Title: Endoplasmic reficulmn stress and cognitive impairment
Abstract:In eukaryotic cells, endoplasmic reticulum (ER) is a locus where the proteins are modified, folded and the calcium is stored. When the harmful factors, such as ischemia/hypoxia, lack of nutrients, vir...In eukaryotic cells, endoplasmic reticulum (ER) is a locus where the proteins are modified, folded and the calcium is stored. When the harmful factors, such as ischemia/hypoxia, lack of nutrients, viral infections, and toxins cause the homeostasis damage in the endoplasmic reticulum, the accumulation of unfolded or misfolded proteins and the calcium imbalance may result in endoplasmic reticulum stress (ERS). ERS induces the expression of endoplasmic reticulum chaperones and endoplasmic reticulum associated degradation components, and reduces the load of the endoplasmic reticulurn by temporarily reducing protein synthesis. Studies have shown that many diseases that can induce cognitive impairment are all associated with ERS.
Key words:
Stress, Physiological; Endoplasmic Reticulum; Cognition DisordersRead More
Publication Year: 2014
Publication Date: 2014-03-28
Language: en
Type: article
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