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'HovinghG.': [83], 'Hovingh': [85, 1177, 1584], 'Meibergdreef': [91, 1387], '9,': [92, 1388], '1105': [93, 1389], 'AZ': [94, 1390], 'Amsterdam,': [95, 1391], 'The': [96, 109, 147, 169, 191, 476, 636, 1075, 1165, 1174, 1219, 1272, 1302, 1315, 1324, 1335, 1392, 1714, 1956, 2427], 'Netherlands.': [97, 1393], 'Email': [98, 1394], 'E-mail': [99], 'Address:': [100], '[email': [101], 'protected]': [102], 'Department': [103, 212], 'of': [104, 127, 130, 213, 216, 220, 269, 319, 356, 405, 534, 549, 559, 570, 574, 617, 658, 673, 733, 796, 853, 870, 890, 893, 907, 932, 984, 996, 1017, 1022, 1078, 1113, 1116, 1124, 1142, 1168, 1355, 1452, 1522, 1558, 1597, 1649, 1685, 1716, 1751, 1771, 1808, 1843, 1891, 1896, 1985, 1988, 1993, 2086, 2118, 2173, 2216, 2274, 2323, 2364, 2382, 2400, 2405, 2429, 2518, 2550, 2577, 2586, 2598, 2612], 'Internal': [105, 1752], 'Medicine,': [106, 128, 214, 1753, 2552], 'Amsterdam': [107], 'UMC,': [108], 'Netherlands': [110, 1183], '(G.K.H.).': [111], 'Search': [112, 135, 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435, 469, 543, 592, 924, 937, 954, 968, 970, 989, 1003, 1005, 1041, 1073, 1083, 1136, 1484, 1526, 1562, 1599, 2159, 2167, 2328, 2590], 'HoFH.': [282, 1074], 'Receptor-defective': [283], 'reduce': [285, 1104], 'function': [288, 306], 'up': [290, 2546], '75%': [292], '(2%': [293], '25%': [295], 'normal': [296, 308], 'activity),': [297], 'whereas': [298], 'receptor-negative': [299], '(or': [300], 'null)': [301], 'completely': [303], 'eliminate': [304], 'its': [305, 2491], '(<2%': [307], 'activity).1': [309], 'Receptor-negative': [310], 'generally': [313], 'associated': [314, 923], 'levels': [318, 462, 505, 718, 786, 827, 831, 896, 1067], 'LDL-C': [320, 326, 386, 487, 500, 530, 561, 757, 785, 805, 830, 951, 976, 997, 1066], 'poor': [322, 797, 871], 'response': [323, 798, 872, 1055], 'therapy.1Guideline-recommended': [325], 'levels1': [327], 'rarely': [329], 'achieved': [330, 725, 755], 'HoFH': [332, 410, 436, 550, 955, 969, 1004, 1127], 'because': [333, 716, 889, 1021], 'established': 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'data': [674, 680, 1372], 'these': [676, 1108], 'provided': [678, 1152], 'sufficient': [679], 'justify': [682], 'long-term': [684, 1100], 'trial': [687], '(ORION-5);': [688], 'hence,': [689], 'further': [691, 1381], 'enrolled.': [694], 'A': [696, 773, 1011, 1647, 1675, 1732, 1882, 1918, 1954, 2052, 2265, 2285, 2288, 2290, 2572], 'through': [697, 753], 'C': [698, 1981, 2320], 'injections': [701], '90;': [706], 'patient': [707, 772], 'D': [708, 754, 819, 2012, 2358, 2482], 'injection': [711], 'only': [712, 821, 885], 'remained': [719, 828], '>70%.All': [722], 'robust,': [726], 'durable': [727, 756, 776], 'reductions': [729, 808, 1016, 1038], 'background': [732], 'high-intensity': [734], 'statins': [735], 'ezetimibe': [737], '(−48.7%': [738], '−83.6%': [740], '90,': [743, 764], '−40.2%': [744], '−80.5%': [746], 'Figure).': [750], 'B': [752, 815, 2259, 2392], 'lowering': [758, 965], '(−11.7%': [759], '−33.1%': [761], '−17.5%': [765], '−37.0%': [767], '180).': [770], 'Although': [771], 'experienced': [774], 'throughout': [779], 'study,': [781, 943, 1119], '(Figure);': [789], 'notably,': [790], 'participant': [792], 'had': [793, 867], 'marketed': [801], 'antibodies.': [804], 'persisted': [809], 'C.': [817], 'Patient': [818], 'dose,': [823], 'although': [825], 'suppressed,': [829], 'returned': [832], 'value': [835], '240': [838], '(Figure).': [839], 'No': [840], 'drug-related': [841], 'adverse': [842], 'events': [843, 1106], 'injection-site': [845], 