Publication Information

{'id': 'https://openalex.org/W3031435968', 'doi': 'https://doi.org/10.7554/elife.52658', 'title': 'Fast and reversible neural inactivation in macaque cortex by optogenetic stimulation of GABAergic neurons', 'display_name': 'Fast and reversible neural inactivation in macaque cortex by optogenetic stimulation of GABAergic neurons', 'publication_year': 2020, 'publication_date': '2020-05-26', 'ids': {'openalex': 'https://openalex.org/W3031435968', 'doi': 'https://doi.org/10.7554/elife.52658', 'mag': '3031435968', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32452766', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7329331'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.52658', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.7554/elife.52658', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5082203989', 'display_name': 'Abhishek De', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}, {'id': 'https://openalex.org/I58610484', 'display_name': 'Seattle University', 'ror': 'https://ror.org/02jqc0m91', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58610484']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Abhishek De', 'raw_affiliation_strings': ['Department of Physiology and Biophysics, Washington National Primate Research Center, University of Washington, Seattle, United States;', 'Graduate Program in Neuroscience, University of Washington, Seattle, United States;'], 'affiliations': [{'raw_affiliation_string': 'Graduate Program in Neuroscience, University of Washington, Seattle, United States;', 'institution_ids': ['https://openalex.org/I201448701', 'https://openalex.org/I58610484']}, {'raw_affiliation_string': 'Department of Physiology and Biophysics, Washington National Primate Research Center, University of Washington, Seattle, United States;', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068080807', 'display_name': 'Yasmine El-Shamayleh', 'orcid': 'https://orcid.org/0000-0002-5396-2823'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yasmine El-Shamayleh', 'raw_affiliation_strings': ['Department of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5034173049', 'display_name': 'Gregory D. Horwitz', 'orcid': 'https://orcid.org/0000-0001-5130-5259'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Gregory D Horwitz', 'raw_affiliation_strings': ['Department of Physiology and Biophysics, Washington National Primate Research Center, University of Washington, Seattle, United States;'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Biophysics, Washington National Primate Research Center, University of Washington, Seattle, United States;', 'institution_ids': ['https://openalex.org/I201448701']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5034173049'], 'corresponding_institution_ids': ['https://openalex.org/I201448701'], 'apc_list': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'apc_paid': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'fwci': 2.686, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.999811, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '9', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12236', 'display_name': 'Photoreceptor and optogenetics research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12236', 'display_name': 'Photoreceptor and optogenetics research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10581', 'display_name': 'Neural dynamics and brain function', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11601', 'display_name': 'Neuroscience and Neural Engineering', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/channelrhodopsin', 'display_name': 'Channelrhodopsin', 'score': 0.68864244}, {'id': 'https://openalex.org/keywords/biological-neural-network', 'display_name': 'Biological neural network', 'score': 0.59830326}, {'id': 'https://openalex.org/keywords/nerve-net', 'display_name': 'Nerve net', 'score': 0.45096758}], 'concepts': [{'id': 'https://openalex.org/C50738837', 'wikidata': 'https://www.wikidata.org/wiki/Q781492', 'display_name': 