Abstract: Maturity-onset diabetes of the young (MODY) is a young-onset diabetes mellitus with a autosomal-dominant mode of transmission.At least thirteen subtypes with distinct genetic aetiologies have been reported:MODY1 (hepatocyte nuclear factor 4α,HNF4α),MODY2 (glucokinase,GCK),MODY3 (hepatocyte nuclear factor 1α,HNF1α),MODY4 (insulin promoter factor 1,IPF1),MODY5 (hepatocyte nuclear factor 1β,HNF1β),MODY6 (neurogenic differentiation factor 1,NEUROD 1),MODY7 (kruppel-like factor 11,KLF11),MODY8 (carboxyl-ester lipase,CEL),MODY9 (paired-homeodomain transcription factor,PAX4),MODY10 (insulin gene),MODY1 1 (B-lymphocyte kinase,BLK),MODY1 2 (ATP-binding cassette,sub-family C member 8,ABCC8,and MODY13 (potassium inwardly-rectifying channel,subfamily J,member 11,KCNJ11).The etiopathogenisis,clinic phenotype and treatment of them are different.
Key words:
Maturity-onset diabetes of the young; Diabetes mellitus; Gene
Publication Year: 2013
Publication Date: 2013-07-20
Language: en
Type: article
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