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'https://openalex.org/W2140797773'], 'abstract_inverted_index': {'目的': [0], '检测热休克蛋白70(heat': [1], 'shock': [2], 'protein,': [3], 'HSP)和90α在小儿肾母细胞瘤组织中的表达,并探讨其临床意义.方法应用免疫组织化学方法及逆转录-聚合酶链反应(RT-PCR)技术检测20例肾母细胞瘤组织及瘤旁正常肾脏组织中HSP70和HSP90α的表达,其中男8例,女12例,年龄19个月至5岁,平均(22.5±13.7)个月.按NWTS3组织分型标准,20例肾母细胞瘤均为预后好的组织结构,包括间叶型5例,胚芽型9例,上皮型6例.临床分期Ⅰ期4例,Ⅱ期8例,Ⅲ期6例,Ⅳ期2例.结果免疫组化结果示HSP70和HSP90α在肿瘤组织中的阳性表达率(75.0%,15/20;80.0%,16/20)明显低于正常肾组织(100%,20/20;100%,20/20),P值分别为0.017和0.035,主要位于胚芽及上皮成分,而肿瘤基质均为阴性.对照组HSP70和HSP90α的表达位于肾小管上皮细胞、肾小球系膜细胞及内皮细胞胞浆内,均为强阳性.RT-PCR结果示对照组HSP70和HSP90αmRNA的扩增产物条带多为阳性或强阳性,而在肾母细胞瘤中多为中度阳性或弱阳性表达.HSP70/β-actin': [4], '在对照组和肿瘤组分别为1.41±0.26和0.73±0.27(P=0.004),HSP90α/β-actin在对照组和肿瘤组分别为0.95±0.04和0.61±0.13(P=0.0009).相关分析表明HSP70和HSP90α蛋白和mRNA的表达均成正相关(r=0.694,': [5], 'P=0.001;r=0.720,': [6], 'P=0.001).HSP70、HSP90α': [7], 'mRNA的表达在不同肿瘤分期之间无明显差别,P值分别为0.13和0.34.随访过程中,无肿瘤复发者HSP70、HSP90α': [8], 'mRNA的表达明显高于复发者,P值分别为0.005和0.003.结论': [9], 'HSP70和HSP90α在小儿肾母细胞瘤中表达降低,二者表达高者术后复发率低,提示HSP70和HSP90α的表达对肾母细胞瘤预后的判定有一定参考价值。': [10]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3031355163', 'counts_by_year': [], 'updated_date': '2024-09-18T09:54:46.609694', 'created_date': '2020-06-05'}