Title: Analysis of clinical and pathological characteristics in 167 children with Henoch Schönlein purpura nephritis
Abstract: Objective
To investigate the clinical, renal pathological characteristics of Henoch Schonlein purpura nephritis (HSPN) in children.
Methods
One hundred and sixty-seven children hospitalized with HSPN from Jan.2008 to Dec.2011 in the First Affiliated Hospital of Zhengzhou University were divided into 2 groups by 24-hour urinary protein quantity: group A with 24-hour urinary protein quantity <25 mg/kg, group B with 24-hour urinary protein quantity ≥25 mg/kg.Age of onset, gender, injury time of kidney, clinical manifestations, 24-hour urinary protein quantity and renal pathological grades of the 2 groups were collected and analyzed.
Results
In 167 HSPN children, the ratio of male to female was 1.8︰1.0.The ages from 5 to 10 years old accounted for 70.7%.Renal injury time was from a day to 5 months, 91.6% of the HSPN children occurred renal damage within 1 month.HSPN children had clinical signs of gastrointestinal involvement in 56 cases(33.5%), at the same time, the digestive tract and joint involvement in 52 cases(31.1%). Pathological classification of 6 grades: 8 cases(4.8%) of grade Ⅰ; 32 cases(19.2%) of grade Ⅱ; 124 cases(74.3%) of grade Ⅲ; 3 cases(1.8%) of grade Ⅳ; no grade Ⅴ or Ⅵ.Pathologic grade of group B was higher than group A, and the difference was significant(P<0.05).
Conclusions
The HSPN children, expecially the boys, were more found with digestive tract injury or multiple organ damage.Most HSPN children occurred renal damage within 1 month.The renal biopsy of HSPN children should be positive, especially when the 24-hour urinary protein quantity is ≥25 mg/kg.
Key words:
Purpura nephritis; Renal biopsy; Pathology; Urinary protein; Child
Publication Year: 2013
Publication Date: 2013-09-05
Language: en
Type: article
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