Title: Effect of the etanercept on the hip pain in children with ankylosing spondylitis
Abstract: Objective
To study the early effect of the etanercept on the hip pain in children with ankylosing spondylitis(AS).
Methods
Seventy-seven patients were randomly divided into etanercept group (group A, n=21 cases), diclofenac sodium group (group B, n=20 cases), sulfasalazine plus methotrexate group (group C, n=19 cases), placebo control group (group D, n=17 cases). Group A was treated with etanercept 0.8 mg/kg, once a week.Group B was given diclofenac sodium enteric-coated tablets 1 mg/kg, 2 times a day.Group C was treated with sulfasalazine tablets 15-25 mg/kg, 2 times a day and methotrexate tablets 10-15 mg/m2, once a week.Group D patients were given vitamin C 0.395 g, 2 times a day, then the effect of different drugs on AS hip pain in children was observed.
Results
One day after administration, the visual analogue scale(VAS) score of the etanercept group and diclofenac sodium group was significantly different statistically compared with the placebo control group, and this effect continued until more than 14 days.Sulfasalazine with methotrexate group had no difference in the experimental time window compared with that of the placebo control group.The VAS score of the etanercept group compared with the diclofenac sodium was significantly different statistically, and this effect continued until more than 14 days.
Conclusion
Etanercept can relieve the hip pain in children with AS rapidly and continuously.
Key words:
Etanercept; Ankylosing spondylitis; Hip joint; Pain
Publication Year: 2014
Publication Date: 2014-06-20
Language: en
Type: article
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