression analysis showed that hypoalbuminemia was the highest risk factor of adverse pregnancy outcomes among pregnant women with hypoproteinemia in the third trimester (OR=1.261, P<0.05).
Conclusions
Preeclampsia plays an important role in the progress of pregnant women with hypoproteinemia in the third trimester. Pregnant women with hypoalbuminemia often accompanied by a variety of abnormal biochemical indicators and adverse pregnant outcomes. Early clinical evaluation of pregnant women with hypoalbuminemia in the third trimester has important significance for avoiding or descresing the incidence rate of adverse pregnant outcomes.
Key words:
Hypoproteinemia; Pregnancy trimester, third; Pregnancy outcome; Risk factors
Publication Year: 2015
Publication Date: 2015-06-01
Language: en
Type: article
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