Title: Research advance in the role of Toll-like receptors in the ovarian cancer
Abstract: The mortality of ovary cancer is the highest in gynecologic cancers. Innate immune system plays an important role in immune defense, particularly in the recognition of pathogens, which is mainly through Toll-like receptors(TLRs). TLRs have been hot research molecules.The discovery of TLRs has changed our understanding about the mechanism of diseases. The activation of TLRs leads to release of cytokines and chemokines.TLRs also activate adaptive immunity. TLRs play an important role in ovary cancer development. The agonists and antagonists of TLRs might become novel therapeutic agents for ovary cancer.
Key words:
Toll-like receptor; Toll-like receptor signaling pathway; Ovarian cancer; Innate immunity; Tumor immunotherapy
Publication Year: 2015
Publication Date: 2015-01-05
Language: en
Type: article
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