Title: Influencing factors and control mechanisms of premature zona hardening during oocyte cryopreservation
Abstract: Oocyte cryopreservation is an important assisted reproductive technology for the preservation of female fertility and the treatments of various fertility problems, but the premature hardening of the zona pellucida induced during oocyte cryopreservation leads to a significant decrease in fertilization rate of the cryopreserved oocytes byin vitro fertilization (IVF). The mechanism of premature hardening of the zona pellucida is unclear. In this paper we systematically reviewed the influencing factors and the control of the premature zona hardening during oocyte cryopreservation for the purpose of strengthening research to improve the effectiveness and safety of oocyte cryopreservation and assisted reproductive technologies.
Key words:
Fertilizationin vitro; Oocyte; Cryopreservation; Premature zona hardening
Publication Year: 2019
Publication Date: 2019-02-25
Language: en
Type: article
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