Publication Information

{'id': 'https://openalex.org/W3029929557', 'doi': 'https://doi.org/10.3760/cma.j.issn.1671-0282.2018.10.005', 'title': 'Effect of KN93 on delayed afterdepolarization and calcium ion in ventricular myocytes of rabbits with heart failure', 'display_name': 'Effect of KN93 on delayed afterdepolarization and calcium ion in ventricular myocytes of rabbits with heart failure', 'publication_year': 2018, 'publication_date': '2018-10-10', 'ids': {'openalex': 'https://openalex.org/W3029929557', 'doi': 'https://doi.org/10.3760/cma.j.issn.1671-0282.2018.10.005', 'mag': '3029929557'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.3760/cma.j.issn.1671-0282.2018.10.005', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5014682106', 'display_name': 'Jun Ke', 'orcid': 'https://orcid.org/0009-0004-6918-2807'}, 'institutions': [{'id': 'https://openalex.org/I4210143087', 'display_name': 'Fujian Provincial Hospital', 'ror': 'https://ror.org/045wzwx52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210143087']}, {'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Ke', 'raw_affiliation_strings': ['Emergency Department, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fujian Emergency Medical Center, Fujian Provincial Institute of Emergency Medicine, Fuzhou 350001, China'], 'affiliations': [{'raw_affiliation_string': 'Emergency Department, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fujian Emergency Medical Center, Fujian Provincial Institute of Emergency Medicine, Fuzhou 350001, China', 'institution_ids': ['https://openalex.org/I4210143087', 'https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101468999', 'display_name': 'Yang Li', 'orcid': 'https://orcid.org/0000-0002-2413-7875'}, 'institutions': [{'id': 'https://openalex.org/I4210101382', 'display_name': "People's Liberation Army No. 150 Hospital", 'ror': 'https://ror.org/014nsap67', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101382']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yang Li', 'raw_affiliation_strings': ['Cardiology Department, General Hospital of People’s Liberation Army, Beijing 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Department, General Hospital of People’s Liberation Army, Beijing 100853, China', 'institution_ids': ['https://openalex.org/I4210101382']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101729329', 'display_name': 'Feng Chen', 'orcid': 'https://orcid.org/0000-0002-9699-0680'}, 'institutions': [{'id': 'https://openalex.org/I4210143087', 'display_name': 'Fujian Provincial Hospital', 'ror': 'https://ror.org/045wzwx52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210143087']}, {'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Feng Chen', 'raw_affiliation_strings': ['Emergency Department, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fujian Emergency Medical Center, Fujian Provincial Institute of Emergency Medicine, Fuzhou 350001, China'], 'affiliations': [{'raw_affiliation_string': 'Emergency Department, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fujian Emergency Medical Center, Fujian Provincial Institute of Emergency Medicine, Fuzhou 350001, China', 'institution_ids': ['https://openalex.org/I4210143087', 'https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032564190', 'display_name': 'Chao Zhu', 'orcid': 'https://orcid.org/0000-0001-7879-7281'}, 'institutions': [{'id': 'https://openalex.org/I4210101382', 'display_name': "People's Liberation Army No. 150 Hospital", 'ror': 'https://ror.org/014nsap67', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101382']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chao Zhu', 'raw_affiliation_strings': ['Cardiology Department, General Hospital of People’s Liberation Army, Beijing 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Department, General Hospital of People’s Liberation Army, Beijing 100853, China', 'institution_ids': ['https://openalex.org/I4210101382']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100459908', 'display_name': 'Xiaoping Wang', 'orcid': 'https://orcid.org/0000-0002-1370-490X'}, 'institutions': [{'id': 'https://openalex.org/I4210143087', 'display_name': 'Fujian Provincial Hospital', 'ror': 'https://ror.org/045wzwx52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210143087']}, {'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoping Wang', 'raw_affiliation_strings': ['Emergency Department, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fujian Emergency Medical Center, Fujian Provincial Institute of Emergency Medicine, Fuzhou 350001, China'], 'affiliations': [{'raw_affiliation_string': 'Emergency Department, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fujian Emergency Medical Center, Fujian Provincial Institute of Emergency Medicine, Fuzhou 350001, China', 