Publication Information

{'id': 'https://openalex.org/W3029517488', 'doi': 'https://doi.org/10.3760/cma.j.issn.1008-6706.2018.22.018', 'title': 'Clinical efficacy of methotrexate combined with leflunomide in the treatment of rheumatoid arthritis', 'display_name': 'Clinical efficacy of methotrexate combined with leflunomide in the treatment of rheumatoid arthritis', 'publication_year': 2018, 'publication_date': '2018-11-15', 'ids': {'openalex': 'https://openalex.org/W3029517488', 'doi': 'https://doi.org/10.3760/cma.j.issn.1008-6706.2018.22.018', 'mag': '3029517488'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN341190201822/1076597.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764697616', 'display_name': 'Zhongguo jiceng yiyao', 'issn_l': '1008-6706', 'issn': ['1008-6706'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 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Pharmacy, Shengzhou Hospital of Traditional Chinese Medicine, Shengzhou, Zhejiang 312400, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, Shengzhou Hospital of Traditional Chinese Medicine, Shengzhou, Zhejiang 312400, China', 'institution_ids': ['https://openalex.org/I4210139110']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017555382', 'display_name': 'Yufang Lou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139110', 'display_name': 'Hangzhou Hospital of Traditional Chinese Medicine', 'ror': 'https://ror.org/03a8g0p38', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139110']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yufang Lou', 'raw_affiliation_strings': ['Department of Rheumatology, Shengzhou Hospital of Traditional Chinese Medicine, Shengzhou, Zhejiang 312400, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Rheumatology, Shengzhou Hospital of Traditional Chinese Medicine, Shengzhou, Zhejiang 312400, China', 'institution_ids': ['https://openalex.org/I4210139110']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 62}, 'biblio': {'volume': '25', 'issue': '22', 'first_page': '2931', 'last_page': '2934'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11316', 'display_name': 'Mycobacterium research and diagnosis', 'score': 0.9842, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9763, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/leflunomide', 'display_name': 'Leflunomide', 'score': 0.9687401}, {'id': 'https://openalex.org/keywords/rheumatoid-factor', 'display_name': 'Rheumatoid factor', 'score': 0.6492755}, {'id': 'https://openalex.org/keywords/clinical-efficacy', 'display_name': 'Clinical efficacy', 'score': 0.5211028}], 'concepts': [{'id': 'https://openalex.org/C2775905006', 'wikidata': 'https://www.wikidata.org/wiki/Q248550', 'display_name': 'Leflunomide', 'level': 3, 'score': 0.9687401}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9665066}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.8350337}, {'id': 'https://openalex.org/C2781059491', 'wikidata': 'https://www.wikidata.org/wiki/Q422232', 'display_name': 'Methotrexate', 'level': 2, 'score': 0.8230784}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6969726}, {'id': 'https://openalex.org/C2776232647', 'wikidata': 'https://www.wikidata.org/wiki/Q702883', 'display_name': 'Rheumatoid factor', 'level': 3, 'score': 0.6492755}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.61164725}, {'id': 'https://openalex.org/C2992053201', 'wikidata': 'https://www.wikidata.org/wiki/Q2585693', 'display_name': 'Clinical efficacy', 'level': 2, 'score': 0.5211028}, {'id': 'https://openalex.org/C197934379', 'wikidata': 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'http://rs.yiigle.com/CN341190201822/1076597.