'reactions': [846], 'reported.Download': [848], 'figureDownload': [849], 'PowerPointFigure.': [850], 'Time': [851], 'course': [852], 'effects.': [865], '*Patient': [866], 'evolocumab': [875, 1600], 'alirocumab': [877], '(<20%': [878], 'decrease': [879], 'LDL-C).': [881], '†Patient': [882], 'Multiplex': [902], 'ligation-dependent': [903], 'probe': [904], 'amplification': [905], 'analysis': [906], '(LDLR)': [912], 'revealed': [914], 'exon': [916], '12–exon': [917], '18': [918], 'deletion,': [919], 'likely': [920], 'be': [922, 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'LDL-C−lowering': [1054, 1090], 'PCSK9-lowering': [1057], 'therapy.5Inclisiran': [1058], 'potentially': [1059], 'represents': [1060], 'novel': [1062, 2295], 'option': [1063], 'lower': [1065, 1868], 'various': [1069], 'populations,': [1070], 'including': [1071], 'unique': [1076, 1131], 'approach': [1077], 'reducing': [1079], 'hepatocyte': [1080], 'synthesis': [1082], 'as': [1085], 'adjunct': [1087], 'conventional': [1089], 'allows': [1092], 'interval': [1096], 'could': [1098], 'enhance': [1099], 'adherence,': [1101], 'may': [1103], 'high-risk': [1109], 'patients.On': [1110], 'results': [1115, 1358, 1530, 1568], '(ORION-5;': [1128], 'URL:': [1129], 'https://www.clinicaltrials.gov;': [1130], 'identifier:': [1132], 'NCT03851705)': [1133], 'ongoing': [1135], 'standard': [1138], 'mg.AcknowledgmentsEditorial': [1146], 'assistance': [1147], 'submission': [1149], 'support': [1150, 1204, 1255, 1270, 1309], 'Cadent': [1154], 'Medical': [1155], 'Communications': [1156], 'LLC,': [1157], 'Syneos': [1159], 'Healthgroup': [1160], 'company,': [1161], 'funded': [1163, 1172], 'Company.Sources': [1167], 'FundingThis': [1169], 'Company.DisclosuresDr': [1176], 'research': [1179, 1203, 1254, 1269, 1308], 'grants': [1180], 'Organization': [1184], 'Scientific': [1186], 'Research': [1187, 1191], '(vidi': [1188], '016.156.445),': [1189], 'CardioVascular': [1190], 'Initiative,': [1192], 'Union': [1195], '(fees': [1196, 1222, 1239], 'paid': [1197, 1223, 1240], 'academic': [1200, 1226, 1243], 'institution);': [1201, 1227, 1244], 'institutional': [1202], 'Aegerion,': [1206, 1235], 'Amgen,': [1207, 1234, 1282, 1313, 1322, 1333], 'AstraZeneca,': [1208], 'Eli': [1209], 'Lilly,': [1210], 'Genzyme,': [1211], 'Ionis,': [1212], 'Kowa,': [1213], 'Pfizer,': [1214], 'Regeneron,': [1215, 1312, 1321, 1332], 'Roche,': [1216], 'Sanofi,': [1217, 1236, 1311, 1320, 1331], 'Company': [1221], 'speaker’s': [1228], 'bureau': [1229], 'consulting': [1231, 1263, 1275, 1328], 'fees': [1232, 1264, 1276, 1329], 'Regeneron': [1238, 1261], 'part-time': [1246], 'employment': [1247, 1297], 'Novo': [1249], 'Nordisk.': [1250], 'Dr': [1251, 1291, 1294, 1305], 'honoraria': [1257, 1280, 1318], 'Sanofi': [1259, 1266], 'Regeneron;': [1268], 'Company;': [1274, 1317, 1326], 'AstraZeneca;': [1278], 'Boehringer': [1283], 'Ingelheim,': [1284], 'Bristol-Myers': [1285], 'Squibb,': [1286], 'Pfizer.': [1288], 'D.': [1289], 'report': [1296], 'stock': [1299], 'options': [1300], 'Company.': [1304], 'Company.Footnoteshttps://www.ahajournals.org/journal/circThe': [1337], 'data,': [1338], 'analytical': [1339], 'methods,': [1340], 'materials': [1343], 'will': [1344], 'made': [1347], 'available': [1348], 'researchers': [1351], 'purposes': [1354], 'reproducing': [1356], 'replicating': [1360], 'procedure.': [1362], 'However,': [1363], 'authors': [1365], 'encourage': [1366], 'parties': [1367], 'interested': [1368], 'collaboration': [1370], 'sharing': [1373], 'contact': [1375], 'corresponding': [1377], 'directly': [1379], 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