Title: Endothelial function-protecting and blood pressure-lowering effects of rosglitazone in elderly patients with type 2 diabetes mellitus
Abstract: Objective To investigate the endothelial function-protecting and blood pressure-lowering effects of rosiglitazone in elderly patients with type 2 diabetes mellitus. Methods 104 cases of elderly pa-tients with type 2 diabetes without history of hypertension were enrolled in this study. According to their first office blood pressure,they were divided into three groups: 42 patients of normal blood pressure( SBP≤120 mm Hg,1 mm Hg =0. 133 kPa) ,33 cases of prehypertension (140 mm Hg≥SBP>120 mm Hg) and 29 ca-ses of hypertension (160 mm Hg≥SBP>140 mm Hg). At baseline and after treatment with 12 weeks of ros-iglitazone (4 mg/d), we measured metabolic parameters such as SBP, DBP, FBG, HbAIc, HOMA-IR, TC, LDL,vWF,WBC,CRP and ADMA. Results After 12 weeks treatment with rosiglitazone,the mean of SBP and DBP were reduced in hypertension group, the mean SBP was reduced in prehypertension group, respec-tively (P < 0.05). Moreover, FBG, HbAlc, HOMA-IR, TC and LDL in 3 groups were decreased (P < 0.05), compared with baseline. The levels of vWF and WBC were also decreased (P<0. 05). Conclusions Rosigl-itazone significantly decreases blood pressure in elderly patients with type 2 diabetes. Rosiglitazone not only ameliorates insulin resistance but also improves endothelial function and chronic inflammation.
Key words:
Rosiglitazone; Type 2 diabetes mellitus; Blood pressure; Insulin resistance; Endothe-lial function
Publication Year: 2009
Publication Date: 2009-07-20
Language: en
Type: article
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