Publication Information

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'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032353966', 'https://openalex.org/W3032267986', 'https://openalex.org/W3032088866', 'https://openalex.org/W3031987883', 'https://openalex.org/W3031906685', 'https://openalex.org/W3031720583', 'https://openalex.org/W3031209468', 'https://openalex.org/W3030320438', 'https://openalex.org/W3029712682', 'https://openalex.org/W3029188903', 'https://openalex.org/W3029076842', 'https://openalex.org/W2403582269', 'https://openalex.org/W2393527387', 'https://openalex.org/W2390067711', 'https://openalex.org/W2376515980', 'https://openalex.org/W2372911027', 'https://openalex.org/W2363924123', 'https://openalex.org/W2359144929', 'https://openalex.org/W2349854825', 'https://openalex.org/W2045728451'], 'abstract_inverted_index': {'目的': [0], '分析慢性乙型病毒性肝炎患者外周血T淋巴细胞亚群CD27和CD28的表达,初步探讨其分化表型.方法': [1], '采集分离健康人和慢性乙型病毒性肝炎患者外周血单个核细胞(PBMC),利用多种荧光标记抗体标记细胞表面分子,再用流式细胞仪检测CD8+和CD4+T淋巴细胞表面CD27和CD28分子的表达.结果': [2], '31例慢性乙型病毒性肝炎患者CD8+CD27+CD28+T细胞占CD8+T细胞(41.13±24.89)%,低于28例健康对照组的(71.93±14.47)%(P＜0.05).而CD8+CD27-CD28-T细胞占CD8+T细胞(42.16±10.98)%,显著高于健康对照组的(9.16±5.24)%(P＜0.01).慢性乙型病毒性肝炎患者CD4+CD27+CD28+T细胞(80.89±7.93)%和健康对照组(83.17±8.31)%比较,差异无统计学意义.结论': [3], '健康人外周血T淋巴细胞以CD27+CD28+早期分化表型为主.而慢性乙型病毒性肝炎患者外周血中不同的亚群分化特征又有所不同,CD4+T淋巴细胞的分化表型仍然以CD27+CD28+早期分化表型为主,而CD8+T淋巴细胞中早期分化表型明显减少,晚期分化表型(CD27-CD28-)显著增加。': [4]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3030392848', 'counts_by_year': [], 'updated_date': '2024-12-24T07:12:49.302545', 'created_date': '2020-06-05'}