Title: Role of IL-6 and NF-kappaB in patients with chronic obstructive pulmonary disease
Abstract:Objective The expression and significance of nuclear factor-κB (NF-κB) and IL-6 were investigated in the peripheral blood of patients with chronic obstructive pulmonary disease (COPD).Methods From Feb...Objective The expression and significance of nuclear factor-κB (NF-κB) and IL-6 were investigated in the peripheral blood of patients with chronic obstructive pulmonary disease (COPD).Methods From February through July 2012,the serum concentrations of IL-6 and the expression of NF-κB of peripheral blood mononuclear cells (PBMC) were compared,using ELISA and Western blotting,respectively,among patients with acute COPD (AECOPD,n =25),patients with stable COPD (SCOPD,n =25) and controls without COPD (n =25).All the data were analysed using SPSS 13.0.Results ①The serum concentration of CRP was significantly higher in the AECOPD group (28.125 7±38.561 3) mg/L,compared with the stable COPD group (8.205 5 ± 16.309 6) mg/L and the control group (2.861 7±4.854 7) mg/L.Nevertheless,there was no significant difference between the stable COPD group and the control group; ②The serum concentration of IL-6 was significantly higher in the AECOPDgroup (31.883 4±19.462 95) ng/L and the stable COPD group (44.461± 16.181 4) ng/L,compared with the control group (23.856±9.930 33) ng/L;③The expression of NF-κB of PBMC were no significant difference in AECOPD group (0.965 9±0.075 4),stable group (0.918 2±0.051 31) and control group (0.949 6±0.143 93) ;④The correlation between the expression of NF-κB of PBMC and the serum concentration of IL-6 was insignificant.Conclusions The overexpression of IL-6 in in stable group may play a critical role in the pathogenesis of COPD,but NF-κB was not concerned with systemic inflammation of COPD.
Key words:
Chronic obstructive pulmonary disease; Interleukin-6; Nuclear factor-κBRead More
Publication Year: 2013
Publication Date: 2013-06-05
Language: en
Type: article
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