Title: Expression of CD69 and CD134 on psoriatic peripheral blood T lymphocytes
Abstract: Objective To investigate the in vivo expression of CD134 by the peripheral blood T cells from psoriasis patients, the regulation of their expression in response to polyclone stimulator. Methods The whole blood culture procedure was applied to mimic the natural conditions of T cell activation in vivo. T cells were activated by polyclone stimulator PMA plus Ionomycine. CD69 and CD134 expressed in vitro on activated T lymphocytes from psoriasis patients and healthy controls were detected with three-color flow cytometry. Results The results showed that the expression rates of CD134 and CD69 on the peripheral T cells from psoriasis patients were much higher than those of healthy controls (P<0.05). In response to the stimulation of PMA plus Ionomycin, there was only significant difference on the expression rates of CD69 on the peripheral blood T cells between these two groups at 24 h post activation. Whereas, the expression rates of CD134 on psoriatic peripheral blood T cells were significantly increased than those of the healthy controls at all time points (P<0.001). Conclusions The results verified the aberrant activation of the peripheral blood T lymphocytes in psoriasis. Moreover, the expression of CD134 on psoriatic peripheral T cells in response to polyclone stimulators PMA plus Ionomycin is in a stronger manner than those of healthy controls.
Key words:
Psoriasis ; T lymphocytes ; CD134(OX40) ;
Publication Year: 2010
Publication Date: 2010-06-10
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot