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'探讨肝硬化腹水患者体内前炎症细胞因子TNF-α、IL-6的变化及临床意义.方法采用双抗体夹心酶联免疫吸附法(ELISA)检测94例肝炎后肝硬化腹水患者腹水、血液标本中TNF-α、IL-6水平,同时应用鲎试剂三肽显色基质偶氮法检测标本内毒素水平,研究以上指标的相互关系及临床意义.结果①肝炎后肝硬化自发性细菌性腹膜炎(SBP)组、无菌性腹水(SA)组血浆内毒素、TNF-α、IL-6浓度均显著高于健康对照组(P值均<0.001);': [1], '②SBP组腹水内毒素、TNF-α、IL-6浓度均显著高于SA组(P值均<0.001);③肝硬化腹水患者血浆内毒素与TNF-α、IL-6水平呈正相关(P值均<0.001).结论肝硬化腹水患者存在细胞因子血症;肝硬化腹水患者TNF-α,IL-6水平升高与体内内毒素水平升高有关。': [2]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3030097694', 'counts_by_year': [], 'updated_date': '2024-09-18T09:47:15.419462', 'created_date': '2020-06-05'}