'Optogenetics', 'level': 2, 'score': 0.98971313}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.8247694}, {'id': 'https://openalex.org/C37218471', 'wikidata': 'https://www.wikidata.org/wiki/Q905325', 'display_name': 'Channelrhodopsin', 'level': 3, 'score': 0.68864244}, {'id': 'https://openalex.org/C2779177108', 'wikidata': 'https://www.wikidata.org/wiki/Q18356742', 'display_name': 'GABAergic', 'level': 3, 'score': 0.659177}, {'id': 'https://openalex.org/C2778950215', 'wikidata': 'https://www.wikidata.org/wiki/Q177601', 'display_name': 'Macaque', 'level': 2, 'score': 0.646913}, {'id': 'https://openalex.org/C118403218', 'wikidata': 'https://www.wikidata.org/wiki/Q43283', 'display_name': 'Biological neural network', 'level': 2, 'score': 0.59830326}, {'id': 'https://openalex.org/C2779345533', 'wikidata': 'https://www.wikidata.org/wiki/Q75785', 'display_name': 'Visual cortex', 'level': 2, 'score': 0.5486232}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.50178576}, {'id': 'https://openalex.org/C17077164', 'wikidata': 'https://www.wikidata.org/wiki/Q1185869', 'display_name': 'Inhibitory postsynaptic potential', 'level': 2, 'score': 0.45818487}, {'id': 'https://openalex.org/C2780196419', 'wikidata': 'https://www.wikidata.org/wiki/Q1762173', 'display_name': 'Nerve net', 'level': 2, 'score': 0.45096758}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42760468}], 'mesh': [{'descriptor_ui': 'D059330', 'descriptor_name': 'GABAergic Neurons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D062308', 'descriptor_name': 'Optogenetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014793', 'descriptor_name': 'Visual Cortex', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000075402', 'descriptor_name': 'Channelrhodopsins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000075402', 'descriptor_name': 'Channelrhodopsins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000229', 'descriptor_name': 'Dependovirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059330', 'descriptor_name': 'GABAergic Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008253', 'descriptor_name': 'Macaca mulatta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014793', 'descriptor_name': 'Visual Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.52658', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/f8eb3c5fc1e64a0f837b6db0157e6714', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7329331', 'pdf_url': 'https://europepmc.org/articles/pmc7329331?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329331', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32452766', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.52658', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R90 DA033461'}, {'funder': 'https://openalex.org/F4320337350', 'funder_display_name': 'National Eye Institute', 'award_id': 'P30 EY01730'}], 'datasets': [], 'versions': [], 'referenced_works_count': 71, 'referenced_works': ['https://openalex.org/W1510035674', 'https://openalex.org/W1514853588', 'https://openalex.org/W1560241183', 'https://openalex.org/W1572568267', 'https://openalex.org/W1900636106', 'https://openalex.org/W1965322047', 'https://openalex.org/W1984279162', 'https://openalex.org/W1985854422', 'https://openalex.org/W1986627859', 'https://openalex.org/W1987173769', 'https://openalex.org/W1987768364', 'https://openalex.org/W1997953085', 'https://openalex.org/W2009759904', 'https://openalex.org/W2014350866', 'https://openalex.org/W2021308189', 'https://openalex.org/W2023230481', 'https://openalex.org/W2040707073', 'https://openalex.org/W2047271528', 'https://openalex.org/W2047340079', 'https://openalex.org/W2047347093', 'https://openalex.org/W2054041034', 'https://openalex.org/W2057748516', 'https://openalex.org/W2060971741', 'https://openalex.org/W2062702120', 'https://openalex.org/W2062764496', 'https://openalex.org/W2063206977', 'https://openalex.org/W2073014936', 'https://openalex.org/W2076546992', 'https://openalex.org/W2084128881', 'https://openalex.org/W2089817334', 'https://openalex.org/W2104698815', 