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'https://openalex.org/W2034895041', 'https://openalex.org/W2013336475', 'https://openalex.org/W1988107840', 'https://openalex.org/W1980069463', 'https://openalex.org/W1971791563'], 'abstract_inverted_index': {'zeste基因增强子同源物2(EZH2)是果蝇zeste基因增强子[E(z)]的人类同源物组蛋白甲基化的重要工具酶,也是多梳基因家族PcG(polycomb': [0], 'group)的核心成员。EZH2参与多梳蛋白复合体2的形成,促使相应组蛋白甲基化,从表观遗传学的角度介导相应靶基因沉默,在肿瘤的发生、发展过程中发挥着重要作用。其高表达与多种恶性肿瘤的发生、发展和极差的预后密切相关。近年来,越来越多的学者对EZH2的致癌机制进行了深入研究,为乳腺癌转移的检测、预后评估及治疗提供了全新的思路。笔者就EZH2表达情况及其与乳腺癌发生、发展、转移及预后之间的关系作一综述,以便临床医师更好地认识这一新的肿瘤标志物。': [1]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3030858043', 'counts_by_year': [], 'updated_date': '2024-08-20T19:21:54.405990', 'created_date': '2020-06-05'}