Title: Clinical manifestations and outcome of vertebral artery dissection: 6 cases studies
Abstract:Objective To assess the clinical features,diagnosis,therapy and the prognosis of vertebral artery dissection presented as ischemie cerebral vascular disease.Methods Clinical and routine laboratory exa...Objective To assess the clinical features,diagnosis,therapy and the prognosis of vertebral artery dissection presented as ischemie cerebral vascular disease.Methods Clinical and routine laboratory examinations were performed in all the 6 patients,who underwent brain DSA,MRI,MRA and cervical vascular duplex ultrasound examinations.They fulfilled at least 1 of 2 imaging criteria used to diagnose vertebral dissection.Results There was sudden neck pain or occipital headache in 4 of the 6 eases.Vertigo and (or) dizziness were the main onset symptoms for all the subjects.Two cases presented Wallenberg syndrome; Three had recent trauma to the neck.DSA showed occlusion or stenosis of the vertebral artery.MRI showed an crescent-shaped intramural hematoma.Cervical vascular duplex ultrasound revealed normal intima-media thickness and no carotid atheroscleretic plaque,and displayed significant stenosis or occlusion of the involved vertebral artery.The dissections were found in the extracranial segment of the vertebral artery in 5 cases.The follow up period for all patients was approximately 26 months.The anticoagulant therapy was administered to all subjects for a period ranging from 9 to 53 months.The modified Rankin Scale (mRS)improved significantly as compared to baselines in all except for one ease,the mRS were4,4,4,2,2,2 vs 4,3,2,1,0,1 (Z=-2.07,P=0.038).Conclusions Vertebral artery dissection has unique clinical features.Neuroimnging is useful in confirming the diagnosis.The occlusive lesion of the involved vertebral artery is reversible under long-term anticoagulant treatment.The prognosis is relatively positive.
Key words:
Aneurysm,false; Vertebrobasilar insufficiency; Anticoagulants; PrognosisRead More
Publication Year: 2008
Publication Date: 2008-12-08
Language: en
Type: article
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