Title: Clinical effect of TACE combined with RFA and 125I radioactive seed implantation in treatment of massive liver cancer
Abstract: Objective:
To investigate the clinical value of transarterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) and 125I radioactive seed implantation for the treatment of liver cancer (≥10 cm) .
Methods:
Fifty-four patients with live cancer clinical or pathological verified of ≥10 cm in our hospital were selected, and all patients underwent TACE. Patients were randomly divided into radiofrequency ablation group (TACE+RFA, control group, n=28) and RFA plus 125I radioactivity seed implantation group (TACE+RFA+125I, combined group, n=26) . All patients were followed up for 1 to 37 months. The treatment efficiency and clinical control rate were compared between the two groups. Survival analysis was performed by Kaplan-Meier. Log-rank test was used to compare the survival curves.
Results:
The effective rate of the combined group was higher than that of the control group (61.5% vs. 32.1%) , with significant difference (χ2=4.685, P=0.030) . The median PFS in combined group and control group was 9 months and 5 months (P=0.010) , and the OS in combined group was longer than that in control group (11 months vs. 6 months, P=0.079) .
Conclusions:
The sequential therapy with TACE, RFA and radioactive particle has advantages in treating liver cancer with the diameter ≥10 cm. The PFS and tumor remission rate in combined group were more favorable than those in control group.
Key words:
Hepatocellular carcinoma; Radiofrequency ablation; Therapeutic effect; Radiology, 125I radioactivity seed implantation
Publication Year: 2019
Publication Date: 2019-05-01
Language: en
Type: article
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Cited By Count: 1
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