Title: Association between rs1079727 polymorphism in the DRD2 gene and the distractibility in the school-age children
Abstract: Objective
To understand the association between rs1079727 polymorphism in the DRD2 gene and the distractibility in the school-age children.
Method
The rs1079727 polymorphisms were genotyped using Sequenom Mass Array and the distractibility was measured based on the Middle Childhood Temperament Questionnaire (MCTQ) in 121 children aged from 8 to 12 years, in order to analyze the function of rs1079727 polymorphism and its interaction with gender or the delivery mode on the distractibility. The results were analyzed with one-way ANOVA and logistic regression analysis.
Results
There was association between the distractibility and rs1079727 polymorphism or delivery mode respectively. The means of distractibility for the genotypes of GG (4.37±0.53) and AG (4.27±0.69) were significantly higher than that of the genotype of AA(4.01±0.67) (P<0.05). The proportion of high distractibility in the cesarean children (48.28%) was significantly higher than that in the natural labor children(33.90%) (P<0.05). The child distractibility occurred through an interaction between rs1079727 polymorphism and gender/ delivery mode. The girls with G alleles possessed increased risk of distractibility (OR=2.231, P<0.05), and the natural labor children with A alleles were tend to be associated with low distractibility(OR=0.048, P<0.01).
Conclusion
The distractibility based the temperament for the school-age children might be influenced by delivery mode, rs1079727 polymorphism and its interaction with gender/ delivery mode.
Key words:
Distractibility; Temperament; Rs1079727 polymorphism; School-age children
Publication Year: 2014
Publication Date: 2014-12-20
Language: en
Type: article
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