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764697616', 'display_name': 'Zhongguo jiceng yiyao', 'issn_l': '1008-6706', 'issn': ['1008-6706'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.78}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032865155', 'https://openalex.org/W3031806097', 'https://openalex.org/W3031725597', 'https://openalex.org/W3030475267', 'https://openalex.org/W2434281538', 'https://openalex.org/W2393781062', 'https://openalex.org/W2380857629', 'https://openalex.org/W2379621749', 'https://openalex.org/W2372708068', 'https://openalex.org/W2370427027', 'https://openalex.org/W2358891966', 'https://openalex.org/W2355995252', 'https://openalex.org/W2350716593', 'https://openalex.org/W2348540491', 'https://openalex.org/W2348375723', 'https://openalex.org/W2347953772', 'https://openalex.org/W2335309749', 'https://openalex.org/W2317243404', 'https://openalex.org/W2267897856', 'https://openalex.org/W2026870379'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'investigate': [1], 'the': [2, 11, 43, 60, 72, 107, 124, 136, 153, 170, 190, 197, 202, 205, 218, 226, 230, 245], 'clinical': [3, 69, 227, 265], 'efficacy': [4, 70], 'of': [5, 13, 29, 71, 97, 115, 186, 220, 242, 244, 255], 'methotrexate': [6, 66], 'combined': [7, 214], 'with': [8, 23, 48, 58, 65, 215, 238], 'leflunomide': [9, 216], 'in': [10, 26, 51, 106, 123, 135, 152, 169, 189, 196, 217, 236], 'treatment': [12, 143, 219], 'rheumatoid': [14, 24, 82, 221], 'arthritis.\r\n\r\n\r\nMethods\r\nFrom': [15], 'January': [16], '2017': [17], 'to': [18, 42], 'February': [19], '2018,': [20], '90': [21], 'patients': [22, 237], 'arthritis': [25, 222], 'Shengzhou': [27], 'Hospital': [28], 'Traditional': [30], 'Chinese': [31], 'Medicine': [32], 'were': [33, 90, 101, 139, 156, 164], 'divided': [34], 'into': [35], 'control': [36, 54, 125, 171, 198, 243], 'group': [37, 40, 55, 62, 109, 126, 155, 172, 192, 199], 'and': [38, 67, 85, 93, 132, 149, 160], 'observation': [39, 61, 108, 154, 191], 'according': [41], 'random': [44], 'number': [45], 'table': [46], 'method,': [47], '45': [49], 'cases': [50], 'each': [52], 'group.The': [53], 'was': [56, 63, 75, 110, 118, 193, 200, 208], 'treated': [57, 64], 'methotrexate,': [59], 'leflunomide.The': [68], 'two': [73, 137, 206], 'groups': [74, 138, 207], 'evaluated.The': [76], 'anti-cyclic': [77], 'citrullinated': [78, 261], 'peptide': [79, 262], 'antibody': [80], '(ACCP),': [81], 'factor': [83], '(RF),': [84], 'C-reactive': [86], 'protein': [87], '(CRP)': [88], 'levels': [89, 134, 151, 235], 'measured': [91], 'before': [92], 'after': [94, 112, 142], '4': [95, 113, 145], 'months': [96, 114], 'treatment.The': [98], 'adverse': [99, 187, 250], 'reactions': [100], 'recorded.\r\n\r\n\r\nResults\r\nThe': [102], 'total': [103], 'effective': [104], 'rate': [105, 185], '95.56%': [111], 'treatment,': [116], 'which': [117, 163, 195], 'significantly': [119, 140, 165, 224], 'higher': [120], 'than': [121, 167], '80.00%': [122], '(χ2=8.196,': [127], 'P=0.016).': [128], 'The': [129, 183], 'ACCP,': [130, 147, 232], 'RF': [131, 148], 'CRP': [133, 150, 234], 'decreased': [141], 'for': [144], 'months.The': [146], '(12': [157], '423.68±174.82)U/L,': [158], '(6.24±2.14)U/L,': [159], '(6.69±3.32)mg/L,': [161], 'respectively,': [162], 'lower': [166], 'those': [168], '[(15': [173], '421.27±287.33)U/L,': [174], '(16.58±3.26)U/L,': [175], '(10.14±5.22)mg/L,': [176], 't=59.787,': [177], '17.786,': [178], '3.741,': [179], 'P=0.000,': [180], '0.000,': [181], '0.000].': [182], 'incidence': [184], 'reaction': [188], '6.67%,': [194], '4.44%,': [201], 'difference': [203], 'between': [204], 'not': [209, 248], 'statistically': [210], 'significant': [211], '(χ2=0.211,': [212], 'P=0.645).\r\n\r\n\r\nConclusion\r\nMethotrexate': [213], 'can': [223], 'improve': [225], 'efficacy,': [228], 'reduce': [229], 'serum': [231], 'RF,': [233], 'a': [239], 'certain': [240, 253], 'degree': [241, 254], 'disease,': [246], 'while': [247], 'increasing': [249], 'reactions,': [251], 'has': [252], 'safety.\r\n\r\n\r\nKey': [256], 'words:': [257], '\r\nArthritis,': [258], 'rheumatoid;\xa0Rheumatoid': [259], 'factor;\xa0Anti-cyclic': [260], 'antibody;\xa0C-reactive': [263], 'protein;\xa0Methotrexate;\xa0Leflunomide;\xa0Controlled': [264], 'trial': [266]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029517488', 'counts_by_year': [], 'updated_date': '2024-12-15T08:15:11.381141', 'created_date': '2020-06-05'}