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'https://openalex.org/W2034485643', 'https://openalex.org/W2031388346', 'https://openalex.org/W2029449560', 'https://openalex.org/W2019134723', 'https://openalex.org/W2005490869', 'https://openalex.org/W1978457906', 'https://openalex.org/W1966159465', 'https://openalex.org/W1599187503'], 'abstract_inverted_index': {'目的': [0], '研究心力衰竭患者外周血淋巴细胞β-受体(β-AR)密度和β1-受体基因(β1-AR': [1], 'mRNA)表达水平的变化规律,探讨不同β-受体阻滞剂对β-AR和β1-AR': [2], 'mRNA表达水平的影响.方法将104例心衰患者随机分为非β-受体阻滞剂治疗组(35例)、美托洛尔治疗组(34例)和卡维地洛治疗组(35例),2个月后复测β-AR和β1-AR': [3], 'mRNA表达水平.结果心衰组β-AR密度和β1-AR': [4], 'mRNA表达水平较正常人明显下降(P<0.01),心功能Ⅳ级患者下降更明显(P<0.01).冠心病与扩张型心肌病两组之间差异无显著意义(P>0.05).治疗后,美托洛尔治疗组β-AR密度和β1-AR': [5], 'mRNA表达水平明显高于卡维地洛治疗组和非β-受体阻滞剂治疗组(P<0.01),卡维地洛治疗组与非β-受体阻滞剂治疗组差异无显著意义.结论心衰时外周血淋巴细胞β-AR密度和β1-AR': [6], 'mRNA表达水平下调,下调幅度与心衰严重程度有关,与病因无关.应用美托洛尔能明显上调β-AR密度和β1-AR': [7], 'mRNA表达水平,卡维地洛则无此作用。': [8]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3031862510', 'counts_by_year': [], 'updated_date': '2024-09-19T19:39:26.333629', 'created_date': '2020-06-05'}