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'https://openalex.org/W2521164502'], 'abstract_inverted_index': {'目的': [0], '研究人参皂甙Rg3抑制人肝癌细胞生长及诱导凋亡作用机制.方法体外培养人癌细胞(SMMC-721),观察人参皂甙Rg3高剂量组(80': [1], 'μg/ml)、中剂量组(40': [2], 'μg/ml)、低剂量组(20': [3], 'μg/ml)、阳性顺铂对照组(DDP,80': [4], 'μg/ml)和空白对照组(PBS)于12': [5], 'h、24': [6], 'h、48': [7], 'h、72': [8], 'h培养后,肝癌细胞的形态学和生长情况.采用MTT法,分析人参皂甙Rg3对细胞生长抑制率的影响.通过电镜观察细胞凋亡的形态学特征.结果应用人参皂甙Rg3后,普通光镜下发现细胞数随Rg3浓度增加而减少,呈剂量依赖性,人参皂甙Rg3高、中、低剂量组细胞生长的抑制率分别为34.6%、19.1%和6.1%,与未处理空白对照组的细胞生长抑制率(5.7%)相比,以人参皂甙Rg3高剂量组于作用72': [9], 'h后对细胞生长的抑制作用最明显(P<0.001),中剂量组次之(P<0.05),低剂量组及Rg3': [10], '2': [11], 'h,24': [12], 'h,48': [13], 'h组未见明显差别.阳性对照顺铂组的细胞生长抑制为22.2%.人参皂甙Rg3作用72': [14], 'h后的电镜分析显示,细胞出现典型的凋亡形态学改变.结论人参皂甙Rg3具有抑制人肝癌细胞生长作用,与促进细胞凋亡机制有关。': [15]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3031167729', 'counts_by_year': [], 'updated_date': '2024-09-18T09:53:33.772650', 'created_date': '2020-06-05'}