Title: CYP2C19 Phenotype and Risk of Proton Pump Inhibitor–Associated Infections
Abstract: In their study, Bernal et al1 conclude that CYP2C19 genotypes influence the metabolism of proton pump inhibitors (PPIs), thereby affecting the future infection rates. Although CYP2C19 is the predominant enzyme, CYP3A4 is also important in the metabolism of PPI although to a lesser extent. Thus, variations in genotypes of both CYP2C19 and CYP3A4 may affect PPI metabolism. Whereas normal metabolizers (NMs) experienced more total infection events as compared to rapid or ultrarapid metabolizers (RM/UMs) in the study by Bernal et al,1 the rate of respiratory tract infections and gastrointestinal tract infections was similar in … E-mail: kunalpgimer{at}gmail.com