'https://openalex.org/W2113592600', 'https://openalex.org/W2117957894', 'https://openalex.org/W2122350352', 'https://openalex.org/W2124196462', 'https://openalex.org/W2135988428', 'https://openalex.org/W2139272195', 'https://openalex.org/W2143237238', 'https://openalex.org/W2148939330', 'https://openalex.org/W2149561999', 'https://openalex.org/W2159217088', 'https://openalex.org/W2161234875', 'https://openalex.org/W2162317853', 'https://openalex.org/W2162738875', 'https://openalex.org/W2171725500', 'https://openalex.org/W2256511972', 'https://openalex.org/W2271615357', 'https://openalex.org/W2516707948', 'https://openalex.org/W2546343095', 'https://openalex.org/W2546661444', 'https://openalex.org/W2558867581', 'https://openalex.org/W2592546275', 'https://openalex.org/W2593801862', 'https://openalex.org/W2606624666', 'https://openalex.org/W2720305698', 'https://openalex.org/W2744000261', 'https://openalex.org/W2749101415', 'https://openalex.org/W2792962347', 'https://openalex.org/W2797742143', 'https://openalex.org/W2803107452', 'https://openalex.org/W2904722622', 'https://openalex.org/W2910968495', 'https://openalex.org/W2921629193', 'https://openalex.org/W2943087032', 'https://openalex.org/W2949734859', 'https://openalex.org/W2950541178', 'https://openalex.org/W2951393361', 'https://openalex.org/W2952431321', 'https://openalex.org/W2953109992', 'https://openalex.org/W3010882950', 'https://openalex.org/W4234482113'], 'related_works': ['https://openalex.org/W4300399588', 'https://openalex.org/W4205165293', 'https://openalex.org/W3048585446', 'https://openalex.org/W2994015988', 'https://openalex.org/W2949578532', 'https://openalex.org/W2898318735', 'https://openalex.org/W2109867632', 'https://openalex.org/W2011814333', 'https://openalex.org/W1985584955', 'https://openalex.org/W1980634122'], 'abstract_inverted_index': {'Optogenetic': [0], 'techniques': [1], 'for': [2, 7, 140], 'neural': [3, 9, 26, 64, 99, 134], 'inactivation': [4, 65, 135], 'are': [5], 'valuable': [6], 'linking': [8], 'activity': [10, 75, 147], 'to': [11, 49, 67], 'behavior': [12, 114], 'but': [13], 'they': [14], 'have': [15, 95], 'serious': [16], 'limitations': [17], 'in': [18, 56, 81, 148], 'macaques.': [19, 149], 'To': [20], 'achieve': [21], 'powerful': [22, 130], 'and': [23, 76, 106, 131], 'temporally': [24], 'precise': [25, 133], 'inactivation,': [27, 102], 'we': [28], 'used': [29], 'an': [30, 61], 'adeno-associated': [31], 'viral': [32], '(AAV)': [33], 'vector': [34], 'carrying': [35], 'the': [36, 40, 57, 82, 88, 107, 110, 142], 'channelrhodopsin-2': [37], 'gene': [38], 'under': [39], 'control': [41], 'of': [42, 84, 109, 145], 'a': [43, 129], 'Dlx5/6': [44], 'enhancer,': [45], 'which': [46, 93], 'restricts': [47], 'expression': [48], 'GABAergic': [50], 'neurons.': [51, 90], 'We': [52, 120], 'tested': [53], 'this': [54, 123], 'approach': [55, 127], 'primary': [58], 'visual': [59, 78], 'cortex,': [60], 'area': [62], 'where': [63], 'leads': [66], 'interpretable': [68], 'behavioral': [69], 'deficits.': [70], 'Optical': [71], 'stimulation': [72], 'modulated': [73], 'spiking': [74], 'reduced': [77], 'sensitivity': [79], 'profoundly': [80], 'region': [83], 'space': [85], 'represented': [86], 'by': [87], 'stimulated': [89], 'Rebound': [91], 'firing,': [92], 'can': [94], 'unwanted': [96], 'effects': [97], 'on': [98, 113], 'circuits': [100], 'following': [101], 'was': [103, 115], 'not': [104], 'observed,': [105], 'efficacy': [108], 'optogenetic': [111, 126], 'manipulation': [112], 'maintained': [116], 'across': [117], '>1000': [118], 'trials.': [119], 'conclude': [121], 'that': [122], 'inhibitory': [124], 'cell-type-specific': [125], 'is': [128], 'spatiotemporally': [132], 'tool': [136], 'with': [137], 'broad': [138], 'utility': [139], 'probing': [141], 'functional': [143], 'contributions': [144], 'cortical': [146]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3031435968', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 3}], 'updated_date': '2025-01-12T13:21:25.811477', 'created_date': '2020-06-05'}