Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3029339808', 'doi': 'https://doi.org/10.3760/cma.j.issn.1008-1372.2008.01.015', 'title': 'Curcumin inhibit the expression of VEGF and HIF-1α protein in human hepatocellular carcinoma BEL-7402 cells by PI3K/AKT/FRAP signal transduction pathway', 'display_name': 'Curcumin inhibit the expression of VEGF and HIF-1α protein in human hepatocellular carcinoma BEL-7402 cells by PI3K/AKT/FRAP signal transduction pathway', 'publication_year': 2008, 'publication_date': '2008-01-10', 'ids': {'openalex': 'https://openalex.org/W3029339808', 'doi': 'https://doi.org/10.3760/cma.j.issn.1008-1372.2008.01.015', 'mag': '3029339808'}, 'language': 'vi', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN431274200801/275125.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306541551', 'display_name': '中国医师杂志', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085378109', 'display_name': '孙军', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': '孙军', 'raw_affiliation_strings': ['辽宁省锦州市中心医院消化内科,辽宁,锦州,121004'], 'affiliations': [{'raw_affiliation_string': '辽宁省锦州市中心医院消化内科,辽宁,锦州,121004', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016256924', 'display_name': '李岩', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': '李岩', 'raw_affiliation_strings': ['中国医科大学盛京医院消化内科'], 'affiliations': [{'raw_affiliation_string': '中国医科大学盛京医院消化内科', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5036755488', 'display_name': '王贺玲', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': '王贺玲', 'raw_affiliation_strings': ['中国医科大学盛京医院消化内科'], 'affiliations': [{'raw_affiliation_string': '中国医科大学盛京医院消化内科', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 63}, 'biblio': {'volume': '10', 'issue': '01', 'first_page': '41', 'last_page': '44'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Metabolic Reprogramming in Cancer Biology', 'score': 0.9847, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Metabolic Reprogramming in Cancer Biology', 'score': 0.9847, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13779', 'display_name': 'Role of Pim Oncogenes in Tumorigenesis', 'score': 0.9806, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Lipid Metabolism in Cancer Pathogenesis', 'score': 0.978, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ly294002', 'display_name': 'LY294002', 'score': 0.77809703}, {'id': 'https://openalex.org/keywords/mole', 'display_name': 'Mole', 'score': 0.51828116}, {'id': 'https://openalex.org/keywords/cancer-cell-metabolism', 'display_name': 'Cancer Cell Metabolism', 'score': 0.515225}], 'concepts': [{'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.7819247}, {'id': 'https://openalex.org/C2776912716', 'wikidata': 'https://www.wikidata.org/wiki/Q4042503', 'display_name': 'LY294002', 'level': 4, 'score': 0.77809703}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.6863265}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.68566406}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5426074}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.532441}, {'id': 'https://openalex.org/C124815738', 'wikidata': 'https://www.wikidata.org/wiki/Q41509', 'display_name': 'Mole', 'level': 2, 'score': 0.51828116}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.41793138}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3004669}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.29083335}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1811626}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN431274200801/275125.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306541551', 'display_name': '中国医师杂志', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/2', 'score': 0.55, 'display_name': 'Zero hunger'}, {'id': 'https://metadata.un.org/sdg/12', 'score': 0.41, 'display_name': 'Responsible consumption and production'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032828046', 'https://openalex.org/W3032673438', 'https://openalex.org/W3032096458', 'https://openalex.org/W3031369225', 'https://openalex.org/W3031239021', 'https://openalex.org/W3030912715', 'https://openalex.org/W3030625209', 'https://openalex.org/W3030522011', 'https://openalex.org/W3030292125', 'https://openalex.org/W3030038589', 'https://openalex.org/W3029343930', 'https://openalex.org/W3029332356', 'https://openalex.org/W3029284436', 'https://openalex.org/W3029168053', 'https://openalex.org/W3028625828', 'https://openalex.org/W2438057350', 'https://openalex.org/W2424702816', 'https://openalex.org/W2382208773', 'https://openalex.org/W2366978942', 'https://openalex.org/W227558992'], 'abstract_inverted_index': {'目的': [0], '探讨MAPK和PI3K信号传导通路在姜黄素调节VEGF和HIF-1α表达中的作用.方法': [1], '分别加入LY29400225': [2], 'μmol/L、50': [3], 'μmol/L,U0126': [4], '10': [5, 31, 35], 'μmol/L、20': [6], 'μmol/L,rapamycin': [7], '5': [8, 28], 'ng/ml、10': [9], 'ng/ml处理人肝癌细胞BEL-7402,30': [10], 'min后加入姜黄素10': [11], 'μmol/L,对照组单独加入0、10': [12], 'μmol/L姜黄素,缺氧环境中培养6': [13], 'h后,行RT-PCR和Western': [14], 'Blot检测VEGF蛋白、mRNA和HIF-1α蛋白表达;分别加入不同浓度的的姜黄素以及LY294002': [15], '25': [16, 22, 41, 44], 'μmol/L处理人肝癌细胞BEL-7402,缺氧环境中培养6': [17], 'h后,行Western': [18], 'Blot检测磷酸化AKT和总AKT蛋白表达.结果': [19], '姜黄素10': [20], 'μmol/L+LY294002': [21, 24], 'μmol/L组、姜黄素10': [23, 26, 36], '50': [25], 'μmol/L+rapamycin': [27, 30], 'ng/ml组、姜黄素10': [29], 'ng/ml组HIF-1α蛋白、VEGF蛋白、mRNA表达分别与姜黄素10': [32], 'μmol/L组相比降低,差异有统计学意义(P<0.01);而姜黄素10': [33], 'μmol/L+U0126': [34, 37], '20': [38], 'μmol/L组HIF-1α蛋白、VEGF蛋白、mRNA表达分别与姜黄素10': [39], 'μmol/L组相比差异无统计学意义(P>0.05);不同浓度的姜黄素、LY294002': [40], 'μmol/L处理的人肝癌细胞BEL-7402缺氧6': [42], 'h后磷酸化AKT蛋白表达逐渐降低,LY294002': [43], 'μmol/L可以基本阻断磷酸化AKT蛋白的表达,而对总AKT蛋白表达无明显变化.结论': [45], '姜黄素对人肝癌细胞BEL-7402中HIF-1α蛋白和VEGF的表达通过PI3K/AKT/FRAP信号传导通路。': [46]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029339808', 'counts_by_year': [], 'updated_date': '2024-09-18T17:34:47.944170', 'created_date': '2020-06-05'}