'institution_ids': ['https://openalex.org/I4210143087', 'https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082057570', 'display_name': 'Bendun Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210143087', 'display_name': 'Fujian Provincial Hospital', 'ror': 'https://ror.org/045wzwx52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210143087']}, {'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bendun Chen', 'raw_affiliation_strings': ['Emergency Department, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fujian Emergency Medical Center, Fujian Provincial Institute of Emergency Medicine, Fuzhou 350001, China'], 'affiliations': [{'raw_affiliation_string': 'Emergency Department, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fujian Emergency Medical Center, Fujian Provincial Institute of Emergency Medicine, Fuzhou 350001, China', 'institution_ids': ['https://openalex.org/I4210143087', 'https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100774430', 'display_name': 'Shifeng Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210143087', 'display_name': 'Fujian Provincial Hospital', 'ror': 'https://ror.org/045wzwx52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210143087']}, {'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shifeng Li', 'raw_affiliation_strings': ['Emergency Department, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fujian Emergency Medical Center, Fujian Provincial Institute of Emergency Medicine, Fuzhou 350001, China'], 'affiliations': [{'raw_affiliation_string': 'Emergency Department, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fujian Emergency Medical Center, Fujian Provincial Institute of Emergency Medicine, Fuzhou 350001, China', 'institution_ids': ['https://openalex.org/I4210143087', 'https://openalex.org/I129708740']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103158071', 'display_name': 'Zheng Gong', 'orcid': 'https://orcid.org/0009-0007-7711-2376'}, 'institutions': [{'id': 'https://openalex.org/I4210143087', 'display_name': 'Fujian Provincial Hospital', 'ror': 'https://ror.org/045wzwx52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210143087']}, {'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zheng Gong', 'raw_affiliation_strings': ['Emergency Department, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fujian Emergency Medical Center, Fujian Provincial Institute of Emergency Medicine, Fuzhou 350001, China'], 'affiliations': [{'raw_affiliation_string': 'Emergency Department, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fujian Emergency Medical Center, Fujian Provincial Institute of Emergency Medicine, Fuzhou 350001, China', 'institution_ids': ['https://openalex.org/I4210143087', 'https://openalex.org/I129708740']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 62}, 'biblio': {'volume': '27', 'issue': '10', 'first_page': '1089', 'last_page': '1094'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9529, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9529, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13142', 'display_name': 'GABA and Rice Research', 'score': 0.9046, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/afterdepolarization', 'display_name': 'Afterdepolarization', 'score': 0.78211254}], 'concepts': [{'id': 'https://openalex.org/C155730078', 'wikidata': 'https://www.wikidata.org/wiki/Q2898697', 'display_name': 'Afterdepolarization', 'level': 4, 'score': 0.78211254}, {'id': 'https://openalex.org/C2778198053', 'wikidata': 'https://www.wikidata.org/wiki/Q181754', 'display_name': 'Heart failure', 'level': 2, 'score': 0.7773106}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.711826}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6090472}, {'id': 'https://openalex.org/C207200792', 'wikidata': 'https://www.wikidata.org/wiki/Q428914', 'display_name': 'Myocyte', 'level': 2, 'score': 0.56201196}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.5447061}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.50780874}, {'id': 'https://openalex.org/C147944092', 'wikidata': 'https://www.wikidata.org/wiki/Q176366', 'display_name': 'Patch clamp', 'level': 3, 'score': 0.4386436}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.39543897}, {'id': 'https://openalex.org/C185263204', 'wikidata': 'https://www.wikidata.org/wiki/Q1154774', 'display_name': 'Electrophysiology', 'level': 2, 'score': 0.25471768}, {'id': 'https://openalex.org/C146403970', 'wikidata': 'https://www.wikidata.org/wiki/Q205729', 'display_name': 'Repolarization', 'level': 3, 'score': 0.17753345}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.3760/cma.j.issn.1671-0282.2018.10.005', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.8, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032578816', 'https://openalex.org/W3029536530', 