Title: Effect of yangxueqingnao particles on the pharmacokinetics of carbamazepine in healthy volunteers
Abstract: Objective To study the effect of yangxueqingnao particles on the pharmacokinetics of carbamazepine in healthy volunteers.Methods Eight subjects were oral administrated with carbamazepine (200 mg) in the morning after fasted ten hours.Blood samples were draw at different time.Yangxueqingnao particles were taken 10 days latter.When yangxueqingnao particles were taken 7 days,carbamazepine (200 mg) was oral given again.Blood was drew off at the same time again.High performance liquid chromatography was used to determine the concentration of carbamazepine.Kinetica 5.0 was used to calculate the pharmacokinetic parameters.Results There was no significant difference between the two groups in the pharmacokinetic parameters of carbamazepine,such as C T T1/2,AUC0-t,CL (P > 0.05).Conclusions The yangxueqingnao particles have no effect on the absorption and metabolism of carbamazepine in human.
Key words:
Yangxueqingnao particles ; Carbamazepine ; Pharmacokinetic
Publication Year: 2013
Publication Date: 2013-10-10
Language: en
Type: article
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