'https://openalex.org/W2512500680', 'https://openalex.org/W2401860437', 'https://openalex.org/W2397642262', 'https://openalex.org/W2395670638', 'https://openalex.org/W2394107738', 'https://openalex.org/W2393907247', 'https://openalex.org/W2382256533', 'https://openalex.org/W2382134643', 'https://openalex.org/W2372658324', 'https://openalex.org/W2367888535', 'https://openalex.org/W2365917297', 'https://openalex.org/W2358521309', 'https://openalex.org/W2353499052', 'https://openalex.org/W2288372591', 'https://openalex.org/W2094287539', 'https://openalex.org/W2052373380', 'https://openalex.org/W2007049912', 'https://openalex.org/W188034730'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'observe': [1], 'the': [2, 27, 48, 99, 107, 117, 186, 209, 251, 260, 267, 274, 279, 283, 291, 297, 303, 306, 320], 'effect': [3, 28], 'of': [4, 19, 29, 163, 169, 180, 188, 195, 212, 227, 230, 239, 250, 254, 262, 269, 276, 285, 296, 305], 'KN93,': [5], 'a': [6, 313], 'CaMKⅡ': [7, 30, 310], 'inhibitor,': [8], 'on': [9, 33], 'delayed': [10], 'afterdepolarization': [11], '(DAD)': [12], 'and': [13, 24, 59, 98, 151, 167, 190, 244, 248, 264, 281, 287, 302, 308], 'calcium': [14, 112, 124, 241, 245, 255, 271, 293], 'ion': [15, 118, 242, 294, 329], 'in': [16, 175, 319], 'ventricular': [17, 87, 177], 'myocytes': [18, 88], 'rabbits': [20, 43], 'with': [21, 62, 82, 182], 'heart': [22, 37, 54, 60, 72, 164, 196, 298, 321], 'failure,': [23, 165, 197], 'to': [25, 205, 222, 237], 'investigate': [26], 'signaling': [31], 'pathway': [32], 'trigged': [34], 'arrhythmia': [35], 'after': [36, 225], 'failure.\r\n\r\n\r\nMethods\r\nThirty': [38], 'male': [39], 'New': [40], 'Zealand': [41], 'White': [42], 'were': [44, 89, 104, 133, 147, 173, 200, 220], 'randomized(random': [45], 'number)': [46], 'into': [47], 'sham': [49], 'operated': [50], 'group': [51, 56, 64], '(sham': [52], 'group),': [53], 'failure': [55, 61, 73, 299], '(HF': [57], 'group)': [58, 66], 'KN93': [63, 181, 231, 235, 258], '(HF+KN93': [65], '(n=10': [67], 'each': [68], 'group).': [69], 'The': [70, 86, 95, 110, 122, 217], 'rabbit': [71, 176], 'model': [74], 'was': [75, 114, 127, 139, 156], 'established': [76], 'by': [77, 91, 106, 116, 129, 135], 'abdominal': [78], 'aortic': [79, 83], 'constriction': [80], 'combined': [81], 'valve': [84], 'regurgitation.': [85], 'isolated': [90], 'double': [92], 'enzyme': [93], 'digestion.': [94], 'action': [96], 'potential': [97, 211], 'transient': [100, 113, 246], 'inward': [101, 327], 'current': [102, 218], '(Iti)': [103], 'recorded': [105], 'whole-cell': [108], 'patch-clamp.': [109], 'intracellular': [111, 240, 270, 292], 'measured': [115], 'concentration': [119, 243, 295], 'measurement': [120], 'system.': [121], 'main': [123], 'transporter': [125], 'protein': [126], 'detected': [128], 'Western': [130], 'blotting.': [131], 'Data': [132], 'analyzed': [134], 'pCLAMP10.2.': [136], 'Statistical': [137], 'analysis': [138], 'performed': [140], 'using': [141, 149], 'SPSS': [142], '17.0.': [143], 'Comparisons': [144], 'among': [145], 'groups': [146], 'conducted': [148], 'ANOVA,': [150], 'SNK-q': [152], 'multiple': [153], 'comparison': [154], 'procedure': [155], 'utilized': [157], 'for': [158, 317], 'post-hoc': [159], 'analysis.\r\n\r\n\r\nResults\r\n(1)': [160], 'After': [161, 193], 'induction': [162, 194], 'DAD': [166, 189, 286, 307], 'increment': [168], 'trigger': [170], 'activity': [171], '(TA)': [172], 'observed': [174], 'myocytes.': [178], 'Treatment': [179], '1.0': [183, 228], 'μmol/L': [184, 229], 'reduced': [185, 221, 282], 'events': [187], 'TA.': [191, 309], '(2)': [192], 'Iti': [198], 'densities': [199, 219], 'increased': [201, 266], 'from': [202], '-0.12±0.02': [203], 'pA/pF': [204, 207, 224], '-0.95±0.06': [206], 'at': [208], 'polarization': [210], '-50': [213], 'mV': [214], '(n=10,': [215, 232], 'P<0.01).': [216, 233], '-0.44±0.04': [223], 'application': [226], '(3)': [234], 'led': [236], 'decrement': [238], 'amplitude,': [247], 'acceleration': [249], 'decay': [252], 'process': [253], 'transient.': [256], '(4)': [257], 'upregulated': [259], 'expression': [261, 275], 'pPLN': [263], 'SERCA2a,': [265], 'uptake': [268], 'ion,': [272], 'downregulated': [273], 'NCX,': [277], 'decreased': [278], 'Iti,': [280], 'occurrence': [284, 304], 'TA.\r\n\r\n\r\nConclusions\r\nKN93': [288], 'can': [289], 'reduce': [290], 'animal': [300], 'model,': [301], 'may': [311], 'be': [312], 'new': [314], 'therapeutic': [315], 'target': [316], 'arrhythmias': [318], 'failure.\r\n\r\n\r\nKey': [322], 'words:': [323], '\r\nKN93;\xa0Heart': [324], 'failure;\xa0Delayed': [325], 'afterdepolarization;\xa0Transient': [326], 'current;\xa0Calcium': [328]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029929557', 'counts_by_year': [], 'updated_date': '2024-12-24T07:13:06.999539', 'created_date': '2020-06-05'}